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Contents SECTION 1 ARCHITECTURE OF THE LIVER 1.1 Macroscopic anatomy of the liver, 000 J.H.D. Fasel, H. Bourquain, H.O. Peitgen and P.E. Majno 1.2 Liver and biliary tract histology, 000 Paulette Bioulac-Sage, Brigitte Le Bail and Charles Balabaud 1.3 Ultrastructure of the hepatocyte and the bile canaliculous, 000 J. Crawford 1.4 Liver sinusoidal endothelial cells, 000 David Semela and Vijay Shah 1.5 Kupffer cells, 000 Hartmut Jaeschke 1.6 The hepatic stellate cell, 000 Massimo Pinzani 1.7 Biliary epithelial cells Jean-Franciois Defour 1.8 Hepatic stem cells, 000 T. Roskams 1.9 Embryology of the liver and intrahepatic biliary tract, 000 Frederic P. Lemaigre SECTION 2 FUNCTIONS OF THE LIVER 2.1 Hepatic circulation 2.1.1 Hepatic blood flow, 000 J.P. Vinel 2.1.2 Hepatic microcirculation, 000 Robert S. McCuskey 2.1.3 Hepatic lymph and lymphatics, 000 Glen A. Laine 2.2 Functions of the liver 2.2.1 Functional organization of the liver, 000 Paulo Renato, A.V. Correa and Michael H. Nathanson 2.2.2 Cell biology of the hepatocyte, 000 Alan W. Wolkoff and Phyllis M. Novikoff 2.2.3 Molecular biology of the liver cell, 000 Saul J. Karpen 2.2.4 Hepatic transport processes, 000 Ronald P.J. Oude Elferink 2.2.5 Modulation of liver function by the hepatic nerves, 000 G.P. Puschel 2.2.6 In vitro techniques: isolated organ perfusion, slices,cells and subcellular elements, 000 Bruno Stieger 2.3 Metabolism: intermediate metabolism 2.3.1 Carbohydrates and the liver, 000 Guenther Boden and Charles Cox Jr 2.3.2 Lipoprotein metabolism, 000 Erez F. Scapa, Keishi Kanno and David E. Cohen 2.3.3 Protein and amino acid metabolism, 000 Margaret E. Brosnan and John T. Brosnan 2.3.4 Mitochondria and energy production, 000 Dominique Pessayre Metabolism: liver-specific functions, 000 2.3.5 Bilirubin metabolism, 000 Namita Roy-Chowdhury, Yang Lu and Jayanta Roy-Chowdhury 2.3.6 Metabolism of bile acids, 000 Peter L.M. Jansen and Klaas N. Faber 2.3.7 Ammonia, urea production and pH regulation, 000 Dieter Häussinger 2.3.8 Protein synthesis and degradation in the liver, 000 Armin Akhavan and Vishwanath R. Lingappa 2.3.9 Glutathione, 000 José C. Fernßndez-Checa and Carmen Garcøa-Ruiz 2.3.10 Haem biosynthesis and excretion of porphyrins, 000 Hervé Puy and Jean-Charles Deybach Metabolism: metabolism of endo/xenobiotics 2.3.11 Vitamins and the liver (A and D), 000 Masataka Okuno, Rie Matsushima-Nishiwaki and Soichi Kojima 2.3.12 Normal iron metabolism, 000 Kyle E. Brown 2.3.13 Normal copper metabolism and reducing copper to abnormal levels for therapeutic purposes, 000 George J. Brewer, E.D. Harris and F.K. Askari 2.3.14 Trace elements and the liver, 000 Brent A. Neuschwander-Tetri 2.3.15 Hepatic metabolism of drugs, 000 Christopher Liddle and Catherine A.M. Stedman 2.4 Synthetic function 2.4.1 Albumin and other carrier proteins, 000 Richard A. Weisiger 2.4.2 The liver and coagulation, 000 Maria T. DeSancho and Stephen M. Pastores 2.4.3 Function and metabolism of collagen and other extracellular matrix proteins, 000 Rebecca G. Wells 2.5 Regulation of the liver cell mass 2.5.1 Control of liver cell proliferation, 000 Nisar P. Malek and K. Lenhard Rudolph 2.5.2 Dynamics and pathways of hepatic regeneration, 000 Anna Mae Diehl 2.6 Excretion 2.6.1 Physiology of bile formation, 000 Michael Trauner 2.6.2 The motility of the biliary tree, 