LOCUS CAA84353 2173 aa linear PRI 07-OCT-2008
DEFINITION voltage-dependent L-type Ca channel alpha 1 subunit [Homo sapiens].
ACCESSION CAA84353
VERSION CAA84353.1 GI:509178
DBSOURCE embl accession Z34822.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 2173)
AUTHORS Soldatov,N.M.
TITLE Molecular diversity of L-type Ca2+ channel transcripts in human
fibroblasts
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (10), 4628-4632 (1992)
PUBMED 1316612
REFERENCE 2 (residues 1 to 2173)
AUTHORS Soldatov,N.M.
TITLE Genomic structure of human L-type Ca2+ channel
JOURNAL Genomics 22 (1), 77-87 (1994)
PUBMED 7959794
REFERENCE 3 (residues 1 to 2173)
AUTHORS Soldatov,N.M.
TITLE Functional Expression of Splice Variants of Human L-type Calcium
Channel (isoform 1 gene)
JOURNAL Unpublished
REFERENCE 4 (residues 1 to 2173)
AUTHORS Soldatov,N.
TITLE Direct Submission
JOURNAL Submitted (15-JUN-1994) Nikolai M. Soldatov, Pharmacology,
University of Bern, Friedbuehlstrasse 49, Bern, CH-3010,
Switzerland
FEATURES Location/Qualifiers
source 1..2173
/organism="Homo sapiens"
/db_xref="taxon:9606"
/cell_line="CRL 1475 (ATCC)"
/cell_type="fibroblast"
/dev_stage="fetal"
Protein 1..2173
/product="voltage-dependent L-type Ca channel alpha 1
subunit"
/function="L-type calcium channel (clone HLCC85) splice
variant"
Region 162..404
/region_name="Ion_trans"
/note="Ion transport protein; pfam00520"
/db_xref="CDD:109571"
Region <163..404
/region_name="PKD_channel"
/note="Polycystin cation channel; pfam08016"
/db_xref="CDD:116626"
Region 559..751
/region_name="Ion_trans"
/note="Ion transport protein; pfam00520"
/db_xref="CDD:109571"
Region 936..1129
/region_name="Ion_trans"
/note="Ion transport protein; pfam00520"
/db_xref="CDD:109571"
Region <1246..1480
/region_name="PKD_channel"
/note="Polycystin cation channel; pfam08016"
/db_xref="CDD:116626"
Region 1253..1475
/region_name="Ion_trans"
/note="Ion transport protein; pfam00520"
/db_xref="CDD:109571"
Region 1611..1642
/region_name="Ca_chan_IQ"
/note="Voltage gated calcium channel IQ domain; pfam08763"
/db_xref="CDD:117333"
CDS 1..2173
/standard_name="CACNL1A1 isoform 1"
/coded_by="Z34822.1:1..6522"
/experiment="experimental evidence, no additional details
recorded"
/note="composed of exons 1-20, 22-30, 32-50"
/db_xref="GDB:126094"
/db_xref="GOA:Q13936"
/db_xref="HGNC:1390"
/db_xref="InterPro:IPR002077"
/db_xref="InterPro:IPR005446"
/db_xref="InterPro:IPR005451"
/db_xref="InterPro:IPR005821"
/db_xref="InterPro:IPR014873"
/db_xref="PDB:1T0J"
/db_xref="PDB:2BE6"
/db_xref="UniProtKB/Swiss-Prot:Q13936"
ORIGIN
