BLASTP 2.0.8 [Jan-05-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= YAR015W ADE1, Chr I from 169366-170286
         (306 letters)

Database: nr
           361,503 sequences; 110,384,460 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

gi|2144564|pir||JQ1395 phosphoribosylaminoimidazolesuccinocarbo...   620  e-177
gi|131634|sp|P27616|PUR7_YEAST PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUC...   617  e-176
gi|1709931|sp|P50124|PUR7_PICJA PHOSPHORIBOSYLAMIDOIMIDAZOLE-SU...   429  e-120
gi|1346914|sp|P27602|PUR7_CANMA PHOSPHORIBOSYLAMIDOIMIDAZOLE-SU...   376  e-103
gi|1172759|sp|P43060|PUR7_CANAL PHOSPHORIBOSYLAMIDOIMIDAZOLE-SU...   375  e-103
gi|1084496|pir||S55292 phosphoribosylaminoimidazolesuccinocarbo...   371  e-102
gi|2118357|pir||S55291 phosphoribosylaminoimidazolesuccinocarbo...   369  e-101
gi|1084497|pir||S55293 phosphoribosylaminoimidazolesuccinocarbo...   358  2e-98
gi|1172760|sp|P43851|PUR7_HAEIN PUTATIVE PHOSPHORIBOSYLAMINOIMI...   260  7e-69
gi|1144522 (U34957) phosphoribosylaminoimidazolesuccinocarboxam...   238  4e-62
gi|2842620|sp|Q59566|PUR7_MYCTU PHOSPHORIBOSYLAMINOIMIDAZOLE-SU...   237  8e-62
gi|2811063|sp|O08361|PUR7_MYCLE PHOSPHORIBOSYLAMINOIMIDAZOLE-SU...   235  4e-61
gi|585762|sp|P38025|PUR7_ARATH PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUC...   138  4e-32
gi|629654|pir||S43323 5'-phosphoribosyl-4-(N-succinocarboxamide...   134  9e-31
gi|1709932|sp|Q07463|PUR7_VIGAC PHOSPHORIBOSYLAMIDOIMIDAZOLE-SU...   134  9e-31
gi|170644 (M92931) 5'-phosphoribosyl-4-(N-succinocarboxamide)-5...   134  9e-31
gi|1084498|pir||S55294 phosphoribosylaminoimidazolesuccinocarbo...    99  3e-20
gi|3256628|gnl|PID|d1030254 (AP000001) 238aa long hypothetical ...    94  1e-18
gi|2129197|pir||G64498 phosphoribosylaminoimidazolesuccinocarbo...    79  3e-14
gi|2984328 (AE000774) phosphoribosylaminoimidazole-succinocarbo...    78  7e-14
gi|585763|sp|Q07296|PUR7_STRPN PHOSPHORIBOSYLAMINOIMIDAZOLE-SUC...    70  2e-11
gi|131631|sp|P12046|PUR7_BACSU PHOSPHORIBOSYLAMINOIMIDAZOLE-SUC...    62  6e-09
gi|2621212 (AE000804) phosphoribosylaminoimidazolesuccinocarbox...    60  2e-08
gi|131633|sp|P21155|PUR7_ECOLI PHOSPHORIBOSYLAMINOIMIDAZOLE-SUC...    59  5e-08
gi|1652590|gnl|PID|d1018244 (D90906) phosphoribosyl aminoidazol...    58  9e-08
gi|131628|sp|P22234|PUR6_HUMAN MULTIFUNCTIONAL PROTEIN ADE2 (PH...    55  5e-07
gi|2649307 (AE001016) phosphoribosylaminoimidazolesuccinocarbox...    55  6e-07
gi|1709928|sp|P51583|PUR6_RAT MULTIFUNCTIONAL PROTEIN ADE2 (PHO...    54  1e-06
gi|4097530 (U64311) phosphoribosylaminoimidazolesuccinocarboxam...    53  3e-06
gi|4043|emb|CAA43043| (X60549) ADE1 [Saccharomyces cerevisiae]        50  2e-05
gi|585761|sp|P38024|PUR6_CHICK MULTIFUNCTIONAL PROTEIN ADE2 (PH...    47  1e-04
gi|1709927|sp|Q10457|PUR6_CAEEL PROBABLE MULTIFUNCTIONAL PROTEI...    46  3e-04

>gi|2144564|pir||JQ1395
           phosphoribosylaminoimidazolesuccinocarboxamide synthase
           (EC 6.3.2.6) - yeast (Saccharomyces cerevisiae)
           >gi|170999 (M67445)
           phosphoribosyl-amino-imidazolesuccinocarboxamide
           synthetase [Saccharomyces cerevisiae] >gi|349755
           (L22015) Ade1p: phosphoribosyl amino
           imidazolesuccinocarbozamide synthetase [Saccharomyces
           cerevisiae]
           Length = 306
           
 Score =  620 bits (1581), Expect = e-177
 Identities = 306/306 (100%), Positives = 306/306 (100%)

Query: 1   MSITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKL 60
           MSITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKL
Sbjct: 1   MSITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKL 60

Query: 61  SEFWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVI 120
           SEFWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVI
Sbjct: 61  SEFWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVI 120

Query: 121 VRGYITGSAWKEYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAA 180
           VRGYITGSAWKEYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAA
Sbjct: 121 VRGYITGSAWKEYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAA 180

Query: 181 ELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDS 240
           ELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDS
Sbjct: 181 ELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDS 240

Query: 241 SRFWNGASYKVGESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLT 300
           SRFWNGASYKVGESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLT
Sbjct: 241 SRFWNGASYKVGESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLT 300

Query: 301 GSKWSH 306
           GSKWSH
Sbjct: 301 GSKWSH 306


>gi|131634|sp|P27616|PUR7_YEAST
           PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE
           (SAICAR SYNTHETASE) >gi|170996 (M61209)
           N-succinyl-5-aminoimidazole-4-carboxamide ribotide
           synthetase [Saccharomyces cerevisiae]
           Length = 306
           
 Score =  617 bits (1574), Expect = e-176
 Identities = 305/306 (99%), Positives = 305/306 (99%)

Query: 1   MSITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKL 60
           MSITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKL
Sbjct: 1   MSITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKL 60

Query: 61  SEFWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVI 120
           SEFWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVI
Sbjct: 61  SEFWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVI 120

Query: 121 VRGYITGSAWKEYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAA 180
           VRGYITGSAWKEYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAA
Sbjct: 121 VRGYITGSAWKEYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAA 180

Query: 181 ELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDS 240
           ELVG DLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDS
Sbjct: 181 ELVGGDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDS 240

Query: 241 SRFWNGASYKVGESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLT 300
           SRFWNGASYKVGESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLT
Sbjct: 241 SRFWNGASYKVGESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLT 300

Query: 301 GSKWSH 306
           GSKWSH
Sbjct: 301 GSKWSH 306


>gi|1709931|sp|P50124|PUR7_PICJA
           PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE
           (SAICAR SYNTHETASE) >gi|543485|pir||JC2039
           phosphoribosylaminoimidazolesuccinocarboxamide synthase
           (EC 6.3.2.6) - yeast (Pichia jadinii)
           >gi|391937|gnl|PID|d1004694 (D17356)
           phosphoribosylaminoimidazolesuccinocarboxamide
           synthetase [Candida utilis] >gi|740931|prf||2006225A
           phosphoribosylaminoimidazolesuccinocarboxamide
           synthetase [Pichia jadinii]
           Length = 301
           
 Score =  429 bits (1092), Expect = e-120
 Identities = 211/304 (69%), Positives = 251/304 (82%), Gaps = 4/304 (1%)

Query: 1   MSITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKL 60
           MSIT+T LD ILPLVARGKVRDIYEVD  TLLFVATDRISAYDVIMEN IP+KG LLT+L
Sbjct: 1   MSITQTNLDNILPLVARGKVRDIYEVDEKTLLFVATDRISAYDVIMENGIPQKGQLLTQL 60

Query: 61  SEFWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVI 120
           SEFWF+FL   ++ HL+++     IF +LP  LSE +YK+QL+  SLLV K+KL+PLEVI
Sbjct: 61  SEFWFEFLKPYIKTHLIEV---DDIFAHLPKVLSEDRYKSQLQGGSLLVRKYKLVPLEVI 117

