Short-Term Prognosis Evaluation of Transient Ischemic Attack Patients Using ABCD2 Score

This study is currently recruiting participants.

Verified by Capital Medical University, January 2009

First Received: November 2, 2007 Last Updated: January 29, 2009 History of Changes

Sponsors and Collaborators:	Capital Medical University Beijing Anzhen Hospital
Information provided by:	Capital Medical University
ClinicalTrials.gov Identifier:	NCT00553241

Purpose

The purpose of this study is to determine whether the ABCD2 score can be used in patients with transient ischemic attack, admitted to Beijing anzhen hospital, to evaluate the prognosis, risk factor of those patients.

Condition
Ischemic Attack, Transient

MedlinePlus related topics: Transient Ischemic Attack

U.S. FDA Resources

Study Type:	Observational
Study Design:	Cohort, Prospective
Official Title:	Phase 1 of Clinical Trial of Risk Factor, Prognosis, Imaging and Standard Management of Transient Ischemic Attack.

Further study details as provided by Capital Medical University:

Primary Outcome Measures:

end points are defined as follow: transient ischemic attack, stroke, angina, myocardial infraction, peripheral vascular disease, intracerebral hemorrhage and other vascular death. [ Time Frame: two year ] [ Designated as safety issue: No ]

Biospecimen Retention: None Retained

Biospecimen Description:

Estimated Enrollment:	1
Study Start Date:	June 2007
Estimated Study Completion Date:	January 2009

Groups/Cohorts
1 Dept. of Neurology, Beijing Anzhen Hospital, Capital Medical University Beijing 100029, P.R.China Every patient admitted to Beijing anzhen hospital with transient ischemic attack will be enrolled in this study, from 06/2007 to 12/2008. duration of the symptom not larger than 1 hour.

Detailed Description:

The feasibility of risk stratification of patients with acute transient ischemic attack admitted to Beijing anzhen hospital by the ABCD2 score system is yet to be determined. The aim of this paper was to evaluate and validate the short-term prognosis of TIA patients in Peking area using this new score system.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

patients diagnosed with transient will be enrolled in this study

Criteria

Inclusion Criteria:

Every patient admitted to Beijing anzhen hospital with transient ischemic attack will be enrolled in this study, from 06/2007 to 12/2008. duration of the symptom not larger than 1 hour.
Magnetic resonance imaging negative on DWI(no fresh infarction).
Old infarction or not the criminal infarction.

Exclusion Criteria:

Patients with hemorrhage stroke were excluded.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00553241

Locations

China
Dept. of Neurology, Beijing Anzhen Hospital, Capital Medical University	Recruiting
Beijing, China, 100029
Contact: li F Wang wlfsjnk@163.com
Principal Investigator: Bi Qi

Sponsors and Collaborators

Capital Medical University

Beijing Anzhen Hospital

Investigators

Study Chair:

Qi Bi

Dept. of Neurology, Beijing Anzhen Hospital, Capital Medical University

More Information

Additional Information:

Related Info This link exits the ClinicalTrials.gov site

Publications of Results:

Johnston SC, Rothwell PM, Nguyen-Huynh MN, Giles MF, Elkins JS, Bernstein AL, Sidney S. Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet. 2007 Jan 27;369(9558):283-92.

Tsivgoulis G, Spengos K, Manta P, Karandreas N, Zambelis T, Zakopoulos N, Vassilopoulos D. Validation of the ABCD score in identifying individuals at high early risk of stroke after a transient ischemic attack: a hospital-based case series study. Stroke. 2006 Dec;37(12):2892-7. Epub 2006 Oct 19.

Rothwell PM, Giles MF, Flossmann E, Lovelock CE, Redgrave JN, Warlow CP, Mehta Z. A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack. Lancet. 2005 Jul 2-8;366(9479):29-36.

Bray JE, Coughlan K, Bladin C. Can the ABCD Score be dichotomised to identify high-risk patients with transient ischaemic attack in the emergency department? Emerg Med J. 2007 Feb;24(2):92-5.

Other Publications:

Prabhakaran S, Chong JY, Sacco RL. Impact of abnormal diffusion-weighted imaging results on short-term outcome following transient ischemic attack. Arch Neurol. 2007 Aug;64(8):1105-9.

Johnston SC, Gress DR, Browner WS, Sidney S. Short-term prognosis after emergency department diagnosis of TIA. JAMA. 2000 Dec 13;284(22):2901-6.

Weisberg LA. Clinical characteristics of transient ischemic attacks in black patients. Neurology. 1991 Sep;41(9):1410-4.

Albers GW, Caplan LR, Easton JD, Fayad PB, Mohr JP, Saver JL, Sherman DG; TIA Working Group. Transient ischemic attack--proposal for a new definition. N Engl J Med. 2002 Nov 21;347(21):1713-6. No abstract available.

Sylaja PN, Coutts SB, Subramaniam S, Hill MD, Eliasziw M, Demchuk AM; VISION Study Group. Acute ischemic lesions of varying ages predict risk of ischemic events in stroke/TIA patients. Neurology. 2007 Feb 6;68(6):415-9.

Correia M, Silva MR, Magalhaes R, Guimaraes L, Silva MC. Transient ischemic attacks in rural and urban northern Portugal: incidence and short-term prognosis. Stroke. 2006 Jan;37(1):50-5. Epub 2005 Dec 1.

Clark TG, Murphy MF, Rothwell PM. Long term risks of stroke, myocardial infarction, and vascular death in "low risk" patients with a non-recent transient ischaemic attack. J Neurol Neurosurg Psychiatry. 2003 May;74(5):577-80.

Giles MF, Flossman E, Rothwell PM. Patient behavior immediately after transient ischemic attack according to clinical characteristics, perception of the event, and predicted risk of stroke. Stroke. 2006 May;37(5):1254-60. Epub 2006 Mar 30.

Coull AJ, Lovett JK, Rothwell PM; Oxford Vascular Study. Population based study of early risk of stroke after transient ischaemic attack or minor stroke: implications for public education and organisation of services. BMJ. 2004 Feb 7;328(7435):326. Epub 2004 Jan 26.

Responsible Party:	Capital Medical University ( Beijing Anzhen Hospital )
Study ID Numbers:	2007020
Study First Received:	November 2, 2007
Last Updated:	January 29, 2009
ClinicalTrials.gov Identifier:	NCT00553241 History of Changes
Health Authority:	China: Ministry of Health

Keywords provided by Capital Medical University:

evaluation
management
prognosis
TIA

Study placed in the following topic categories:

Ischemic Attack, Transient
Vascular Diseases
Central Nervous System Diseases
Brain Ischemia

Ischemia
Brain Diseases
Cerebrovascular Disorders

Additional relevant MeSH terms:

Ischemic Attack, Transient
Pathologic Processes
Cerebrovascular Disorders
Nervous System Diseases
Vascular Diseases

Central Nervous System Diseases
Brain Ischemia
Cardiovascular Diseases
Ischemia
Brain Diseases

ClinicalTrials.gov processed this record on March 16, 2009