BLASTP 2.0.8 [Jan-05-1999]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= YOR237W HES1, Chr XV from 781992-783296
         (434 letters)

Database: nr
           361,503 sequences; 110,384,460 total letters

Searching..................................................done

                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

gi|547627|sp|P35843|HES1_YEAST HES1 PROTEIN >gi|630294|pir||S42...   891  0.0
gi|547769|sp|P35844|KES1_YEAST KES1 PROTEIN >gi|630295|pir||S42...   631  e-180
gi|3925781|emb|CAA22202| (AL034353) ergosterol biosynthesis pro...   295  4e-79
gi|3327884|gnl|PID|d1032707 (AB016222) KES1 [Schizosaccharomyce...   295  4e-79
gi|2995326|gnl|PID|e1284390 (AL022242) ergosterol biosynthesis ...   275  4e-73
gi|2950457|emb|CAA17807| (AL022071) hypothetical protein [Schiz...   232  3e-60
gi|401638|sp|Q02201|YKY3_YEAST HYPOTHETICAL 51.6 KD PROTEIN IN ...   123  2e-27
gi|731627|sp|P38755|YHG1_YEAST HYPOTHETICAL 49.8 KD PROTEIN IN ...   115  5e-25
gi|2058345|emb|CAA73224| (Y12693) oxysterol-binding protein [Ne...   115  6e-25
gi|2734081 (AF000195) similar to oxysterol-binding proteins [Ca...   110  2e-23
gi|3881530|emb|CAA94223| (Z70269) predicted using Genefinder; S...   104  1e-21
gi|3551523|gnl|PID|d1033978 (AB017026) oxysterol-binding protei...    79  5e-14
gi|4160344|emb|CAA22812| (AL035216) probable involvement in erg...    79  6e-14
gi|3882265|gnl|PID|d1035473 (AB018315) KIAA0772 protein [Homo s...    67  2e-10
gi|2239236|emb|CAB10154| (Z97211) probable involvement in ergos...    67  2e-10
gi|3875913|emb|CAB02934| (Z81061) Similarity to Human oxysterol...    61  1e-08
gi|1077164|pir||S52500 SWH1 protein homolog YDL019c - yeast (Sa...    61  2e-08
gi|731674|sp|P38713|YHN3_YEAST HYPOTHETICAL 113.8 KD PROTEIN IN...    58  1e-07
gi|1078406|pir||S47536 SWH1 protein (version 2) - yeast (Saccha...    57  3e-07
gi|548437|sp|P35845|OSH1_YEAST OSH1 PROTEIN >gi|1078479|pir||S5...    57  3e-07
gi|3327222|gnl|PID|d1032640 (AB014604) KIAA0704 protein [Homo s...    52  1e-05
gi|4377460|emb|CAA74289| (Y13951) oxysterol binding protein hom...    50  4e-05
gi|3041847 (AC004542) OXYSTEROL-BINDING PROTEIN-like; similar t...    47  2e-04

>gi|547627|sp|P35843|HES1_YEAST HES1 PROTEIN >gi|630294|pir||S42677
           HES1 protein - yeast (Saccharomyces cerevisiae)
           >gi|433365 (U03914) Hes1p [Saccharomyces cerevisiae]
           >gi|1420543|emb|CAA99458| (Z75145) ORF YOR237w
           [Saccharomyces cerevisiae]
           Length = 434
           
 Score =  891 bits (2277), Expect = 0.0
 Identities = 434/434 (100%), Positives = 434/434 (100%)

Query: 1   MSQHASSSSWTSFLKSISSFNGDLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLID 60
           MSQHASSSSWTSFLKSISSFNGDLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLID
Sbjct: 1   MSQHASSSSWTSFLKSISSFNGDLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLID 60

Query: 61  GENYKDHCPFDPNVESKEVAQMLAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFV 120
           GENYKDHCPFDPNVESKEVAQMLAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFV
Sbjct: 61  GENYKDHCPFDPNVESKEVAQMLAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFV 120

Query: 121 GKWKNDEHPEFGETVLLSEQVSHHPPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTVK 180
           GKWKNDEHPEFGETVLLSEQVSHHPPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTVK
Sbjct: 121 GKWKNDEHPEFGETVLLSEQVSHHPPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTVK 180

Query: 181 PYGHVILKIKDETYLITTPPLHIEGILVASPFVELGGRSFIQSSNGMLCVIEFSGRGYFT 240
           PYGHVILKIKDETYLITTPPLHIEGILVASPFVELGGRSFIQSSNGMLCVIEFSGRGYFT
Sbjct: 181 PYGHVILKIKDETYLITTPPLHIEGILVASPFVELGGRSFIQSSNGMLCVIEFSGRGYFT 240

Query: 241 GKKNSFKARIYRSPQEHSHKENALYLISGQWSGVSTIIKKDSQVSHQFYDSSETPTEHLL 300
           GKKNSFKARIYRSPQEHSHKENALYLISGQWSGVSTIIKKDSQVSHQFYDSSETPTEHLL
Sbjct: 241 GKKNSFKARIYRSPQEHSHKENALYLISGQWSGVSTIIKKDSQVSHQFYDSSETPTEHLL 300

Query: 301 VKPIEEQHPLESRRAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERVKGVEWQRRW 360
           VKPIEEQHPLESRRAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERVKGVEWQRRW
Sbjct: 301 VKPIEEQHPLESRRAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERVKGVEWQRRW 360

Query: 361 FKQVDYMNENTSNDVEKASEDDAFRKLASKLQLSVKNVPSGTLIGGKDDKKDVSTALHWR 420
           FKQVDYMNENTSNDVEKASEDDAFRKLASKLQLSVKNVPSGTLIGGKDDKKDVSTALHWR
Sbjct: 361 FKQVDYMNENTSNDVEKASEDDAFRKLASKLQLSVKNVPSGTLIGGKDDKKDVSTALHWR 420

Query: 421 FDKNLWMRENEITI 434
           FDKNLWMRENEITI
Sbjct: 421 FDKNLWMRENEITI 434


>gi|547769|sp|P35844|KES1_YEAST KES1 PROTEIN >gi|630295|pir||S42676
           KES1 protein - yeast (Saccharomyces cerevisiae)
           >gi|433363 (U03913) Kes1p [Saccharomyces cerevisiae]
           >gi|1244772 (U43703) Kes1p [Saccharomyces cerevisiae]
           >gi|1370310|emb|CAA97849| (Z73501) ORF YPL145c
           [Saccharomyces cerevisiae] >gi|1403564|emb|CAA65548|
           (X96770) P2614 product [Saccharomyces cerevisiae]
           Length = 434
           
 Score =  631 bits (1610), Expect = e-180
 Identities = 302/435 (69%), Positives = 354/435 (80%), Gaps = 2/435 (0%)

Query: 1   MSQHASSSSWTSFLKSISSFNGDLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLID 60
           MSQ+ASSSSWTSFLKSI+SFNGDLSSLSAPPFILSP SLTEFSQYWAEHP LFLEPS I+
Sbjct: 1   MSQYASSSSWTSFLKSIASFNGDLSSLSAPPFILSPISLTEFSQYWAEHPELFLEPSFIN 60

Query: 61  GENYKDHCPFDPNVESKEVAQMLAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFV 120
            +NYK+HC  DP VES E+A+MLAV +WFISTL+SQYCSR+ES+GSEKKPLNPFLGE+FV
Sbjct: 61  DDNYKEHCLIDPEVESPELARMLAVTKWFISTLKSQYCSRNESLGSEKKPLNPFLGELFV 120

Query: 121 GKWKNDEHPEFGETVLLSEQVSHHPPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTVK 180
           GKW+N EHPEFGETVLLSEQVSHHPP+TAFSIFN+KN V +QGYNQIK  FTK+L LTVK
Sbjct: 121 GKWENKEHPEFGETVLLSEQVSHHPPVTAFSIFNDKNKVKLQGYNQIKASFTKSLMLTVK 180

