National Toxicology Program

CASRN: 91-22-5

Formula: C9-H7-N

Synonyms/Common Names:

• 1-AZANAPHTHALENE
• BENZOPYRIDINE
• LEUKOL

Known Uses:

ANATOMICAL SPECIMEN PRESERVATIVE, SOLVENT, CHEM. INT., INGREDIENT IN PHARMACEUTICALS, CORROSION INHIBITOR, NATURALLY OBTAINED FROM DISTILLATION OF BONES & COAL TAR OR SYNTHESIZED

Genetic Toxicology

• Chromosome Aberrations  (745521) Completed 
  • Citation: McFee, A.F. Genotoxic potency of three quinoline compounds evaluated in vivo in mouse bone marrow cells. Environ. Molec. Mutagen. Vol. 13 (1989) 325-331
  • Citation: McFee, A.F. Genotoxic potency of three quinoline compounds evaluated in vivo in mouse bone marrow cells. Environ. Molec. Mutagen. Vol. 13 (1989) 325-331
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (038247) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• In Vitro Cytogenetics (CA/SCE)  (256407) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• In Vitro Cytogenetics (CA/SCE)  (563472) Completed 
  • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
  • Chromosome Aberation Weakly Positive 
  • Sister Chromatid Exchange Positive 
• In Vitro Cytogenetics (CA/SCE)  (725295) Completed 
  • Chromosome Aberation Inconclusive 
  • Sister Chromatid Exchange Positive 
• In Vitro Cytogenetics (CA/SCE)  (760472) Completed 
  • Citation: Galloway, S., Bloom, A., Resnick, M., Margolin, B., Nakamura, F., Archer, P., and Zeiger, E. Development of a standard protocol for in vitro cytogenetic testing with CHO cells: Comparison of results for 22 compounds in two laboratories. Environ. Mutagen. Vol. 7 (1985) 1-52
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Drosophila  (263640) Completed 
  • Citation: Valencia, R., Mason, J.M., and Zimmering, S. Chemical mutagenesis testing in Drosophila. IV. Interlaboratory comparison of mutagenicity tests after treatment of larvae. Environ. Molec. Mutagen. Vol. 14 (1989) 238-244
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Drosophila  (765617) Completed 
  • Citation: Valencia, R., Mason, J.M., and Zimmering, S. Chemical mutagenesis testing in Drosophila. IV. Interlaboratory comparison of mutagenicity tests after treatment of larvae. Environ. Molec. Mutagen. Vol. 14 (1989) 238-244
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Drosophila  (869472) Completed 
  • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (359723) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Positive 
• Salmonella  (100014) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive 
• Sister Chromatid Exchanges  (745521) Completed 
  • Citation: McFee, A.F. Genotoxic potency of three quinoline compounds evaluated in vivo in mouse bone marrow cells. Environ. Molec. Mutagen. Vol. 13 (1989) 325-331
  • Citation: McFee, A.F. Genotoxic potency of three quinoline compounds evaluated in vivo in mouse bone marrow cells. Environ. Molec. Mutagen. Vol. 13 (1989) 325-331
  • Mice
  • Sister Chromatid  Negative