100016 |
cd02187 |
beta_tubulin |
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins. |
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-,... |
true |
true |
true |
425 |
< 1.0e-180 |
948.64 |
100.00 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 2 REIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPF 81
cd02187 1 REIVHIQAGQCGNQIGAKFWEVISDEHGLDPTGTYKGDSDLQLERINVYFNEASGGKYVPRAILVDLEPGTMDSVRSGPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 82 GQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPD 161
cd02187 81 GQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 162 RIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLR 241
cd02187 161 RIMATFSVFPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICFRTLKLTNPTYGDLNHLVSAVMSGITTCLR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 242 FPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRM 321
cd02187 241 FPGQLNSDLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTAAAIFRGRV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 322 SMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGE 401
cd02187 321 SMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGE 400
|
410 420
....*....|....*....|....*
2HXF_B 402 GMDEMEFTEAESNMNDLVSEYQQYQ 426
cd02187 401 GMDEMEFTEAESNMNDLVSEYQQYQ 425
|
|
cl10017 |
127335 |
Tubulin_FtsZ |
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. |
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-... |
0 |
100023 |
cd06059 |
Tubulin |
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins. Also included in this group is the mitochondrial Misato/DML1 protein family, involved in mitochondrial fusion and in mitochondrial distribution and morphology. |
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-,... |
false |
true |
false |
382 |
9e-135 |
475.23 |
100.00 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 3 EIVHIQAGQCGNQIGAKFWEVisdehgidptgsyhgdsdlqlerinvyyneaagnkyvprAILVDLEPGTMDSVRSGPFG 82
cd06059 1 EIISIQIGQCGNQIGNKFWEL---------------------------------------LILVDLDPRVINEILQGQLS 41
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 83 QIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDR 162
cd06059 42 KLFDPNQLVNGKEGSGNNWARGYYTIGPELIDEILDRIRKQVEKCDSLQGFQITHSLGGGTGSGLGSLLLELLSDEYPKI 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 163 IMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRF 242
cd06059 122 LINTFSIFPSPQGSSNVVEPYNSILSLNHLLENSDSVILFDNEALYNILTRQLDIDEPSFDDLNNIIAQIISSITASLRF 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 243 PGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMS 322
cd06059 202 PGYLNFDLRKLATNLVPFPRLHFLTPSFAPLISYDSQTTEKLNLLQIINELFNNDNSFFSCDPTKGRYLAAALIFRGDVF 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 323 MKEVDEQMLNVQNKNssYFVEWIPNNVKTAVCDIPPRG-LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGE 401
cd06059 282 QSEIQEAINKLKNKL--NIQSWIPDGFKVSNCKKPPRAeLGKSALFLSNSTSIGESLERLIEKFDKLYKRKAFLHWYLGE 359
|
410 420
....*....|....*....|...
2HXF_B 402 GMDEMEFTEAESNMNDLVSEYQQ 424
cd06059 360 GMDEMEFTEAESSLEDLIQSYQE 382
|
|
cl10017 |
127335 |
Tubulin_FtsZ |
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. |
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-... |
-1 |
100015 |
cd02186 |
alpha_tubulin |
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins. |
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-,... |
false |
true |
false |
434 |
3e-116 |
413.61 |
99.77 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 2 REIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDS--DLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSG 79
cd02186 1 REVISIHIGQAGIQIGNACWELYCLEHGIQPDGQMPSDKtiGGGDDAFNTFFSETGSGKHVPRAVFIDLEPTVIDEVRTG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 80 PFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEY 159
cd02186 81 TYRQLFHPEQLISGKEDAANNFARGHYTIGKEIIDLVLDRIRKLADNCTGLQGFLIFHSFGGGTGSGFGSLLLERLSVDY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 160 PDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTC 239
cd02186 161 GKKSKLEFTVYPSPQVSTAVVEPYNSVLTTHSLLEHSDCSFMVDNEAIYDICRRNLDIERPTYTNLNRLIAQVVSSITAS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 240 LRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRG 319
cd02186 241 LRFDGALNVDLNEFQTNLVPYPRIHFPLVSYAPIISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 320 RMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGL--------KMSATFIGNSTAIQELFKRISEQFTAMFRR 391
cd02186 321 DVVPKDVNAAVATIKTKRTIQFVDWCPTGFKVGINYQPPTVVpggdlakvQRAVCMLSNTTAIAEAWSRLDHKFDLMYSK 400
|
410 420 430
....*....|....*....|....*....|...