Query: 181 PYGHVILKIKDETYLITTPPLHIEGILVASPFVELGGRSFIQSSNGMLCVIEFSGRGYFT 240
            +GH +L IKDE+YL+T PPLHIEGILVASPFVEL G+S+IQSS G+LCVIEFSGRGYF+
Sbjct: 181 QFGHTMLDIKDESYLVTPPPLHIEGILVASPFVELEGKSYIQSSTGLLCVIEFSGRGYFS 240

Query: 241 GKKNSFKARIYRSPQEHSHKENALYLISGQWSGVSTIIKKD-SQVSHQFYDSSETPTEHL 299
           GKKNSFKARIY+  ++   KE ALY ISGQWSG S IIK +  + S  FYD++  P EHL
Sbjct: 241 GKKNSFKARIYKDSKDSKDKEKALYTISGQWSGSSKIIKANKKEESRLFYDAARIPAEHL 300

Query: 300 LVKPIEEQHPLESRRAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERVKGVEWQRR 359
            VKP+EEQHPLESR+AW DVA AI+ G+ ++I KTK ELE  QR LR++E  KG+ WQRR
Sbjct: 301 NVKPLEEQHPLESRKAWYDVAGAIKLGDFNLIAKTKTELEETQRELRKEEEAKGISWQRR 360

Query: 360 WFKQVDYMNENTSNDVEKASEDDAFRKLASKLQLSVKNVPSGTLIGGKDDKKDVSTALHW 419
           WFK  DY +           +DD F KLAS L LS KN PSGTL+G K+D+K+  +++HW
Sbjct: 361 WFKDFDY-SVTPEEGALVPEKDDTFLKLASALNLSTKNAPSGTLVGDKEDRKEDLSSIHW 419

Query: 420 RFDKNLWMRENEITI 434
           RF + LW  E EI +
Sbjct: 420 RFQRELWDEEKEIVL 434


>gi|3925781|emb|CAA22202| (AL034353) ergosterol biosynthesis protein
           [Schizosaccharomyces pombe]
           Length = 388
           
 Score =  295 bits (747), Expect = 4e-79
 Identities = 166/366 (45%), Positives = 223/366 (60%), Gaps = 31/366 (8%)

Query: 6   SSSSWTSFLKSISSFNGDLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLIDGENYK 65
           + S+W SFLKSI++F+GDLSSL+AP FILS TSL E+S YWAEHP LF+  SL  GE   
Sbjct: 23  TKSTWLSFLKSIATFSGDLSSLTAPSFILSSTSLIEYSAYWAEHPELFI--SLPRGET-- 78

Query: 66  DHCPFDPNVESKEVAQMLAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFVGKWKN 125
                        + + L V +WF STL++QY +R+E  GSEKKPLNP LGE+F GKW  
Sbjct: 79  ------------PLERQLLVTKWFASTLKNQYAARNERYGSEKKPLNPILGELFTGKWNT 126

Query: 126 DEHPEFGE-TVLLSEQVSHHPPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTVKPYGH 184
           D     GE T L SEQVSHHPP+TA+ I+N+K  V ++GYN  K+GF+    + VK  GH
Sbjct: 127 D----IGEDTELTSEQVSHHPPITAYHIYNKKAGVRLEGYNGHKSGFSGP-QIHVKQIGH 181

Query: 185 --VILKIKDETYLITTPPLHIEGILVASPFVELGGRSFIQSSNGMLCVIEFSGRGYFTGK 242
             +IL+  +E Y IT P + +EG+   SP++ELG +S+I S++G L  IE+SG+GYFTGK
Sbjct: 182 ARLILEPHNEVYYITFPLVTLEGLWYGSPYIELGKKSYIISTSGYLTTIEYSGKGYFTGK 241

Query: 243 KNSFKARIYRSPQEHSHKENALYLISGQWSGV---STIIKKDSQVSHQFYDSSETPTEHL 299
           KN+FKA I  +      K   +Y I G W+G+    T   +       F D       ++
Sbjct: 242 KNTFKATIVNA----KTKSEPIYRIEGSWTGMLKYCTFEDQKRSAWEDFLDCGNYKPVNI 297

Query: 300 LVKPIEEQHPLESRRAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERVKGVEWQRR 359
            V PIEEQ   ESRR WK+ A A+  G+ +   + K ++E  QR LR QE      W R+
Sbjct: 298 SVAPIEEQGEYESRRVWKNFAVALDAGDYAAASQEKSKIEEGQRELRRQEEEHNEVWHRK 357

Query: 360 WFKQVD 365
           +F+  D
Sbjct: 358 YFEWKD 363


>gi|3327884|gnl|PID|d1032707 (AB016222) KES1 [Schizosaccharomyces
           pombe]
           Length = 386
           
 Score =  295 bits (747), Expect = 4e-79
 Identities = 166/366 (45%), Positives = 223/366 (60%), Gaps = 31/366 (8%)

Query: 6   SSSSWTSFLKSISSFNGDLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLIDGENYK 65
           + S+W SFLKSI++F+GDLSSL+AP FILS TSL E+S YWAEHP LF+  SL  GE   
Sbjct: 21  TKSTWLSFLKSIATFSGDLSSLTAPSFILSSTSLIEYSAYWAEHPELFI--SLPRGET-- 76

Query: 66  DHCPFDPNVESKEVAQMLAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFVGKWKN 125
                        + + L V +WF STL++QY +R+E  GSEKKPLNP LGE+F GKW  
Sbjct: 77  ------------PLERQLLVTKWFASTLKNQYAARNERYGSEKKPLNPILGELFTGKWNT 124

Query: 126 DEHPEFGE-TVLLSEQVSHHPPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTVKPYGH 184
           D     GE T L SEQVSHHPP+TA+ I+N+K  V ++GYN  K+GF+    + VK  GH
Sbjct: 125 D----IGEDTELTSEQVSHHPPITAYHIYNKKAGVRLEGYNGHKSGFSGP-QIHVKQIGH 179

Query: 185 --VILKIKDETYLITTPPLHIEGILVASPFVELGGRSFIQSSNGMLCVIEFSGRGYFTGK 242
             +IL+  +E Y IT P + +EG+   SP++ELG +S+I S++G L  IE+SG+GYFTGK
Sbjct: 180 ARLILEPHNEVYYITFPLVTLEGLWYGSPYIELGKKSYIISTSGYLTTIEYSGKGYFTGK 239

Query: 243 KNSFKARIYRSPQEHSHKENALYLISGQWSGV---STIIKKDSQVSHQFYDSSETPTEHL 299
           KN+FKA I  +      K   +Y I G W+G+    T   +       F D       ++
Sbjct: 240 KNTFKATIVNA----KTKSEPIYRIEGSWTGMLKYCTFEDQKRSAWEDFLDCGNYKPVNI 295

Query: 300 LVKPIEEQHPLESRRAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERVKGVEWQRR 359
            V PIEEQ   ESRR WK+ A A+  G+ +   + K ++E  QR LR QE      W R+
Sbjct: 296 SVAPIEEQGEYESRRVWKNFAVALDAGDYAAASQEKSKIEEGQRELRRQEEEHNEVWHRK 355

Query: 360 WFKQVD 365
           +F+  D
Sbjct: 356 YFEWKD 361


>gi|2995326|gnl|PID|e1284390 (AL022242) ergosterol biosynthesis
           protein [Schizosaccharomyces pombe]
           Length = 360
           
 Score =  275 bits (696), Expect = 4e-73
 Identities = 157/351 (44%), Positives = 210/351 (59%), Gaps = 31/351 (8%)