Query: 121 VRGYITGSAWKEYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAA 180
           VRGYITGSAWK Y K+GTVHG+K  +GL+ESQEFP PIFTPSTKAEQGEHDENIS  QA 
Sbjct: 118 VRGYITGSAWKVYKKSGTVHGVKAAEGLQESQEFPTPIFTPSTKAEQGEHDENISVEQAE 177

Query: 181 ELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDS 240
            +VG++L+ ++ ++AV+LYSK K YA  +GIIIADTKFEFG+D+  NE++LVDEVLTPDS
Sbjct: 178 AIVGKELADKIGKVAVELYSKAKGYAAGRGIIIADTKFEFGLDD-DNELVLVDEVLTPDS 236

Query: 241 SRFWNGASYKVGESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLT 300
           SRFWN  +Y+VG+ QDSYDKQFLRDWLT+N L G  GV M +DI  R+R KY+EAYE LT
Sbjct: 237 SRFWNAKTYEVGKGQDSYDKQFLRDWLTSNGLAGKEGVSMTEDIATRSRVKYVEAYEALT 296

Query: 301 GSKW 304
           G KW
Sbjct: 297 GKKW 300


>gi|1346914|sp|P27602|PUR7_CANMA
           PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE
           (SAICAR SYNTHETASE) >gi|83924|pir||JH0489
           phosphoribosylaminoimidazolesuccinocarboxamide synthase
           (EC 6.3.2.6) - yeast (Candida maltosa) >gi|170816
           (M58322)
           phosphoribosyl-amidoimidazole-succinocarboxamide
           synthetase [Candida maltosa] >gi|218521|gnl|PID|d1001191
           (D00855) C-ADE1 [Candida maltosa]
           Length = 291
           
 Score =  376 bits (954), Expect = e-103
 Identities = 198/303 (65%), Positives = 234/303 (76%), Gaps = 15/303 (4%)

Query: 3   ITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSE 62
           +T T L+G  PL+A+GKVRDIY+VD  TLLFVATDRISAYDVIM N IP KG +LTKLSE
Sbjct: 1   MTSTNLEGTFPLIAKGKVRDIYQVDDNTLLFVATDRISAYDVIMSNGIPNKGKILTKLSE 60

Query: 63  FWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVR 122
           FWF FL   + NHL+       IF   P    EP Y+ QLE RSLLV K KLIPLEVIVR
Sbjct: 61  FWFDFLP--IENHLIK----GDIFQKYPQL--EP-YRNQLEGRSLLVRKLKLIPLEVIVR 111

Query: 123 GYITGSAWKEYVKTGTVHGLKQPQG-LKESQEFPEPIFTPSTKAEQGEHDENISPAQAAE 181
           GYITGS WKEY K+ TVHG+  P G + ESQ+   PIFTPSTKAEQGEHDENI+  QA +
Sbjct: 112 GYITGSGWKEYQKSKTVHGI--PIGDVVESQQIT-PIFTPSTKAEQGEHDENITKEQADK 168

Query: 182 LVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSS 241
           +VG++L  R+ ++A+ LY+K +DYA  KGIIIADTKFEFG+D   + I+LVDEVLTPDSS
Sbjct: 169 IVGKELCDRIEKIAIDLYTKARDYAATKGIIIADTKFEFGLDG--DNIVLVDEVLTPDSS 226

Query: 242 RFWNGASYKVGESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLTG 301
           RFWN A Y+VG+SQDSYDKQFLRDWLT+N + G +GV MP+DIV  T++KY+EAYE LTG
Sbjct: 227 RFWNAAKYEVGKSQDSYDKQFLRDWLTSNGVAGKDGVAMPEDIVTETKSKYVEAYENLTG 286

Query: 302 SKW 304
            KW
Sbjct: 287 DKW 289


>gi|1172759|sp|P43060|PUR7_CANAL
           PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE
           (SAICAR SYNTHETASE) >gi|295566 (L12463)
           phosphoribosyl-amidoimidazole-succinocarboxamide
           synthetase [Candida albicans]
           Length = 291
           
 Score =  375 bits (952), Expect = e-103
 Identities = 197/303 (65%), Positives = 234/303 (77%), Gaps = 15/303 (4%)

Query: 3   ITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSE 62
           +T T L+G  PL+ARGKVRDIY+VD  TLLFVATDRISAYDVIM N IP KG +LTKLSE
Sbjct: 1   MTSTNLEGTFPLIARGKVRDIYQVDDNTLLFVATDRISAYDVIMANGIPNKGKILTKLSE 60

Query: 63  FWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVR 122
           FWF FL  D  NHL+       IF+  P      KY+ QLE RSLLV K KLIPLEVIVR
Sbjct: 61  FWFAFLPID--NHLIK----GDIFEKYPQL---EKYRDQLEGRSLLVRKLKLIPLEVIVR 111

Query: 123 GYITGSAWKEYVKTGTVHGLKQPQG-LKESQEFPEPIFTPSTKAEQGEHDENISPAQAAE 181
           GYITGS WKEY K+ TVHG+  P G + ESQ+   PIFTPSTKAEQGEHDENI+  QA +
Sbjct: 112 GYITGSGWKEYTKSKTVHGI--PIGDVVESQQIT-PIFTPSTKAEQGEHDENITKEQADK 168

Query: 182 LVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSS 241
           +VG++L  R+ ++A+ LY+K +DYA  KGIIIADTKFEFG+D   ++I+LVDEVLTPDSS
Sbjct: 169 IVGKELCDRIEKIAIDLYTKARDYAATKGIIIADTKFEFGLDG--DKIVLVDEVLTPDSS 226

Query: 242 RFWNGASYKVGESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLTG 301
           RFW+ A YK+G+SQ+SYDKQFLRDWLTAN + G +GV MP+DI  +T+ KY+EAYE LTG
Sbjct: 227 RFWSAAKYKLGQSQESYDKQFLRDWLTANGVAGKDGVAMPEDIAVQTKQKYVEAYENLTG 286

Query: 302 SKW 304
            KW
Sbjct: 287 EKW 289


>gi|1084496|pir||S55292
           phosphoribosylaminoimidazolesuccinocarboxamide synthase
           (EC 6.3.2.6) (clone CipA400) - yeast (Candida maltosa)
           Length = 291
           
 Score =  371 bits (943), Expect = e-102
 Identities = 196/303 (64%), Positives = 233/303 (76%), Gaps = 15/303 (4%)

Query: 3   ITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSE 62
           +T T L+G  PL+A+GKVRDIY+VD  TLLFVATDRISAYDVIM N IP KG +LTKLSE
Sbjct: 1   MTSTNLEGTFPLIAKGKVRDIYQVDDNTLLFVATDRISAYDVIMSNGIPNKGKILTKLSE 60

Query: 63  FWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVR 122
           FWF FL   + NHL+       IF   P    EP Y+ QLE RSLLV K KLIPLEVIVR
Sbjct: 61  FWFDFLP--IENHLIK----GDIFQKYPQL--EP-YRNQLEGRSLLVRKLKLIPLEVIVR 111

Query: 123 GYITGSAWKEYVKTGTVHGLKQPQG-LKESQEFPEPIFTPSTKAEQGEHDENISPAQAAE 181
           GYITGS WKEY K+ TVHG+  P G + ESQ+   PIFTP+TKAEQGEH ENI+  QA +
Sbjct: 112 GYITGSGWKEYQKSKTVHGI--PIGDVVESQQIT-PIFTPTTKAEQGEHAENITKEQADK 168

Query: 182 LVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSS 241
           +VG++L  R+ ++A+ LY+K +DYA  KGIIIADTKFEFG+D   + I+LVDEVLTPDSS
Sbjct: 169 IVGKELCDRIEKIAIDLYTKARDYAATKGIIIADTKFEFGLDG--DNIVLVDEVLTPDSS 226

Query: 242 RFWNGASYKVGESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLTG 301
           RFWN A Y+VG+SQDSYDKQFLRDWLT+N + G +GV MP+DIV  T++KY+EAYE LTG
Sbjct: 227 RFWNAAKYEVGKSQDSYDKQFLRDWLTSNGVAGKDGVAMPEDIVTETKSKYVEAYENLTG 286

Query: 302 SKW 304
            KW
Sbjct: 287 DKW 289


>gi|2118357|pir||S55291
           phosphoribosylaminoimidazolesuccinocarboxamide synthase
           (EC 6.3.2.6) (clone CipA300) - yeast (Candida maltosa)
           Length = 291
           
