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The Francis Crick Papers

Title:
Letter from Francis Crick to Aaron Klug pdf (222,940 Bytes) ocr (4,730 Bytes)
Description:
Crick here evaluated research results by two of his coauthors, Leth Bak and Jesper Zeuthen, used in an article the three wrote on the structure and folding of DNA and its associated proteins in human chromosomes during cell division (mitosis). In their article they postulated that chromatids, the one-half of a chromosome that splits off from the other half during cell division, were organized in a hierarchy of helices: the chromatid is a folded and coiled super-solenoid (a long, regular, hollow cylindrical structure), also called the unit fiber, which in turn is formed by a coiled solenoid of smaller diameter, which in turn is formed by coiling the string of nucleosomes, bead-like complexes of DNA and protein.
See Leth Bak, Jesper Zeuthen, and Crick, "Higher-Order Structure of Human Mitotic Chromosomes," Proceedings of the National Academy of Sciences, vol. 74 (April 1977), pp. 1595-99.
Number of Image Pages:
2 (222,940 Bytes)
Date:
1977-10-04 (October 4, 1977)
Creator:
Crick, Francis
Recipient:
Klug, Aaron
Source:
Original Repository: Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
URL: http://archives.wellcome.ac.uk/
Rights:
Reproduced with permission of the Wellcome Library for the History and Understanding of Medicine.
URL: http://library.wellcome.ac.uk/
Subject:
Medical Subject Headings (MeSH):
DNA
Chromosomes
Exhibit Category:
From Molecular Biology to Neurobiology, 1976-2004
Relation:
Metadata Record Letter from Aaron Klug to Francis Crick (October 31, 1977)
Metadata Record Higher-Order Structure of Human Mitotic Chromosomes (April 1977)
Box Number: 23
Folder Number: PP/CRI/D/2/19
Unique Identifier:
SCBBQW
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence
SubSeries: Individual Correspondents
Folder: Correspondence: Klug, Aaron
Metadata Last Modified Date:
2005-07-08
U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894
National Institutes of Health, Department of Health & Human Services
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