Query: 21  NGDLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLIDGENYKDHCPFDPNVESKEVA 80
           +GDLSSL+AP FILS TSL E+S YWAEHP LF+  SL  GE                + 
Sbjct: 10  SGDLSSLTAPSFILSSTSLIEYSAYWAEHPELFI--SLPRGET--------------PLE 53

Query: 81  QMLAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFVGKWKNDEHPEFGE-TVLLSE 139
           + L V +WF STL++QY +R+E  GSEKKPLNP LGE+F GKW  D     GE T L SE
Sbjct: 54  RQLLVTKWFASTLKNQYAARNERYGSEKKPLNPILGELFTGKWNTD----IGEDTELTSE 109

Query: 140 QVSHHPPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTVKPYGH--VILKIKDETYLIT 197
           QVSHHPP+TA+ I+N+K  V ++GYN  K+GF+    + VK  GH  +IL+  +E Y IT
Sbjct: 110 QVSHHPPITAYHIYNKKAGVRLEGYNGHKSGFSGP-QIHVKQIGHARLILEPHNEVYYIT 168

Query: 198 TPPLHIEGILVASPFVELGGRSFIQSSNGMLCVIEFSGRGYFTGKKNSFKARIYRSPQEH 257
            P + +EG+   SP++ELG +S+I S++G L  IE+SG+GYFTGKKN+FKA I  +    
Sbjct: 169 FPLVTLEGLWYGSPYIELGKKSYIISTSGYLTTIEYSGKGYFTGKKNTFKATIVNA---- 224

Query: 258 SHKENALYLISGQWSGV---STIIKKDSQVSHQFYDSSETPTEHLLVKPIEEQHPLESRR 314
             K   +Y I G W+G+    T   +       F D       ++ V PIEEQ   ESRR
Sbjct: 225 KTKSEPIYRIEGSWTGMLKYCTFEDQKRSAWEDFLDCGNYKPVNISVAPIEEQGEYESRR 284

Query: 315 AWKDVAEAIRQGNISMIKKTKEELENKQRALREQERVKGVEWQRRWFKQVD 365
            WK+ A A+  G+ +   + K ++E  QR LR QE      W R++F+  D
Sbjct: 285 VWKNFAVALDAGDYAAASQEKSKIEEGQRELRRQEEEHNEVWHRKYFEWKD 335


>gi|2950457|emb|CAA17807| (AL022071) hypothetical protein
           [Schizosaccharomyces pombe]
           Length = 371
           
 Score =  232 bits (586), Expect = 3e-60
 Identities = 130/351 (37%), Positives = 202/351 (57%), Gaps = 31/351 (8%)

Query: 16  SISSFN--GDLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLIDGENYKDHCPFDPN 73
           SI+ FN  GDLS+LSAP FILS TSL E+  YW E P LF+  +++D    K+       
Sbjct: 2   SIALFNLTGDLSTLSAPSFILSGTSLLEYMSYWFEFPELFV--TIVDFPTPKE------- 52

Query: 74  VESKEVAQMLAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFVGKWKNDEHPEFGE 133
                  +MLAV++W+I+ L  +Y SR+++ G+EKKPLNP LGE+F G W + +    G+
Sbjct: 53  -------RMLAVLKWYITGLSREYASRNKNYGTEKKPLNPILGELFYGSWDSSK----GK 101

Query: 134 TVLLSEQVSHHPPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTVKPYGHVILKIK--D 191
             L +EQVSHH P +A  +  ++  ++V  +N+ ++GF+   T+ V   G + + ++  +
Sbjct: 102 VELTAEQVSHHGPESAAHVVCKEAGITVDTHNKYRSGFSGR-TVYVNQLGQLRVHLEKYN 160

Query: 192 ETYLITTPPLHIEGILVASPFVELGGRSFIQSSNGMLCVIEFSGRGYFTGKKNSFKARIY 251
           ETY IT P + +EG+   +P++EL G ++I S+   +  I++SGRGYF G KNSFKA I+
Sbjct: 161 ETYYITLPNISLEGLWFMAPYIELYGSTYIVSNTNYITKIDYSGRGYFRGTKNSFKATIF 220

Query: 252 RSPQEHSHKENALYLISGQWSGVSTIIKKDSQVSHQFYDSSETPTEHLLVKPIEEQHPLE 311
                    E+  Y++ G W+G S +     + +  F          + VKP  E    E
Sbjct: 221 EK------NEDPDYIVEGVWTGESKLTIPSLKSTIFFLSIPSLEATPITVKPESEMGDWE 274

Query: 312 SRRAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERVKGVEWQRRWFK 362
           SR  WK+V+ A+  GN  ++   K  +E  QR +R++E  +G  W RR+FK
Sbjct: 275 SRNVWKEVSAALASGNYDIVSSKKSTIEQSQRDMRKKEEAEGAVWARRYFK 325


>gi|401638|sp|Q02201|YKY3_YEAST HYPOTHETICAL 51.6 KD PROTEIN IN
           PAP1-MRPL13 INTERGENIC REGION >gi|283318|pir||S25324
           hypothetical protein YKR003w - yeast (Saccharomyces
           cerevisiae) >gi|3526|emb|CAA46249| (X65124) homology
           with Human  oxysterol binding protein [Saccharomyces
           cerevisiae] >gi|486489|emb|CAA82073| (Z28228) ORF
           YKR003w [Saccharomyces cerevisiae]
           Length = 448
           
 Score =  123 bits (307), Expect = 2e-27
 Identities = 97/350 (27%), Positives = 159/350 (44%), Gaps = 42/350 (12%)

Query: 23  DLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLIDGENYKDHCPFDPNVESKEVAQM 82
           DL+ ++ P FIL   S+ E      + P   L+           H   DP      + + 
Sbjct: 63  DLTRITLPTFILEKKSMLERVTNQLQFPEFLLQA----------HSEKDP------LKRF 106

Query: 83  LAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFVGKWKNDEHPEFGETVLLSEQVS 142
           L V++W+++           +  + KKPLNP LGE F   W   + P   +   +SEQ S
Sbjct: 107 LYVMKWYLAGWHI-------APKAVKKPLNPVLGEYFTAYW---DLPNKQQAYYISEQTS 156

Query: 143 HHPPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTVKPYGHVI--LKIKD-----ETYL 195
           HHPP  A+     ++ + V G    K+ F    +  +     V+  L IKD     E Y+
Sbjct: 157 HHPPECAYFYMIPESSIRVDGVVIPKSRFLGNSSAAMMDGSTVLQFLDIKDGNGKPEKYV 216

Query: 196 ITTPPLHIEGILVASPFVELGGRSFIQSSNGMLCVIEFSGRGYFTGKKNSFKARIYRSPQ 255
           +T P +++ GIL     +ELG    I+S N     IEF  +GY  G  ++ +  +     
Sbjct: 217 LTQPNVYVRGILFGKMRIELGDHMIIKSPN-FQADIEFKTKGYVFGTYDAIEGTV----- 270

Query: 256 EHSHKENALYLISGQWSGVSTI--IKKDSQVSHQFYDSSETPTEHLLVKPIEEQHPLESR 313
              +  NA Y ISG+W+ V  +  +K+       F D+ +       V+P+ EQ   ESR
Sbjct: 271 -KDYDGNAYYEISGKWNDVMYLKDLKQPRSSPKVFLDTHKESPLRPKVRPLSEQGEYESR 329

Query: 314 RAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERVKGVEWQRRWFKQ 363
           + WK V +A+   N  +  + K ++E+ QR L ++    GVE+  + F++
Sbjct: 330 KLWKKVTDALAVRNHPVATEEKFQIEDHQRQLAKKRIEDGVEFHPKLFRR 379


>gi|731627|sp|P38755|YHG1_YEAST HYPOTHETICAL 49.8 KD PROTEIN IN
           RPL14B-GPA1 INTERGENIC REGION >gi|626721|pir||S46796
           hypothetical protein YKR003w homolog - yeast
           (Saccharomyces cerevisiae) >gi|500816 (U10555) Yhr001wp
           [Saccharomyces cerevisiae]
           Length = 437
           