 Score =  369 bits (936), Expect = e-101
 Identities = 195/303 (64%), Positives = 231/303 (75%), Gaps = 15/303 (4%)

Query: 3   ITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSE 62
           +T T L+G  PL+A+GKVRDIY+VD  TLLFVATDRISAYDVIM   IP KG +LTKLSE
Sbjct: 1   MTSTNLEGTFPLIAKGKVRDIYQVDDNTLLFVATDRISAYDVIMSKGIPNKGKILTKLSE 60

Query: 63  FWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVR 122
           FWF FL   + NHL+       IF   P    EP Y+ QLE RSLLV K KLIPLEVIVR
Sbjct: 61  FWFDFLP--IENHLIK----GDIFQKYPQL--EP-YRNQLEGRSLLVRKLKLIPLEVIVR 111

Query: 123 GYITGSAWKEYVKTGTVHGLKQPQG-LKESQEFPEPIFTPSTKAEQGEHDENISPAQAAE 181
           GYITGS WKEY K+ TVHG+  P G + ESQ+   PIFTPSTKAEQGEHDENI+  QA +
Sbjct: 112 GYITGSGWKEYQKSKTVHGI--PIGDVVESQQIT-PIFTPSTKAEQGEHDENITKEQADK 168

Query: 182 LVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSS 241
           +VG++L  R+ ++A+ LY+K +DYA  KGIIIADTKFEFG+D   + I+LVDEVL PDSS
Sbjct: 169 IVGKELCDRIEKIAIDLYTKARDYAATKGIIIADTKFEFGLDG--DNIVLVDEVLPPDSS 226

Query: 242 RFWNGASYKVGESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLTG 301
            FWN A Y+VG+SQDSYDKQFLRDWLT+N + G +GV MP+DIV  T++KY+EAYE LTG
Sbjct: 227 TFWNAAKYEVGKSQDSYDKQFLRDWLTSNGVAGKDGVAMPEDIVTETKSKYVEAYENLTG 286

Query: 302 SKW 304
            KW
Sbjct: 287 DKW 289


>gi|1084497|pir||S55293
           phosphoribosylaminoimidazolesuccinocarboxamide synthase
           (EC 6.3.2.6) (clone CipA10) - yeast (Candida maltosa)
           Length = 291
           
 Score =  358 bits (910), Expect = 2e-98
 Identities = 192/302 (63%), Positives = 228/302 (74%), Gaps = 15/302 (4%)

Query: 3   ITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSE 62
           +T T L+G  PL+A+GKVRDI +VD  TLLFVATDRISAYDVIM N IP KG +LTK SE
Sbjct: 1   MTATNLEGTFPLIAKGKVRDINQVDDNTLLFVATDRISAYDVIMSNGIPNKGKILTKFSE 60

Query: 63  FWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVR 122
           FWF FL   + NHL+       IF   P    EP Y+ QLE RSLLV K KLIPLEVIVR
Sbjct: 61  FWFDFLP--IENHLIK----GDIFQKYPQL--EP-YRNQLEGRSLLVRKLKLIPLEVIVR 111

Query: 123 GYITGSAWKEYVKTGTVHGLKQPQG-LKESQEFPEPIFTPSTKAEQGEHDENISPAQAAE 181
           GYITGS WKEY K+ TVHG+  P G + ESQ+   PIFTPSTKAEQGEHDENI+  QA +
Sbjct: 112 GYITGSGWKEYQKSKTVHGI--PIGDVVESQQIT-PIFTPSTKAEQGEHDENITKEQADK 168

Query: 182 LVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSS 241
           +VG++L  R+ + A+   +K +DYA  KGIIIADTKFEFG+D   + I+LVDEVLTPDSS
Sbjct: 169 IVGKELCDRIEKFAIDFSTKARDYAATKGIIIADTKFEFGLDG--DNIVLVDEVLTPDSS 226

Query: 242 RFWNGASYKVGESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLTG 301
           RFWN A Y+VG+SQDSYDKQFLRDWLT+N + G +GV +P+DIV  T++KY+EAYE LTG
Sbjct: 227 RFWNAAKYEVGKSQDSYDKQFLRDWLTSNGVAGKDGVDLPEDIVTETKSKYVEAYEKLTG 286

Query: 302 SK 303
            K
Sbjct: 287 DK 288


>gi|1172760|sp|P43851|PUR7_HAEIN PUTATIVE
           PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE
           (SAICAR SYNTHETASE) >gi|1075294|pir||E64138 SAICAR
           synthetase (purC) homolog - Haemophilus influenzae
           (strain Rd KW20) >gi|1574582 (U32845)
           phosphoribosylaminoimidazole-succinocarboxamide synthase
           (purC) [Haemophilus influenzae Rd]
           Length = 306
           
 Score =  260 bits (658), Expect = 7e-69
 Identities = 135/290 (46%), Positives = 195/290 (66%), Gaps = 11/290 (3%)

Query: 12  LPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSND 71
           L  +  GKVRD+YE+D   +L V +DR+SA+DVI+++ IP KG +LT++S FWF  L++ 
Sbjct: 26  LKKIYSGKVRDLYEIDDKRMLMVTSDRLSAFDVILDDPIPRKGEILTQISNFWFNKLAHI 85

Query: 72  VRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWK 131
           + NH      G +++D LP + ++      + DR+++  +   I +E IVRGY+TGS  K
Sbjct: 86  MPNHFT----GDSVYDVLPKEEAD-----LIRDRAVVCKRLNPIKIESIVRGYLTGSGLK 136

Query: 132 EYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAAELVGEDLSRRV 191
           +Y +TGT+ GLK P+GL E+ + PE IFTPS+K E G HD NIS A+  +L+G DL+ +V
Sbjct: 137 DYKQTGTICGLKLPEGLVEASKLPEAIFTPSSKEEVGNHDINISYAECEKLIGADLAAQV 196

Query: 192 AELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASYKV 251
            E A+ LY+   +YA  KGIII DTKFEFG+DE    + L+DEVLTPDSSRFW+  +Y+ 
Sbjct: 197 KEKAIALYTVAAEYALTKGIIICDTKFEFGLDE-NGTLTLMDEVLTPDSSRFWSVDTYQA 255

Query: 252 GESQDSYDKQFLRDWLTANKLN-GVNGVKMPQDIVDRTRAKYIEAYETLT 300
           G +  S+DKQF+RDWL  +  N      K+P++I+ +T  KY EA + LT
Sbjct: 256 GTNPPSFDKQFVRDWLENSGWNKQAPAPKVPENIIQKTVDKYQEALDLLT 305


>gi|1144522 (U34957) phosphoribosylaminoimidazolesuccinocarboxamide
           synthase [Mycobacterium tuberculosis]
           Length = 297
           
 Score =  238 bits (601), Expect = 4e-62
 Identities = 126/295 (42%), Positives = 185/295 (62%), Gaps = 21/295 (7%)

Query: 15  VARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVRN 74
           VA GKVR+IY VD   LL VA+DRISAYD +++++IP+KG +LT +S F+F  +  D  N
Sbjct: 11  VASGKVREIYRVDDEHLLLVASDRISAYDYVLDSTIPDKGRVLTAMSAFFFGLV--DAPN 68

Query: 75  HLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYV 134
           HL                  +P+   ++  R+L+V + +++P+E + RGY+TGS   +Y 
Sbjct: 69  HLA-------------GPPDDPRIPDEVLGRALVVRRLEMLPVECVARGYLTGSGLLDYQ 115

Query: 135 KTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAAELVGEDLSRRVAEL 194
            TG V G++ P GL E+  F  P+FTP+TKA  G+HDENIS  +  E+VG   + ++ + 
Sbjct: 116 ATGKVCGIRLPPGLVEASRFATPLFTPATKAALGDHDENISFDRVVEMVGPLRANQLRDR 175

Query: 195 AVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASYKVGES 254
            ++ Y +  D+A  +GIIIADTKFEFGID   N ++L DE+ TPDSSR+W    Y+ G  
Sbjct: 176 TLQTYVQAADHALTRGIIIADTKFEFGIDRHGN-LLLADEIFTPDSSRYWPADDYRAGVV 234