000 Mayank Bhandari and James Toouli 2.7 Immunology of the liver 2.7.1 Cytokines and the liver, 000 Tom Luedde and Christian Trautwein 2.7.2 Intrahepatic lymphocytes, 000 Wajahat Z. Mehal 2.7.3 Antibody production and transport in the liver, 000 Alvin Imaeda and Wajahat Z. Mehal SECTION 3 BASIC CONCEPTS IN PATHOBIOLOGY 3.1 Hepatocyte apoptosis and necrosis, 000 Henning Schulze-Bergkamen, Marcus Schuchmann and Peter R. Galle 3.2 Ischemia reperfusion injury to the liver, 000 Nazia Selzne and Pierre-A. Clavien 3.3 Genetics and liver diseases 3.3.1 Polymorphisms, 000 Hongjin Huang 3.3.2 Immunogenetics of liver disease, 000 Peter T. Donaldson 3.3.3 Genetic determinants, 000 Frank Lammert 3.4 Cellular cholestasis, 000 ` Stefano Fiorucci 3.5 Oncogenes and tumour suppressor genes, 000 Dipanker Chattopadhyay and Helen Reeves 3.6 Genomics, gene arrays and proteomics in the study of liver disease, 000 Geoffrey W. McCaughan, Nicholas A. Shackel, Rohan Williams, Devanshi Seth, Paul S. Haber and Mark D. Gorrell SECTION 4 PATHOLOGY 4.1 Histological features, 000 Ian R. Wanless 4.2 Classification, scoring systems and morphometry in liver pathology, 000 Pierre Bedossa and Valerie Paradis SECTION 5 ASSESSMENT OF HEPATOBILIARY DISEASE 5.1 Signs and symptoms of liver disease, 000 Jürg Reichen 5.2 Biochemical investigations in the management of liver disease, 000 Igino Rigato, Jay D. Ostrow and Claudio Tiribelli 5.3 Hepatic removal kinetics: importance for quantitative measurements of liver function, 000 Susanne Keiding and Michael S°rensen 5.4 Immunological investigations in liver diseases, 000 Michael Manns 5.5 Biopsy and laparoscopy, 000 Arthur Zimmermann 5.6 Imaging of the liver 5.6.1 Ultrasonography, 000 Luigi Bolondi, Valeria Camaggi and Fabio Piscaglia 5.6.2 Computerized tomography imaging of the liver, 000 Daniel T. Cohen and Dushyant V. Sahani 5.6.3 Magnetic resonance imaging, 000 Christoforos Stoupis 5.6.4 Angiography, 000 Sanjeeva P. Kalva and Dushyant V. Sahani 5.6.5 Endoscopic retrograde cholangiopancreatography, 000 Alan J. Wigg and James Toouli 5.7 Interventional radiology in hepatobiliary diseases, 000 Yves Menu 5.8 Positron emission tomography of the liver, 000 Susanne Keiding and Michael S°rensen 5.9 Splanchnic haemodynamic investigations, 000 Didier Lebrec 5.10 The Cochrane Hepatobiliary Group, 000 Christian Gluud SECTION 6 CIRRHOSIS 6.1 The evolution of cirrhosis, 000 John P. Iredale 6.2 Cellular and molecular pathobiology of liver fibrosis and its pharmacological intervention, 000 Scott Friedman 6.3 Cirrhosis: clinical aspects, 000 John P. Iredale SECTION 7 PORTAL HYPERTENSION AND ITS COMPLICATIONS 7.1 Anatomy of the portal venous system in portal hypertension, 000 Ian Wanless 7.2 Pathophysiology of portal hypertension, 000 Roberto Groszmann 7.3 Clinical manifestion as and management of bleeding episodes in cirrhotics, 000 Jaume Bosch, Juan Gonzalez-Abraldes and Juan C. Garcøa-Pagßn 7.4 Hemodynamic assessment of portal hypertension, 000 Juan C. Garcøa-Pagßn 7.5 Ascites, 000 Vincente Arroyo 7.6 Hepatorenal syndrome, 000 Pere Ginès and Mónica Guevara 7.7 Pulmonary complications of portal hypertension, 000 Michael J. Krowka 7.8 Hepatic encephalopathy, 000 Andres Blei and Dieter Haussinger 7.9 Bacterial infections, 000 M. Navasa 7.10 Hypersplenism, 000 P. Aiden McCormick SECTION 8 CONGENITAL HEPATIC FIBROSIS AND NON PARASITIC DISEASES OF THE LIVER 