 Score =  115 bits (286), Expect = 5e-25
 Identities = 95/352 (26%), Positives = 163/352 (45%), Gaps = 42/352 (11%)

Query: 23  DLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLIDGENYKDHCPFDPNVESKEVAQM 82
           DLS ++ P FIL   S+ E      + P + LE       + KD            + + 
Sbjct: 63  DLSRITLPTFILEKKSMLERITNQLQFPDVLLE-----AHSNKDG-----------LQRF 106

Query: 83  LAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFVGKWKNDEHPEFGETVLLSEQVS 142
           + VV W+++              + KKPLNP LGE F   W   + P   +   ++EQ S
Sbjct: 107 VKVVAWYLAGWHI-------GPRAVKKPLNPILGEHFTAYW---DLPNKQQAFYIAEQTS 156

Query: 143 HHPPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTVKPYGHVI--LKIKD-----ETYL 195
           HHPP +A+     ++++ V G    K+ F    +  +     V+  L IKD     E Y 
Sbjct: 157 HHPPESAYFYMIPESNIRVDGVVVPKSKFLGNSSAAMMEGLTVLQFLDIKDANGKPEKYT 216

Query: 196 ITTPPLHIEGILVASPFVELGGRSFIQSSNGMLCVIEFSGRGYFTGKKNSFKARIYRSPQ 255
           ++ P ++  GIL     +ELG    I      +  IEF  +G+ +G  ++ +  I    +
Sbjct: 217 LSQPNVYARGILFGKMRIELGDHMVIMGPKYQVD-IEFKTKGFISGTYDAIEGTI----K 271

Query: 256 EHSHKENALYLISGQWSGVSTI--IKKDSQVSHQFYDSSETPTEHLLVKPIEEQHPLESR 313
           ++  KE   Y ISG+W+ +  I  +++ S      +D+ +       V+P+EEQ   ESR
Sbjct: 272 DYDGKE--YYQISGKWNDIMYIKDLREKSSKKTVLFDTHQHFPLAPKVRPLEEQGEYESR 329

Query: 314 RAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERVKGVEWQRRWFKQVD 365
           R WK V +A+   +  +  + K ++EN+QR L ++    GVE+  + F++ +
Sbjct: 330 RLWKKVTDALAVRDHEVATEEKFQIENRQRELAKKRAEDGVEFHSKLFRRAE 381


>gi|2058345|emb|CAA73224| (Y12693) oxysterol-binding protein
           [Neurospora crassa]
           Length = 360
           
 Score =  115 bits (285), Expect = 6e-25
 Identities = 92/337 (27%), Positives = 158/337 (46%), Gaps = 47/337 (13%)

Query: 23  DLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLIDGENYKDHCPFDPNVESKEVAQM 82
           DLS +  P FIL P S+ E    +  HP + L    ID          DP      V + 
Sbjct: 55  DLSRVVLPTFILEPRSMLERITNFMCHPEMLLPIPEID----------DP------VQRF 98

Query: 83  LAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFVGKWKNDEHPEFGETVLLSEQVS 142
           +AVV++++S    +           KKPLNP LGE+F   W   + P+      +SEQ S
Sbjct: 99  VAVVKFYLSGWHIR-------PPGVKKPLNPVLGEIFTCYW---DFPDKTRGYYISEQTS 148

Query: 143 HHPPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTVKPYGHVILKI--------KDETY 194
           HHPP +++      +++ V G  + ++ F      ++   G  IL +        + E Y
Sbjct: 149 HHPPKSSYFYMVPGHNIRVDGTLKPRSKFLGNSAASMME-GIAILSLLNRGKDPQRGERY 207

Query: 195 LITTPPLHIEGILVASPFVELGGRSFIQSSN-GMLCVIEFSGRGYFTGKKNSFKARIYRS 253
           ++T P ++  GIL      ELG  S+++     ++  +EF  +G+ +G  N+    I R 
Sbjct: 208 ILTQPNMYARGILFGKMKYELGDHSYVRCPELDLVADVEFKTKGWVSGTYNAIGGTIRRE 267

Query: 254 PQEHSHKENALYLISGQWSGVSTIIKKDSQVSHQ--FYDSSETPTEHLLVKPIEEQHPLE 311
                     LY +SG WS    +  +D +  H+  F+++    +   + +PIEEQ   E
Sbjct: 268 STGE-----ILYELSGLWS--EEMYLRDVKTGHKEMFFNALHAKSSPPIARPIEEQEERE 320

Query: 312 SRRAWKDVAEAIRQGN--ISMIKKTKEELENKQRALR 346
           S++ W   A+A+++ N  ++ I+KTK E + ++ A +
Sbjct: 321 SQKIWAATAKAVKERNHELATIEKTKIEDQQREEAAK 357


>gi|2734081 (AF000195) similar to oxysterol-binding proteins
           [Caenorhabditis elegans]
           Length = 676
           
 Score =  110 bits (272), Expect = 2e-23
 Identities = 101/370 (27%), Positives = 156/370 (41%), Gaps = 47/370 (12%)

Query: 14  LKSISSFNGDLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLIDGENYKDHCPFDPN 73
           L S  S   DL+ ++ P FIL   SL E    +  HP LF+                  N
Sbjct: 319 LLSQVSVGMDLTKVTLPTFILERRSLLEMYADFFAHPDLFIAT----------------N 362

Query: 74  VESKEVAQMLAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFVGKW---------- 123
                  +M+AVVR++   L S Y +R    G  KKP N  LGE F  ++          
Sbjct: 363 GNDSAEKRMIAVVRYY---LNSFYAARKS--GVAKKPYNAILGETFRCRYSVPNSSLSGK 417

Query: 124 KNDEHPEFG----ETVLLSEQVSHHPPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTV 179
           K +  P  G    +   ++EQVSHHPP++AF        +S   +   K+ F   L++ V
Sbjct: 418 KTESGPWPGSDEKQLTFIAEQVSHHPPISAFYAEMPSEGISFNAHIYTKSSFLG-LSIGV 476

Query: 180 KPYGHVILKIK---DETYLITTPPLHIEGILVASPFVELGGRSFIQ-SSNGMLCVIEFSG 235
              G  IL +    DE Y IT P  +   I+ ++P+ E GG+  ++    G    IEF  
Sbjct: 477 ASIGEGILTLHNYGDEQYTITFPSGYGRSIM-STPWFEFGGKVKVECEKTGYRADIEFLT 535

Query: 236 RGYFTGKKNSFKARIYRSPQEHSHKENALYLISGQWSGVSTIIKKDSQVSHQFYDSSETP 295
           + +F GK +  +  I R   +       +  + G+W+G +   K  +   + F D    P
Sbjct: 536 KPFFGGKPHRIQGSICRDGAK-----KPVLTLRGEWNG-TMYAKTQNGEEYVFVDVKAKP 589

Query: 296 TEHLLVKPIEEQHPLESRRAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERVKGVE 355
                  P+ +Q   ESRR W+ V  A+ +  I     +K  +E +QR   ++    G +
Sbjct: 590 EVKKECVPVMQQGKRESRRLWRHVTAALLRNRIQTATTSKRFIEQRQRKEAKERLESGEK 649

Query: 356 WQRRWFKQVD 365
           W    F   D
Sbjct: 650 WTPLLFDTTD 659


>gi|3881530|emb|CAA94223| (Z70269) predicted using Genefinder;
           Similarity to Yeast hypothetical protein YHG1
           (SW:YHG1_YEAST); cDNA EST EMBL:Z14824 comes from this
           gene; cDNA EST CEMSC19F comes from this gene; cDNA EST
           EMBL:T00546 comes from this gene; c...
           Length = 751
           
 Score =  104 bits (257), Expect = 1e-21
 Identities = 101/392 (25%), Positives = 168/392 (42%), Gaps = 56/392 (14%)

Query: 1   MSQHASSSSWTSFLKSISSFNGDLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLID 60
           + +   S  WT  LK I     DLS +  P FIL P S  E    +  H  L  E     
Sbjct: 222 VGEENKSLIWT-LLKQIRP-GMDLSKVVLPTFILEPRSFLEKLADYYYHADLISEAV--- 276

Query: 61  GENYKDHCPFDPNVESKEVAQMLAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFV 120
                         E     +++ V ++F+S     +  + + +   KKP NP LGE F 
Sbjct: 277 -------------AEPDPFQRIVKVTKFFLSG----FYKKPKGL---KKPYNPILGETFR 316

Query: 121 GKWKNDEHPEFGETVLLSEQVSHHPPMTAFSIFNEKNDVSVQGYNQIKTG-FTKTLTLTV 179
            KW   EHP+   T  ++EQVSHHPP+++  I N K   ++ G    K+  +  +L+  +
Sbjct: 317 CKW---EHPDGSTTFYMAEQVSHHPPVSSLFITNRKAGFNISGTILAKSKYYGNSLSAIL 373

Query: 180 KPYGHVILKIKDETYLITTPPLHIEGILVASPFVELGGRSFIQ-SSNGMLCVIEFSGRGY 238
                + L    ETY++  P  + +GI++ +  +ELGG   I+    G    ++F  +  
Sbjct: 374 AGKLRLTLLNLGETYIVNLPYANCKGIMIGTMTMELGGEVNIECEKTGYRTTLDFKLKPM 433

Query: 239 FTGKKNSFKARIYRSPQEHSHKENALYLISGQWSGVSTIIKKDSQVSHQFYDSSETPTEH 298
             G  N  +  I        +  + L  I G W GV  I   D +   + ++ +    + 
Sbjct: 434 LGGAYNQIEGSI-------KYGSDRLASIEGAWDGVIRIKGPDGK--KELWNPTPEVIKT 484

Query: 299 LLVK---PIEEQHPLESRRAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERVKGVE 355
            L +    ++EQ   ES + W+ V EAI   +     + K  LEN QRA  +     G+ 
Sbjct: 485 RLPRYEINMDEQGEWESAKLWRHVTEAISNEDQYKATEEKTALENDQRARAK----SGIP 540

Query: 356 WQRRWFKQ----------VDYMNENTSNDVEK 377
            + ++FK+           DY   + +ND+++
Sbjct: 541 HETKFFKKQHGDDYVYIHADYRPWDNNNDIQQ 572


>gi|3551523|gnl|PID|d1033978 (AB017026) oxysterol-binding protein
           [Mus musculus]
           Length = 410
           
 Score = 79.2 bits (192), Expect = 5e-14
 Identities = 102/414 (24%), Positives = 156/414 (37%), Gaps = 98/414 (23%)

Query: 8   SSWTSFLKSISSFNGDLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLIDGENYKDH 67
           S W+   K I     +LS ++ P     P S  +    + EH  L  + S +        
Sbjct: 8   SIWSILRKCIGM---ELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSL-------- 56

Query: 68  CPFDPNVESKEVAQMLAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFVGKWKNDE 127
                   S  V +M  V  + +S + SQ+    E  G   KP NP LGE +        
Sbjct: 57  --------SDLVERMQCVAAFAVSAVASQW----ERTG---KPFNPLLGETY-----ELV 96

Query: 128 HPEFGETVLLSEQVSHHPPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTVKPYGHVIL 187
             + G   L+SEQVSHHPP++AF      ND    G    K  F    ++  +P G + L
Sbjct: 97  RDDLGFR-LISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGK-SVEAEPKGTITL 154

Query: 188 KIKD--ETYLITTPPLHIEGILVASPFVE-LGGRSFIQSSNGMLCVIEFSGRGYFTGKKN 244
           ++ D  E Y  T P   +  I+V   ++E  G    I    G  CV+ F   G F  + +
Sbjct: 155 ELLDHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELH 214

Query: 245 SFKARIYRSPQEHSHKENALYLISGQWSGV------------------STIIKKDSQVSH 286
             +  I    Q+ S K+  L  + G+W+                    +T  KK+S+ + 
Sbjct: 215 KVEGYI----QDKSKKK--LCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQTS 268

Query: 287 QFYDSSETP---TEHLLV----------------------------------KPIEEQHP 309
              +S E P   +E + +                                  K +E   P
Sbjct: 269 SSEESDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKEMESVIP 328

Query: 310 LESRRAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERVKGVEWQRRWFKQ 363
               R   D+  A+  G I +  + K+ LE KQRA R+       +W+ RWF Q
Sbjct: 329 KTDCRLRPDI-RAMENGEIDLASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQ 381


>gi|4160344|emb|CAA22812| (AL035216) probable involvement in
           ergosterol biosynthesis [Schizosaccharomyces pombe]
           Length = 516
           
 Score = 78.8 bits (191), Expect = 6e-14
 Identities = 64/241 (26%), Positives = 95/241 (38%), Gaps = 14/241 (5%)

Query: 135 VLLSEQVSHHPPMTAFSIFNEKNDVSVQGYNQIKTGFT----KTLTLTVKPYGHVILKIK 190
           V ++EQ SHHP ++AF +      + V G +QI  GFT    K     +    +V    +
Sbjct: 245 VFMAEQTSHHPAVSAFYVTCPSKGIEVYGQDQIAVGFTGTSFKVCAGDLNKGVYVRFNKR 304

Query: 191 D-ETYLITTPPLHIEGILVASPFVELGGRSFIQSSNGMLCVIEFSGRGYFTGKKNSFKAR 249
           D E YL T P   + GIL  +  + L   + I      +  I       + GK  S    
Sbjct: 305 DNEEYLCTHPSASVGGILRGNLHINLLDSTVILCPKTRIKTIITYIEERWLGKPRSLVEG 364

Query: 250 I-YRSPQEHSH--------KENALYLISGQWSGVSTIIKKDSQVSHQFYDSSETPTEHLL 300
           + YR    +          KEN L    G W             S    D +E    H  
Sbjct: 365 VCYRYDPSNDTIDSIKAVPKENILATFKGNWRNCIFYSYAGESESRMLVDLNELDLVHKR 424

Query: 301 VKPIEEQHPLESRRAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERVKGVEWQRRW 360
             P+++Q P ESR+ W  V   I   + +   K K+E+E++QR           EW+ R+
Sbjct: 425 CPPLDKQFPFESRKIWFPVTHNILAKHYTQATKAKQEIEDQQRQASAAREESHTEWKPRF 484

Query: 361 F 361
           F
Sbjct: 485 F 485


>gi|3882265|gnl|PID|d1035473 (AB018315) KIAA0772 protein [Homo
           sapiens]
           Length = 468
           
 Score = 67.1 bits (161), Expect = 2e-10
 Identities = 83/340 (24%), Positives = 143/340 (41%), Gaps = 51/340 (15%)

Query: 1   MSQHASSSSWTSFLKSISSFNGDLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLID 60
           M   +  S WT   K +     +LS ++ P     P S  +    + EH  L        
Sbjct: 56  MFSRSDFSVWTILKKCVGL---ELSKITMPIAFNEPLSFLQRITEYMEHVYLI------- 105

Query: 61  GENYKDHCPFDPNVESKEVAQMLAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFV 120
              ++  C   P      + +M +V  + +S + SQ+    E  G   KP NP LGE + 
Sbjct: 106 ---HRASCQPQP------LERMQSVAAFAVSAVASQW----ERTG---KPFNPLLGETYE 149

Query: 121 GKWKNDEHPEFGETVLLSEQVSHHPPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTVK 180
              + D    F     +SEQVSHHPP++AF      +D    G    K  F    ++  +
Sbjct: 150 -LIREDLGFRF-----ISEQVSHHPPISAFHSEGLNHDFLFHGSIYPKLKFWGK-SVEAE 202