Query: 255 QDSYDKQFLRDWLTANKLNGVNG-----VKMPQDIVDRTRAKYIEAYETLTGSKW 304
           Q S+DKQF+R WLT ++     G       +P+ IV+ TRA+YI AYE ++  K+
Sbjct: 235 QTSFDKQFVRSWLTGSESGWDRGSDRPPPPLPEHIVEATRARYINAYERISELKF 289


>gi|2842620|sp|Q59566|PUR7_MYCTU
           PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE
           (SAICAR SYNTHETASE) >gi|1550658|emb|CAB02370| (Z80226)
           purC [Mycobacterium tuberculosis]
           Length = 297
           
 Score =  237 bits (598), Expect = 8e-62
 Identities = 126/295 (42%), Positives = 184/295 (61%), Gaps = 21/295 (7%)

Query: 15  VARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVRN 74
           VA GKVR+IY VD   LL VA+DRISAYD +++++IP+KG +LT +S F+F  +  D  N
Sbjct: 11  VASGKVREIYRVDDEHLLLVASDRISAYDYVLDSTIPDKGRVLTAMSAFFFGLV--DAPN 68

Query: 75  HLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYV 134
           HL                  +P+   ++  R+L+V + +++P+E + RGY+TGS   +Y 
Sbjct: 69  HLA-------------GPPDDPRIPDEVLGRALVVRRLEMLPVECVARGYLTGSGLLDYQ 115

Query: 135 KTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAAELVGEDLSRRVAEL 194
            TG V G+  P GL E+  F  P+FTP+TKA  G+HDENIS  +  E+VG   + ++ + 
Sbjct: 116 ATGKVCGIALPPGLVEASRFATPLFTPATKAALGDHDENISFDRVVEMVGALRANQLRDR 175

Query: 195 AVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASYKVGES 254
            ++ Y +  D+A  +GIIIADTKFEFGID   N ++L DE+ TPDSSR+W    Y+ G  
Sbjct: 176 TLQTYVQAADHALTRGIIIADTKFEFGIDRHGN-LLLADEIFTPDSSRYWPADDYRAGVV 234

Query: 255 QDSYDKQFLRDWLTANKLNGVNG-----VKMPQDIVDRTRAKYIEAYETLTGSKW 304
           Q S+DKQF+R WLT ++     G       +P+ IV+ TRA+YI AYE ++  K+
Sbjct: 235 QTSFDKQFVRSWLTGSESGWDRGSDRPPPPLPEHIVEATRARYINAYERISELKF 289


>gi|2811063|sp|O08361|PUR7_MYCLE
           PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE
           (SAICAR SYNTHETASE) >gi|2076622|emb|CAB08411| (Z95151)
           PurC [Mycobacterium leprae]
           Length = 297
           
 Score =  235 bits (592), Expect = 4e-61
 Identities = 121/292 (41%), Positives = 185/292 (62%), Gaps = 21/292 (7%)

Query: 15  VARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVRN 74
           +A GKVR+IY +D   LL VA+DRISA+D +++++IP+KG +LT +S F+F F+  D  N
Sbjct: 11  LASGKVREIYRIDDEHLLMVASDRISAFDYVLDSTIPDKGRILTAMSVFFFSFV--DAPN 68

Query: 75  HLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYV 134
           HL                  +P+   ++  R+L+V +  ++P+E + RGY+TGS   +Y 
Sbjct: 69  HLA-------------GPPDDPRIPEEVLGRALVVRQLDMLPMECVARGYLTGSGLLDYQ 115

Query: 135 KTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAAELVGEDLSRRVAEL 194
            TG V G+  P GL E+  F  P+FTP+ KA  GEHDENIS ++  E+VG   + ++ + 
Sbjct: 116 ATGKVCGIPLPPGLVEASRFAAPLFTPAMKAVLGEHDENISFSRMIEMVGVVRANQLRDR 175

Query: 195 AVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASYKVGES 254
            +++Y +  D+A + GIIIADTKFEFGID   N ++L DE+ TPDSSR+W+   Y+VG  
Sbjct: 176 TLQIYLQAADHALKTGIIIADTKFEFGIDRDGN-LLLADEIFTPDSSRYWSVDDYRVGVV 234

Query: 255 QDSYDKQFLRDWLTAN-----KLNGVNGVKMPQDIVDRTRAKYIEAYETLTG 301
           Q S+DKQF+R+WL +      +   ++   +P DI++ TR  Y+E YE ++G
Sbjct: 235 QRSFDKQFVRNWLVSPESGWVRAGALSPPSLPDDIIEATRLCYVEVYERISG 286


>gi|585762|sp|P38025|PUR7_ARATH
           PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE
           PRECURSOR (SAICAR SYNTHETASE) >gi|453384 (U05599) SAICAR
           synthetase [Arabidopsis thaliana]
           Length = 411
           
 Score =  138 bits (345), Expect = 4e-32
 Identities = 105/302 (34%), Positives = 156/302 (50%), Gaps = 44/302 (14%)

Query: 17  RGKVRDIYEVDAGT-LLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVRNH 75
           +GKVRDIY  DAG  L+ + TDR+SA+D  +  SIP KG +L + S +WF        N+
Sbjct: 111 KGKVRDIY--DAGDYLVLITTDRLSAFDRNLA-SIPFKGQVLNETSLWWF--------NN 159

Query: 76  LVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKH-KLIPLEVIVRGYITGSA----W 130
              I P   ++                 DR++++ K   + P+E +VRGY+TGS     W
Sbjct: 160 TQHITPNAMLYS---------------PDRNVVIAKKCSVFPIEFVVRGYVTGSTDTSLW 204

Query: 131 KEYVK-TGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAAE--LVGEDL 187
             Y K      G +   GL ++Q+ P  I TP+TKA   +HD  ISP +  E   + +  
Sbjct: 205 TVYNKGVRNYCGNELSDGLVKNQKLPANILTPTTKA--ADHDVPISPNEIVEGGFMTQAE 262

Query: 188 SRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGA 247
               +  A+ L+   +  AK+ G+I+ DTK+EFG       I+L+DE+ TPDSSR+W   
Sbjct: 263 FDEASMKALSLFEFGQGVAKKHGLILVDTKYEFG-RSSDGSILLIDEIHTPDSSRYWLAG 321

Query: 248 SY----KVGESQDSYDKQFLRDWLTANKLNGVNGV--KMPQDIVDRTRAKYIEAYETLTG 301
           SY    + G   ++ DK+FLR W   N     + V    P ++V     +YI  YET+TG
Sbjct: 322 SYEERFQKGLEPENVDKEFLRLWFKENCNPYEDEVLPAAPAELVTELAWRYIFLYETITG 381

Query: 302 SK 303
           S+
Sbjct: 382 SR 383


>gi|629654|pir||S43323 5'-phosphoribosyl-4-(N-succinocarboxamide
           )-5-ami noimidazole synthetase - moth bean
           Length = 341
           
 Score =  134 bits (333), Expect = 9e-31
 Identities = 104/285 (36%), Positives = 153/285 (53%), Gaps = 47/285 (16%)

Query: 3   ITKTELDGILP-LVA--RGKVRDIYEVDAGT-LLFVATDRISAYDVIMENSIPEKGILLT 58
           +++T L   +P LV+  RGKVRDIY  DAG  L+ V TDR SA+D I+  SIP KG +L 
Sbjct: 70  LSETNLHNTVPGLVSKTRGKVRDIY--DAGDYLVLVTTDRQSAFDRILA-SIPFKGQVLN 126

Query: 59  KLSEFWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLE 118
           + S +WF+     V N +V  AP K +                      +  K  + P+E
Sbjct: 127 ETSLWWFERTKQIVPNAVVS-APDKNV---------------------TIAKKCSVFPVE 164

Query: 119 VIVRGYITGSA----WKEYVKTGTVH-GLKQPQGLKESQEFPEPIFTPSTKAEQGEHDEN 173
            + RG++TGS     W  Y K    + G   P G+ ++Q+  E I TP+TKA   +HD  
Sbjct: 165 FVARGFVTGSTDTSLWTVYNKGARNYCGNVLPDGMVKNQKLSENILTPTTKA--ADHDVP 222

Query: 174 ISPAQAAE--LVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNE--I 229
           ++P +  E  L+       V+E A+ L+   +  A E G+I+ DTK+EFG   K N+  I
Sbjct: 223 VTPDEIIERGLMTRSDYEEVSEKALSLFEYGQQVASEHGLILVDTKYEFG---KANDGSI 279