2HXF_B 392 KAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQ 424
cd02186 401 RAFVHWYVGEGMEEGEFSEAREDLAALEKDYEE 433
|
|
cl10017 |
127335 |
Tubulin_FtsZ |
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. |
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-... |
-1 |
100014 |
cd00286 |
Tubulin_FtsZ |
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. |
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-... |
false |
true |
false |
328 |
2e-112 |
401.40 |
100.00 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 3 EIVHIQAGQCGNQIGAKFWEVIsdehgidptgsyhgdsdlqlerinvyyneaagnkyvpraILVDLEPGTMDSVRSGPFG 82
cd00286 1 EIVTIQLGQAGNQIGAKFWEQL---------------------------------------VLVDTEPGVIDETLSGPYR 41
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 83 QIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDR 162
cd00286 42 LLFCIGQLITHGGGAGNNWAFGHETAGEEYQEEILDIIRKEAEECDSLQGFFITHSLGGGTGSGLGPVLAERLKDEYPKR 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 163 IMNTFSVVPSPKVSdTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRF 242
cd00286 122 LKITFSILPGPDEG-VIVRPYNSILTLHTLTEHSDCLVVIDNEALFDICPRPLHIDKPTFDHINELLATALSSLTTPLRF 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 243 PGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMS 322
cd00286 201 DGSLNVDLRELSENLVPFPRLHFLMVGYAPLDSEGSATPTTLRVAELVRQALRSKNQMVVCDPTHGGYIAALLLVRGPVS 280
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
2HXF_B 323 MKEVDEQMLNVQNKNSSYfvEWIPNNVKTAVCDIPPR-GLKMSATFIGNS 371
cd00286 281 PSEVREGIARVAPRTSHL--SWSPPGIKVGVSPTPPAsEHKVSALLLSNS 328
|
|
cl10017 |
127335 |
Tubulin_FtsZ |
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. |
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-... |
-1 |
100017 |
cd02188 |
gamma_tubulin |
Gamma-tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily. Gamma is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes. Gamma-tubulin recruits the alpha/beta-tubulin dimers that form the minus ends of microtubules and is thought to be involved in microtubule nucleation and capping. |
Gamma-tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily.... |
false |
true |
false |
431 |
3e-95 |
343.86 |
100.00 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 2 REIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPF 81
cd02188 1 REIITLQVGQCGNQIGSEFWKQLCAEHGISPDGILEDFATDGGDRKDVFFYQADDEHYVPRAILIDLEPRVINSIQNSEY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 82 GQIFRPDNFVFGQS--GAGNNWAKGhYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEY 159
cd02188 81 RNLYNPENIFLSKHggGAGNNWASG-YSQGEEVQEEILDIIDREADGSDSLEGFVLCHSIAGGTGSGMGSYLLERLNDRY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 160 PDRIMNTFSVVP-SPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTT 238
cd02188 160 PKKLIQTYSVFPnQDESSDVVVQPYNSILTLKRLILNADCVVVLDNTALNRIATDRLHIQNPTFDQINSLVSTVMSASTT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 239 CLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTS-RGSQQYRALTVPELTQQMFDAKNMMAACDP-RHGRYLTVAAV 316
cd02188 240 TLRYPGYMNNDLISLIASLIPTPRLHFLMTSYTPLTSdQIAASVRKTTVLDVMRRLLQPKNIMVSTATrKNGCYISILNI 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 317 FRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPP---RGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKA 393
cd02188 320 IQGEVDPTQVHKSLQRIRERRLANFIPWGPASIQVALSKKSPyvpTAHRVSGLMLANHTSIASLFERILKQFDKLRKRRA 399
|
410 420 430
....*....|....*....|....*....|..
