Thiebaut R, Receveur MC, Malvy D, Djossou F, Morlat P, Mercie P, Le Bras M, Dabis F; International Conference on AIDS.

Int Conf AIDS. 2000 Jul 9-14; 13: abstract no. WePeB4239.

R. Thiebaut, INSERM U330, 146 rue Leo Saignat, 33046 Bordeaux cedex, France, Tel.: +33 5 57 57 11 40, Fax: +33 5 56 99 13 60, E-mail: rodolphe.thiebaut@dim.u-bordeaux2.fr

Background: The number of HIV-infected travellers is increasing. However, data on yellow fever (YF) vaccination of such patients are sparse. Objective: To describe HIV-infected patients intending to travel in YF endemic areas and the HIV-related immuno-virological impact of YF vaccination. Method: Eligible patients were HIV infected travellers who consulted at the Bordeaux Hospital International Vaccination centre in 1998-1999. When YF vaccination was performed, CD4 cell count and viral load evolutions were described using the GECSA (Groupe d'Epidemiologie Clinique du SIDA en Aquitaine) information system. Results: Among 24 HIV infected patients requesting vaccination in the centre, 17 intended to travel to YF endemic area (Senegal, Ivory coast and French Guiana). 3 of these were already protected because of a prior vaccination (control serology titer was > 1/20) and were not offered a re-vaccination. 2 patients were refused vaccination because of a CD4 cell count > 200 cells/mm3. Finally, 12 patients were vaccinated with YF (17D strain vaccine): 4 in 1998 and 8 in 1999. At the time of vaccination, median CD4 cell count was 523 (range 500;779) and median viral load 1500 copies/ml (range 50;330000). Follow-up is available at 6 months for 6 vaccinated patients so far. Median differences were -36 CD4 cells/mm3 (range -195;+108) and +70 HIV RNA copies/ml (range -319346;+726). No patient had experienced an acute infection between the two biological result. Conclusion: Among HIV patients included in this study, 71% travelled in an area where YF vaccination was mandatory. Among the patients who were vaccinated accounting for their immunological status, CD4 cells count and viral load evolution did not appear to be modified by the vaccination. Additional data from the 6 other patients will allow to test the differences between M0 and M6 values.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Blood Transfusion
• CD4 Lymphocyte Count
• Cote d'Ivoire
• France
• French Guiana
• HIV Infections
• HIV Seropositivity
• Humans
• Senegal
• Vaccination
• Viral Load

Other ID:

• GWAIDS0002957

UI: 102240451

From Meeting Abstracts