Query: 230 ILVDEVLTPDSSRFWNGASY----KVGESQDSYDKQFLRDWLTAN 270
           +L+DEV TPDSSR+W  +SY    + G   ++ DK+FLR W  ++
Sbjct: 280 MLIDEVHTPDSSRYWIASSYPERFQNGLEPENIDKEFLRLWFKSH 324


>gi|1709932|sp|Q07463|PUR7_VIGAC
           PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE
           PRECURSOR (SAICAR SYNTHETASE) >gi|629655|pir||S45524
           5'-phosphoribosyl-4-(N-succinocarboxamide
           )-5-aminoimidazole synthetase - moth bean
           Length = 341
           
 Score =  134 bits (333), Expect = 9e-31
 Identities = 104/285 (36%), Positives = 153/285 (53%), Gaps = 47/285 (16%)

Query: 3   ITKTELDGILP-LVA--RGKVRDIYEVDAGT-LLFVATDRISAYDVIMENSIPEKGILLT 58
           +++T L   +P LV+  RGKVRDIY  DAG  L+ V TDR SA+D I+  SIP KG +L 
Sbjct: 70  LSETNLHNTVPGLVSKTRGKVRDIY--DAGDYLVLVTTDRQSAFDRILA-SIPFKGQVLN 126

Query: 59  KLSEFWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLE 118
           + S +WF+     V N +V  AP K +                      +  K  + P+E
Sbjct: 127 ETSLWWFERTKQIVPNAVVS-APDKNV---------------------TIAKKCSVFPVE 164

Query: 119 VIVRGYITGSA----WKEYVKTGTVH-GLKQPQGLKESQEFPEPIFTPSTKAEQGEHDEN 173
            + RG++TGS     W  Y K    + G   P G+ ++Q+  E I TP+TKA   +HD  
Sbjct: 165 FVARGFVTGSTDTSLWTVYNKGARNYCGNVLPDGMVKNQKLSENILTPTTKA--ADHDVP 222

Query: 174 ISPAQAAE--LVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNE--I 229
           ++P +  E  L+       V+E A+ L+   +  A E G+I+ DTK+EFG   K N+  I
Sbjct: 223 VTPDEIIERGLMTRSDYEEVSEKALSLFEYGQQVASEHGLILVDTKYEFG---KANDGSI 279

Query: 230 ILVDEVLTPDSSRFWNGASY----KVGESQDSYDKQFLRDWLTAN 270
           +L+DEV TPDSSR+W  +SY    + G   ++ DK+FLR W  ++
Sbjct: 280 MLIDEVHTPDSSRYWIASSYPERFQNGLEPENIDKEFLRLWFKSH 324


>gi|170644 (M92931) 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-ami
           noimidazole synthetase [Vigna aconitifolia]
           Length = 308
           
 Score =  134 bits (333), Expect = 9e-31
 Identities = 104/285 (36%), Positives = 153/285 (53%), Gaps = 47/285 (16%)

Query: 3   ITKTELDGILP-LVA--RGKVRDIYEVDAGT-LLFVATDRISAYDVIMENSIPEKGILLT 58
           +++T L   +P LV+  RGKVRDIY  DAG  L+ V TDR SA+D I+  SIP KG +L 
Sbjct: 37  LSETNLHNTVPGLVSKTRGKVRDIY--DAGDYLVLVTTDRQSAFDRILA-SIPFKGQVLN 93

Query: 59  KLSEFWFKFLSNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLE 118
           + S +WF+     V N +V  AP K +                      +  K  + P+E
Sbjct: 94  ETSLWWFERTKQIVPNAVVS-APDKNV---------------------TIAKKCSVFPVE 131

Query: 119 VIVRGYITGSA----WKEYVKTGTVH-GLKQPQGLKESQEFPEPIFTPSTKAEQGEHDEN 173
            + RG++TGS     W  Y K    + G   P G+ ++Q+  E I TP+TKA   +HD  
Sbjct: 132 FVARGFVTGSTDTSLWTVYNKGARNYCGNVLPDGMVKNQKLSENILTPTTKA--ADHDVP 189

Query: 174 ISPAQAAE--LVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNE--I 229
           ++P +  E  L+       V+E A+ L+   +  A E G+I+ DTK+EFG   K N+  I
Sbjct: 190 VTPDEIIERGLMTRSDYEEVSEKALSLFEYGQQVASEHGLILVDTKYEFG---KANDGSI 246

Query: 230 ILVDEVLTPDSSRFWNGASY----KVGESQDSYDKQFLRDWLTAN 270
           +L+DEV TPDSSR+W  +SY    + G   ++ DK+FLR W  ++
Sbjct: 247 MLIDEVHTPDSSRYWIASSYPERFQNGLEPENIDKEFLRLWFKSH 291


>gi|1084498|pir||S55294
          phosphoribosylaminoimidazolesuccinocarboxamide synthase
          (EC 6.3.2.6) - yeast (Candida maltosa)
          Length = 82
          
 Score = 99.5 bits (244), Expect = 3e-20
 Identities = 49/75 (65%), Positives = 57/75 (75%), Gaps = 2/75 (2%)

Query: 3  ITKTELDGILPLVARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSE 62
          +T T L+G  PL+A+GK RDI +VD  TLLFVATDRISAYDVIM N IP KG +LTK SE
Sbjct: 1  MTSTNLEGTFPLIAKGKGRDINQVDDHTLLFVATDRISAYDVIMSNGIPNKGKILTKFSE 60

Query: 63 FWFKFLSNDVRNHLV 77
          FWF FL   + NHL+
Sbjct: 61 FWFDFL--PIENHLI 73


>gi|3256628|gnl|PID|d1030254 (AP000001) 238aa long hypothetical
           phosphoribosylaminoimidazole-succinocarboxamide synthase
           [Pyrococcus horikoshii]
           Length = 238
           
 Score = 94.0 bits (230), Expect = 1e-18
 Identities = 86/291 (29%), Positives = 127/291 (43%), Gaps = 64/291 (21%)

Query: 15  VARGKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLS-NDVR 73
           V  GK + +  +D   L+    D  +A+D   +     KG L  +LS  +FK L  + ++
Sbjct: 7   VYEGKAKKMIPIDDDKLIMEFKDDATAFDGTKKARFKGKGWLNAQLSVIFFKLLEEHGIK 66

Query: 74  NHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEY 133
            H + +A G                        L+V K  + PLEV+VR  + GS     
Sbjct: 67  THFIGVAGGNR----------------------LIVEKLDMYPLEVVVRNVVAGS----- 99

Query: 134 VKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAAEL-VGEDLSRRVA 192
                   LK+   L E  E PEPI     K ++  HD  I+   A  L +  D  +++ 
Sbjct: 100 --------LKKRLPLPEGYELPEPIVELYYKNDE-LHDPMINYYHAKVLGISLDEIKKIE 150

Query: 193 ELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASYKVG 252
           E+A+K+    KDY  +KGII+ D K EFG D K  +I+L DE+ +PD+ RFW+       
Sbjct: 151 EIALKVNEILKDYLAKKGIILVDFKLEFGKD-KNGDIVLADEI-SPDTCRFWD------A 202

Query: 253 ESQDSYDKQFLRDWLTANKLNGVNGVKMPQDIVDRTRAKYIEAYETLTGSK 303
           +++ S DK   R                  D  D   A Y E YE +TG K
Sbjct: 203 KTKRSLDKDVFR-----------------FDKGDLIEA-YKEIYERITGEK 235


>gi|2129197|pir||G64498
           phosphoribosylaminoimidazolesuccinocarboxamide synthase
           (EC 6.3.2.6) - Methanococcus jannaschii >gi|1592203
           (U67599) phosphoribosylaminoimidazolesuccinocarboxamide
           synthase (purC) [Methanococcus jannaschii]
           Length = 242
           
 Score = 79.2 bits (192), Expect = 3e-14
 Identities = 71/249 (28%), Positives = 109/249 (43%), Gaps = 45/249 (18%)

Query: 18  GKVRDIYEVDAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLS-NDVRNHL 76
           GK + IYE+D   +L    D I+A +    +    KG L   +S   F+ L  N V+ H 
Sbjct: 17  GKAKSIYEIDDDKVLIEFRDDITAGNGAKHDVKQGKGYLNALISSKLFEALEENGVKTHY 76

