National Toxicology Program

CASRN: 22398-80-7

Formula: IN-P

Known Uses:

USED IN ELECTRONICS INDUSTRY; IN SEMICONDUCTOR DEVICES, INJECTOR LASERS, AND SOLAR CELLS. PROPOSED TO REPLACE SILICON IN COMPUTER MICROCHIPS.

Nomination Background

Short-Term Toxicity

• 3-DAY (Inhalation)  (C88124) Completed 
  • NTIS No. PB2002-100069  (Peer Review 05/18/2000)
    Citation: Toxicology and Carcinogenesis Studies of Indium Phosphide (CAS No. 22398-80-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 100 OR 300 MG/M3; 10/SEX/GROUP (NOSE ONLY)
• 13-WEEK (Inhalation)  (C88124) Completed 
  • NTIS No. PB2002-100069  (Peer Review 05/18/2000)
    Citation: Toxicology and Carcinogenesis Studies of Indium Phosphide (CAS No. 22398-80-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 1, 3, 10, 30, OR 100 MG/M3; 10/SEX/GROUP

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C88124) Report Complete 
  • TR-499 (NTIS No. PB2002-100069)  (Peer Review 05/18/2000)
    Toxicology and Carcinogenesis Studies of Indium Phosphide (CAS No. 22398-80-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats Clear Evidence 
  • Male Mice Clear Evidence 
  • Female Mice Clear Evidence 
  • Dose: R&M: 0, 0.03, 0.1, OR 0.3 MG/M3

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage)  (S0260) Completed 
  • M Rats: F344/N
  • Dose: 10 MG/KG

Genetic Toxicology

• Micronucleus  (A49283) Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative