BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= STr0786
(311 letters)
Database: nr
5,470,121 sequences; 1,894,087,724 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55820838|ref|YP_139280.1| 5,10-methylenetetrahydrofolate... 619 e-176
gi|116627654|ref|YP_820273.1| 5,10-methylenetetrahydrofolat... 610 e-173
gi|149002267|ref|ZP_01827209.1| 5-methyltetrahydropteroyltr... 506 e-142
gi|149010794|ref|ZP_01832165.1| polynucleotide phosphorylas... 502 e-140
gi|15900495|ref|NP_345099.1| 5,10-methylenetetrahydrofolate... 501 e-140
gi|148988950|ref|ZP_01820350.1| 5,10-methylenetetrahydrofol... 501 e-140
gi|15902559|ref|NP_358109.1| 5,10-methylenetetrahydrofolate... 497 e-139
gi|125717284|ref|YP_001034417.1| 5,10-methylenetetrahydrofo... 472 e-131
gi|157074526|gb|ABV09209.1| 5,10-methylenetetrahydrofolate ... 470 e-131
gi|81177180|ref|ZP_00876045.1| 5,10-methylenetetrahydrofola... 456 e-127
gi|146319429|ref|YP_001199141.1| 5,10-methylenetetrahydrofo... 456 e-126
gi|125624052|ref|YP_001032535.1| MetF protein [Lactococcus ... 322 1e-86
gi|116512094|ref|YP_809310.1| 5,10-methylenetetrahydrofolat... 321 3e-86
gi|15673236|ref|NP_267410.1| 5,10-methylenetetrahydrofolate... 319 2e-85
gi|13374134|emb|CAC34449.1| 5,10-methylenetetrahydrofolate ... 273 1e-71
gi|114566466|ref|YP_753620.1| 5,10-methylenetetrahydrofolat... 272 2e-71
gi|57505233|ref|ZP_00371162.1| 5,10-methylenetetrahydrofola... 263 1e-68
gi|86150317|ref|ZP_01068543.1| 5,10-methylenetetrahydrofola... 262 2e-68
gi|148926205|ref|ZP_01809890.1| 5,10-methylenetetrahydrofol... 261 3e-68
gi|86150790|ref|ZP_01069006.1| 5,10-methylenetetrahydrofola... 261 4e-68
gi|86152732|ref|ZP_01070937.1| 5,10-methylenetetrahydrofola... 261 5e-68
gi|121612730|ref|YP_001000877.1| 5,10-methylenetetrahydrofo... 261 5e-68
gi|57238074|ref|YP_179323.1| 5,10-methylenetetrahydrofolate... 260 9e-68
gi|57168082|ref|ZP_00367221.1| 5,10-methylenetetrahydrofola... 259 2e-67
gi|153951782|ref|YP_001397705.1| 5,10-methylenetetrahydrofo... 257 7e-67
gi|15792526|ref|NP_282349.1| 5,10-methylenetetrahydrofolate... 256 1e-66
gi|154487397|ref|ZP_02028804.1| hypothetical protein BIFADO... 239 1e-61
gi|119025775|ref|YP_909620.1| 5,10-methylenetetrahydrofolat... 238 5e-61
gi|116494174|ref|YP_805908.1| 5,10-methylenetetrahydrofolat... 234 6e-60
gi|23465373|ref|NP_695976.1| 5,10-methylenetetrahydrofolate... 233 8e-60
gi|154482518|ref|ZP_02024966.1| hypothetical protein EUBVEN... 233 1e-59
gi|46191194|ref|ZP_00206701.1| COG0685: 5,10-methylenetetra... 231 6e-59
gi|148379582|ref|YP_001254123.1| 5,10-methylenetetrahydrofo... 227 7e-58
gi|153938503|ref|YP_001390959.1| 5,10-methylenetetrahydrofo... 226 1e-57
gi|106893157|ref|ZP_01360283.1| 5,10-methylenetetrahydrofol... 216 2e-54
gi|116514292|ref|YP_813198.1| 5,10-methylenetetrahydrofolat... 216 2e-54
gi|154499971|ref|ZP_02038009.1| hypothetical protein BACCAP... 215 3e-54
gi|148322742|gb|EDK87992.1| 5,10-methylenetetrahydrofolate ... 215 3e-54
gi|153853053|ref|ZP_01994462.1| hypothetical protein DORLON... 207 6e-52
gi|121535729|ref|ZP_01667532.1| 5,10-methylenetetrahydrofol... 203 1e-50
gi|106887797|ref|ZP_01355076.1| 5,10-methylenetetrahydrofol... 203 1e-50
gi|154502468|ref|ZP_02039528.1| hypothetical protein RUMGNA... 198 4e-49
gi|153814714|ref|ZP_01967382.1| hypothetical protein RUMTOR... 197 5e-49
gi|51245464|ref|YP_065348.1| similar to 5,10-methylenetetra... 195 2e-48
gi|114565935|ref|YP_753089.1| 5,10-methylenetetrahydrofolat... 195 3e-48
gi|115379397|ref|ZP_01466500.1| 5,10-methylenetetrahydrofol... 195 3e-48
gi|108760527|ref|YP_631248.1| 5,10-methylenetetrahydrofolat... 192 2e-47
gi|95929439|ref|ZP_01312182.1| 5,10-methylenetetrahydrofola... 192 3e-47
gi|68552087|ref|ZP_00591479.1| 5,10-methylenetetrahydrofola... 189 2e-46
gi|139438198|ref|ZP_01771751.1| Hypothetical protein COLAER... 186 1e-45
gi|150391113|ref|YP_001321162.1| Methylenetetrahydrofolate ... 185 3e-45
gi|68549543|ref|ZP_00589006.1| 5,10-methylenetetrahydrofola... 183 1e-44
gi|125972623|ref|YP_001036533.1| 5,10-methylenetetrahydrofo... 182 2e-44
gi|156863259|gb|EDO56690.1| hypothetical protein CLOL250_02... 182 3e-44
gi|145219514|ref|YP_001130223.1| 5,10-methylenetetrahydrofo... 181 5e-44
gi|153005527|ref|YP_001379852.1| 5,10-methylenetetrahydrofo... 180 1e-43
gi|53802580|ref|YP_112676.1| 5,10-methylenetetrahydrofolate... 179 3e-43
gi|78189075|ref|YP_379413.1| 5,10-methylenetetrahydrofolate... 178 3e-43
gi|15606607|ref|NP_213987.1| 5,10-methylenetetrahydrofolate... 177 7e-43
gi|77919330|ref|YP_357145.1| 5,10-methylenetetrahydrofolate... 176 1e-42
gi|119357520|ref|YP_912164.1| 5,10-methylenetetrahydrofolat... 176 2e-42
gi|21674190|ref|NP_662255.1| 5,10-methylenetetrahydrofolate... 176 2e-42
gi|67919462|ref|ZP_00513039.1| 5,10-methylenetetrahydrofola... 174 5e-42
gi|91774547|ref|YP_544303.1| 5,10-methylenetetrahydrofolate... 172 2e-41
gi|149174500|ref|ZP_01853126.1| 5,10-methylenetetrahydrofol... 172 2e-41
gi|46199958|ref|YP_005625.1| methylenetetrahydrofolate redu... 172 3e-41
gi|24217063|ref|NP_714546.1| 5,10-methylenetetrahydrofolate... 170 8e-41
gi|45655587|ref|YP_003396.1| 5,10 methylene tetrahydrofolat... 170 9e-41
gi|7582424|gb|AAF64321.1|AF253051_1 5,10 methylene tetrahyd... 170 9e-41
gi|119475425|ref|ZP_01615778.1| 5,10-methylenetetrahydrofol... 169 1e-40
gi|86159098|ref|YP_465883.1| 5,10-methylenetetrahydrofolate... 169 2e-40
gi|134300036|ref|YP_001113532.1| 5,10-methylenetetrahydrofo... 168 3e-40
gi|83746006|ref|ZP_00943062.1| Methylenetetrahydrofolate re... 168 4e-40
gi|82703654|ref|YP_413220.1| 5,10-methylenetetrahydrofolate... 168 4e-40
gi|149918735|ref|ZP_01907222.1| 5,10-methylenetetrahydrofol... 167 5e-40
gi|116329561|ref|YP_799280.1| 5,10-methylenetetrahydrofolat... 165 3e-39
gi|153885348|ref|ZP_02006505.1| 5,10-methylenetetrahydrofol... 165 4e-39
gi|17544810|ref|NP_518212.1| PROBABLE 5,10-METHYLENETETRAHY... 164 6e-39
gi|73539921|ref|YP_294441.1| 5,10-methylenetetrahydrofolate... 164 7e-39
gi|121528677|ref|ZP_01661290.1| putative 5,10-methylenetetr... 164 9e-39
gi|91792004|ref|YP_561655.1| 5,10-methylenetetrahydrofolate... 163 1e-38
gi|113866277|ref|YP_724766.1| 5,10-Methylenetetrahydrofolat... 163 2e-38
gi|91785597|ref|YP_560803.1| 5,10-methylenetetrahydrofolate... 162 2e-38
gi|50123164|ref|YP_052331.1| 5,10-methylenetetrahydrofolate... 162 2e-38
gi|94309117|ref|YP_582327.1| 5,10-methylenetetrahydrofolate... 162 3e-38
gi|67939413|ref|ZP_00531915.1| 5,10-methylenetetrahydrofola... 162 3e-38
gi|59712916|ref|YP_205692.1| 5,10-methylenetetrahydrofolate... 161 4e-38
gi|94501839|ref|ZP_01308351.1| 5,10-methylenetetrahydrofola... 161 5e-38
gi|83644379|ref|YP_432814.1| 5,10-methylenetetrahydrofolate... 161 6e-38
gi|117621243|ref|YP_858383.1| 5,10-methylenetetrahydrofolat... 161 6e-38
gi|118032263|ref|ZP_01503713.1| 5,10-methylenetetrahydrofol... 160 9e-38
gi|37528569|ref|NP_931914.1| 5,10-methylenetetrahydrofolate... 160 1e-37
gi|114771528|ref|ZP_01448938.1| 5,10-methylenetetrahydrofol... 160 1e-37
gi|34496421|ref|NP_900636.1| 5,10-methylenetetrahydrofolate... 160 1e-37
gi|152988219|ref|YP_001345925.1| 5,10-methylenetetrahydrofo... 159 2e-37
gi|78486163|ref|YP_392088.1| 5,10-methylenetetrahydrofolate... 159 2e-37
gi|118040259|ref|ZP_01511655.1| 5,10-methylenetetrahydrofol... 159 2e-37
gi|116618884|ref|YP_819255.1| 5,10-methylenetetrahydrofolat... 159 3e-37
gi|46579410|ref|YP_010218.1| 5,10-methylenetetrahydrofolate... 158 4e-37
gi|148977254|ref|ZP_01813881.1| 5,10-methylenetetrahydrofol... 158 4e-37
gi|6016545|sp|P71319|METF_PECCC 5,10-methylenetetrahydrofol... 158 5e-37
gi|78187206|ref|YP_375249.1| 5,10-methylenetetrahydrofolate... 158 5e-37
gi|16416900|gb|AAL18459.1| unknown [Photorhabdus luminescens] 158 5e-37
gi|32474881|ref|NP_867875.1| 5,10-methylenetetrahydrofolate... 157 6e-37
gi|120555954|ref|YP_960305.1| 5,10-methylenetetrahydrofolat... 157 7e-37
gi|146284248|ref|YP_001174401.1| 5,10-methylenetetrahydrofo... 157 8e-37
gi|148244912|ref|YP_001219606.1| 5,10-methylenetetrahydrofo... 157 9e-37
gi|77956365|ref|ZP_00820470.1| COG0685: 5,10-methylenetetra... 157 9e-37
gi|78064854|ref|YP_367623.1| 5,10-methylenetetrahydrofolate... 157 1e-36
gi|110597927|ref|ZP_01386209.1| 5,10-methylenetetrahydrofol... 157 1e-36
gi|49083086|gb|AAT50943.1| PA0430 [synthetic construct] 157 1e-36
gi|107024376|ref|YP_622703.1| 5,10-methylenetetrahydrofolat... 157 1e-36
gi|84363502|ref|ZP_00988081.1| COG0685: 5,10-methylenetetra... 157 1e-36
gi|88705488|ref|ZP_01103199.1| 5,10-methylenetetrahydrofola... 157 1e-36
gi|33593993|ref|NP_881637.1| putative methylenetetrahydrofo... 156 1e-36
gi|104783957|ref|YP_610455.1| 5,10-methylenetetrahydrofolat... 156 2e-36
gi|118711673|ref|ZP_01564247.1| 5,10-methylenetetrahydrofol... 156 2e-36
gi|118594099|ref|ZP_01551446.1| metF; 5,10-methylenetetrahy... 156 2e-36
gi|71905825|ref|YP_283412.1| 5,10-methylenetetrahydrofolate... 156 2e-36
gi|113971767|ref|YP_735560.1| 5,10-methylenetetrahydrofolat... 156 2e-36
gi|126358338|ref|ZP_01715337.1| 5,10-methylenetetrahydrofol... 156 2e-36
gi|134294350|ref|YP_001118085.1| 5,10-methylenetetrahydrofo... 156 2e-36
gi|127511456|ref|YP_001092653.1| 5,10-methylenetetrahydrofo... 156 2e-36
gi|74318535|ref|YP_316275.1| 5,10-methylenetetrahydrofolate... 156 2e-36
gi|121603404|ref|YP_980733.1| 5,10-methylenetetrahydrofolat... 155 2e-36
gi|77960049|ref|ZP_00823947.1| COG0685: 5,10-methylenetetra... 155 2e-36
gi|126642375|ref|YP_001085359.1| 510-methylenetetrahydrofol... 155 2e-36
gi|77461502|ref|YP_351009.1| 5,10-methylenetetrahydrofolate... 155 2e-36
gi|84356259|ref|ZP_00981113.1| COG0685: 5,10-methylenetetra... 155 2e-36
gi|77976264|ref|ZP_00831769.1| COG0685: 5,10-methylenetetra... 155 3e-36
gi|91227302|ref|ZP_01261727.1| 5,10-methylenetetrahydrofola... 155 3e-36
gi|86147309|ref|ZP_01065623.1| 5,10-methylenetetrahydrofola... 155 3e-36
gi|84390837|ref|ZP_00991529.1| 5,10-methylenetetrahydrofola... 155 3e-36
gi|118720061|ref|ZP_01572589.1| 5,10-methylenetetrahydrofol... 155 3e-36
gi|152999088|ref|YP_001364769.1| 5,10-methylenetetrahydrofo... 155 4e-36
gi|24375541|ref|NP_719584.1| 5,10-methylenetetrahydrofolate... 155 4e-36
gi|15595627|ref|NP_249121.1| 5,10-methylenetetrahydrofolate... 155 4e-36
gi|118593283|ref|ZP_01550668.1| Methylenetetrahydrofolate r... 155 4e-36
gi|16120462|ref|NP_403775.1| 5,10-methylenetetrahydrofolate... 155 4e-36
gi|115421264|emb|CAJ47769.1| 5,10-methylenetetrahydrofolate... 155 4e-36
gi|29655326|ref|NP_821018.1| 5,10-methylenetetrahydrofolate... 155 4e-36
gi|82546293|ref|YP_410240.1| 5,10-methylenetetrahydrofolate... 155 4e-36
gi|83814829|ref|YP_446200.1| 5,10-methylenetetrahydrofolate... 155 4e-36
gi|124545548|ref|ZP_01704741.1| 5,10-methylenetetrahydrofol... 155 4e-36
gi|120600344|ref|YP_964918.1| 5,10-methylenetetrahydrofolat... 154 5e-36
gi|70733084|ref|YP_262857.1| 5,10-methylenetetrahydrofolate... 154 5e-36
gi|153206974|ref|ZP_01945792.1| 5,10-methylenetetrahydrofol... 154 6e-36
gi|119856482|ref|ZP_01637915.1| 5,10-methylenetetrahydrofol... 154 6e-36
gi|154706556|ref|YP_001425447.1| 5,10-methylenetetrahydrofo... 154 6e-36
gi|113947237|ref|ZP_01432903.1| 5,10-methylenetetrahydrofol... 154 6e-36
gi|16131779|ref|NP_418376.1| 5,10-methylenetetrahydrofolate... 154 7e-36
gi|75765836|pdb|1ZP3|A Chain A, E. Coli Methylenetetrahydro... 154 7e-36
gi|6729702|pdb|1B5T|A Chain A, Escherichia Coli Methylenete... 154 7e-36
gi|15804538|ref|NP_290578.1| 5,10-methylenetetrahydrofolate... 154 7e-36
gi|99032263|pdb|2FMN|A Chain A, Ala177val Mutant Of E. Coli... 154 8e-36
gi|151937691|gb|EDN56542.1| 5,10-methylenetetrahydrofolate ... 154 8e-36
gi|116184187|ref|ZP_01474134.1| hypothetical protein VEx2w_... 154 9e-36
gi|115350244|ref|YP_772083.1| 5,10-methylenetetrahydrofolat... 154 9e-36
gi|16767371|ref|NP_462986.1| 5,10-methylenetetrahydrofolate... 154 1e-35
gi|82778864|ref|YP_405213.1| 5,10-methylenetetrahydrofolate... 153 1e-35
gi|149375976|ref|ZP_01893742.1| 5,10-methylenetetrahydrofol... 153 1e-35
gi|114778670|ref|ZP_01453482.1| 5,10-methylenetetrahydrofol... 153 1e-35
gi|114564699|ref|YP_752213.1| 5,10-methylenetetrahydrofolat... 153 1e-35
gi|118700256|ref|ZP_01558326.1| 5,10-methylenetetrahydrofol... 153 1e-35
gi|157084464|gb|ABV14142.1| hypothetical protein CKO_03051 ... 153 1e-35
gi|148550052|ref|YP_001270154.1| 5,10-methylenetetrahydrofo... 153 2e-35
gi|47779|emb|CAA30531.1| unnamed protein product [Salmonell... 153 2e-35
gi|29143817|ref|NP_807159.1| 5,10-methylenetetrahydrofolate... 153 2e-35
gi|75765839|pdb|1ZP4|A Chain A, Glu28gln Mutant Of E. Coli ... 152 2e-35
gi|153835464|ref|ZP_01988131.1| 5,10-methylenetetrahydrofol... 152 2e-35
gi|30248672|ref|NP_840742.1| metF; 5,10-methylenetetrahydro... 152 2e-35
gi|88794556|ref|ZP_01110263.1| 5,10-methylenetetrahydrofola... 152 2e-35
gi|149189175|ref|ZP_01867462.1| 5,10-methylenetetrahydrofol... 152 2e-35
gi|126665867|ref|ZP_01736848.1| 5,10-methylenetetrahydrofol... 152 3e-35
gi|16762329|ref|NP_457946.1| 5,10-methylenetetrahydrofolate... 152 3e-35
gi|118602824|ref|YP_904039.1| 5,10-methylenetetrahydrofolat... 152 3e-35
gi|84701754|ref|ZP_01016329.1| 5,10-methylenetetrahydrofola... 152 4e-35
gi|26991654|ref|NP_747079.1| 5,10-methylenetetrahydrofolate... 152 4e-35
gi|123440514|ref|YP_001004508.1| 5,10-methylenetetrahydrofo... 151 4e-35
gi|121593047|ref|YP_984943.1| 5,10-methylenetetrahydrofolat... 151 5e-35
gi|26250713|ref|NP_756753.1| 5,10-methylenetetrahydrofolate... 151 5e-35
gi|56476457|ref|YP_158046.1| 5,10-methylenetetrahydrofolate... 151 5e-35
gi|118069248|ref|ZP_01537495.1| 5,10-methylenetetrahydrofol... 151 5e-35
gi|37681190|ref|NP_935799.1| 5,10-methylenetetrahydrofolate... 151 5e-35
gi|145590179|ref|YP_001156776.1| 5,10-methylenetetrahydrofo... 151 5e-35
gi|134096106|ref|YP_001101181.1| 5,10-methylenetetrahydrofo... 151 6e-35
gi|156972427|ref|YP_001443334.1| hypothetical protein VIBHA... 151 6e-35
gi|90020117|ref|YP_525944.1| 5,10-methylenetetrahydrofolate... 150 7e-35
gi|118731860|ref|ZP_01580375.1| 5,10-methylenetetrahydrofol... 150 7e-35
gi|118756992|ref|ZP_01604760.1| 5,10-methylenetetrahydrofol... 150 7e-35
gi|28899537|ref|NP_799142.1| 5,10-methylenetetrahydrofolate... 150 7e-35
gi|146305485|ref|YP_001185950.1| 5,10-methylenetetrahydrofo... 150 8e-35
gi|152972739|ref|YP_001337885.1| 5,10-methylenetetrahydrofo... 150 8e-35
gi|150378688|ref|ZP_01917885.1| 5,10-methylenetetrahydrofol... 150 8e-35
gi|54307484|ref|YP_128504.1| 5,10-methylenetetrahydrofolate... 150 8e-35
gi|90413611|ref|ZP_01221601.1| 5,10-methylenetetrahydrofola... 150 9e-35
gi|120612695|ref|YP_972373.1| 5,10-methylenetetrahydrofolat... 150 1e-34
gi|77972987|ref|ZP_00828541.1| COG0685: 5,10-methylenetetra... 150 1e-34
gi|27364761|ref|NP_760289.1| 5,10-methylenetetrahydrofolate... 150 1e-34
gi|87311048|ref|ZP_01093173.1| 5,10-methylenetetrahydrofola... 150 1e-34
gi|83721420|ref|YP_443657.1| 5,10-methylenetetrahydrofolate... 150 1e-34
gi|58261226|ref|XP_568023.1| methylenetetrahydrofolate redu... 150 1e-34
gi|92112529|ref|YP_572457.1| 5,10-methylenetetrahydrofolate... 149 1e-34
gi|53720898|ref|YP_109884.1| 5,10-methylenetetrahydrofolate... 149 1e-34
gi|119776301|ref|YP_929041.1| 5,10-methylenetetrahydrofolat... 149 2e-34
gi|146313665|ref|YP_001178739.1| 5,10-methylenetetrahydrofo... 149 2e-34
gi|118053934|ref|ZP_01522476.1| 5,10-methylenetetrahydrofol... 149 2e-34
gi|118071193|ref|ZP_01539389.1| 5,10-methylenetetrahydrofol... 149 2e-34
gi|134281583|ref|ZP_01768291.1| 5,10-methylenetetrahydrofol... 149 2e-34
gi|85060140|ref|YP_455842.1| 5,10-methylenetetrahydrofolate... 149 2e-34
gi|67154852|ref|ZP_00416597.1| 5,10-methylenetetrahydrofola... 149 2e-34
gi|149928231|ref|ZP_01916475.1| 5,10-Methylenetetrahydrofol... 149 3e-34
gi|71734161|ref|YP_272753.1| 5,10-methylenetetrahydrofolate... 149 3e-34
gi|58583433|ref|YP_202449.1| 5,10-methylenetetrahydrofolate... 149 3e-34
gi|66043726|ref|YP_233567.1| 5,10-methylenetetrahydrofolate... 148 3e-34
gi|91789969|ref|YP_550921.1| 5,10-methylenetetrahydrofolate... 148 4e-34
gi|89899465|ref|YP_521936.1| 5,10-methylenetetrahydrofolate... 148 5e-34
gi|114331866|ref|YP_748088.1| 5,10-methylenetetrahydrofolat... 148 5e-34
gi|50085383|ref|YP_046893.1| 5,10-methylenetetrahydrofolate... 148 5e-34
gi|88798492|ref|ZP_01114076.1| 5,10-methylenetetrahydrofola... 148 5e-34
gi|28872182|ref|NP_794801.1| 5,10-methylenetetrahydrofolate... 147 6e-34
gi|109900254|ref|YP_663509.1| 5,10-methylenetetrahydrofolat... 147 6e-34
gi|15232215|ref|NP_191556.1| MTHFR1 (METHYLENETETRAHYDROFOL... 147 7e-34
gi|114321413|ref|YP_743096.1| 5,10-methylenetetrahydrofolat... 147 7e-34
gi|30695094|ref|NP_850723.1| MTHFR1 (METHYLENETETRAHYDROFOL... 147 1e-33
gi|15642680|ref|NP_232313.1| 5,10-methylenetetrahydrofolate... 146 1e-33
gi|30695097|ref|NP_850724.1| MTHFR1 (METHYLENETETRAHYDROFOL... 146 1e-33
gi|116190674|ref|ZP_01480411.1| hypothetical protein VchoM_... 146 2e-33
gi|62290343|ref|YP_222136.1| MetF, 5,10-methylenetetrahydro... 146 2e-33
gi|156935926|ref|YP_001439842.1| hypothetical protein ESA_0... 146 2e-33
gi|90418221|ref|ZP_01226133.1| metF, 5,10-methylenetetrahyd... 146 2e-33
gi|150008401|ref|YP_001303144.1| 5,10-methylenetetrahydrofo... 146 2e-33
gi|21230213|ref|NP_636130.1| 5,10-methylenetetrahydrofolate... 146 2e-33
gi|50545621|ref|XP_500349.1| hypothetical protein [Yarrowia... 146 2e-33
gi|119896875|ref|YP_932088.1| 5,10-methylenetetrahydrofolat... 145 2e-33
gi|121729836|ref|ZP_01682268.1| 5,10-methylenetetrahydrofol... 145 3e-33
gi|115456165|ref|NP_001051683.1| Os03g0815200 [Oryza sativa... 145 3e-33
gi|108711743|gb|ABF99538.1| Methylenetetrahydrofolate reduc... 145 3e-33
gi|94676929|ref|YP_588624.1| 5,10-methylenetetrahydrofolate... 145 3e-33
gi|152979823|ref|YP_001354884.1| 5,10-methylenetetrahydrofo... 145 3e-33
gi|154294630|ref|XP_001547755.1| hypothetical protein BC1G_... 145 4e-33
gi|119877074|ref|ZP_01644098.1| 5,10-methylenetetrahydrofol... 145 4e-33
gi|153009053|ref|YP_001370268.1| 5,10-methylenetetrahydrofo... 145 4e-33
gi|27904555|ref|NP_777681.1| 5,10-methylenetetrahydrofolate... 145 5e-33
gi|60687510|ref|NP_001011685.1| 5,10-methylenetetrahydrofol... 144 5e-33
gi|156045151|ref|XP_001589131.1| hypothetical protein SS1G_... 144 5e-33
gi|23502319|ref|NP_698446.1| 5,10-methylenetetrahydrofolate... 144 6e-33
gi|118579522|ref|YP_900772.1| 5,10-methylenetetrahydrofolat... 144 6e-33
gi|114326870|ref|YP_744027.1| methylenetetrahydrofolate red... 144 6e-33
gi|111058868|gb|EAT79988.1| hypothetical protein SNOG_12690... 144 6e-33
gi|75313356|sp|Q9SE94|MTHR1_MAIZE Methylenetetrahydrofolate... 144 6e-33
gi|110634378|ref|YP_674586.1| 5,10-methylenetetrahydrofolat... 144 6e-33
gi|148682851|gb|EDL14798.1| 5,10-methylenetetrahydrofolate ... 144 7e-33
gi|15794085|ref|NP_283907.1| 5,10-methylenetetrahydrofolate... 144 7e-33
gi|149695388|ref|XP_001492020.1| PREDICTED: similar to meth... 144 7e-33
gi|122890000|emb|CAM14893.1| 5,10-methylenetetrahydrofolate... 144 9e-33
gi|149911769|ref|ZP_01900374.1| 5,10-methylenetetrahydrofol... 144 9e-33
gi|37718877|gb|AAR01748.1| methylenetetrahydrofolate reduct... 144 9e-33
gi|31543271|ref|NP_034970.2| 5,10-methylenetetrahydrofolate... 144 9e-33
gi|47212082|emb|CAF90576.1| unnamed protein product [Tetrao... 144 1e-32
gi|115384530|ref|XP_001208812.1| methylenetetrahydrofolate ... 144 1e-32
gi|74213830|dbj|BAE29349.1| unnamed protein product [Mus mu... 144 1e-32
gi|59801325|ref|YP_208037.1| 5,10-methylenetetrahydrofolate... 144 1e-32
gi|147860393|emb|CAN82572.1| hypothetical protein [Vitis vi... 143 1e-32
gi|153893227|ref|ZP_02013998.1| 5,10-methylenetetrahydrofol... 143 1e-32
gi|10720103|sp|Q9WU20|MTHR_MOUSE Methylenetetrahydrofolate ... 143 1e-32
gi|94493854|ref|ZP_01301057.1| hypothetical protein Rgryl_0... 143 1e-32
gi|148826947|ref|YP_001291700.1| 5,10-methylenetetrahydrofo... 143 2e-32
gi|13471575|ref|NP_103141.1| 5,10-methylenetetrahydrofolate... 142 2e-32
gi|28198329|ref|NP_778643.1| 5,10-methylenetetrahydrofolate... 142 2e-32
gi|16273351|ref|NP_439596.1| 5,10-methylenetetrahydrofolate... 142 2e-32
gi|144900543|emb|CAM77407.1| 5,10-methylenetetrahydrofolate... 142 3e-32
gi|116196022|ref|XP_001223823.1| conserved hypothetical pro... 142 3e-32
gi|29611407|gb|AAO91908.1| 5,10-methylentetrahydrofolate re... 142 3e-32
gi|85709301|ref|ZP_01040366.1| 5,10-methylenetetrahydrofola... 142 4e-32
gi|42631746|ref|ZP_00157284.1| COG0685: 5,10-methylenetetra... 142 4e-32
gi|15889404|ref|NP_355085.1| hypothetical protein AGR_C_385... 141 5e-32
gi|148652721|ref|YP_001279814.1| 5,10-methylenetetrahydrofo... 141 5e-32
gi|15676836|ref|NP_273981.1| 5,10-methylenetetrahydrofolate... 141 6e-32
gi|71892360|ref|YP_278094.1| 5,10-methylenetetrahydrofolate... 140 7e-32
gi|39595956|emb|CAE67459.1| Hypothetical protein CBG12960 [... 140 7e-32
gi|66815655|ref|XP_641844.1| methylenetetrahydrofolate redu... 140 8e-32
gi|56552643|ref|YP_163482.1| 5,10-methylenetetrahydrofolate... 140 8e-32
gi|84516033|ref|ZP_01003394.1| 5,10-methylenetetrahydrofola... 140 8e-32
gi|42629473|ref|ZP_00155019.1| COG0685: 5,10-methylenetetra... 140 8e-32
gi|19114136|ref|NP_593224.1| hypothetical protein SPAC56F8.... 140 9e-32
gi|48428748|gb|AAT42397.1| 5,10-methylenetetrahydrofolate r... 140 9e-32
gi|17936007|ref|NP_532797.1| 5,10-methylenetetrahydrofolate... 140 1e-31
gi|154492837|ref|ZP_02032463.1| hypothetical protein PARMER... 140 1e-31
gi|78357568|ref|YP_389017.1| 5,10-methylenetetrahydrofolate... 140 1e-31
gi|18406468|ref|NP_566011.1| MTHFR2 (METHYLENETETRAHYDROFOL... 140 1e-31
gi|13877629|gb|AAK43892.1|AF370515_1 putative methylenetetr... 140 1e-31
gi|148259239|ref|YP_001233366.1| 5,10-methylenetetrahydrofo... 140 1e-31
gi|52424842|ref|YP_087979.1| 5,10-methylenetetrahydrofolate... 139 2e-31
gi|67539426|ref|XP_663487.1| hypothetical protein AN5883.2 ... 139 2e-31
gi|146338099|ref|YP_001203147.1| 5,10-methylenetetrahydrofo... 139 2e-31
gi|154246770|ref|YP_001417728.1| 5,10-methylenetetrahydrofo... 139 2e-31
gi|103485533|ref|YP_615094.1| 5,10-methylenetetrahydrofolat... 139 2e-31
gi|126328740|ref|XP_001371469.1| PREDICTED: similar to meth... 139 2e-31
gi|149500602|ref|XP_001516302.1| PREDICTED: similar to meth... 139 3e-31
gi|149185712|ref|ZP_01864028.1| 5,10-methylenetetrahydrofol... 139 3e-31
gi|108997188|ref|XP_001105108.1| PREDICTED: similar to 5,10... 139 3e-31
gi|108997191|ref|XP_001105017.1| PREDICTED: similar to 5,10... 139 3e-31
gi|121607648|ref|YP_995455.1| 5,10-methylenetetrahydrofolat... 139 3e-31
gi|108997185|ref|XP_001105188.1| PREDICTED: similar to 5,10... 139 3e-31
gi|118745573|ref|ZP_01593544.1| Methylenetetrahydrofolate r... 138 3e-31
gi|68250024|ref|YP_249136.1| 5,10-methylenetetrahydrofolate... 138 4e-31
gi|62087806|dbj|BAD92350.1| 5,10-methylenetetrahydrofolate ... 138 4e-31
gi|62287023|sp|Q60HE5|MTHR_MACFA Methylenetetrahydrofolate ... 138 4e-31
gi|148258264|ref|YP_001242849.1| 5,10-methylenetetrahydrofo... 138 5e-31
gi|5823583|emb|CAB53783.1| methylenetetrahydrofolate reduct... 138 5e-31
gi|119178804|ref|XP_001241039.1| hypothetical protein CIMG_... 138 5e-31
gi|46201622|ref|ZP_00054658.2| COG0685: 5,10-methylenetetra... 138 5e-31
gi|89070489|ref|ZP_01157782.1| 5,10-methylenetetrahydrofola... 138 6e-31
gi|4753778|emb|CAB41971.1| methylenetetrahydrofolate reduct... 138 6e-31
gi|119592114|gb|EAW71708.1| 5,10-methylenetetrahydrofolate ... 138 6e-31
gi|114553992|ref|XP_001141277.1| PREDICTED: 5,10-methylenet... 138 6e-31
gi|114553988|ref|XP_001141040.1| PREDICTED: 5,10-methylenet... 137 6e-31
gi|87240000|ref|NP_005948.3| 5,10-methylenetetrahydrofolate... 137 6e-31
gi|4336819|gb|AAD17965.1|AAD17965 methylenetetrahydrofolate... 137 6e-31
gi|114553986|ref|XP_001141362.1| PREDICTED: 5,10-methylenet... 137 6e-31
gi|31566107|gb|AAH53509.1| 5,10-methylenetetrahydrofolate r... 137 6e-31
gi|113461273|ref|YP_719342.1| 5,10-methylenetetrahydrofolat... 137 7e-31
gi|55962397|emb|CAI15889.1| 5,10-methylenetetrahydrofolate ... 137 7e-31
gi|58040634|ref|YP_192598.1| Methylenetetrahydrofolate redu... 137 7e-31
gi|83769822|dbj|BAE59957.1| unnamed protein product [Asperg... 137 7e-31
gi|85374846|ref|YP_458908.1| 5,10-methylenetetrahydrofolate... 137 7e-31
gi|121541236|ref|ZP_01672990.1| 5,10-methylenetetrahydrofol... 137 7e-31
gi|53728544|ref|ZP_00132341.2| COG0685: 5,10-methylenetetra... 137 1e-30
gi|121998453|ref|YP_001003240.1| 5,10-methylenetetrahydrofo... 137 1e-30
gi|145231993|ref|XP_001399463.1| hypothetical protein An02g... 136 2e-30
gi|145620527|ref|ZP_01776555.1| Methylenetetrahydrofolate r... 136 2e-30
gi|115525770|ref|YP_782681.1| 5,10-methylenetetrahydrofolat... 135 2e-30
gi|16126379|ref|NP_420943.1| 5,10-methylenetetrahydrofolate... 135 3e-30
gi|119503496|ref|ZP_01625579.1| 5,10-methylenetetrahydrofol... 135 3e-30
gi|75674482|ref|YP_316903.1| 5,10-methylenetetrahydrofolate... 135 4e-30
gi|124268472|ref|YP_001022476.1| 5,10-methylenetetrahydrofo... 135 4e-30
gi|126733395|ref|ZP_01749142.1| 5,10-methylenetetrahydrofol... 135 4e-30
gi|111221597|ref|YP_712391.1| 5,10-methylenetetrahydrofolat... 135 4e-30
gi|22040813|gb|AAL91367.2|AF441241_1 chimera1 [synthetic co... 135 4e-30
gi|93006275|ref|YP_580712.1| 5,10-methylenetetrahydrofolate... 135 4e-30
gi|145595765|ref|YP_001160062.1| 5,10-methylenetetrahydrofo... 135 5e-30
gi|148228896|ref|NP_001080092.1| 5,10-methylenetetrahydrofo... 135 5e-30
gi|15602100|ref|NP_245172.1| 5,10-methylenetetrahydrofolate... 134 5e-30
gi|153093275|gb|EDN74271.1| methylenetetrahydrofolate reduc... 134 5e-30
gi|85713522|ref|ZP_01044512.1| 5,10-methylenetetrahydrofola... 134 5e-30
gi|15616671|ref|NP_239883.1| 5,10-methylenetetrahydrofolate... 134 6e-30
gi|77166138|ref|YP_344663.1| 5,10-methylenetetrahydrofolate... 134 6e-30
gi|115589742|gb|ABJ15730.1| 5,10-methylene-tetrahydrofolate... 134 8e-30
gi|25147441|ref|NP_741028.1| C06A8.1b [Caenorhabditis elega... 134 9e-30
gi|71065527|ref|YP_264254.1| probable methylenetetrahydrofo... 134 1e-29
gi|25147436|ref|NP_741027.1| C06A8.1a [Caenorhabditis elega... 134 1e-29
gi|83592865|ref|YP_426617.1| 5,10-methylenetetrahydrofolate... 133 1e-29
gi|145641606|ref|ZP_01797183.1| 5,10-methylenetetrahydrofol... 133 1e-29
gi|148555316|ref|YP_001262898.1| 5,10-methylenetetrahydrofo... 133 1e-29
gi|46136113|ref|XP_389748.1| hypothetical protein FG09572.1... 133 1e-29
gi|17986842|ref|NP_539476.1| 5,10-METHYLENETETRAHYDROFOLATE... 133 1e-29
gi|150005608|ref|YP_001300352.1| 5,10-methylenetetrahydrofo... 133 2e-29
gi|156717848|ref|NP_001096464.1| hypothetical protein LOC10... 133 2e-29
gi|27808705|ref|NP_011390.2| Isozyme of methylenetetrahydro... 132 2e-29
gi|110835480|ref|YP_694339.1| 5,10-methylenetetrahydrofolat... 132 2e-29
gi|6681420|dbj|BAA88680.1| 5,10-methylenetetrahydrofolate r... 132 2e-29
gi|85706329|ref|ZP_01037423.1| 5,10-methylenetetrahydrofola... 132 2e-29
gi|86748888|ref|YP_485384.1| 5,10-methylenetetrahydrofolate... 132 2e-29
gi|119881366|ref|ZP_01647662.1| 5,10-methylenetetrahydrofol... 132 3e-29
gi|113932551|ref|ZP_01418453.1| 5,10-methylenetetrahydrofol... 132 3e-29
gi|119717307|ref|YP_924272.1| 5,10-methylenetetrahydrofolat... 132 3e-29
gi|83858938|ref|ZP_00952460.1| putative 5,10-methylenetetra... 132 3e-29
gi|50287689|ref|XP_446274.1| unnamed protein product [Candi... 132 3e-29
gi|56697849|ref|YP_168220.1| 5,10-methylenetetrahydrofolate... 132 3e-29
gi|45184995|ref|NP_982713.1| AAR170Wp [Ashbya gossypii ATCC... 132 3e-29
gi|114767286|ref|ZP_01446126.1| 5,10-methylenetetrahydrofol... 132 4e-29
gi|119481141|ref|XP_001260599.1| methylenetetrahydrofolate ... 131 5e-29
gi|87201220|ref|YP_498477.1| 5,10-methylenetetrahydrofolate... 131 5e-29
gi|71001564|ref|XP_755463.1| methylenetetrahydrofolate redu... 131 6e-29
gi|72161454|ref|YP_289111.1| 5,10-methylenetetrahydrofolate... 130 7e-29
gi|154273667|ref|XP_001537685.1| methylenetetrahydrofolate ... 130 7e-29
gi|149202289|ref|ZP_01879262.1| 5,10-methylenetetrahydrofol... 130 8e-29
gi|150004384|ref|YP_001299128.1| 5,10-methylenetetrahydrofo... 130 8e-29
gi|39936763|ref|NP_949039.1| putative 5,10-methylenetetrahy... 130 9e-29
gi|110679060|ref|YP_682067.1| 5,10-methylenetetrahydrofolat... 130 1e-28
gi|116514975|ref|YP_802604.1| 5,10-methylenetetrahydrofolat... 130 1e-28
gi|84687879|ref|ZP_01015747.1| 5,10-methylenetetrahydrofola... 129 2e-28
gi|86740095|ref|YP_480495.1| 5,10-methylenetetrahydrofolate... 129 2e-28
gi|84496185|ref|ZP_00995039.1| 5,10-methylenetetrahydrofola... 129 2e-28
gi|121715622|ref|XP_001275420.1| methylenetetrahydrofolate ... 129 2e-28
gi|32033497|ref|ZP_00133824.1| COG0685: 5,10-methylenetetra... 129 2e-28
gi|71897695|ref|ZP_00679940.1| 5,10-methylenetetrahydrofola... 129 3e-28
gi|150397316|ref|YP_001327783.1| 5,10-methylenetetrahydrofo... 129 3e-28
gi|114570988|ref|YP_757668.1| 5,10-methylenetetrahydrofolat... 129 3e-28
gi|15965952|ref|NP_386305.1| PROBABLE 5,10-METHYLENETETRAHY... 129 3e-28
gi|68477623|ref|XP_717124.1| methylenetetrahydrofolate redu... 128 4e-28
gi|78046398|ref|YP_362573.1| 5,10-methylenetetrahydrofolate... 128 4e-28
gi|92115991|ref|YP_575720.1| 5,10-methylenetetrahydrofolate... 128 4e-28
gi|21241561|ref|NP_641143.1| 5,10-methylenetetrahydrofolate... 128 4e-28
gi|145613335|ref|XP_363802.2| hypothetical protein MGG_0172... 128 4e-28
gi|124007447|ref|ZP_01692153.1| 5,10-methylenetetrahydrofol... 128 5e-28
gi|146329233|ref|YP_001209760.1| 5,10-methylenetetrahydrofo... 128 5e-28
gi|90415443|ref|ZP_01223377.1| 5,10-methylenetetrahydrofola... 127 7e-28
gi|23012829|ref|ZP_00052824.1| COG0685: 5,10-methylenetetra... 127 8e-28
gi|10185100|emb|CAC08536.1| 5,10-methylenetetrahydrofolate ... 127 9e-28
gi|126729019|ref|ZP_01744834.1| 5,10-methylenetetrahydrofol... 127 1e-27
gi|86131391|ref|ZP_01049989.1| putative 5,10-methylenetetra... 127 1e-27
gi|91978005|ref|YP_570664.1| 5,10-methylenetetrahydrofolate... 127 1e-27
gi|83951098|ref|ZP_00959831.1| 5,10-methylenetetrahydrofola... 126 1e-27
gi|153824272|ref|ZP_01976939.1| 5,10-methylenetetrahydrofol... 126 1e-27
gi|86358474|ref|YP_470366.1| 5,10-methylenetetrahydrofolate... 126 2e-27
gi|154252843|ref|YP_001413667.1| 5,10-methylenetetrahydrofo... 126 2e-27
gi|27376530|ref|NP_768059.1| 5,10-methylenetetrahydrofolate... 126 2e-27
gi|69936150|ref|ZP_00631010.1| 5,10-methylenetetrahydrofola... 125 3e-27
gi|33520033|ref|NP_878865.1| 5,10-methylenetetrahydrofolate... 125 3e-27
gi|71276043|ref|ZP_00652324.1| 5,10-methylenetetrahydrofola... 125 3e-27
gi|29832642|ref|NP_827276.1| 5,10-methylenetetrahydrofolate... 125 3e-27
gi|156386381|ref|XP_001633891.1| predicted protein [Nematos... 125 3e-27
gi|99081541|ref|YP_613695.1| 5,10-methylenetetrahydrofolate... 125 4e-27
gi|156860351|gb|EDO53782.1| hypothetical protein BACUNI_023... 125 4e-27
gi|126725119|ref|ZP_01740962.1| 5,10-methylenetetrahydrofol... 125 4e-27
gi|89053517|ref|YP_508968.1| 5,10-methylenetetrahydrofolate... 125 5e-27
gi|68233525|ref|ZP_00572643.1| 5,10-methylenetetrahydrofola... 125 5e-27
gi|90425218|ref|YP_533588.1| 5,10-methylenetetrahydrofolate... 124 6e-27
gi|126648950|ref|ZP_01721430.1| putative 5,10-methylenetetr... 124 6e-27
gi|149024594|gb|EDL81091.1| 5,10-methylenetetrahydrofolate ... 124 7e-27
gi|149024598|gb|EDL81095.1| 5,10-methylenetetrahydrofolate ... 124 8e-27
gi|109475762|ref|XP_342976.2| PREDICTED: similar to Methyle... 124 8e-27
gi|83941188|ref|ZP_00953650.1| 5,10-methylenetetrahydrofola... 124 9e-27
gi|149024597|gb|EDL81094.1| 5,10-methylenetetrahydrofolate ... 124 1e-26
gi|94498758|ref|ZP_01305306.1| 5,10-methylenetetrahydrofola... 123 1e-26
gi|156718948|ref|ZP_02060602.1| 5,10-methylenetetrahydrofol... 123 1e-26
gi|114769316|ref|ZP_01446942.1| 5,10-methylenetetrahydrofol... 123 1e-26
gi|125824890|ref|XP_001336209.1| PREDICTED: hypothetical pr... 123 2e-26
gi|83854678|ref|ZP_00948208.1| 5,10-methylenetetrahydrofola... 123 2e-26
gi|15837723|ref|NP_298411.1| 5,10-methylenetetrahydrofolate... 123 2e-26
gi|116505930|gb|EAU88825.1| hypothetical protein CC1G_01198... 122 2e-26
gi|116253072|ref|YP_768910.1| putative 5,10-methylenetetrah... 122 2e-26
gi|29349229|ref|NP_812732.1| 5,10-methylenetetrahydrofolate... 122 3e-26
gi|150865877|ref|XP_001385268.2| predicted protein [Pichia ... 121 4e-26
gi|149915815|ref|ZP_01904340.1| 5,10-methylenetetrahydrofol... 121 5e-26
gi|26541562|gb|AAN85549.1|AF484556_71 5,10-methylenetetrahy... 121 5e-26
gi|146419740|ref|XP_001485830.1| hypothetical protein PGUG_... 121 5e-26
gi|6016546|sp|O54235|METF_STRLI 5,10-methylenetetrahydrofol... 121 5e-26
gi|21220583|ref|NP_626362.1| 5,10-methylenetetrahydrofolate... 121 6e-26
gi|126740712|ref|ZP_01756398.1| 5,10-methylenetetrahydrofol... 120 9e-26
gi|117928199|ref|YP_872750.1| 5,10-methylenetetrahydrofolat... 120 9e-26
gi|149277450|ref|ZP_01883591.1| 5,10-methylenetetrahydrofol... 120 1e-25
gi|1322687|emb|CAA96833.1| unnamed protein product [Sacchar... 119 2e-25
gi|149369761|ref|ZP_01889613.1| 5,10-methylenetetrahydrofol... 119 2e-25
gi|1628449|emb|CAA63833.1| G2882 [Saccharomyces cerevisiae] 119 3e-25
gi|39595957|emb|CAE67460.1| Hypothetical protein CBG12961 [... 119 3e-25
gi|50291379|ref|XP_448122.1| unnamed protein product [Candi... 118 5e-25
gi|114706992|ref|ZP_01439891.1| 5,10-methylenetetrahydrofol... 118 5e-25
gi|58259285|ref|XP_567055.1| methylenetetrahydrofolate redu... 118 5e-25
gi|146278356|ref|YP_001168515.1| 5,10-methylenetetrahydrofo... 118 5e-25
gi|154249958|ref|YP_001410783.1| Methylenetetrahydrofolate ... 117 8e-25
gi|114798390|ref|YP_760800.1| 5,10-methylenetetrahydrofolat... 117 9e-25
gi|88806872|ref|ZP_01122388.1| 5,10-methylenetetrahydrofola... 117 9e-25
gi|45198975|ref|NP_986004.1| AFR457Wp [Ashbya gossypii ATCC... 116 2e-24
gi|145623212|ref|ZP_01779152.1| Methylenetetrahydrofolate r... 116 2e-24
gi|88713211|ref|ZP_01107295.1| 5,10-methylenetetrahydrofola... 115 3e-24
gi|126461613|ref|YP_001042727.1| 5,10-methylenetetrahydrofo... 115 3e-24
gi|77462720|ref|YP_352224.1| 5,10-methylenetetrahydrofolate... 115 4e-24
gi|154318662|ref|XP_001558649.1| hypothetical protein BC1G_... 115 4e-24
gi|84502711|ref|ZP_01000830.1| 5,10-methylenetetrahydrofola... 115 4e-24
gi|71021057|ref|XP_760759.1| hypothetical protein UM04612.1... 115 5e-24
gi|116670913|ref|YP_831846.1| Deleted entry [Arthrobacter s... 115 5e-24
gi|120434701|ref|YP_860388.1| methylenetetrahydrofolate red... 115 5e-24
gi|21672336|ref|NP_660403.1| 5,10-methylenetetrahydrofolate... 114 5e-24
gi|156603877|ref|XP_001618923.1| hypothetical protein NEMVE... 114 6e-24
gi|149126372|ref|ZP_01851234.1| 5,10-methylenetetrahydrofol... 114 8e-24
gi|86138612|ref|ZP_01057185.1| 5,10-methylenetetrahydrofola... 114 8e-24
gi|83771444|dbj|BAE61576.1| unnamed protein product [Asperg... 114 9e-24
gi|122890367|emb|CAL34093.1| putative 5,10-methylen-tetrahy... 114 1e-23
gi|145242648|ref|XP_001393897.1| hypothetical protein An09g... 113 1e-23
gi|85104388|ref|XP_961729.1| hypothetical protein [Neurospo... 113 1e-23
gi|67902456|ref|XP_681484.1| hypothetical protein AN8215.2 ... 113 1e-23
gi|71023965|ref|XP_762212.1| hypothetical protein UM06065.1... 113 2e-23
gi|134098297|ref|YP_001103958.1| 5,10-methylenetetrahydrofo... 112 2e-23
gi|30795020|ref|NP_851470.1| probable 5,10-methylenetetrahy... 112 2e-23
gi|156063782|ref|XP_001597813.1| hypothetical protein SS1G_... 112 4e-23
gi|6325234|ref|NP_015302.1| Isozyme of methylenetetrahydrof... 112 4e-23
gi|156838358|ref|XP_001642886.1| hypothetical protein Kpol_... 111 4e-23
gi|85091156|ref|XP_958764.1| hypothetical protein [Neurospo... 111 5e-23
gi|121718356|ref|XP_001276185.1| methylenetetrahydrofolate ... 111 5e-23
gi|154346694|ref|XP_001569284.1| methylenetetrahydrofolate ... 111 6e-23
gi|151942769|gb|EDN61115.1| hypothetical protein SCY_5700 [... 110 1e-22
gi|72138674|ref|XP_794308.1| PREDICTED: similar to Mthfr-pr... 109 2e-22
gi|115433102|ref|XP_001216688.1| conserved hypothetical pro... 109 2e-22
gi|50424331|ref|XP_460752.1| hypothetical protein DEHA0F098... 109 2e-22
gi|15554328|gb|AAK98793.1| MetF [Streptomyces fradiae] 109 3e-22
gi|116206412|ref|XP_001229015.1| hypothetical protein CHGG_... 108 4e-22
gi|149240377|ref|XP_001526064.1| conserved hypothetical pro... 108 5e-22
gi|68471621|ref|XP_720117.1| putative methylenetetrahydrofo... 107 7e-22
gi|110637839|ref|YP_678046.1| 5,10-methylenetetrahydrofolat... 107 7e-22
gi|153809050|ref|ZP_01961718.1| hypothetical protein BACCAC... 107 8e-22
gi|153898498|ref|ZP_02019064.1| 5,10-methylenetetrahydrofol... 107 8e-22
gi|156448419|ref|ZP_02054804.1| 5,10-methylenetetrahydrofol... 107 8e-22
gi|134100430|ref|YP_001106091.1| 5,10-methylenetetrahydrofo... 107 1e-21
gi|50307253|ref|XP_453605.1| unnamed protein product [Kluyv... 107 1e-21
gi|53715376|ref|YP_101368.1| 5,10-methylenetetrahydrofolate... 107 1e-21
gi|46125499|ref|XP_387303.1| hypothetical protein FG07127.1... 106 1e-21
gi|156109285|gb|EDO11030.1| hypothetical protein BACOVA_036... 106 2e-21
>gi|55820838|ref|YP_139280.1| 5,10-methylenetetrahydrofolate reductase [Streptococcus
thermophilus LMG 18311]
gi|55822753|ref|YP_141194.1| 5,10-methylenetetrahydrofolate reductase [Streptococcus
thermophilus CNRZ1066]
gi|55736823|gb|AAV60465.1| 5,10-methylenetetrahydrofolate reductase [Streptococcus
thermophilus LMG 18311]
gi|55738738|gb|AAV62379.1| 5,10-methylenetetrahydrofolate reductase [Streptococcus
thermophilus CNRZ1066]
Length = 311
Score = 619 bits (1597), Expect = e-176, Method: Composition-based stats.
Identities = 310/311 (99%), Positives = 311/311 (100%)
Query: 1 LTLIKMLLSQQKSKTKKVKLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFIS 60
+TLIKMLLSQQKSKTKKVKLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFIS
Sbjct: 1 MTLIKMLLSQQKSKTKKVKLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFIS 60
Query: 61 VTASNNKYNIKETTVPLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILA 120
VTASNNKYNIKETTVPLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILA
Sbjct: 61 VTASNNKYNIKETTVPLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILA 120
Query: 121 LRGDIIPGVEPLKDFRYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKV 180
LRGDIIPGVEPLKDFRYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKV
Sbjct: 121 LRGDIIPGVEPLKDFRYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKV 180
Query: 181 DAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLP 240
DAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLP
Sbjct: 181 DAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLP 240
Query: 241 RKFRAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHS 300
RKFRAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHS
Sbjct: 241 RKFRAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHS 300
Query: 301 LFKHHSQVGAL 311
LFKHHSQVGAL
Sbjct: 301 LFKHHSQVGAL 311
>gi|116627654|ref|YP_820273.1| 5,10-methylenetetrahydrofolate reductase [Streptococcus
thermophilus LMD-9]
gi|116100931|gb|ABJ66077.1| 5,10-methylenetetrahydrofolate reductase [Streptococcus
thermophilus LMD-9]
Length = 306
Score = 610 bits (1573), Expect = e-173, Method: Composition-based stats.
Identities = 305/306 (99%), Positives = 306/306 (100%)
Query: 6 MLLSQQKSKTKKVKLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASN 65
MLLSQQKSKTKKVKLMTSQTPSLSFEVFPPNPAVGN+KILLALDDMKGSAPHFISVTASN
Sbjct: 1 MLLSQQKSKTKKVKLMTSQTPSLSFEVFPPNPAVGNKKILLALDDMKGSAPHFISVTASN 60
Query: 66 NKYNIKETTVPLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDI 125
NKYNIKETTVPLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDI
Sbjct: 61 NKYNIKETTVPLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDI 120
Query: 126 IPGVEPLKDFRYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCS 185
IPGVEPLKDFRYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCS
Sbjct: 121 IPGVEPLKDFRYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCS 180
Query: 186 SLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRA 245
SLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRA
Sbjct: 181 SLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRA 240
Query: 246 ILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFKHH 305
ILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFKHH
Sbjct: 241 ILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFKHH 300
Query: 306 SQVGAL 311
SQVGAL
Sbjct: 301 SQVGAL 306
>gi|149002267|ref|ZP_01827209.1| 5-methyltetrahydropteroyltriglutamate--homocysteine
methyltransferase [Streptococcus pneumoniae SP14-BS69]
gi|147759582|gb|EDK66573.1| 5-methyltetrahydropteroyltriglutamate--homocysteine
methyltransferase [Streptococcus pneumoniae SP14-BS69]
Length = 288
Score = 506 bits (1302), Expect = e-142, Method: Composition-based stats.
Identities = 249/286 (87%), Positives = 270/286 (94%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADH 80
M+ QTPSLSFEVFPPNPAVGN+ I+LAL DM+ APHFISVTASNNK+NIKETTV LAD
Sbjct: 1 MSCQTPSLSFEVFPPNPAVGNDNIILALQDMQELAPHFISVTASNNKFNIKETTVRLADF 60
Query: 81 IQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATD 140
IQNDLAIPTIAHLPAIYL+K+KVA+T+ +LD VGV +ILALRGDIIP VEP KDFRYATD
Sbjct: 61 IQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATD 120
Query: 141 LIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
LIEFIK +AP+FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD
Sbjct: 121 LIEFIKEQAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 180
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
FQDKC LAGIDVPI+AGIMPILNRNQALRLLKTCENIHLPRKF+AILDKYEHDPESLRAA
Sbjct: 181 FQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAA 240
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFKHHS 306
GLAYAVDQIVDLVTQDVAGVHLYTMNNA+TA++I++ATH+LF H S
Sbjct: 241 GLAYAVDQIVDLVTQDVAGVHLYTMNNADTAKYIHQATHALFNHQS 286
>gi|149010794|ref|ZP_01832165.1| polynucleotide phosphorylase/polyadenylase [Streptococcus
pneumoniae SP19-BS75]
gi|147765275|gb|EDK72204.1| polynucleotide phosphorylase/polyadenylase [Streptococcus
pneumoniae SP19-BS75]
Length = 288
Score = 502 bits (1293), Expect = e-140, Method: Composition-based stats.
Identities = 248/286 (86%), Positives = 268/286 (93%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADH 80
M+ QTPSLSFEVFPPNPAVGN I+ AL DM+ APHFISVTASNNK+NIKETTV LAD
Sbjct: 1 MSRQTPSLSFEVFPPNPAVGNGNIISALQDMQELAPHFISVTASNNKFNIKETTVRLADF 60
Query: 81 IQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATD 140
IQNDLAIPTIAHLPAIYL+K+KVA+T+ +LD VGV +ILALRGDIIP VEP KDFRYATD
Sbjct: 61 IQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATD 120
Query: 141 LIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
LIEFIK +AP+FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD
Sbjct: 121 LIEFIKEQAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 180
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
FQDKC LAGIDVPI+AGIMPILNRNQALRLLKTCENIHLPRKF+AILDKYEHDPESLRAA
Sbjct: 181 FQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAA 240
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFKHHS 306
GLAYAVDQIVDLVTQDVAGVHLYTMNNA+TA++I++ATH+LF H S
Sbjct: 241 GLAYAVDQIVDLVTQDVAGVHLYTMNNADTAKYIHQATHALFNHQS 286
>gi|15900495|ref|NP_345099.1| 5,10-methylenetetrahydrofolate reductase, putative [Streptococcus
pneumoniae TIGR4]
gi|111657668|ref|ZP_01408398.1| hypothetical protein SpneT_02001145 [Streptococcus pneumoniae
TIGR4]
gi|148983968|ref|ZP_01817287.1| 5,10-methylenetetrahydrofolate reductase, putative [Streptococcus
pneumoniae SP3-BS71]
gi|148992302|ref|ZP_01822025.1| polynucleotide phosphorylase/polyadenylase [Streptococcus
pneumoniae SP9-BS68]
gi|149021549|ref|ZP_01835604.1| 5-methyltetrahydropteroyltriglutamate--homocysteine
methyltransferase [Streptococcus pneumoniae SP23-BS72]
gi|14972060|gb|AAK74739.1| putative 5,10-methylenetetrahydrofolate reductase [Streptococcus
pneumoniae TIGR4]
gi|147924115|gb|EDK75227.1| 5,10-methylenetetrahydrofolate reductase, putative [Streptococcus
pneumoniae SP3-BS71]
gi|147928928|gb|EDK79940.1| polynucleotide phosphorylase/polyadenylase [Streptococcus
pneumoniae SP9-BS68]
gi|147930245|gb|EDK81230.1| 5-methyltetrahydropteroyltriglutamate--homocysteine
methyltransferase [Streptococcus pneumoniae SP23-BS72]
Length = 288
Score = 501 bits (1291), Expect = e-140, Method: Composition-based stats.
Identities = 247/286 (86%), Positives = 268/286 (93%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADH 80
M+ QTPSLSFEVFPPNPAVGN+ I+ AL DM+ APHFISVTASNNK+NIKETTV LAD
Sbjct: 1 MSRQTPSLSFEVFPPNPAVGNDNIISALQDMQELAPHFISVTASNNKFNIKETTVRLADF 60
Query: 81 IQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATD 140
IQNDLAIPTIAHLPAIYL+K+KVA+T+ +LD VGV +ILALRGDIIP VEP KDFRYATD
Sbjct: 61 IQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATD 120
Query: 141 LIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
LIEFIK + P+FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD
Sbjct: 121 LIEFIKEQTPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 180
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
FQDKC LAGIDVPI+AGIMPILNRNQALRLLKTCENIHLPRKF+AILDKYEHDPESLRAA
Sbjct: 181 FQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAA 240
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFKHHS 306
GLAYAVDQIVDLVTQDVAGVHLYTMNNA+TA++I++ATH+LF H S
Sbjct: 241 GLAYAVDQIVDLVTQDVAGVHLYTMNNADTAKYIHQATHALFNHQS 286
>gi|148988950|ref|ZP_01820350.1| 5,10-methylenetetrahydrofolate reductase, putative [Streptococcus
pneumoniae SP6-BS73]
gi|148998262|ref|ZP_01825731.1| 5,10-methylenetetrahydrofolate reductase, putative [Streptococcus
pneumoniae SP11-BS70]
gi|149005698|ref|ZP_01829437.1| 5,10-methylenetetrahydrofolate reductase, putative [Streptococcus
pneumoniae SP18-BS74]
gi|147755905|gb|EDK62949.1| 5,10-methylenetetrahydrofolate reductase, putative [Streptococcus
pneumoniae SP11-BS70]
gi|147762638|gb|EDK69598.1| 5,10-methylenetetrahydrofolate reductase, putative [Streptococcus
pneumoniae SP18-BS74]
gi|147925447|gb|EDK76524.1| 5,10-methylenetetrahydrofolate reductase, putative [Streptococcus
pneumoniae SP6-BS73]
Length = 288
Score = 501 bits (1290), Expect = e-140, Method: Composition-based stats.
Identities = 247/286 (86%), Positives = 267/286 (93%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADH 80
M+ QTPSLSFEVFPPNPAVGN I+ AL DM+ APHFISVTASNNK+NIKETTV LAD
Sbjct: 1 MSRQTPSLSFEVFPPNPAVGNGNIISALQDMQELAPHFISVTASNNKFNIKETTVRLADF 60
Query: 81 IQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATD 140
IQNDLAIPTIAHLPAIYL+K+KVA+T+ +LD VGV +ILALRGDIIP VEP KDFRYATD
Sbjct: 61 IQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATD 120
Query: 141 LIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
LIEFIK + P+FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD
Sbjct: 121 LIEFIKEQTPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 180
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
FQDKC LAGIDVPI+AGIMPILNRNQALRLLKTCENIHLPRKF+AILDKYEHDPESLRAA
Sbjct: 181 FQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAA 240
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFKHHS 306
GLAYAVDQIVDLVTQDVAGVHLYTMNNA+TA++I++ATH+LF H S
Sbjct: 241 GLAYAVDQIVDLVTQDVAGVHLYTMNNADTAKYIHQATHALFNHQS 286
>gi|15902559|ref|NP_358109.1| 5,10-methylenetetrahydrofolate reductase [Streptococcus pneumoniae
R6]
gi|116516593|ref|YP_816013.1| 5,10-methylenetetrahydrofolate reductase [Streptococcus pneumoniae
D39]
gi|15458088|gb|AAK99319.1| 5,10-methylenetetrahydrofolate reductase [Streptococcus pneumoniae
R6]
gi|116077169|gb|ABJ54889.1| 5,10-methylenetetrahydrofolate reductase [Streptococcus pneumoniae
D39]
Length = 288
Score = 497 bits (1280), Expect = e-139, Method: Composition-based stats.
Identities = 245/286 (85%), Positives = 266/286 (93%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADH 80
M+ QTPSLSFEVFPP PAVGN+ I+ AL DM+ APHFISVTASNNK+NIKETTV LAD
Sbjct: 1 MSRQTPSLSFEVFPPTPAVGNDNIISALQDMQELAPHFISVTASNNKFNIKETTVRLADF 60
Query: 81 IQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATD 140
IQNDLAIPTIAHLPAIYL+K+KVA+T+ +LD VGV +ILALRGDIIP VEP KDFRYATD
Sbjct: 61 IQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATD 120
Query: 141 LIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
LIE IK AP+FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD
Sbjct: 121 LIELIKERAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 180
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
FQDKC LAGIDVPI+AGIMPILNRNQALRLLKTCENIHLPRKF+AILDKYEHDPESLRAA
Sbjct: 181 FQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAA 240
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFKHHS 306
GLAYAVDQIVDLVTQD+AGVHLYTMNNA+TA++I++ATH+LF H S
Sbjct: 241 GLAYAVDQIVDLVTQDIAGVHLYTMNNADTAKYIHQATHALFNHQS 286
>gi|125717284|ref|YP_001034417.1| 5,10-methylenetetrahydrofolate reductase, putative [Streptococcus
sanguinis SK36]
gi|125497201|gb|ABN43867.1| 5,10-methylenetetrahydrofolate reductase, putative [Streptococcus
sanguinis SK36]
Length = 292
Score = 472 bits (1214), Expect = e-131, Method: Composition-based stats.
Identities = 232/289 (80%), Positives = 258/289 (89%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLAD 79
++ TPSLSFEVFPPNPAVGN+KI AL +M+ APHFISVTASNNK++I+ETTV L +
Sbjct: 1 MVRRHTPSLSFEVFPPNPAVGNDKIFQALREMQDLAPHFISVTASNNKFDIEETTVRLTE 60
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYAT 139
I N+L IPTIAHLPA+YL+K+ V++ L+ LD VGV++ILALRGDI P V P DF YAT
Sbjct: 61 FIANELQIPTIAHLPAVYLTKDMVSNILQSLDRVGVHQILALRGDIFPDVAPKDDFTYAT 120
Query: 140 DLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFY 199
DLIE+IK EAP+FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFY
Sbjct: 121 DLIEYIKTEAPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFY 180
Query: 200 DFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRA 259
DFQDKC LAGI+VPI+AGIMPILNRNQALRLLKTCENI LPRKFRAILDKYEHDPESLRA
Sbjct: 181 DFQDKCILAGIEVPIHAGIMPILNRNQALRLLKTCENIKLPRKFRAILDKYEHDPESLRA 240
Query: 260 AGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFKHHSQV 308
AGLAYAVDQIVDLVTQDVAG+HLYTMNNA TA HIY+ATH+LF H+ V
Sbjct: 241 AGLAYAVDQIVDLVTQDVAGIHLYTMNNAATAYHIYKATHALFNHNPSV 289
>gi|157074526|gb|ABV09209.1| 5,10-methylenetetrahydrofolate reductase [Streptococcus gordonii
str. Challis substr. CH1]
Length = 284
Score = 470 bits (1210), Expect = e-131, Method: Composition-based stats.
Identities = 228/283 (80%), Positives = 258/283 (91%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLAD 79
++ TPSLSFEVFPPNPAVGNEKI+ AL +M+ APH+ISVTASNNK+NI+ETTV LAD
Sbjct: 1 MVRHHTPSLSFEVFPPNPAVGNEKIIQALREMQDIAPHYISVTASNNKFNIEETTVRLAD 60
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYAT 139
I NDL IPTIAHLPA+YL+KE V+DTL+ LD VGV+RILALRGDI P V P DF+YAT
Sbjct: 61 FIYNDLKIPTIAHLPAVYLTKEMVSDTLQALDKVGVHRILALRGDIFPDVAPKDDFKYAT 120
Query: 140 DLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFY 199
DLIE+IK EAP+FDIIGACYPEGHPDSP+++SDI+NLKKKVDAGCSSLVTQLFFDN+RFY
Sbjct: 121 DLIEYIKEEAPHFDIIGACYPEGHPDSPDRVSDIRNLKKKVDAGCSSLVTQLFFDNDRFY 180
Query: 200 DFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRA 259
DFQ++C LAGI+VPI+AGIMPILNRNQALRLLKTCENI LPRKFRAILDKYEHDPESL++
Sbjct: 181 DFQERCILAGIEVPIHAGIMPILNRNQALRLLKTCENIKLPRKFRAILDKYEHDPESLKS 240
Query: 260 AGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLF 302
AGLAYA+DQIVDLVTQDVAGVHLYTMNNA TA HIY+ATH+ F
Sbjct: 241 AGLAYAIDQIVDLVTQDVAGVHLYTMNNAATAHHIYQATHTFF 283
>gi|81177180|ref|ZP_00876045.1| 5,10-methylenetetrahydrofolate reductase (FADH) [Streptococcus suis
89/1591]
gi|80976145|gb|EAP39789.1| 5,10-methylenetetrahydrofolate reductase (FADH) [Streptococcus suis
89/1591]
Length = 286
Score = 456 bits (1173), Expect = e-127, Method: Composition-based stats.
Identities = 220/286 (76%), Positives = 254/286 (88%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADH 80
M QTPSLSFE+FPP P VGNEKI+ LD+M+G APHFISVT SNN N++ETTV LA+H
Sbjct: 1 MIGQTPSLSFEIFPPKPEVGNEKIIQTLDEMQGLAPHFISVTCSNNNLNVEETTVKLANH 60
Query: 81 IQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATD 140
++N+L IPTIAHLPA YL+KEKV L LD +GV++ILALRGDII G+ P +DF+YATD
Sbjct: 61 VRNELHIPTIAHLPAAYLTKEKVRSVLHSLDEIGVHQILALRGDIIEGLPPKEDFQYATD 120
Query: 141 LIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
LI FIK EAP+FDIIGACYPE HP+SPN +SDI+NLKKKVDAGCS+LVTQLFFDNE FY+
Sbjct: 121 LISFIKEEAPHFDIIGACYPEVHPESPNSVSDIKNLKKKVDAGCSTLVTQLFFDNEAFYN 180
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
FQ+KC+LA I+VPI AGIMPI+NRNQALRLLKTCENI LPRKF+AIL+KYEH+PESLRAA
Sbjct: 181 FQEKCSLADIEVPIIAGIMPIINRNQALRLLKTCENIRLPRKFKAILEKYEHNPESLRAA 240
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFKHHS 306
GLAYAVDQIVDLVT DVAG+HLYTMNNAETAR I++ATHSLFKH+S
Sbjct: 241 GLAYAVDQIVDLVTNDVAGIHLYTMNNAETARTIHQATHSLFKHYS 286
>gi|146319429|ref|YP_001199141.1| 5,10-methylenetetrahydrofolate reductase [Streptococcus suis
05ZYH33]
gi|146321632|ref|YP_001201343.1| 5,10-methylenetetrahydrofolate reductase [Streptococcus suis
98HAH33]
gi|145690235|gb|ABP90741.1| 5,10-methylenetetrahydrofolate reductase [Streptococcus suis
05ZYH33]
gi|145692438|gb|ABP92943.1| 5,10-methylenetetrahydrofolate reductase [Streptococcus suis
98HAH33]
Length = 286
Score = 456 bits (1172), Expect = e-126, Method: Composition-based stats.
Identities = 220/286 (76%), Positives = 255/286 (89%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADH 80
M QTPSLSFE+FPP PAVGNEKI+ LD+M+G APHFISVT SNN N++ETTV LA+H
Sbjct: 1 MIGQTPSLSFEIFPPKPAVGNEKIIQTLDEMQGLAPHFISVTCSNNNLNVEETTVKLANH 60
Query: 81 IQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATD 140
++N+L IPTIAHLPA YL+KEKV L LD +GV++ILALRGDII G+ P +DF+YATD
Sbjct: 61 VRNELHIPTIAHLPAAYLTKEKVRSVLHSLDEIGVHQILALRGDIIEGLPPKEDFQYATD 120
Query: 141 LIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
LI FIK EAP+FDIIGACYPE HP+SPN +SDI+NLKKKVDAGCS+LVTQLFFDNE FY+
Sbjct: 121 LISFIKEEAPHFDIIGACYPEVHPESPNSVSDIKNLKKKVDAGCSTLVTQLFFDNEAFYN 180
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
FQ+KC+LA I+VPI AGIMPI+N+NQALRLLKTCENI LPRKF+AIL+KYEH+PESLRAA
Sbjct: 181 FQEKCSLADIEVPIIAGIMPIINKNQALRLLKTCENIRLPRKFKAILEKYEHNPESLRAA 240
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFKHHS 306
GLAYAVDQIVDLVT DVAG+HLYTMNNAETAR I++ATHSLFKH+S
Sbjct: 241 GLAYAVDQIVDLVTNDVAGIHLYTMNNAETARTIHQATHSLFKHYS 286
>gi|125624052|ref|YP_001032535.1| MetF protein [Lactococcus lactis subsp. cremoris MG1363]
gi|124492860|emb|CAL97817.1| MetF protein [Lactococcus lactis subsp. cremoris MG1363]
Length = 285
Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats.
Identities = 163/284 (57%), Positives = 209/284 (73%), Gaps = 3/284 (1%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKY-NIKETTVPLAD 79
MTS + LSFEVFPP VG+ ++ LD ++ +P FISVT SNN Y NI +TT+ AD
Sbjct: 1 MTSDSKILSFEVFPPTTQVGSSHLVKTLDSLRALSPDFISVTCSNNNYENIADTTIKFAD 60
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYAT 139
++ N L IP +AHLPA YL K +V + L L ++LALRGDI KDF+YA+
Sbjct: 61 YVNNTLNIPAVAHLPAAYLDKTQVIEILERLREKQTMKVLALRGDISDEATK-KDFKYAS 119
Query: 140 DLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFY 199
DL++FIK +F+++GACYP+ HP+S N+ISD LK+KVD+G L+TQLFFDN FY
Sbjct: 120 DLVKFIKDYDSSFEVLGACYPDVHPESINRISDFHYLKEKVDSGADKLITQLFFDNNSFY 179
Query: 200 DFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRA 259
DFQ++C +A I+VPI AGIMP++NRNQ LRLLK C N LP KF IL+KYEH+P +LR
Sbjct: 180 DFQERCAIAEINVPILAGIMPVINRNQILRLLKNC-NTPLPAKFIRILEKYEHNPVALRD 238
Query: 260 AGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFK 303
AG+AYA+DQIVDLVT+DVAG+HLYTMNN+ETAR I+ + SLFK
Sbjct: 239 AGIAYAIDQIVDLVTEDVAGIHLYTMNNSETARSIHSSISSLFK 282
>gi|116512094|ref|YP_809310.1| 5,10-methylenetetrahydrofolate reductase [Lactococcus lactis subsp.
cremoris SK11]
gi|116107748|gb|ABJ72888.1| 5,10-methylenetetrahydrofolate reductase [Lactococcus lactis subsp.
cremoris SK11]
Length = 285
Score = 321 bits (823), Expect = 3e-86, Method: Composition-based stats.
Identities = 162/284 (57%), Positives = 210/284 (73%), Gaps = 3/284 (1%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKY-NIKETTVPLAD 79
MTS + LSFEVFPP VG+ ++ LD ++ +P FISVT SNN Y NI +TT+ AD
Sbjct: 1 MTSDSKILSFEVFPPTTQVGSSHLVKTLDSLRALSPDFISVTCSNNNYENIADTTIKFAD 60
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYAT 139
++ N L IP +AHLPA YL K +V + L L + ++LALRGDI KDF+YA+
Sbjct: 61 YVNNTLNIPAVAHLPAAYLDKTQVIEILERLREKQIMKVLALRGDISDEATK-KDFKYAS 119
Query: 140 DLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFY 199
DL++FIK +F+++GACYP+ HP+S N+ISD LK+KVD+G L+TQLFFDN FY
Sbjct: 120 DLVKFIKDYDSSFEVLGACYPDVHPESINRISDFHYLKEKVDSGSDKLITQLFFDNNSFY 179
Query: 200 DFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRA 259
DFQ++C +A I+VPI AGIMP++NRNQ LRLLK C N LP KF IL+KYEH+P +LR
Sbjct: 180 DFQERCAIAEINVPILAGIMPVINRNQILRLLKNC-NTPLPAKFIRILEKYEHNPVALRD 238
Query: 260 AGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFK 303
AG+AYA+DQIV+LVT+DVAG+HLYTMNN+ETAR I+ + SLFK
Sbjct: 239 AGIAYAIDQIVNLVTEDVAGIHLYTMNNSETARSIHSSISSLFK 282
>gi|15673236|ref|NP_267410.1| 5,10-methylenetetrahydrofolate reductase [Lactococcus lactis subsp.
lactis Il1403]
gi|12724227|gb|AAK05352.1|AE006357_7 5,10-methylenetetrahydrofolate reductase (EC 1.7.99.5) [Lactococcus
lactis subsp. lactis Il1403]
Length = 283
Score = 319 bits (817), Expect = 2e-85, Method: Composition-based stats.
Identities = 161/284 (56%), Positives = 211/284 (74%), Gaps = 5/284 (1%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKY-NIKETTVPLAD 79
MTS + LSFEVFPP +G+ ++ LD ++ +P FISVT SNN Y NI +TT+ AD
Sbjct: 1 MTSNSKILSFEVFPPTTQIGSTNLVKTLDSLRTLSPDFISVTCSNNNYDNIGDTTIKFAD 60
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKD-FRYA 138
++ N L IP +AHLPA YL K +V + L L + +ILALRGDI EP+KD F++A
Sbjct: 61 YVNNTLDIPAVAHLPAAYLDKAQVIEILERLKDKQIKKILALRGDI--SDEPMKDDFKFA 118
Query: 139 TDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERF 198
+DL++FIK +F+++GACYP+ HP+S N++SD LK+KVDAGC L+TQLFFDN+ F
Sbjct: 119 SDLVKFIKDYDDSFEVLGACYPDIHPESVNRVSDFHYLKEKVDAGCDRLITQLFFDNDSF 178
Query: 199 YDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLR 258
YDFQ++C +A I+ PI+AGIMP++NRNQ LRLLK C N LP KF IL+KYEH+ +LR
Sbjct: 179 YDFQERCAIAEINTPIFAGIMPVINRNQILRLLKNC-NTPLPAKFIRILEKYEHNLIALR 237
Query: 259 AAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLF 302
AG+AYA+DQIVDLVT+DVAG+HLYTMNNA TA I+ + SLF
Sbjct: 238 DAGIAYAIDQIVDLVTEDVAGIHLYTMNNANTAHSIHASISSLF 281
>gi|13374134|emb|CAC34449.1| 5,10-methylenetetrahydrofolate reductase [Streptococcus
thermophilus]
Length = 130
Score = 273 bits (697), Expect = 1e-71, Method: Composition-based stats.
Identities = 130/130 (100%), Positives = 130/130 (100%)
Query: 182 AGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPR 241
AGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPR
Sbjct: 1 AGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPR 60
Query: 242 KFRAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
KFRAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL
Sbjct: 61 KFRAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 120
Query: 302 FKHHSQVGAL 311
FKHHSQVGAL
Sbjct: 121 FKHHSQVGAL 130
>gi|114566466|ref|YP_753620.1| 5,10-methylenetetrahydrofolate reductase [Syntrophomonas wolfei
subsp. wolfei str. Goettingen]
gi|114337401|gb|ABI68249.1| 5,10-methylenetetrahydrofolate reductase [Syntrophomonas wolfei
subsp. wolfei str. Goettingen]
Length = 287
Score = 272 bits (696), Expect = 2e-71, Method: Composition-based stats.
Identities = 134/275 (48%), Positives = 187/275 (68%), Gaps = 2/275 (0%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
LS E+FPP I L++++G P FISVT T+ +A I+N+ I
Sbjct: 13 LSLEIFPPRRTASIGIIYKTLEELQGLNPDFISVTYGAGGSETNTATLEIASAIKNNYGI 72
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
++AHLP I L+K++V + L GV ILALRGD+ P P +DFRYA+DL+ FIK
Sbjct: 73 ESVAHLPCINLNKDEVLNMLEGFKQAGVENILALRGDVNPARVPKQDFRYASDLVSFIK- 131
Query: 148 EAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTL 207
E +F+IIGACYPEGH +SP+ + DI++LK KVDAG L+TQLFFDN FY F+++ ++
Sbjct: 132 ENGDFNIIGACYPEGHSESPSLLDDIRHLKIKVDAGTDQLITQLFFDNSYFYSFRERASV 191
Query: 208 AGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAVD 267
AGI+V I AGIMP++N+ Q R++ C + LP+KF ++++YE++PE++R AG+AYAVD
Sbjct: 192 AGINVAIEAGIMPVVNKRQIERMVALC-GVKLPKKFVTMMERYENNPEAMRDAGIAYAVD 250
Query: 268 QIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLF 302
QIVDL+ Q V G+HLYTMNN A+ IY A +L
Sbjct: 251 QIVDLIAQGVDGIHLYTMNNPYIAKKIYAAISTLL 285
>gi|57505233|ref|ZP_00371162.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter upsaliensis
RM3195]
gi|57016369|gb|EAL53154.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter upsaliensis
RM3195]
Length = 286
Score = 263 bits (672), Expect = 1e-68, Method: Composition-based stats.
Identities = 138/281 (49%), Positives = 181/281 (64%), Gaps = 2/281 (0%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
S SFEVFPP + + L+D+ +P+FISVT + T+ +A IQ
Sbjct: 3 SFSFEVFPPRRNETIKNLDAILEDLGRLSPNFISVTFGAGGSINSKNTLEVASLIQEKYQ 62
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
IP+I HLP I+ SKEK+ L+E G+N+ILALRGD+ G+E KDF YA DLI FIK
Sbjct: 63 IPSIVHLPCIHSSKEKITAILKECKQRGLNKILALRGDVCEGLEKSKDFSYANDLISFIK 122
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ NF+I ACYPE H ++ N I DI +LK KV+ G L+TQLF+DNE FY F+ C
Sbjct: 123 KQE-NFEIYAACYPEKHSEAKNIIEDIHHLKNKVNVGTDKLITQLFYDNEDFYAFKQNCA 181
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
L+GI VPIYAGIMPI N+ Q L++ + C +P KF IL+KYE++ +L AG+AYA+
Sbjct: 182 LSGIKVPIYAGIMPITNKRQILKISQLC-GAKIPTKFTKILEKYENNTLALEDAGIAYAI 240
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFKHHSQ 307
DQIVDL+T V G+HLYTMN + A IYEA L K ++
Sbjct: 241 DQIVDLITSGVDGIHLYTMNKTKAAIRIYEAVKHLPKEENE 281
>gi|86150317|ref|ZP_01068543.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter jejuni
subsp. jejuni CF93-6]
gi|85839142|gb|EAQ56405.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter jejuni
subsp. jejuni CF93-6]
Length = 282
Score = 262 bits (669), Expect = 2e-68, Method: Composition-based stats.
Identities = 139/277 (50%), Positives = 180/277 (64%), Gaps = 2/277 (0%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
S SFEVFPP + + LDD+ +P+FISVT + T+ +A IQ +
Sbjct: 3 SFSFEVFPPRKDENIKNLHAILDDLGQLSPNFISVTFGAGGSINSQNTLEIASLIQEEYQ 62
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
IP+I HLP I+ SKEK+ L++ +N+ILALRGDI +E KDF YA+DLI FIK
Sbjct: 63 IPSIVHLPCIHSSKEKITQILQKCKEKNLNQILALRGDICENLEKSKDFSYASDLISFIK 122
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ F+I ACYPE H +S N I DI +LK KV+AG L+TQLF+DNE FY F+ C
Sbjct: 123 KQE-YFEIYAACYPEKHNESKNFIEDIHHLKTKVNAGTDKLITQLFYDNEDFYTFKQNCA 181
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
LAGID+PIYAGIMPI N+ Q L++ + C +P KF IL+KYE++ +L AG+AYA
Sbjct: 182 LAGIDIPIYAGIMPITNKRQVLKISQLC-GAKIPPKFVKILEKYENNTLALEDAGIAYAC 240
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFK 303
DQIVDL+T V G+HLYTMN ++ A IYEA L K
Sbjct: 241 DQIVDLITSGVDGIHLYTMNKSKAAIKIYEAVKHLLK 277
>gi|148926205|ref|ZP_01809890.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter jejuni
subsp. jejuni CG8486]
gi|145845376|gb|EDK22469.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter jejuni
subsp. jejuni CG8486]
Length = 282
Score = 261 bits (668), Expect = 3e-68, Method: Composition-based stats.
Identities = 139/277 (50%), Positives = 180/277 (64%), Gaps = 2/277 (0%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
S SFEVFPP + + LDD+ +P+FISVT + T+ +A IQ +
Sbjct: 3 SFSFEVFPPRKDENIKNLHAILDDLGQLSPNFISVTFGAGGSINSQNTLEVASLIQEEYQ 62
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
IP+I HLP I+ SKEK+ L++ +N+ILALRGDI +E KDF YA+DLI FIK
Sbjct: 63 IPSIVHLPCIHSSKEKITQILQKCKEKNLNQILALRGDICENLEKSKDFSYASDLISFIK 122
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ F+I ACYPE H +S N I DI +LK KV+AG L+TQLF+DNE FY F+ C
Sbjct: 123 KQE-YFEIYAACYPEKHNESKNFIEDIHHLKTKVNAGTDKLITQLFYDNEDFYTFKQNCA 181
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
LAGID+PIYAGIMPI N+ Q L++ + C +P KF IL+KYE++ +L AG+AYA
Sbjct: 182 LAGIDIPIYAGIMPITNKRQVLKISQLC-GAKIPPKFVKILEKYENNALALEDAGIAYAC 240
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFK 303
DQIVDL+T V G+HLYTMN ++ A IYEA L K
Sbjct: 241 DQIVDLITSGVDGIHLYTMNKSKAAIKIYEAVKHLLK 277
>gi|86150790|ref|ZP_01069006.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter jejuni
subsp. jejuni 260.94]
gi|85841960|gb|EAQ59206.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter jejuni
subsp. jejuni 260.94]
Length = 282
Score = 261 bits (667), Expect = 4e-68, Method: Composition-based stats.
Identities = 138/277 (49%), Positives = 181/277 (65%), Gaps = 2/277 (0%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
+ SFEVFPP + + LDD+ +P+FISVT + T+ +A IQ +
Sbjct: 3 NFSFEVFPPRKDENIKNLHAILDDLGQLSPNFISVTFGAGGSINSQNTLEIASLIQKEYQ 62
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
IP+I HLP I+ SKEK+ L++ +N+ILALRGDI +E KDF YA+DLI FIK
Sbjct: 63 IPSIVHLPCIHSSKEKITQILQKCKEKNLNQILALRGDICENLEKSKDFSYASDLISFIK 122
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ +F+I ACYPE H +S N I DI +LK KV+AG L+TQLF+DNE FY F+ C
Sbjct: 123 KQE-DFEIYAACYPEKHNESKNFIEDIHHLKTKVNAGTDKLITQLFYDNEDFYTFKQNCA 181
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
LAGID+PIYAGIMPI N+ Q L++ + C +P KF IL+KYE++ +L AG+AYA
Sbjct: 182 LAGIDIPIYAGIMPITNKRQVLKISQLC-GAKIPPKFVKILEKYENNTLALEDAGIAYAC 240
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFK 303
DQIVDL+T V G+HLYTMN ++ A IYEA L K
Sbjct: 241 DQIVDLITSGVDGIHLYTMNKSKAAIKIYEAVKYLLK 277
>gi|86152732|ref|ZP_01070937.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter jejuni
subsp. jejuni HB93-13]
gi|85843617|gb|EAQ60827.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter jejuni
subsp. jejuni HB93-13]
Length = 282
Score = 261 bits (666), Expect = 5e-68, Method: Composition-based stats.
Identities = 139/282 (49%), Positives = 181/282 (64%), Gaps = 2/282 (0%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
+ SFEVFPP + + LDD+ +P+FISVT + T+ +A IQ +
Sbjct: 3 NFSFEVFPPRKDENIKNLHAILDDLGQLSPNFISVTFGAGGSINSQNTLEVASLIQEEYQ 62
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
IP+I HLP I+ SKEK+ L++ +N+ILALRGDI +E KDF YA+DLI FIK
Sbjct: 63 IPSIVHLPCIHSSKEKITQILQKCKEKNLNQILALRGDICENLEKSKDFSYASDLISFIK 122
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ F+I ACYPE H +S N I DI +LK KV+AG L+TQLF+DNE FY F+ C
Sbjct: 123 KQE-YFEIYAACYPEKHNESKNFIEDIHHLKTKVNAGTDKLITQLFYDNEDFYTFKQNCA 181
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
LAGID+PIYAGIMPI N+ Q L++ + C +P KF IL+KYE++ +L AG+AYA
Sbjct: 182 LAGIDIPIYAGIMPITNKRQVLKISQLC-GAKIPPKFVKILEKYENNALALEDAGIAYAC 240
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFKHHSQV 308
DQIVDL+T V G+HLYTMN ++ A IYEA L K V
Sbjct: 241 DQIVDLITSGVDGIHLYTMNKSKAAIKIYEAVKHLLKEELHV 282
>gi|121612730|ref|YP_001000877.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter jejuni
subsp. jejuni 81-176]
gi|87249294|gb|EAQ72255.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter jejuni
subsp. jejuni 81-176]
Length = 282
Score = 261 bits (666), Expect = 5e-68, Method: Composition-based stats.
Identities = 139/277 (50%), Positives = 179/277 (64%), Gaps = 2/277 (0%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
S SFEVFPP + + LDD+ +P+FISVT + T+ +A IQ +
Sbjct: 3 SFSFEVFPPRKDENIKNLHAILDDLGQLSPNFISVTFGAGGSINSQNTLEVASLIQEEYQ 62
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
IP+I HLP I+ SKEK+ L++ +N+ILALRGDI +E KDF YA+DLI FIK
Sbjct: 63 IPSIVHLPCIHSSKEKITQILQKCKEKNLNQILALRGDICENLEKSKDFSYASDLISFIK 122
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ F+I ACYPE H +S N I DI LK KV+AG L+TQLF+DNE FY F+ C
Sbjct: 123 KQE-YFEIYAACYPEKHNESKNFIEDIHYLKTKVNAGTDKLITQLFYDNEDFYTFKQNCA 181
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
LAGID+PIYAGIMPI N+ Q L++ + C +P KF IL+KYE++ +L AG+AYA
Sbjct: 182 LAGIDIPIYAGIMPITNKRQVLKISQLC-GAKIPPKFVKILEKYENNALALEDAGIAYAC 240
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFK 303
DQIVDL+T V G+HLYTMN ++ A IYEA L K
Sbjct: 241 DQIVDLITSGVDGIHLYTMNKSKAAIKIYEAVKHLLK 277
>gi|57238074|ref|YP_179323.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter jejuni
RM1221]
gi|57166878|gb|AAW35657.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter jejuni
RM1221]
Length = 282
Score = 260 bits (664), Expect = 9e-68, Method: Composition-based stats.
Identities = 138/277 (49%), Positives = 179/277 (64%), Gaps = 2/277 (0%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
S SFEVFPP + + LDD+ +P+FISVT + T+ +A IQ +
Sbjct: 3 SFSFEVFPPRKDENIKNLHAILDDLGQLSPNFISVTFGAGGSINSQNTLEVASLIQEEYQ 62
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
IP+I HLP I+ SKEK+ L++ +N+IL LRGDI +E KDF YA+DLI FIK
Sbjct: 63 IPSIVHLPCIHSSKEKITQILQKCKEKNLNQILTLRGDICENLEKSKDFSYASDLISFIK 122
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ F+I ACYPE H +S N I DI +LK KV+AG L+TQLF+DNE FY F+ C
Sbjct: 123 KQE-YFEIYAACYPEKHNESKNFIEDIHHLKTKVNAGTDKLITQLFYDNEDFYTFKQNCA 181
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
LAGID+PIYAGIMPI N+ Q L++ + C +P KF IL+KYE++ +L AG+AYA
Sbjct: 182 LAGIDIPIYAGIMPITNKRQVLKISQLC-GAKIPPKFVKILEKYENNALALEDAGIAYAC 240
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFK 303
DQIVDL+T V G+HLYTMN ++ A IYEA L K
Sbjct: 241 DQIVDLITSGVDGIHLYTMNKSKAAIKIYEAVKHLLK 277
>gi|57168082|ref|ZP_00367221.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter coli
RM2228]
gi|57020456|gb|EAL57125.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter coli
RM2228]
Length = 282
Score = 259 bits (661), Expect = 2e-67, Method: Composition-based stats.
Identities = 136/277 (49%), Positives = 180/277 (64%), Gaps = 2/277 (0%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
S SFE+FPP + + LDD+ +P+FISVT + T+ A IQ +
Sbjct: 3 SFSFEIFPPRRDENIKNLNAILDDLGQLSPNFISVTFGAGGSINSKNTLETASLIQEEYK 62
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
IP+I HLP I+ SKEK+ L+E +++ILALRGD+ +E KDF YA+DLI FI+
Sbjct: 63 IPSIVHLPCIHSSKEKIISILQECKERQLDKILALRGDVCNDLEKSKDFSYASDLISFIR 122
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ F+I ACYPE H +S N I DI +LK KVDAG L+TQLF+DNE FY F+ C
Sbjct: 123 KQG-EFEIYAACYPEKHNESRNFIEDIHHLKNKVDAGTDKLITQLFYDNEDFYTFKQNCA 181
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
LAGI++PIYAGIMPI N+ Q L++ + C +P KF IL+KYE++ +L AG+AYA+
Sbjct: 182 LAGINIPIYAGIMPITNKRQVLKISQLC-GAKIPPKFAKILEKYENNTLALEDAGIAYAI 240
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFK 303
DQIVDL+T V G+HLYTMN ++ A IYEA L K
Sbjct: 241 DQIVDLITSGVDGIHLYTMNKSKAAIKIYEAVKYLLK 277
>gi|153951782|ref|YP_001397705.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter jejuni
subsp. doylei 269.97]
gi|152939228|gb|ABS43969.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter jejuni
subsp. doylei 269.97]
Length = 282
Score = 257 bits (656), Expect = 7e-67, Method: Composition-based stats.
Identities = 136/277 (49%), Positives = 178/277 (64%), Gaps = 2/277 (0%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
S SFE+FPP + + LDD+ +P+FISVT + T+ A IQ +
Sbjct: 3 SFSFEIFPPRRDENIKNLNAILDDLGQLSPNFISVTFGAGGSINSKNTLETASLIQEEYK 62
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
IP+I HLP I+ SKEK+ L+E +++ILALRGD+ +E KDF YA+DLI FI+
Sbjct: 63 IPSIVHLPCIHSSKEKIISILQECKERQLDKILALRGDVCNDLEKSKDFSYASDLISFIQ 122
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ F+I ACYPE H +S N I DI +LK KV+AG L+TQLF+DNE FY F+ C
Sbjct: 123 KQG-EFEIYAACYPEKHNESKNFIEDIHHLKTKVNAGTDKLITQLFYDNEDFYTFKQNCA 181
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
LAGID+PIYAGIMPI N+ Q L++ + C +P KF IL+KYE++ +L AG+AYA
Sbjct: 182 LAGIDIPIYAGIMPITNKRQVLKISQLC-GAKIPPKFAKILEKYENNTLALEDAGIAYAC 240
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFK 303
DQIVDL+T V G+HLYTMN + A IYEA L K
Sbjct: 241 DQIVDLITSGVDGIHLYTMNKPKAAIKIYEAVKHLLK 277
>gi|15792526|ref|NP_282349.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter jejuni
subsp. jejuni NCTC 11168]
gi|88596830|ref|ZP_01100067.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter jejuni
subsp. jejuni 84-25]
gi|88191671|gb|EAQ95643.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter jejuni
subsp. jejuni 84-25]
gi|112360520|emb|CAL35317.1| 5,10-methylenetetrahydrofolate reductase [Campylobacter jejuni
subsp. jejuni NCTC 11168]
Length = 282
Score = 256 bits (655), Expect = 1e-66, Method: Composition-based stats.
Identities = 137/277 (49%), Positives = 179/277 (64%), Gaps = 2/277 (0%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
S SFEVFPP + + LDD+ +P+FISVT + T+ +A IQ +
Sbjct: 3 SFSFEVFPPRKDENIKNLHAILDDLGQLSPNFISVTFGAGGSINSQNTLEVASLIQEEYQ 62
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
IP+I HLP I+ SKEK+ L++ +N+ILALRGDI ++ KDF YA+DLI FIK
Sbjct: 63 IPSIVHLPCIHSSKEKITQILQKCKEKNLNQILALRGDICENLKKSKDFSYASDLISFIK 122
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ F+I ACYPE H +S N I DI +LK KV+AG L+TQLF+DNE FY F+ C
Sbjct: 123 KQE-YFEIYAACYPEKHNESKNFIEDIHHLKTKVNAGTDKLITQLFYDNEDFYTFKQNCA 181
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
LA ID+PIYAGIMPI N+ Q L++ + C +P KF IL+KYE++ +L AG+AYA
Sbjct: 182 LADIDIPIYAGIMPITNKRQVLKISQLC-GAKIPPKFVKILEKYENNTLALEDAGIAYAC 240
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFK 303
DQIVDL+T V G+HLYTMN ++ A IYEA L K
Sbjct: 241 DQIVDLITSGVDGIHLYTMNKSKAAIKIYEAVKHLLK 277
>gi|154487397|ref|ZP_02028804.1| hypothetical protein BIFADO_01249 [Bifidobacterium adolescentis
L2-32]
gi|154083915|gb|EDN82960.1| hypothetical protein BIFADO_01249 [Bifidobacterium adolescentis
L2-32]
Length = 279
Score = 239 bits (611), Expect = 1e-61, Method: Composition-based stats.