8.1 Congenital hepatic cystic diseases 8.1.1 Congenital hepatic fibrosis, 000 Jean-Pierre Benhamou 8.1.2 Simple cyst of the liver, 000 Valarie Vilagrain 8.1.3 Adult dominant polycystic kidney disease, 000 Valarie Vilagrain 8.1.4 Adult dominant polycystic liver disease, 000 Valarie Vilagrain 8.1.5 Biliary hamartomas, 000 Valarie Vilagrain 8.1.6 Peribiliary cysts, 000 Valarie Vilagrain 8.1.7 Caroli syndrome, 000 Jean-Pierre Benhamou 8.1.8 Choledochal cyst, 000 Jean-Pierre Benhamou 8.1.9 Foregut cyst, 000 Jean F. Cadranel 8.2 Acquired conditions 8.2.1 Inflammatory, 000 Jean F. Cadranel 8.2.2 Neoplastic including cystadenoma, 000 P. Starkel and Andre P. Geubel 8.2.3 Post-traumatic, 000 Jean F. Cadranel SECTION 9 VIRAL INFECTIONS OF THE LIVER 9.1 Viral hepatitis 9.1.1 Introduction, 000 Mario Rizzetto 9.1.2 The viruses of hepatitis, 000 i) Structure, replication and laboratory diagnosis of hBV and HDV, 000 Wolfram H. Gerlich and Stephan Schaefer ii) Structure, replication and laboratory diagnosis of HCV, 000 Ralf Bartenschlager iii) Hepatitis A, 000 J. Dienstag iv) Hepatitis B, 000 Geoffrey M. Dusheiko v) Hepatitis D, 000 Antonella Smedile and Mario Rizzetto vi) Hepatitis C, 000 Alfredo Alberti vii) Hepatitis E, 000 Kris Krawczynski and Rakesh Aggarwal 9.1.3 Prevention and treatment of viral hepatitis i) Vaccines against hepatitis A, 000 Pierre Van Damme, Koen Van Herck and Philippe Beutels ii) Hepatitis B vaccines and immunization, 000 Daniel Lavanchy iii) Therapy of acute viral hepatitis, 000 Michael Manns iv) Antiviral therapy of chronic hepatitis B, 000 Fabien Zoulim v) Therapy of chronic hepatitis C, 000 Mario Rizzetto 9.2 Systemic virosis producing hepatitis, 000 M.Rizzetto 9.3 HIV and the liver, 000 Vincent Soriano 9.4 Exotic virus infections of the liver, 000 Pierre Rollin SECTION 10 OTHER INFECTIONS OF THE LIVER 10.1 Bacterial infection and leptospirosis, 000 Sanchez Tapias 10.2 Fungal infections affecting the liver, 000 Roderick J. Hay 10.3 Protozoal infections affecting the liver 10.3.1 Amoebiasis, giardiasis and cryptosporidiosis, 000 David Kershenobich, Guillermo Robles Diaz and Juan Miguel Abdo 10.3.2 Malaria, 000 Pedro Alonso 10.3.3 Visceral leishmaniasis, 000 Manuel Corachan 10.4 Helminthiasis 10.4.1 Blood flukes (schistomes) and liver flukes, 000 Flair Carrilho 10.4.2 Echinococcosis of the liver, 000 Solange Bresson-Hadni 10.4.3 Ascariasis, visceral larva migrans, capillariasis, strongyloidiasis and pentastomiasis, 000 Edna Strauss and M. Ferreira SECTION 11 IMMUNE DISORDERS OF THE LIVER 11.1 Primary bililary cirrhosis, 000 Jenny Heathcote and Piotr Milkiewicz 11.2 Autoimmune hepatitis, 000 Diego Vergani and Giorgina Mieli-Vergani 11.3 Scleroising cholangitis, 000 Konstantinos N. Lazaridis and Nicolas F. La Russo 11.4 Vanishing bile duct syndrome, 000 Frank Grünhage and Tilman Sauerbruch 11.5 Overlap syndromes, 000 Ulrich Beuers SECTION 12 ALCOHOLIC LIVER DISEASE 12.1 Epidemiological aspects of alcoholic liver disease, 000 Juan Caballeria 12.2 Ethanol metabolism and pathogenesis of alcoholic liver injury, 000 Christopher Day and Steven Stewart 12.3 Pathology of alcoholic liver disease, 000 Elie Serge Zafrani 12.4 Natural history, diagnosis, clinical features, evaluation, management, prognosis and prevention, 000 Laurent Spahr and Antoine Hadengue 12.5 Management of the alcoholic patient, 000 Georges Pageaux SECTION 13 HEPATIC NON-ALCOHOLIC STEATOSIS 13 Hepatic non-alcoholic steatosis, 000 Geoffrey Farrell SECTION 14 TOXIC LIVER INJURY 14.1 Drug-induced liver injury, 000 Dominique Pessayre 14.2 Toxic liver injury, 000 Basuki Gunawan and Neil Kaplowitz 14.3 Hepatic injury due to physical agents, 000 Bernhard H. Lauterburg 14.4 Hepatic toxicity induced by herbal medicines, 000 Felix Stickel and Detlef Schuppan SECTION 15 ACUTE LIVER FAILURE 15 Acute liver failure and related syndromes François Durand and Jaques Bernuau SECTION 16 GENETIC AND METABOLIC DISEASES 16.1 Wilson¿s disease, 000 M. Schilsky 16.2 Haemochromatosis, 000 Antonello Pietrangelo 16.3 Alpha 1-antitrypsin deficiency and related disorders, 000 Jeffrey H. Teckman 16.4 The liver in cystic fibrosis, 000 Andrew P. Feranchak 16.5 Human hereditary porphyrias, 000 Elisabeth I. Minder 16.6 Hyperbilirubinaemia, 000 Peter L.M. Jansen 16.7 The liver in intracellular and extracellular lipidosis, 000 Dominique Germain 16.8 Glycogen storage diseases, 000 Philippe Labrune 16.9 Mitochondriopathies, 000 Pierre Rustin 16.10 Genetic cholestatic diseases, 000 Ronald P.J. Oude Elferink SECTION 17 VASCULAR DISEASES 17.1 Hepatic artery diseases, 000 P.C. Hayes 17.2 Obstruction of the portal vein, 000 Juan C. Garcøa-Pagßn, M. Hernßndez-Guerra and J. Bosch 17.3 Disorders of the hepatic vein and hepatic sinusoids, 000 Dominique Charles Valla 17.4 Vascular malformations, 000 Guadalupe Garcøa Tsao SECTION 18 TUMOURS OF THE LIVER 18.1 Benign hepatic tumours 18.1.1 Liver haemangioma, 000 Jean-Pierre Benhamou 18.1.2 Benign hepatocellular tumours, 000 Massimo Colombo 18.2 Malignant tumours 18.2.1 Primary liver cell carcinoma, 000 Jordi Bruix 18.2.2 Malignant mesenchymal tumours of the liver, 000 Miguel Bruguera and Juan Rodés 18.3 Metastatic tumours, 000 18.3.1 Metastatic liver disease, 000 Masamichi Kojiro and Antoni Castells 18.3.2 Carcinoid tumours, 000 H.J.F. Hodgson SECTION 19 BILIARY TRACT DISEASES 19.1 Intrahepatic cholestasis, 000 Oliver Chazouilleres 19.2 Extrahepatic biliary obstruction: systemic effects, diagnosis, management, 000 James Dooley 19.3 Gallstone diseases, 000 Frank Lammert, Franz Ludwig Dumoulin and Tilman Sauerbruch 19.4 Cholangitis and biliary tract infections, 000 Ulrich Beuers 19.5 Haemobilia, 000 Antoni Lacy 19.6 Biliary dysmotility, 000 Giles J. Toogood and Ritchie Chalmers 19.7 Benign biliary tumours, 000 Miguel Bruguera 19.8 Gallbladder carcinoma, 000 Thomas A. Aloia, Christopher H. Crane and Jean-Nicolas Vauthey 19.9 Cholangiocarcinoma, 000 Steven S. Strasberg and William G. Hawkins SECTION 20 THE LIVER IN DISEASES OF OTHER SYSTEMS 20.1 The liver in cardiovascular diseases, 000 M. Gheorghiade 20.2 The liver in lung diseases, 000 Andres Blei and Jacob I. Sznajder 20.3 The effect of gastrointestinal diseases on the liver and biliary tract, 000 Roger Chapman and Peter Angus 20.4 Total parenteral nutrition and the liver, 000 Alan Buchman and Shean Kopley 20.5 The effect of skin diseases on the liver, 000 Malcolm Rustin and Daniel Glass 20.6 The liver in urogenital diseases, 000 Juan Rodés 20.7 The effect of haematological and lymphatic diseases on the liver, 000 Miguel Bruguera 20.8 The liver in graft versus host disease, 000 Enric Carreras and Emil Montserrat 20.9 The effect of endocrine diseases on liver function, 000 Anthony DeSantis and Andres Blei 20.10 Rheumatological diseases and the liver, 000 