Query: 181 PYGHVILKI--KDETYLITTPPLHIEGILVASPFVE-LGGRSFIQSSNGMLCVIEFSGRG 237
           P G + L++   +E Y  T P   +  +++   ++E  G    +    G  CV+ F   G
Sbjct: 203 PRGTITLELLKHNEAYTWTNPTCCVHNVIIGKLWIEQYGTVEILNHRTGHKCVLHFKPCG 262

Query: 238 YFTGKKNSFKARIYRSPQEHSHKENALYLISGQWSGVSTIIKKDSQVSHQFYDSSETPTE 297
            F  + +  +  I    Q+ + K+  L++I G+W+     I     VS++ +   E   +
Sbjct: 263 LFGKELHKVEGHI----QDKNKKK--LFMIYGKWTECLWGI---DPVSYESFKKQERRGD 313

Query: 298 HLLVKPIEEQHPLESRRAWKDVAE--AIRQGNISMIKKTK 335
           HL    ++E    +S +A  DVA+   + Q  + +I  +K
Sbjct: 314 HLRKAKLDE----DSGKADSDVADDVPVAQETVQVIPGSK 349


>gi|2239236|emb|CAB10154| (Z97211) probable involvement in ergosterol
            synthesis [Schizosaccharomyces pombe]
            Length = 1213
            
 Score = 67.1 bits (161), Expect = 2e-10
 Identities = 82/345 (23%), Positives = 138/345 (39%), Gaps = 50/345 (14%)

Query: 71   DPNVESKEVAQMLAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFVGKWKNDEHPE 130
            D    +K+  Q +  V  F +   S+Y S   ++    KP NP LGE +        HP+
Sbjct: 883  DQASHNKDPYQRILYVAAFAA---SEYAS---TLNRVAKPFNPLLGETY-----EFCHPQ 931

Query: 131  FGETVLLSEQVSHHPPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTVKPYGHVILKIK 190
             G   ++ EQVSHHPP+ A   ++E  +    G + +K+ F    +  + P G   L+++
Sbjct: 932  RGFRFIV-EQVSHHPPVGA--AYSESANWKYYGESSVKSKFYGK-SFDISPLGTWFLELR 987

Query: 191  D-----ETYLITTPPLHIEGILVASPFVE-LGGRSFIQSSNGMLCVIEFSGRGYFTGKKN 244
                  E Y        + GI++ SP V+  G    +  S+G+ CV++F  RG+     +
Sbjct: 988  HPSGEVELYTWKKVTSSVVGIILGSPSVDNYGQMHIVNHSSGINCVLDFKPRGWRGTNAH 1047

Query: 245  SFKARIYRSPQEHSHKENALYLISGQWSGVSTIIKKDSQVSHQFYDSSETPTE------- 297
              K  +       S  +   ++++G W+      ++ +      + + E P         
Sbjct: 1048 EVKGSV------QSTDDTPKWMVNGHWND-KIFGQQPNGNKILLWQNHERPPRPFNLTPF 1100

Query: 298  ----HLLVKPIEEQHPLESRRAWKDVAEAIRQGNISMIKKTKEELENKQRALRE-QERVK 352
                + L   ++   P    R   D   A+  G   +    K  LE KQR  R  +E+ +
Sbjct: 1101 AISLNALTPQLKPWLPPTDTRLRPD-QRAMENGQYDLAASEKNRLEEKQRKKRRMREQGE 1159

Query: 353  GVEWQRRWFKQV-------DYMNENTSNDVEKASEDDAFRKLASK 390
               W  RWF          DY   N  N+  K  E+     LA K
Sbjct: 1160 MPPWSPRWFSAAKHPVTGEDYWQFN--NEYWKIREEAGEAHLAGK 1202


>gi|3875913|emb|CAB02934| (Z81061) Similarity to Human
           oxysterol-binding protein (SW:OXYB_HUMAN)
           [Caenorhabditis elegans]
           Length = 424
           
 Score = 61.3 bits (146), Expect = 1e-08
 Identities = 49/166 (29%), Positives = 73/166 (43%), Gaps = 18/166 (10%)

Query: 109 KPLNPFLGEVFVGKWKNDEHPEFGETVLLSEQVSHHPPMTAFSIFNEKNDVSVQGYNQIK 168
           KP NP L E F          E      L+EQVSHHPP++A  ++ E ++ +V+G  +  
Sbjct: 154 KPFNPLLLETF--------ELERNGVRFLAEQVSHHPPISA--VYAESDEFTVEGTVEPT 203

Query: 169 TGFTKTLTLTVKPYGHVILKIK--DETYLITTPPLHIEGILVASPFVELGGRSFIQSSNG 226
            GF  T  L   P+ H+ L  K   ETY  + P   I  +++   ++       I+SS  
Sbjct: 204 LGFWMT-KLLANPHAHLKLTFKKTGETYSWSAPKCAIYNVIMGKMYMNFTSHMKIESSGT 262

Query: 227 MLCVIEFSGRGYFTGKKNSFKARIYRSPQEHSHKENALYLISGQWS 272
              V  F  +GY+  K       +     E  +K  ALY   G W+
Sbjct: 263 YDAVFSFDNKGYYNHKGGD--VHVEGHIFEGKNKIKALY---GNWT 303


>gi|1077164|pir||S52500 SWH1 protein homolog YDL019c - yeast
            (Saccharomyces cerevisiae) >gi|683678|emb|CAA88340|
            (Z48432) homolog of yeast SWH1 protein (X74552)
            [Saccharomyces cerevisiae] >gi|1430988|emb|CAA98578|
            (Z74067) ORF YDL019c [Saccharomyces cerevisiae]
            Length = 1283
            
 Score = 60.9 bits (145), Expect = 2e-08
 Identities = 73/316 (23%), Positives = 123/316 (38%), Gaps = 60/316 (18%)

Query: 91   STLRSQYC------SRSESMGSEKKPLNPFLGEVFVGKWKNDEHPEFGETVLLSEQVSHH 144
            STLR+ Y       S + +     KP NP LGE F     + ++  F      +EQVSHH
Sbjct: 948  STLRTLYVAAFTASSYASTTKRVAKPFNPLLGETFEYSRPDKQYRFF------TEQVSHH 1001

Query: 145  PPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTVKPYG--HVILK----IKDETYLITT 198
            PP++A   + E       G + + T F    +  VK  G  H+ L+     K+E Y    
Sbjct: 1002 PPISA--TWTESPRWDFWGESFVDTKFNGR-SFNVKHLGLWHIKLRPNDNEKEELYTWKK 1058

Query: 199  PPLHIEGILVASPFVELGGR-SFIQSSNGMLCVIEFSGRGYFTGKKNSFKARIYRSPQEH 257
            P   + GIL+ +P V+  G  + +  + G  C + F  RG+ +         +Y      
Sbjct: 1059 PNNTVIGILIGNPQVDNHGEVNVVNHTTGDHCKLYFKARGWRSSGAYEITGEVY------ 1112

Query: 258  SHKENALYLISGQWSGV--STIIKKDSQVSHQ--------------------FYDSSETP 295
            + K+  ++++ G W+    +  + KD  +S +                     + +++ P
Sbjct: 1113 NKKKQKVWILGGHWNEAIFAKKVVKDGDLSLEKTRTAASAGNGPTDDGTKFLIWKANDRP 1172

Query: 296  TEHLLVKP--IEEQHPLESRRAW--------KDVAEAIRQGNISMIKKTKEELENKQRAL 345
             E   + P  I    P      W        +    A+  G        K  +E KQRA 
Sbjct: 1173 EEPFNLTPFAITLNAPQPHLLPWLPPTDTRLRPDQRAMEDGRYDEAGDEKFRVEEKQRAA 1232

