Testing Information

Testing Status of Agents at NTP

CAS Registry Number: 4342-03-4

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http://ntp.niehs.nih.gov/go/25243

Selected information from two of the National Library of Medicine's databases: ChemIDPlus1 and HSDB2.

Names (NTP)

  • Dacarbazine
  • 5-(3,3-DIMETHYL-L-TRIAZENYL)-1H-IMIDAZOLE-4-CARBOXAMIDE (9CI)
  • DIC

Structure

Chemical Structure for CAS Registry Number 4342-03-4 from NLM

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Chemical Properties2

Property Description
Color/Form
  • IVORY MICROCRYSTALINE SUBSTANCE
Odor
  • None found
Taste
  • None found
Boiling Point
  • None found
Melting Point
  • 205 DEG C
Molecular Weight
  • 182.18
Corrosivity
  • None found
Critical Temperature & Pressure
  • None found
Density/Specific Gravity
  • None found
Disassociation Constants
  • pKa= 4.42
Heat of Combustion
  • None found
Heat of Vaporization
  • None found
log P (octanol-water)
  • log P = -0.24
pH
  • None found
Solubilities
  • Water: (1 mg/ml at room temp)
Spectral Properties
  • MAX ABSORPTION (0.1 N HCL): 223 NM (7500), (PH 7): 237 NM (11,200)
Surface Tension
  • None found
Vapor Density
  • None found
Vapor Pressure
  • None found
Relative Evaporation Rate
  • None found
Viscosity
  • None found
Other Properties
  • Melting point: 250-255 deg C (explosive decomposition)
  • Sensitive to oxidation; stable in neutral solutions in absence of light. Extremely light-sensitive: rapidly undergoes chemical decomposition to form 4-diazoimidazole-5-carboxamide ... .

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Uses2

  • MEDICATION **PEER REVIEWED**

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Superlist Classes1

  • Overall Carcinogenic Evaluation: Group 2B
  • Reasonably anticipated to be a carcinogen

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Notes (Sources: NTP,HSDB,RTECS,MESH)1

  • None found

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Other Registry Numbers1

  • 37626-23-6

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Synonyms (Sources: NTP, HSDB,RTECS,MESH)1

  • Biocarbazine R
  • Dacarbazine
  • Deticene
  • (Dimethyltriazeno)imidazolecarboxamide
  • 4-(3,3-Dimethyl-1-triazeno)imidazole-5-carboxamide
  • 4-(Dimethyltriazeno)imidazole-5-carboxamide
  • 4-(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide
  • 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide
  • 5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide
  • 5-(Dimethyltriazeno)imidazole-4-carboxamide
  • HSDB 3219
  • 1H-imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-
  • Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-
  • NCI-C04717
  • NSC-45388

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Links to Additional Information1

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Footnotes

1 Source: the National Library of Medicine's ChemIDPlus, 10/28/2007.

2 Source: the National Library of Medicine's Hazardous Substance Database, 10/28/2007.

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Web page last updated on May 14, 2008