Douglas Labrecque 20.11 Amyloidosis, 000 Philip Hawkins 20.12 Hepatic granulomas and sarcoidosis, 000 Scott Budinger SECTION 21 THE IMPACT OF LIVER DISEASE ON OTHER SYSTEMS 21.1 Effect of liver disease on the cardiovascular system, 000 Jens H. Henriksen and S°ren M°ller 21.2 Effect of liver disease on the endocrine system, 000 Anthony DeSantis 21.3 Haematological abnormalities in liver disease, 000 Andrew Burroughs and Marco Senzolo 21.4 Haemostasis in liver disease, 000 Stephen Caldwell 21.5 Effect of liver disease on the gastrointestinal tract, 000 Roger Chapman and Peter Angus 21.6 Effect of liver disease on the skin, 000 Malcolm Rustin and Daniel Glass 21.7 Effect of liver on the urogenital tract, 000 Juan Rodés 21.8 The nervous system in liver disease, 000 Andres Blei 21.9 The effect of liver disease on bone metabolism, 000 Juliet Compston 21.10 The effect of liver disease on nutritional and energy metabolism, 000 Michael Charlton SECTION 22 THE LIVER IN SPECIFIC SETTINGS 22.1 Pediatric liver diseases, 000 Giorgina Mieli-Vergani 22.2 Liver diseases in the elderly, 000 Oliver James 22.3 Liver diseases and pregnancy, 000 Andrew K. Burroughs and Evangelos Cholongitas SECTION 23 THE MANAGEMENT OF LIVER DISEASES 23.1 The general management of liver disease, 000 Dominique Guyader 23.2 Nutritional aspects of liver and biliary disease, 000 Bernard Campillo 23.3 Prescribing drugs in liver disease, 000 Dominique Larrey 23.4 Management of pre-transplant patients, 000 François Durand SECTION 24 SURGERY, ANAESTHESIA AND THE LIVER 24.1 General surgical aspects and the risks of liver surgery in patients with hepatic disease, 000 Jacques Belghiti 24.2 Anaesthesia and liver disease, 000 Susan Mallett and Kalpana Reddy 24.3 Postoperative jaundice, 000 Peter Fickert and Michael Trauner 24.4 Hepatobiliary trauma, 000 Giles J. Toogood, Raj Prasad and Paddy Couglin SECTION 25 LIVER TRANSPLANTATION 25.1 Surgical techniques 25.1.1 Liver transplantation, 000 Peter Neuhaus 25.1.2 Split liver transplantation, 000 Juan C. Garcia-Valdecasas 25.1.3 Living donor liver transplantation, 000 E. Pomfret 25.2 Indications/contraindications/results, 000 Gregory T. Everson and Fernando E. Membreno 25.3 Perioperative care and complications of liver transplantation, 000 Mark T. Keegan and David J. Plevak 25.4 Immunnosuppression, 000 James Neuberger 25.5 Recurrent disease and management, 000 Xavier Forns 25.6 Post transplantation management and complications, 000 Faouzi Saliba and Didier Samuel 25.7 Quality of life after liver transplantation, 000 M. Navasa 25.8 Emerging therapies 25.8.1 Hepatocyte transplantation, 000 Ira Fox 25.8.2 Artificial liver support systems, 000 Rajiv Jalan SECTION 26 MATHEMATICS IN HEPATOLOGY 26.1 Models in clinical hepatology, 000 Kim Woong 26.2 Outcomes research in hepatology, 000 Raymond S. Koff 26.3 Meta-analysis, 000 Giocchino Leandro and Andrew K. Burroughs 26.4 Economic considerations in hepatology, 000 John B. Wong 26.5 The virtual liver: mapping interactome network, 000 Ravi Lyengar SECTION 27 APPENDICES 27.1 Geographic distribution of infections causing liver disease, 000 Harriet Hughes and Tom Doherty 27.2 Liver injury in man from non-drug chemicals and natural toxins, 000 Regine Kahl 27.3 Rare diseases with hepatic abnormalities, 000 Miguel Bruguera
Library of Congress Subject Headings for this publication:
Liver -- Diseases.
Liver Diseases.