Query: 77  VDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKT 136
           +              K  EP+Y        ++  K ++IP+EVIVR    GS  + Y   
Sbjct: 77  I--------------KYIEPRY--------MIAKKVEIIPIEVIVRNIAAGSLCRRYP-- 112

Query: 137 GTVHGLKQPQGLKESQEFPEPIFTPSTKAEQ-GEHDENISPAQAAELVGEDLSRRVAELA 195
                       +E +E P PI     K ++ G+   N   A A  L   +   ++ E+A
Sbjct: 113 -----------FEEGKELPFPIVQFDYKNDEYGDPMLNEDIAVALGLATREELNKIKEIA 161

Query: 196 VKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASYKVGESQ 255
           +K+    K    EKGII+ D K E G D + N  +LV + ++PD+ R W+       E++
Sbjct: 162 LKVNEVLKKLFDEKGIILVDFKIEIGKDREGN--LLVADEISPDTMRLWD------KETR 213

Query: 256 DSYDKQFLR 264
           D  DK   R
Sbjct: 214 DVLDKDVFR 222


>gi|2984328 (AE000774)
           phosphoribosylaminoimidazole-succinocarboxamide synthase
           [Aquifex aeolicus]
           Length = 216
           
 Score = 78.0 bits (189), Expect = 7e-14
 Identities = 64/232 (27%), Positives = 108/232 (45%), Gaps = 42/232 (18%)

Query: 18  GKVRDIYEVDA-GTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSND-VRNH 75
           GK + +YE D    L+    D  +A+D + +  I  KG L  ++S   F+ L +  ++ H
Sbjct: 10  GKAKIVYETDEKDKLILEFKDVATAFDGVKKEEIKGKGSLNNEISSLIFEILEDHGIKTH 69

Query: 76  LVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVK 135
                                 Y  +L DR +LV + +  P+EV+VR Y  GS  K Y  
Sbjct: 70  ----------------------YIKKLSDREMLVWRAERFPVEVVVRNYAAGSFVKRY-- 105

Query: 136 TGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDEN--ISPAQAAELVGEDLSRRVAE 193
                      G+KE  +  +P+     K+++  HD    I+  +  +L   +L   + +
Sbjct: 106 -----------GVKEGTKLEQPLVEFFMKSDE-LHDPMVCINHIKVLKLAPAELVPEMEK 153

Query: 194 LAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWN 245
           +A+K+    K   +EKGI++ D K EFG    + E+ +VDE+ +PDS R W+
Sbjct: 154 IALKVNEILKKIFEEKGILLVDFKLEFG-RLPSGELAIVDEI-SPDSMRLWD 203


>gi|585763|sp|Q07296|PUR7_STRPN
           PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE
           (SAICAR SYNTHETASE) >gi|625868|pir||A36941
           phosphoribosylaminoimidazolesuccinocarboxamide synthase
           (EC 6.3.2.6) - Streptococcus pneumoniae >gi|295192
           (L15190) SAICAR synthetase [Streptococcus pneumoniae]
           >gi|663281 (M36180) SAICAR synthetase [Streptococcus
           pneumoniae]
           Length = 235
           
 Score = 69.9 bits (168), Expect = 2e-11
 Identities = 67/234 (28%), Positives = 103/234 (43%), Gaps = 38/234 (16%)

Query: 14  LVARGKVRDIYEV-DAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSN-D 71
           L+  GK +DIY   D   ++    D+ +A++ + +  I  KG+L  ++S F F+ L+   
Sbjct: 5   LIYSGKAKDIYTTEDENLIISTYKDQATAFNGVKKEQIAGKGVLNNQISSFIFEKLNAAG 64

Query: 72  VRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWK 131
           V  H V+                      +L D   L  K K+IPLEV++R Y  GS  K
Sbjct: 65  VATHFVE----------------------KLSDTEQLNKKVKIIPLEVVLRNYTAGSFSK 102

Query: 132 EYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAAELVGEDLSRRV 191
            +   G   G+     + E     + +  P    E  +  +     Q A L  E  +RR+
Sbjct: 103 RF---GVDEGIALETPIVEFYYKNDDLDDPFINDEHVKFLQIADDQQIAYLKEE--ARRI 157

Query: 192 AELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWN 245
            EL        K +  E G+ + D K EFG D K  +IIL DE  +PD+ R W+
Sbjct: 158 NEL-------LKVWFAEIGLKLIDFKLEFGFD-KDGKIILADE-FSPDNCRLWD 202


>gi|131631|sp|P12046|PUR7_BACSU
           PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE
           (SAICAR SYNTHETASE) (VEGETATIVE PROTEIN 286A) (VEG286A)
           >gi|68623|pir||CEBSSC
           phosphoribosylaminoimidazolesuccinocarboxamide synthase
           (EC 6.3.2.6) - Bacillus subtilis >gi|143367 (J02732)
           phosphoribosyl aminoidazole succinocarboxamide
           synthetase (PUR-C; gtg start codon) [Bacillus subtilis]
           >gi|2632959|emb|CAB12465| (Z99107)
           phosphoribosylaminoimidazole succinocarboxamide
           synthetase [Bacillus subtilis]
           Length = 241
           
 Score = 61.7 bits (147), Expect = 6e-09
 Identities = 73/297 (24%), Positives = 125/297 (41%), Gaps = 75/297 (25%)

Query: 1   MSITKTELDGILPLVARGKVRDIYEVD-AGTLLFVATDRISAYDVIMENSIPEKGILLTK 59
           M+I K EL      +  GK + IY+ D   TL  V  D  +A++   +  I  KG L  +
Sbjct: 1   MNIVKNEL------LYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAEISGKGRLNNE 54

Query: 60  LSEFWFKFL-SNDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLE 118
           +S   FK L +  + NH ++                      ++ +   L+ K  ++PLE
Sbjct: 55  ISSLIFKHLHAKGINNHFIE----------------------RISETEQLIKKVTIVPLE 92

Query: 119 VIVRGYITGSAWKEY-VKTGTVHGLKQP--QGLKESQEFPEPIFTPS----TKAEQGEHD 171
           V+VR  + GS  K   +  GT   L+QP  +   +     +P+ T       KA   E  
Sbjct: 93  VVVRNVVAGSMSKRLGIPEGT--ELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQV 150

Query: 172 ENISPAQAAELVGEDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIIL 231
           E I       +V E+L          ++  C        + + D K EFG+D +  +++L
Sbjct: 151 ETIK--SITTIVNEELQ--------SIFDDCH-------VRLIDFKLEFGLDAE-GQVLL 192

Query: 232 VDEVLTPDSSRFWNGASYK----------VGESQDSYDKQFLRDWLTANKLNGVNGV 278
            DE+ +PD+ R W+  + +          +G   D+Y++ F       N+L G++ V
Sbjct: 193 ADEI-SPDTCRLWDKETNEKLDKDLFRRNLGSLTDAYEEIF-------NRLGGIHHV 241


>gi|2621212 (AE000804)
           phosphoribosylaminoimidazolesuccinocarboxamide synthase
           [Methanobacterium thermoautotrophicum]
           Length = 248
           
 Score = 59.7 bits (142), Expect = 2e-08
 Identities = 47/162 (29%), Positives = 72/162 (44%), Gaps = 16/162 (9%)

Query: 85  IFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTGTVHGLKQ 144
           IF+ L       +Y    E   +L  K ++IP+EVI R    GS  + +  T        
Sbjct: 59  IFEVLEEAGVPTQYLELREPGCILARKLEMIPIEVITRNIAAGSIVRRFPFT-------- 110

Query: 145 PQGLKESQEFPEPIFTPSTKA-EQGEHDENISPAQAAELVGEDLSRRVAELAVKLYSKCK 203
                E QEF  P+     K+ E G+   N     A  +   D    +  + + + S  +
Sbjct: 111 -----EGQEFVPPLIQMDYKSDEHGDPMLNDDIILALGIATRDELEEIRRITLHINSVLR 165

Query: 204 DYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWN 245
           D+ K +G+I+ D K EFG D  +  I L DEV +PD+ R W+
Sbjct: 166 DFLKSRGLILPDFKLEFGRD-SSGRIRLGDEV-SPDTCRLWD 205