Query: 346  REQERVKGVEWQRRWF 361
            R +     +E+  +WF
Sbjct: 1233 RRKREENNLEYHPQWF 1248


>gi|731674|sp|P38713|YHN3_YEAST HYPOTHETICAL 113.8 KD PROTEIN IN
           ERG7-NMD2 INTERGENIC REGION >gi|626630|pir||S46812
           hypothetical protein YHR073w - yeast (Saccharomyces
           cerevisiae) >gi|500833 (U10556) Yhr073wp [Saccharomyces
           cerevisiae]
           Length = 996
           
 Score = 57.8 bits (137), Expect = 1e-07
 Identities = 86/371 (23%), Positives = 149/371 (39%), Gaps = 53/371 (14%)

Query: 5   ASSSSWTSFLKSISSFNGDLSSLSAPPFILSPTSLTEFSQYWAEHPALFLEPSLIDGENY 64
           AS  S  SFL+   +   DLSS++ P     P S+ +      E+  L            
Sbjct: 638 ASPPSLLSFLRK--NVGKDLSSIAMPVTSNEPISILQLISETFEYAPLL----------- 684

Query: 65  KDHCPFDPNVESKEVAQMLAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFVGKWK 124
                     ++ +    +  V  F  +  S Y  ++ ++   +KP NP L E F     
Sbjct: 685 ---------TKATQRPDPITFVSAFAISFLSIYRDKTRTL---RKPFNPLLAETF----- 727

Query: 125 NDEHPEFGETVLLSEQVSHHPPMTAFSIFNEKNDVSVQ-GYNQIKTGFTKTLTLTVKPYG 183
            +   E     L+SE+VSH PP+ AF  F E  D          +  + K++ L  +   
Sbjct: 728 -ELIREDMGFRLISEKVSHRPPVFAF--FAEHLDWECSYTVTPSQKFWGKSIELNNEGIL 784

Query: 184 HVILKIKDETYLITTPPLHIEGILVASPFVELGGRSFIQSSNGMLCVIEFSGRGYFTGKK 243
            +  K   E +  T P   ++ ++    ++E      + SS G    I F   G F+G+ 
Sbjct: 785 RLKFKTTGELFEWTQPTTILKNLIAGERYMEPVNEFEVHSSKGDKSHILFDKAGMFSGRS 844

Query: 244 NSFKARIYRSPQEHSHKENALYLISGQWSGV-------STIIKKDSQVSH--QFYDSSET 294
             FK  I   P  +  KE     ++G+W+          TI +    VS+  + Y  ++ 
Sbjct: 845 EGFKVSIIPPPSSNRKKET----LAGKWTQSLANETTHETIWEVGDLVSNPKKKYGFTKF 900

Query: 295 PTEHLLVKPIEEQH-PLESRRAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERVKG 353
                 +  IE+ + P    R   D+  A  +GN+   ++ K +LE  QR    + R KG
Sbjct: 901 TANLNEITEIEKGNLPPTDSRLRPDI-RAYEEGNVDKAEEWKLKLEQLQR----ERRNKG 955

Query: 354 VEWQRRWFKQV 364
            + + ++F++V
Sbjct: 956 QDVEPKYFEKV 966


>gi|1078406|pir||S47536 SWH1 protein (version 2) - yeast
            (Saccharomyces cerevisiae) >gi|402658|emb|CAA52646|
            (X74552) SWH1 [Saccharomyces cerevisiae]
            >gi|1090523|prf||2019253A oxysterol-binding protein-like
            protein [Saccharomyces cerevisiae]
            Length = 1190
            
 Score = 56.6 bits (134), Expect = 3e-07
 Identities = 68/315 (21%), Positives = 123/315 (38%), Gaps = 62/315 (19%)

Query: 95   SQYCSRSESMGSEKKPLNPFLGEVFVGKWKNDEHPEFGETVLLSEQVSHHPPMTA----- 149
            S Y S +  +    KP NP LGE F     + ++  F      +EQVSHHPP++A     
Sbjct: 865  SMYASTTNRVS---KPFNPLLGETFEYARTDGQYRFF------TEQVSHHPPISATWTES 915

Query: 150  --FSIFNEKNDVSVQGYNQIKTGFTKTLTLTVKPYGHVILKIKDETYLITTPPLHIEGIL 207
              +  + E N  S                +T++P  ++   + +ETY    P   + GIL
Sbjct: 916  PKWDFYGECNVDSSFNGRTFAVQHLGLWYITIRPDHNI--SVPEETYSWKKPNNTVIGIL 973

Query: 208  VASPFVELGGRSFIQS-SNGMLCVIEFSGRGYFTGKKNSFKARIYRSPQEHSHKENALYL 266
            +  P V+  G   + + + G  C++ +   G+ +      +  ++      +  +  L++
Sbjct: 974  MGKPQVDNSGDVKVTNHTTGDYCMLHYKAHGWTSAGAYEVRGEVF------NKDDKKLWV 1027

Query: 267  ISGQWS------------GVSTI--IKKDSQVS---------HQFYDSSETP------TE 297
            + G W+            G  T+  IK  +  +            + ++E P      T 
Sbjct: 1028 LGGHWNDSIYGKKVTARGGELTLDRIKTANSATGGPKLDGSKFLIWKANERPSVPFNLTS 1087

Query: 298  HLLVKPIEEQH------PLESRRAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERV 351
              L       H      P +SR   +    A+  G        K  +E KQRA +++   
Sbjct: 1088 FALTLNALPPHLIPYLAPTDSR--LRPDQRAMENGEYDKAAAEKHRVEVKQRAAKKEREQ 1145

Query: 352  KGVEWQRRWFKQVDY 366
            KG E++ +WF Q ++
Sbjct: 1146 KGEEYRPKWFVQEEH 1160


>gi|548437|sp|P35845|OSH1_YEAST OSH1 PROTEIN >gi|1078479|pir||S53463
           SWH1 protein (version 1) - yeast (Saccharomyces
           cerevisiae) >gi|456143 (L28920) Osh1p [Saccharomyces
           cerevisiae]
           Length = 859
           
 Score = 56.6 bits (134), Expect = 3e-07
 Identities = 68/315 (21%), Positives = 123/315 (38%), Gaps = 62/315 (19%)

Query: 95  SQYCSRSESMGSEKKPLNPFLGEVFVGKWKNDEHPEFGETVLLSEQVSHHPPMTA----- 149
           S Y S +  +    KP NP LGE F     + ++  F      +EQVSHHPP++A     
Sbjct: 534 SMYASTTNRVS---KPFNPLLGETFEYARTDGQYRFF------TEQVSHHPPISATWTES 584

Query: 150 --FSIFNEKNDVSVQGYNQIKTGFTKTLTLTVKPYGHVILKIKDETYLITTPPLHIEGIL 207
             +  + E N  S                +T++P  ++   + +ETY    P   + GIL
Sbjct: 585 PKWDFYGECNVDSSFNGRTFAVQHLGLWYITIRPDHNI--SVPEETYSWKKPNNTVIGIL 642

Query: 208 VASPFVELGGRSFIQS-SNGMLCVIEFSGRGYFTGKKNSFKARIYRSPQEHSHKENALYL 266
           +  P V+  G   + + + G  C++ +   G+ +      +  ++      +  +  L++
Sbjct: 643 MGKPQVDNSGDVKVTNHTTGDYCMLHYKAHGWTSAGAYEVRGEVF------NKDDKKLWV 696

Query: 267 ISGQWS------------GVSTI--IKKDSQVS---------HQFYDSSETP------TE 297
           + G W+            G  T+  IK  +  +            + ++E P      T 
Sbjct: 697 LGGHWNDSIYGKKVTARGGELTLDRIKTANSATGGPKLDGSKFLIWKANERPSVPFNLTS 756