2HXF_B 394 FLHWYTGEGMDEM---EFTEAESNMNDLVSEY 422
cd02188 400 FLDNYRKEDMFSDnldEFDESREVVQSLIEEY 431
|
|
cl10017 |
127335 |
Tubulin_FtsZ |
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. |
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-... |
-1 |
100019 |
cd02190 |
epsilon_tubulin |
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The epsilon-tubulins which are widespread but not ubiquitous among eukaryotes play a role in basal body/centriole morphogenesis. |
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-,... |
false |
true |
false |
379 |
9e-77 |
282.67 |
99.74 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 2 REIVHIQAGQCGNQIGAKFWEVISDEHgidptgsyhgdsdLQlerinvyyneaagnkyvPRAILVDLEPGTMDSVRSGPF 81
cd02190 1 REIIVVQVGQCGNQIGCRFWDLALREH-------------LK-----------------ARAVLIDMEEGVVNEILKGPL 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 82 GQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPD 161
cd02190 51 RDLFDETQLVTDVSGAGNNWAVGYHQYGHQYIDSILEKIRKAAEKCDSLQSFFILHSLGGGTGSGLGTYVLELLADEFPE 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 162 RIMNTFSVVPSpKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDicfrtlklttptYGDLNHLVSATMSGVTTCLR 241
cd02190 131 VYRFVTSVYPS-ADDDVITSPYNSVLALRELIEHADCVLPIENQALVP------------FDAMNSIVANLLLNLTSSMR 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 242 FPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRM 321
cd02190 198 FEGSLNVDLNEITMNLVPFPRLHFLVSSLSPLYPLADVNVPPRRLDQMFSDAFSRNHQLIRADPKHGLYLACALLVRGNV 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 322 SMKEVDEqmlNV-QNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTG 400
cd02190 278 SVSDLRR---NIeRLKPKLKFVKWNQEGWKIGLCSVPPVGHSYSLLCLANNTCIKGTFTELKERFMKLYKRKAHLHHYTQ 354
|
410 420
....*....|....*....|....
2HXF_B 401 EGMDEMEFTEAESNMNDLVSEYQQ 424
cd02190 355 VGMEQGDFTEALESISNLIDEYDY 378
|
|
cl10017 |
127335 |
Tubulin_FtsZ |
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. |
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-... |
-1 |
100018 |
cd02189 |
delta_tubulin |
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. Delta-tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies. |
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-,... |
false |
true |
false |
446 |
7e-54 |
206.40 |
99.55 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 4 IVHIQAGQCGNQIGAKFWEVISDEhgidptGSYHGDSDLQLERINVYYN--EAAGNKYVPRAILVDLEPGTMDSVRSGPF 81
cd02189 2 VVTVQLGQCGNQLGHELFDTLAKE------ASSSDDEGYKYERDAQERFfsEKSDGQPIARSVLVDMEPKVIESTLSKSS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 82 GQI--FRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEY 159
cd02189 76 GGTwkYDKKNVICQQSGSGNNWAYGYYVHGPQIKEDILDLIRKEVEKCDSFEGFLVLHSLAGGTGSGLGSRVTELLRDEY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 160 PDR-IMNTfsVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGV-- 236
cd02189 156 PESlLLNI--VVWPYTTGEVIVQNYNTVLTLAHLYESSDAIILLENDDIHRICSKLRNLKNVSLSDINKVIAHQLASLlq 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 237 ---TTCLRFPGqlNADLRKLAVNM-----VPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQ---QMFDAKNMMAACDP 305
cd02189 234 pslDSTGSNGA--LAGRSTNPLNDlvedlCPHPAYKLLTIRSLPQMPEKSLAFSTFSWSALLKrlhQMLIAGSFMEEGID 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 306 RHGR-------------------YLTVAAVFRGRMSMKEVDEQMlnvqnKNSSYFVEWIPNNVKTAVcDIPPRGLK---M 363
cd02189 312 WTVRpegsaasllsgnksthfnkSLANLLILRGKDVTSADERKF-----RDPLLYVNWSPSPVRFSI-SSHKRSFSkyeK 385
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 364 SATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQ 423