>gi|131633|sp|P21155|PUR7_ECOLI
           PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE
           (SAICAR SYNTHETASE) >gi|96295|pir||C36146
           phosphoribosylaminoimidazolesuccinocarboxamide synthase
           (EC 6.3.2.6) - Escherichia coli >gi|147410 (M33928)
           5'-phosphoribosyl-5-aminoimidazole-4-
           N-succinocarboxamide synthetase (EC 6.3.2.6)
           [Escherichia coli] >gi|1788820 (AE000334)
           phosphoribosylaminoimidazole-succinocarboxamide
           synthetase = SAICAR synthetase [Escherichia coli]
           >gi|1799903|gnl|PID|d1017082 (D90876)
           phosphoribosylaminoimidazolesuccinocarboxamide synthase
           (EC 6.3.2.6) [Escherichia coli]
           >gi|1805534|gnl|PID|d1017092 (D90877)
           phosphoribosylaminoimidazolesuccinocarboxamide synthase
           (EC 6.3.2.6) [Escherichia coli]
           Length = 237
           
 Score = 58.6 bits (139), Expect = 5e-08
 Identities = 49/164 (29%), Positives = 75/164 (44%), Gaps = 23/164 (14%)

Query: 88  YLPAKLSEPKYKTQLE----DRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTGTVHGLK 143
           ++ +KL+E    TQ+E    D   LV K  ++P+E +VR    GS  K            
Sbjct: 56  FIMSKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL---------- 105

Query: 144 QPQGLKESQEFPEPIFTPSTKAEQGEHDE--NISPAQAAELVGEDLSRRVAELAVKLYSK 201
              G++E  E   P+F    K +   HD   N S  +    V ++   R+ EL  K    
Sbjct: 106 ---GIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYKANDV 161

Query: 202 CKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWN 245
            K    + G+I+ D K EFG+ +   E++L DE  +PD SR W+
Sbjct: 162 LKKLFDDAGLILVDFKLEFGLYK--GEVVLGDE-FSPDGSRLWD 202


>gi|1652590|gnl|PID|d1018244 (D90906) phosphoribosyl aminoidazole
           succinocarboxamide synthetase [Synechocystis sp.]
           Length = 264
           
 Score = 57.8 bits (137), Expect = 9e-08
 Identities = 62/236 (26%), Positives = 99/236 (41%), Gaps = 46/236 (19%)

Query: 18  GKVRDIYEV-DAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSN-DVRNH 75
           GK + +Y   D   LL +  D  +A++   +  I  KG +   +S   F++L    +  H
Sbjct: 23  GKAKILYPTEDPDVLLTIFKDDATAFNAQKKGQIQGKGAINCAISAALFRWLETLGIPTH 82

Query: 76  LVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVK 135
            +D                        ++  +LV    +IPLEV+VR    GS  K+   
Sbjct: 83  YIDCP----------------------QNDQMLVKAVNIIPLEVVVRNIAAGSLCKQ--- 117

Query: 136 TGTVHGLKQPQGLKE----SQEFPEPIFTPSTKAEQGEHDENISPAQAAELVGEDLSRRV 191
           TG   GL  P  L E         +P+ T       G  DE    A+   L  +DL+  +
Sbjct: 118 TGLKEGLVLPNPLVEFYFKDDALGDPLLTWERALLLGVTDE----ARLQTL--KDLALNI 171

Query: 192 AELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGA 247
            +   + +++C        I + D K EFG D +  +IIL DE+ +PD+ R W+ A
Sbjct: 172 NQHLQRFFAQC-------DITLVDFKLEFGGD-RQGKIILADEI-SPDTCRLWDNA 218


>gi|131628|sp|P22234|PUR6_HUMAN MULTIFUNCTIONAL PROTEIN ADE2
           (PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE
           SYNTHASE (SAICAR SYNTHETASE) /
           PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE (AIR
           CARBOXYLASE) (AIRC)) >gi|106347|pir||S14147 hypothetical
           protein - human >gi|28384|emb|CAA37801| (X53793) 5' half
           of the product is  homologues to Bacillus subtiis SAICAR
           synthetase,  3' half corresponds to the catalytic
           subunit of  AIR carboxylase [Homo sapiens]
           Length = 425
           
 Score = 55.4 bits (131), Expect = 5e-07
 Identities = 60/257 (23%), Positives = 104/257 (40%), Gaps = 48/257 (18%)

Query: 18  GKVRDIYEV--DAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVRNH 75
           GK +++YE+    G +L  + D+I+A +   +N +  K  +  K++   F+ L       
Sbjct: 16  GKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQE----- 70

Query: 76  LVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVK 135
               A  KT F              +  + + +  + ++IP+E + R   TGS       
Sbjct: 71  ----AGIKTAFT------------RKCGETAFIAPQCEMIPIEWVCRRIATGSF------ 108

Query: 136 TGTVHGLKQPQGLKESQEFPEP----IFTPSTKAEQGEHDENISPAQ---AAELVGEDLS 188
                 LK+  G+KE  +F  P     F      +    +E +  A+   A  L+G+   
Sbjct: 109 ------LKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEV 162

Query: 189 RRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGAS 248
             ++     ++   +     +   + D K EFG+D  T EI+L D V+  DS R W    
Sbjct: 163 DIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLAD-VIDNDSWRLWPS-- 219

Query: 249 YKVGESQDSYDKQFLRD 265
              G+     DKQ  RD
Sbjct: 220 ---GDRSQQKDKQSYRD 233


>gi|2649307 (AE001016)
           phosphoribosylaminoimidazolesuccinocarboxamide synthase
           (purC) [Archaeoglobus fulgidus]
           Length = 331
           
 Score = 55.0 bits (130), Expect = 6e-07
 Identities = 76/300 (25%), Positives = 133/300 (44%), Gaps = 36/300 (12%)

Query: 33  FVATDRISAYDV-IMENSIPEKGILLTKLSEFWFKFLSN-DVRNHLVDIAPGKTI--FDY 88
           F+ ++R S +D   M + I +KG  L  ++ ++F+ L    +  H + +  G  +  FD 
Sbjct: 22  FIFSNRYSVFDYGEMPDKIEDKGRALCMVTAYFFEKLEEAGIATHYLGLVEGGKVRRFDE 81

Query: 89  LPAKLSEPKYKT------QLEDRSLL--VHKHKLIPLEVIVRGYIT-GSAWKEYVKTGTV 139
           +   ++E + K       +  D S+   +  + L+PLE+I R  I  GS+    ++ G  
Sbjct: 82  VENAVNEMEVKLVRVIKPKNGDYSIFKTLKGNFLVPLEIIYRNSIPEGSSLLRRIERGEA 141

Query: 140 H----GLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAAELVG--EDLSRRVAE 193
                GL +   ++       PI   STK E  + D  +S ++A E+ G  ++    + E
Sbjct: 142 KPEDFGLTK---IEAGMRLERPIVDFSTKLE--DVDRYLSHSEAKEISGLSDEEFEALKE 196

Query: 194 LAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRF-WNGASYKVG 252
           L VK+         + G+I  D K E  +D++ N +++VD V TPD  RF ++G      
Sbjct: 197 LVVKVDEIITREVSKAGLINEDGKIEVALDDERN-LMVVDAVGTPDECRFSFDGFEVSKE 255

Query: 253 ESQDSYDKQFLRDWLTANKLNGVNG----VKMPQDIVDRTRAKYIEAYET----LTGSKW 304
             ++ Y K    D     +L G  G    V +P  + D  R      Y      +TG K+
Sbjct: 256 LLREYYRKTEWYD--KVRQLKGQEGWREAVGLPPPLPDEVREGVSNLYRAFCNEVTGRKF 313


>gi|1709928|sp|P51583|PUR6_RAT MULTIFUNCTIONAL PROTEIN ADE2
           (PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE
           SYNTHASE (SAICAR SYNTHETASE) /
           PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE (AIR
           CARBOXYLASE) (AIRC)) >gi|1363267|pir||S55684
           aminoimidazole ribonucleotide carboxylase - rat
           >gi|976252|gnl|PID|d1007775 (D37979) AIR
           carboxylase-SAICAR synthetase [Rattus norvegicus]
           >gi|1096145|prf||2111238A aminoimidazole ribonucleotide
           carboxylase [Rattus norvegicus]
           Length = 425
           
 Score = 53.9 bits (127), Expect = 1e-06
 Identities = 59/257 (22%), Positives = 103/257 (39%), Gaps = 48/257 (18%)

Query: 18  GKVRDIYEV--DAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDVRNH 75
           GK +++YE+    G +L  + D+I+A +   +N +  K  +  K++   F+ L       
Sbjct: 16  GKTKEVYELLDSPGRVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQE----- 70

