Mallolas J, Pontes JC, Gatell JM, Miro JM, Zamora L, Valls ME, Soriano E; International Conference on AIDS.

Int Conf AIDS. 1992 Jul 19-24; 8: B122 (abstract no. PoB 3212).

Infectious Disease and Microbiology Services, Hospital Clinic, Barcelona, Spain.

OBJECTIVE. To describe the characteristics and evaluate the efficacy of SMS 201-995 (in a subgroup) in 56 consecutive Cryptosporidium enteritis in HIV patients. METHOD. We included all HIV infected patients suffering from chronic cryptosporidium enteritis. The epidemiological, clinical, and outcome characteristics as well as the efficacy and tolerance to therapy were prospectively recorded. RESULTS. From 1984 to 1991 we have diagnosed 56 consecutive Cryptosporidium enteritis in HIV patients among a total number of about 750 AIDS case (7.4%). The mean age was 35.9 years, 49 (87.5%) were males and the behavioral risk for HIV was: Homosexual male 26 (46%), intravenous drug abuser 20 (36%), heterosexual contact 4 (7%) and unknown 6 (11%). Un 12 patients (22%) the enteritis was considered severe (more than 5 bowel movements/day). It was the first AIDS indicator in 8 (14%), in 24 (42%) presented together other AIDS indicator and in 24 cases was detected in the follow-up. The mean CD4 cell count per milliliter was 64 (standard deviation 67). Thirty eight (67%) received spiramycin, 12 somatostatin analog SMS 201-995 and in 13 cases no therapy was started. All 12 treated with SMS 201-995 were severe cases and no response could be obtained with conventional therapy; in 10 (83%) the initial response was good (less than 3 bowel movements/day). Thirty nine patients (69%) have already died but only in 3 of them the death was clearly related with the enteritis. CONCLUSIONS. Cryptosporidium enteritis is a relatively frequent manifestation in AIDS and appear in advanced stages. Until now, no specific therapy can be available but SMS 201-995 could be an alternative in selected cases to control the diarrhea.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Animals
• Antiretroviral Therapy, Highly Active
• CD4 Lymphocyte Count
• Cryptosporidium
• Cryptosporidium parvum
• Diarrhea
• Enteritis
• HIV Infections
• HIV Seropositivity
• Humans
• Male
• drug therapy
• therapy

Other ID:

• 92400944

UI: 102198657

From Meeting Abstracts