cd02189 386 SVTLVSNSQTIIDPLDNILEKAWNMFASGAYLHQYEKYGLEEEDFLDAFATLEQIIASYK 445
|
|
cl10017 |
127335 |
Tubulin_FtsZ |
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. |
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-... |
-1 |
109159 |
pfam00091 |
Tubulin |
Tubulin/FtsZ family, GTPase domain |
Tubulin/FtsZ family, GTPase domain |
false |
false |
false |
232 |
1e-60 |
229.12 |
100.00 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 3 EIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSyhgdsDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFg 82
pfam00091 1 EIIVIGVGGAGNNIGNELWELLCKEHGIDPDGM-----LFKADKINVFFEESGDGVYGPRFIAIDTDPQVLNEIKAGNK- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 83 qIFRPDNFVFGQSGAGNNWAKGHYTeGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDR 162
pfam00091 75 -LFIGNNLTKGLEGAGNNPAVGYYT-HKEAAEESLEEIRKELEKCDGLDGFFITAGLGGGTGSGAAPVIAEILKELYPGA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 163 IMNTFSVVPSPKvSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRF 242
pfam00091 153 LTVAVVTFPFLK-SEGVVRPYNAILGLKELIEHSDSVIVIDNDALYEICNNQLDIKSPAFKNANEVIAQAISGITESIRF 231
|
.
2HXF_B 243 P 243
pfam00091 232 P 232
|
|
cl10017 |
127335 |
Tubulin_FtsZ |
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. |
Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-... |
-1 |
112752 |
pfam03953 |
Tubulin_C |
Tubulin/FtsZ family, C-terminal domain |
Tubulin/FtsZ family, C-terminal domain |
false |
false |
false |
128 |
5e-56 |
213.59 |
100.00 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 246 LNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKE 325
pfam03953 1 LNVDLADLRTNLVPFPRLHFAMMGYGPLTGDGKAEHRALSVLELTRQAFSPPNLMVACDPRHGAYGALANTGGGDVSLKE 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
2HXF_B 326 VDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTA 373
pfam03953 81 VNEAIQRIREKNSANFVEWAPIIFKTAIDDEPPYVLRVSVVMLGNTTA 128
|
|
pfam03953 |
112752 |
Tubulin_C |
Tubulin/FtsZ family, C-terminal domain |
Tubulin/FtsZ family, C-terminal domain |
-1 |
34628 |
COG5023 |
COG5023 |
Tubulin [Cytoskeleton] |
Tubulin [Cytoskeleton] |
true |
true |
false |
443 |
< 1.0e-180 |
646.96 |
97.52 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 1 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGP 80
COG5023 1 MREIITLQVGQCGNQIGNAFWETLCLEHGIGPDGTLLDSSDEGDERFDVFFYEASDGKFVPRAILVDLEPGVIDQVRNGP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 81 FGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYP 160
COG5023 81 YGSLFHPENIIFGKEGAGNNWARGHYTVGKEIIDDVMDMIRREADGCDGLQGFLLLHSLGGGTGSGLGSLLLERLREEYP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 161 DRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL 240
COG5023 161 KKIKLTFSVFPAPKVSDVVVEPYNSVLTLHRLLENSDCTFVVDNEALYDICRRNLRIQNPSYDDLNQLISTVMSSVTTSL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 241 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGR 320
COG5023 241 RFPGYLNVDLRSIQTNLVPYPRLHFPLVSYTPFTSDGSAAHEKNSVSEVTNQLFDPKNQMVSCDPRKGRYMAVCLLFRGD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2HXF_B 321 MSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPP---RGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHW 397
COG5023 321 VDPRDVSRAVTRVQSKRTIQFVEWCPTGFKVAICKRPPsepAEVDVSGCMLSNTTSIAEAFKRIDDQFDLMFKKRAFLHW 400
|
410 420 430
....*....|....*....|....*....|..
2HXF_B 398 YTGEGMDEMEFTEAESNMNDLVSEYQQYQDAT 429
COG5023 401 YVGEGMEEGEFSEAREDVADLEEEYEAAEQDS 432
|
|
|
|
|
|
|
-1 |
|