1 mvnentrmyi peenhqgsny gsprpahanm nanaaaglap ehiptpgaal swqaaidaar
61 qaklmgsagn atistvsstq rkrqqygkpk kqgsttatrp prallcltlk npirracisi
121 vewkpfeiii lltifancva laiyipfped dsnatnsnle rveylfliif tveaflkvia
181 ygllfhpnay lrngwnlldf iivvvglfsa ileqatkadg analggkgag fdvkalrafr
241 vlrplrlvsg vpslqvvlns iikamvpllh iallvlfvii iyaiiglelf mgkmhktcyn
301 qegiadvpae ddpspcalet ghgrqcqngt vckpgwdgpk hgitnfdnfa famltvfqci
361 tmegwtdvly wvndavgrdw pwiyfvtlii igsffvlnlv lgvlsgefsk erekakargd
421 fqklrekqql eedlkgyldw itqaedidpe nedegmdeek prnmsmptse tesvntenva
481 ggdiegencg arlahrisks kfsrywrrwn rfcrrkcraa vksnvfywlv iflvflntlt
541 iasehynqpn wltevqdtan kallalftae mllkmyslgl qayfvslfnr fdcfvvcggi
601 letilvetki msplgisvlr cvrllrifki trywnslsnl vasllnsvrs iaslllllfl
661 fiiifsllgm qlfggkfnfd emqtrrstfd nfpqslltvf qiltgedwns vmydgimayg
721 gpsfpgmlvc iyfiilficg nyillnvfla iavdnladae sltsaqkeee eekerkklar
781 taspekkqel vekpavgesk eekielksit adgesppatk inmddlqpne nedkspypnp
841 ettgeedeee pempvgprpr plselhlkek avpmpeasaf fifssnnrfr lqchrivndt
901 iftnlilffi llssislaae dpvqhtsfrn hilgnadyvf tsiftleiil kmtaygaflh
961 kgsfcrnyfn ildllvvsvs lisfgiqssa invvkilrvl rvlrplrain rakglkhvvq
1021 cvfvairtig nivivttllq fmfacigvql fkgklytcsd sskqteaeck gnyitykdge
1081 vdhpiiqprs wenskfdfdn vlaammalft vstfegwpel lyrsidshte dkgpiynyrv
1141 eisiffiiyi iiiaffmmni fvgfvivtfq eqgeqeyknc eldknqrqcv eyalkarplr
1201 ryipknqhqy kvwyvvnsty feylmfvlil lnticlamqh ygqsclfkia mnilnmlftg
1261 lftvemilkl iafkpkhyfc dawntfdali vvgsivdiai tevnpaehtq cspsmnaeen
1321 srisitffrl frvmrlvkll srgegirtll wtfiksfqal pyvallivml ffiyavigmq
1381 vfgkialndt teinrnnnfq tfpqavlllf rcatgeawqd imlacmpgkk capesepsns
1441 tegetpcgss favfyfisfy mlcafliinl fvavimdnfd yltrdwsilg phhldefkri
1501 waeydpeakg rikhldvvtl lrriqpplgf gklcphrvac krlvsmnmpl nsdgtvmfna
1561 tlfalvrtal riktegnleq aneelraiik kiwkrtsmkl ldqvvppagd devtvgkfya
1621 tfliqeyfrk fkkrkeqglv gkpsqrnals lqaglrtlhd igpeirrais gdltaeeeld
1681 kamkeavsaa seddifrrag glfgnhvsyy qsdgrsafpq tfttqrplhi nkagssqgdt
1741 espsheklvd stftpssyss tgsnaninna nntalgrlpr pagypstvst veghgpplsp
1801 airvqevawk lssnrerhvp vcedlelrrd sgsagtqahc lllrranpsr chsresqaam
1861 agqeetsqde tyevkmnhdt eacsepslls temlsyqdde nrqltlpeed krdirqspkr
1921 gflrsaslgr rasfhleclk rqkdrggdis qktvlplhlv hhqalavagl spllqrshsp
1981 asfprpfatp patpgsrgwp pqpvptlrle gvesseklns sfpsihcgsw aettpggggs
2041 saarrvrpvs lmvpsqagap grqfhgsass lveavliseg lgqfaqdpkf ievttqelad
2101 acdmtieeme saadnilsgg apqspngall pfvncrdagq draggeedag cvrargapse
2161 eelqdsrvyv ssl
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