Query: 76  LVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKEYVK 135
               A  KT F              +  + + +  + ++IP+E + R   TGS       
Sbjct: 71  ----AGIKTAFT------------KKCGETAFIAPQCEMIPIEWVCRRIATGSF------ 108

Query: 136 TGTVHGLKQPQGLKESQEFPEP----IFTPSTKAEQGEHDENISPAQ---AAELVGEDLS 188
                 LK+  G+KE   F  P     F      +    +E +  A+   A  ++G+   
Sbjct: 109 ------LKRNPGVKEGYRFYPPKVEMFFKDDANNDPQWSEEQLIAAKFCFAGLVIGQTEV 162

Query: 189 RRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGAS 248
             ++     ++   +     +   + D K EFG+D  T EI+L D V+  DS R W    
Sbjct: 163 DIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLAD-VIDNDSWRLWPS-- 219

Query: 249 YKVGESQDSYDKQFLRD 265
              G+     DKQ  RD
Sbjct: 220 ---GDRSQQKDKQSYRD 233


>gi|4097530 (U64311) phosphoribosylaminoimidazolesuccinocarboxamide
           synthetase [Lactococcus lactis]
           Length = 236
           
 Score = 52.7 bits (124), Expect = 3e-06
 Identities = 57/233 (24%), Positives = 102/233 (43%), Gaps = 36/233 (15%)

Query: 14  LVARGKVRDIYEVDAGTLLFVA-TDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDV 72
           L+  GK + +Y  D   +L+V   D+ +A +   +  I  KG L  +++           
Sbjct: 6   LLYEGKAKKLYFTDDSNVLWVEYCDQATALNGARKEQITGKGALNNQITSL--------- 56

Query: 73  RNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKE 132
                       IF+ L A+  E  +  +L     L  K  +IPLEV++R  + GS  K 
Sbjct: 57  ------------IFEKLNAEGLETHFIKKLSKTEQLNKKVSIIPLEVVLRNVVAGSFAKR 104

Query: 133 YVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAAELVGEDLSRRVA 192
           +   G   G+   + + E     + +  P    E  +   NI+     E + ++ +R++ 
Sbjct: 105 F---GLEEGIVLEEPIVEFYYKDDALDDPFINDEHVKF-LNIASDSEIEFLKKE-TRKIN 159

Query: 193 ELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWN 245
           ++  K+++       E G+ + D K EFG       IIL DE+ +PD+SR W+
Sbjct: 160 KILKKIWT-------EIGLTLVDFKLEFG-RLADGSIILADEI-SPDTSRLWD 203


>gi|4043|emb|CAA43043| (X60549) ADE1 [Saccharomyces cerevisiae]
           Length = 22
           
 Score = 50.4 bits (118), Expect = 2e-05
 Identities = 22/22 (100%), Positives = 22/22 (100%)

Query: 285 VDRTRAKYIEAYETLTGSKWSH 306
           VDRTRAKYIEAYETLTGSKWSH
Sbjct: 1   VDRTRAKYIEAYETLTGSKWSH 22


>gi|585761|sp|P38024|PUR6_CHICK MULTIFUNCTIONAL PROTEIN ADE2
           (PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE
           SYNTHASE (SAICAR SYNTHETASE) /
           PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE (AIR
           CARBOXYLASE) (AIRC)) >gi|104510|pir||A35641
           5-aminoimidazole ribonucleotide
           carboxylase-5-aminoimidazole-4-N-succinocarboxamide
           ribonucleotide - chicken >gi|211194 (M31764)
           5-aminoimidazole ribonucleotide (AIR) carboxylase-5-
           aminoimidazole-4-N-succinocarboxamide ribonucleotide
           (SAICAR) synthetase [Gallus gallus]
           Length = 426
           
 Score = 47.3 bits (110), Expect = 1e-04
 Identities = 60/261 (22%), Positives = 101/261 (37%), Gaps = 50/261 (19%)

Query: 15  VARGKVRDIYEVD--AGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLSNDV 72
           V  GK +++YE+    G +L  + D+I+A +   ++ +  K  +    +   F+ L    
Sbjct: 14  VNEGKTKEVYELPDIPGCVLMQSKDQITAGNAARKDRMEGKAAISNTTTSCVFQLLQE-- 71

Query: 73  RNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWKE 132
                  A  KT F              +  D + +    ++IP+E + R   TGS    
Sbjct: 72  -------AGIKTAF------------VRKQSDTAFIAAHCEMIPIEWVCRRIATGSF--- 109

Query: 133 YVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAAEL--------VG 184
                    LK+  G+KE  +F  P      K +   +D   S  Q  E         +G
Sbjct: 110 ---------LKRNPGVKEGYKFYPPKIEMFYK-DDANNDPQWSEEQLIEAKFSFAGLTIG 159

Query: 185 EDLSRRVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFW 244
           +     +A     ++   +   + +   + D K EFG++  T EI+L D V+  DS R W
Sbjct: 160 KTEVDIMARSTQAIFEILEKSWQPQNCTLVDLKIEFGVNILTKEIVLAD-VIDNDSWRLW 218

Query: 245 NGASYKVGESQDSYDKQFLRD 265
                  G+     DKQ  RD
Sbjct: 219 PS-----GDRSQQKDKQSYRD 234


>gi|1709927|sp|Q10457|PUR6_CAEEL PROBABLE MULTIFUNCTIONAL PROTEIN
           ADE2 (PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE
           SYNTHASE (SAICAR SYNTHETASE) /
           PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE (AIR
           CARBOXYLASE) (AIRC)) >gi|1053219 (U39848) coded for by
           C. elegans cDNA yk92a5.5; coded for by C. elegans cDNA
           yk58g5.5; coded for by C. elegans cDNA yk55a3.5; coded
           for by C. elegans cDNA yk70b1.5; coded for by C. elegans
           cDNA yk58g5.5; coded for by C. elegans cDNA yk124e4....
           Length = 423
           
 Score = 46.1 bits (107), Expect = 3e-04
 Identities = 62/266 (23%), Positives = 108/266 (40%), Gaps = 55/266 (20%)

Query: 12  LPLVARGKVRDIYEV--DAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLS 69
           L L+A GK + I+++  +   +L  + D ++A++ + +N +  K  + +K +        
Sbjct: 14  LELLAEGKTKQIFDIKGEKDYVLIRSKDSLTAFNAVRKNELEGKSRIASKTTS------- 66

Query: 70  NDVRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSA 129
                          +F+YL        ++  + +   +  K  +IP+E + R   TGS 
Sbjct: 67  --------------NVFEYLQLLGLPTHFEKSISETEFVARKCTMIPIEWVARRVATGSF 112

Query: 130 WKEYVKTGTVHGLKQPQGLKESQEFP----EPIFTPSTKAEQGEHDENISPAQAAELVGE 185
                       LK+  G+KE   F     E  F      +    DE I    +  L+ +
Sbjct: 113 ------------LKRNPGVKEGFRFNDLKLETFFKDDANDDPQWTDEQI---VSNGLMID 157

Query: 186 DLSRRVAELA-VKLYSKCKDYAKEKGIIIA-----DTKFEFGIDEKTNEIILVDEVLTPD 239
            L     E++ +K  +K    A EKG  ++     D K EFG+  +  EI+L D V+  D
Sbjct: 158 HLKIGREEISLMKKMTKLVFRALEKGWALSNSALIDMKIEFGVTVE-GEILLAD-VIDND 215

Query: 240 SSRFWNGASYKVGESQDSYDKQFLRD 265
           S R W        + +   DKQ  RD
Sbjct: 216 SWRVW-----PENDRRLQLDKQVYRD 236


  Database: nr
    Posted date:  Mar 13, 1999  7:20 PM
  Number of letters in database: 110,384,460
  Number of sequences in database:  361,503
  
Lambda     K      H
   0.315    0.135    0.388 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66920058
Number of Sequences: 361503
Number of extensions: 2802762
Number of successful extensions: 5270
Number of sequences better than 1.0e-03: 32
Number of HSP's better than  0.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 5191
Number of HSP's gapped (non-prelim): 32
length of query: 306
length of database: 110384460
effective HSP length: 56
effective length of query: 250
effective length of database: 90140292
effective search space: 22535073000
effective search space used: 22535073000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (22.0 bits)
S2: 103 (44.5 bits)