Query: 298 HLLVKPIEEQH------PLESRRAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERV 351
             L       H      P +SR   +    A+  G        K  +E KQRA +++   
Sbjct: 757 FALTLNALPPHLIPYLAPTDSR--LRPDQRAMENGEYDKAAAEKHRVEVKQRAAKKEREQ 814

Query: 352 KGVEWQRRWFKQVDY 366
           KG E++ +WF Q ++
Sbjct: 815 KGEEYRPKWFVQEEH 829


>gi|3327222|gnl|PID|d1032640 (AB014604) KIAA0704 protein [Homo
           sapiens]
           Length = 667
           
 Score = 51.5 bits (121), Expect = 1e-05
 Identities = 65/300 (21%), Positives = 118/300 (38%), Gaps = 16/300 (5%)

Query: 95  SQYCSRSESMGSEKKPLNPFLGEVFVGKWKNDEHPEFGETVLLSEQVSHHPPMTAFSIFN 154
           S Y S     GS  KP NP LGE +    + D+  +F      SEQVSHHPP++A     
Sbjct: 371 SAYASSYYRAGS--KPFNPVLGETYECI-REDKGFQF-----FSEQVSHHPPISACHA-E 421

Query: 155 EKNDVSVQGYNQIKTGFTKTLTLTVKPYGHVILKIKDETYLITTPPLHIEGILVASPFVE 214
            +N V  Q        + K++ +      HV L +  + +        I  IL    ++E
Sbjct: 422 SRNFVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIE 481

Query: 215 LGGRSFIQS--SNGMLCVIEFSGRGYFTGKKNSFKARIYRSPQEHSHK-----ENALYLI 267
             G   I++   +   C + F    Y++   +  +  ++    +  H+       ++Y  
Sbjct: 482 HYGEIVIKNLHDDSCYCKVNFIKAKYWSTNAHEIEGTVFDRSGKAVHRLFGKWHESIYCG 541

Query: 268 SGQWSGVSTIIKKDSQVSHQFYDSSETPTEHLLVKPIEEQHPLESRRAWKDVAEAIRQGN 327
            G  S          +   Q+Y  ++   E   + P  +     +   ++     + +GN
Sbjct: 542 GGSSSACVWRANPMPKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGN 601

Query: 328 ISMIKKTKEELENKQRALREQERVKGVEWQRRWFKQVDYMNENTSNDVEKASEDDAFRKL 387
           +   +  K+ +E  QR  R       VE Q R+F++ D  +  ++    +  +D  F KL
Sbjct: 602 LEEAEIQKQRIEQLQRERRRVLEENHVEHQPRFFRKSDDDSWVSNGTYLELRKDLGFSKL 661


>gi|4377460|emb|CAA74289| (Y13951) oxysterol binding protein
           homologue [Drosophila melanogaster]
           Length = 784
           
 Score = 49.6 bits (116), Expect = 4e-05
 Identities = 71/308 (23%), Positives = 116/308 (37%), Gaps = 58/308 (18%)

Query: 95  SQYCSRSESMGSEKKPLNPFLGEVFVGKWKNDEHPEFGETVLLSEQVSHHPPMTAFSIFN 154
           S Y + +   G   KP NP LGE +    + D   ++G   L +EQVSHHPP+ A     
Sbjct: 463 SAYATTTNRTG---KPFNPLLGETY----ECDRMDDYGWRCL-AEQVSHHPPVAALHC-E 513

Query: 155 EKNDVSVQGYNQIKTGFTKTLTLTVKPYGHVILKIKD--ETYLITTPPLHIEGILVASPF 212
            KN    Q ++   T   +   + + P G V ++  +    Y        +  I+V   +
Sbjct: 514 SKNWTCWQEFSM--TSKFRGKYVQINPLGGVYVQFPNSGRRYSWRKVTTTVNNIIVGKLW 571

Query: 213 VELGGRSFI---QSSNGMLCVIEFSGRGYFT-GKKNSFKARIYRSPQEHSHKENALYLIS 268
           V+  G   I   Q++ G  C++ F    YF+   + S K  +     E        +++ 
Sbjct: 572 VDQHGEMEIRGSQAAEGHKCILNFIPYSYFSRDVQRSVKGVVMNKDNE------VKWVVR 625

Query: 269 GQWS---GVSTIIKKDSQVSHQFYDSSE--------------------TPTEHLLVKPIE 305
           G W     ++ ++K    VS   Y + E                    T     L +  E
Sbjct: 626 GTWDMKIEIAPVLKTSGSVSSPTYTTGEFKLAWRRRPAPPDSDKFYNFTTLACQLNEEEE 685

Query: 306 EQHPLESRRAWKDVAEAIRQGNISMIKKTKEELENKQRALREQERVKGVE---------- 355
              P +SR   +     + QG+     K K  LE KQR  R +   +  E          
Sbjct: 686 GVAPTDSR--LRPDQRLMEQGDWDESNKEKLRLEEKQRTERRRRENEAEEAAAEGRPYPA 743

Query: 356 WQRRWFKQ 363
           ++  WFK+
Sbjct: 744 YEPMWFKR 751


>gi|3041847 (AC004542) OXYSTEROL-BINDING PROTEIN-like; similar to
           P22059 (PID:g129308) [Homo sapiens]
           Length = 569
           
 Score = 47.3 bits (110), Expect = 2e-04
 Identities = 56/245 (22%), Positives = 98/245 (39%), Gaps = 31/245 (12%)

Query: 76  SKEVAQMLAVVRWFISTLRSQYCSRSESMGSEKKPLNPFLGEVFVGKWKNDEHPEFGETV 135
           +  V QM  V  + +S       S S ++    KP NP LGE F    + D   + G   
Sbjct: 290 TSSVEQMCLVAAFSVS-------SYSTTVHRIAKPFNPMLGETF----ELDRLDDMGLRS 338

Query: 136 LLSEQVSHHPPMTAFSIFNEKNDVSVQGYNQIKTGFTKTLTLTVKPYG--HVILKIKDET 193
           L  EQVSHHPP  A  +F+ K+  S+     I + F +   +++ P G  H+  +     
Sbjct: 339 LC-EQVSHHPPSAAHYVFS-KHGWSLWQEITISSKF-RGKYISIMPLGAIHLEFQASGNH 395

Query: 194 YLITTPPLHIEGILVASPFVELGGR-SFIQSSNGMLCVIEFSGRGYFTGKKNSFKARIYR 252
           Y+       +  I+V   +++  G    +       C ++F    YF+ +       +  
Sbjct: 396 YVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVS 455

Query: 253 SPQEHSHKENALYLISGQWSGVSTIIKKDSQVSHQFYDSSETPTEHLLVKPIEEQHPLES 312
             Q  +H     Y++SG W        +  + S   + S  +P+     K + +   L +
Sbjct: 456 DSQGKAH-----YVLSGSWD-------EQMECSKVMHSSPSSPSSDGKQKTVYQ--TLSA 501

Query: 313 RRAWK 317
           +  WK
Sbjct: 502 KLLWK 506


  Database: nr
    Posted date:  Mar 13, 1999  7:20 PM
  Number of letters in database: 110,384,460
  Number of sequences in database:  361,503
  
Lambda     K      H
   0.315    0.131    0.385 

Gapped
Lambda     K      H
   0.270   0.0470    0.230 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99819687
Number of Sequences: 361503
Number of extensions: 4223525
Number of successful extensions: 9393
Number of sequences better than 1.0e-03: 23
Number of HSP's better than  0.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 9328
Number of HSP's gapped (non-prelim): 31
length of query: 434
length of database: 110384460
effective HSP length: 57
effective length of query: 377
effective length of database: 89778789
effective search space: 33846603453
effective search space used: 33846603453
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.8 bits)
X3: 64 (24.9 bits)
S1: 42 (22.0 bits)
S2: 105 (45.3 bits)