Identities = 129/279 (46%), Positives = 165/279 (59%), Gaps = 2/279 (0%)
Query: 24 QTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQN 83
+P S EVFPP I LD ++G P FISVT K + + T +A H N
Sbjct: 2 HSPIFSLEVFPPKRTSPVGTIYDTLDGLQGLDPDFISVTYGTGKSSDRTLTARIA-HTVN 60
Query: 84 DLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIE 143
+ IP +AHL A YL K+ V + L D V+ +LALRGD + G EP F +A+DL
Sbjct: 61 EYGIPAVAHLTAQYLDKDDVNEALDLFDQAKVSGVLALRGDRVEGAEPAGVFDHASDLAA 120
Query: 144 FIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQD 203
+I+ + PN I GACYPE HP + DI NLKKKVDAG S L++QLF+DNE F F D
Sbjct: 121 YIREKRPNLKIYGACYPEKHPQAATLEEDIDNLKKKVDAGVSHLISQLFYDNEDFLRFVD 180
Query: 204 KCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLA 263
K AGIDVPI AGIMP++N LR+ K CE+ +P K +LDK+ D L+ AG+A
Sbjct: 181 KARAAGIDVPIEAGIMPVMNAKSVLRMSKMCES-RVPEKLAVLLDKWGSDTALLKEAGIA 239
Query: 264 YAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLF 302
YA +QI DL + V GVHLYTMN+ +R I+ F
Sbjct: 240 YASEQICDLAARGVDGVHLYTMNHPCVSRRIWSNVKPFF 278
>gi|119025775|ref|YP_909620.1| 5,10-methylenetetrahydrofolate reductase [Bifidobacterium
adolescentis ATCC 15703]
gi|118765359|dbj|BAF39538.1| 5,10-methylenetetrahydrofolate reductase [Bifidobacterium
adolescentis ATCC 15703]
Length = 279
Score = 238 bits (606), Expect = 5e-61, Method: Composition-based stats.
Identities = 128/279 (45%), Positives = 165/279 (59%), Gaps = 2/279 (0%)
Query: 24 QTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQN 83
+P S EVFPP I LD ++G P FISVT K + + T +A H N
Sbjct: 2 HSPIFSLEVFPPKRTSPVGTIYDTLDGLQGLDPDFISVTYGTGKSSDRTLTARIA-HTVN 60
Query: 84 DLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIE 143
+ IP +AHL A YL K+ V + L D V+ +LALRGD + G EP F +A+DL
Sbjct: 61 EYGIPAVAHLTAQYLDKDDVDEALDLFDQAKVSGVLALRGDRVEGAEPAGVFDHASDLAA 120
Query: 144 FIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQD 203
+I+ + P+ I GACYPE HP + DI NLKKKVDAG S L++QLF+DNE F F D
Sbjct: 121 YIREKRPDLKIYGACYPEKHPQAATLEEDIDNLKKKVDAGVSHLISQLFYDNEDFLRFVD 180
Query: 204 KCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLA 263
K AGIDVPI AGIMP++N LR+ K CE+ +P K +LDK+ D L+ AG+A
Sbjct: 181 KARAAGIDVPIEAGIMPVMNAKSVLRMSKMCES-RVPEKLAVLLDKWGSDTALLKEAGIA 239
Query: 264 YAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLF 302
YA +QI DL + V GVHLYTMN+ +R I+ F
Sbjct: 240 YASEQICDLAARGVDGVHLYTMNHPCVSRRIWSNVKPFF 278
>gi|116494174|ref|YP_805908.1| 5,10-methylenetetrahydrofolate reductase [Lactobacillus casei ATCC
334]
gi|116104324|gb|ABJ69466.1| 5,10-methylenetetrahydrofolate reductase [Lactobacillus casei ATCC
334]
Length = 290
Score = 234 bits (597), Expect = 6e-60, Method: Composition-based stats.
Identities = 124/277 (44%), Positives = 179/277 (64%), Gaps = 5/277 (1%)
Query: 28 LSFEVFPPNPAVGN---EKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQND 84
+SFEVFPP N IL LD +K + P F+SVT N T+ +A I+++
Sbjct: 13 ISFEVFPPRKNASNIALTPILNTLDAVKEADPDFVSVTFGANGNKPHMGTLEVAKLIKDE 72
Query: 85 LAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEF 144
+ +AHLPA L++E+V LR G++ ILALRGDI DF YA DLIE
Sbjct: 73 FDMEPVAHLPAAQLTREQVDAELRGFQDAGIDNILALRGDIPKSGRVSNDFPYACDLIEH 132
Query: 145 IKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDK 204
I + +F+++ ACYPE HP+SP+ +SDI +LK+KVD+G S L++QLFFDN+ FY F+++
Sbjct: 133 IH-QVGDFNVVAACYPEKHPESPDVVSDIHHLKEKVDSGASQLISQLFFDNQVFYRFRER 191
Query: 205 CTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAY 264
LAGI+VPI AGIMP++N +Q R + T ++LP KF A++ + + E++R AG+AY
Sbjct: 192 AQLAGINVPIEAGIMPVINEHQIER-MATMAGVNLPPKFVAMMQHFSGNKEAMRDAGIAY 250
Query: 265 AVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
A+DQIVDL+ V G+H+YTM+N + I AT ++
Sbjct: 251 AIDQIVDLLVHGVDGIHIYTMDNPTVVKRIAAATQTI 287
>gi|23465373|ref|NP_695976.1| 5,10-methylenetetrahydrofolate reductase [Bifidobacterium longum
NCC2705]
gi|23326018|gb|AAN24612.1| 5,10-methylenetetrahydrofolate reductase [Bifidobacterium longum
NCC2705]
Length = 284
Score = 233 bits (595), Expect = 8e-60, Method: Composition-based stats.
Identities = 122/282 (43%), Positives = 173/282 (61%), Gaps = 5/282 (1%)
Query: 24 QTPSLSFEVFPP--NPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHI 81
+P + EVFPP N VG I LD ++G P FISVT + ++ + T +A I
Sbjct: 2 HSPMFTLEVFPPKRNAPVGT--IYDTLDGLEGLNPDFISVTYGHGTHSDRTATARIAHTI 59
Query: 82 QNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDL 141
+ IP +AHL A+Y K K+ + L + GV+ +LALRGD I G + + +F +A+DL
Sbjct: 60 SKEYGIPAVAHLTALYSDKAKIDEALDMFEEAGVSAVLALRGDYIDGEQLVGEFNHASDL 119
Query: 142 IEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDF 201
+ +I++ P+F + GACYPEGH + + DI+NLK KVDAG + L++QLF+DNE FY F
Sbjct: 120 VSYIRSVKPDFKVFGACYPEGHYQADSLDQDIENLKIKVDAGVTHLISQLFYDNEDFYRF 179
Query: 202 QDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAG 261
DK AGI VPI AGIMP+ R+ + + +P + +L+K+ D +SLRAAG
Sbjct: 180 LDKARAAGITVPIEAGIMPVRGAKSVRRMAERNAS-RIPDRLNTLLNKWGDDIQSLRAAG 238
Query: 262 LAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFK 303
+ YA +QI DLV DV GVHLY+MN+ T R I+ LF+
Sbjct: 239 ILYASEQIADLVAHDVDGVHLYSMNHPATTRRIWRNAEPLFR 280
>gi|154482518|ref|ZP_02024966.1| hypothetical protein EUBVEN_00185 [Eubacterium ventriosum ATCC
27560]
gi|149736648|gb|EDM52534.1| hypothetical protein EUBVEN_00185 [Eubacterium ventriosum ATCC
27560]
Length = 292
Score = 233 bits (593), Expect = 1e-59, Method: Composition-based stats.
Identities = 131/285 (45%), Positives = 181/285 (63%), Gaps = 2/285 (0%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVT-ASNNKYNIKETTVPLA 78
L + SFEVFPP G E I L+++K P FISVT + K TT+ L
Sbjct: 6 LFKKEHTVFSFEVFPPKKESGIETIYSTLNELKNLNPDFISVTYGAGGKGVANATTIDLC 65
Query: 79 DHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYA 138
+I+N+L TIAHL +Y +KE + L ELD GV ILALRGD+ P KDF+YA
Sbjct: 66 SYIKNELGTETIAHLSCLYNTKESIDRILDELDEKGVKNILALRGDVNPDFAIEKDFKYA 125
Query: 139 TDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERF 198
+DL E+I ++ F+I GACYPE H ++ N I DIQNLKKKVD+G L++QLFFD++ F
Sbjct: 126 SDLTEYIMSKNRGFNISGACYPEVHQEAANMIEDIQNLKKKVDSGADHLISQLFFDDQVF 185
Query: 199 YDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLR 258
+DFQ+K +AGI+VPI AGIMP+ N+ Q R++ C +P K +L ++ + E++R
Sbjct: 186 FDFQEKARIAGINVPIEAGIMPVTNKKQIERMVSMC-GASIPAKLSKVLQRFGDNHEAMR 244
Query: 259 AAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFK 303
AG++YA+DQI++L V GVH+YTMN+ AR I E ++ K
Sbjct: 245 DAGISYAIDQIIELAAHGVDGVHIYTMNDPYVARRISEGVKNILK 289
>gi|46191194|ref|ZP_00206701.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Bifidobacterium
longum DJO10A]
Length = 280
Score = 231 bits (588), Expect = 6e-59, Method: Composition-based stats.
Identities = 121/278 (43%), Positives = 171/278 (61%), Gaps = 5/278 (1%)
Query: 28 LSFEVFPP--NPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDL 85
+ EVFPP N VG I LD ++G P FISVT + ++ + T +A I +
Sbjct: 2 FTLEVFPPKRNAPVGT--IYDTLDGLEGLNPDFISVTYGHGTHSDRTATARIAHTISKEY 59
Query: 86 AIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFI 145
IP +AHL A+Y K K+ + L + GV+ +LALRGD I G + + +F +A+DL+ +I
Sbjct: 60 GIPAVAHLTALYSDKAKIDEALDMFEEAGVSAVLALRGDYIDGEQLVGEFNHASDLVSYI 119
Query: 146 KAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKC 205
++ P+F + GACYPEGH + + DI+NLK KVDAG + L++QLF+DNE FY F DK
Sbjct: 120 RSVKPDFKVFGACYPEGHYQADSLDQDIENLKIKVDAGVTHLISQLFYDNEDFYRFLDKA 179
Query: 206 TLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYA 265
AGI VPI AGIMP+ R+ + + +P + +L+K+ D +SLRAAG+ YA
Sbjct: 180 RAAGITVPIEAGIMPVRGAKSVRRMAERNAS-RIPDRLNTLLNKWGDDIQSLRAAGILYA 238
Query: 266 VDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFK 303
+QI DLV DV GVHLY+MN+ T R I+ LF+
Sbjct: 239 SEQIADLVAHDVDGVHLYSMNHPATTRRIWRNAEPLFR 276
>gi|148379582|ref|YP_001254123.1| 5,10-methylenetetrahydrofolate reductase [Clostridium botulinum A
str. ATCC 3502]
gi|153931965|ref|YP_001383961.1| 5,10-methylenetetrahydrofolate reductase [Clostridium botulinum A
str. ATCC 19397]
gi|153937107|ref|YP_001387506.1| 5,10-methylenetetrahydrofolate reductase [Clostridium botulinum A
str. Hall]
gi|148289066|emb|CAL83156.1| 5,10-methylenetetrahydrofolate reductase [Clostridium botulinum A
str. ATCC 3502]
gi|152928009|gb|ABS33509.1| 5,10-methylenetetrahydrofolate reductase [Clostridium botulinum A
str. ATCC 19397]
gi|152933021|gb|ABS38520.1| 5,10-methylenetetrahydrofolate reductase [Clostridium botulinum A
str. Hall]
Length = 295
Score = 227 bits (579), Expect = 7e-58, Method: Composition-based stats.
Identities = 126/284 (44%), Positives = 174/284 (61%), Gaps = 2/284 (0%)
Query: 19 KLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLA 78
+L + SFE+FPP + I L+++K P FISVT T L+
Sbjct: 5 ELFNEKKLVFSFEIFPPKVTSSIKTIYETLEELKDLTPDFISVTYGAGGSLKNNKTCELS 64
Query: 79 DHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYA 138
++N I +AHL I +K+ + ++EL + ILALRGDI + + ++ YA
Sbjct: 65 SLVKNKYGIEALAHLTCINSTKDDIDLIIKELKENNIKNILALRGDIPKDKDIIGEYNYA 124
Query: 139 TDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERF 198
+LIE IKA + NF I GACYPEGH + + DI+ LK+KVDAG L++QLFFDN F
Sbjct: 125 FELIEKIKA-SNNFGISGACYPEGHIECKSLDQDIRELKRKVDAGAEHLISQLFFDNNIF 183
Query: 199 YDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLR 258
Y+F +K I+VPI AGIMP++N+ Q R++K LP+KF ILDKYE+D +++
Sbjct: 184 YEFLNKTQEKSINVPIQAGIMPVVNKKQIERIVKI-SGATLPKKFMKILDKYEYDKKAME 242
Query: 259 AAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLF 302
AG+AYAV+QIVDLV+ V G+HLYTMNN AR I E+T S+F
Sbjct: 243 DAGIAYAVEQIVDLVSSGVKGIHLYTMNNPYIARKITESTKSIF 286
>gi|153938503|ref|YP_001390959.1| 5,10-methylenetetrahydrofolate reductase [Clostridium botulinum F
str. Langeland]
gi|152934399|gb|ABS39897.1| 5,10-methylenetetrahydrofolate reductase [Clostridium botulinum F
str. Langeland]
Length = 295
Score = 226 bits (576), Expect = 1e-57, Method: Composition-based stats.
Identities = 125/284 (44%), Positives = 172/284 (60%), Gaps = 2/284 (0%)
Query: 19 KLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLA 78
+L + SFE+FPP + I L+++K P FISVT T L+
Sbjct: 5 ELFNEKKLVFSFEIFPPKVTSSIKTIYETLEELKDLTPDFISVTYGAGGSLKNNKTCELS 64
Query: 79 DHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYA 138
++N I +AHL I +K+ + ++EL + ILALRGDI + ++ YA
Sbjct: 65 SLVKNKYGIEALAHLTCINSTKDDIDLIIKELKENNIENILALRGDIPKDKNIIGEYNYA 124
Query: 139 TDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERF 198
+LIE IKA NF + GACYPEGH + + DI+ LK+KVDAG L++QLFFDN F
Sbjct: 125 FELIEKIKANN-NFGVSGACYPEGHIECESLKQDIRELKRKVDAGAEHLISQLFFDNNIF 183
Query: 199 YDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLR 258
Y+F +K I+VPI AGIMP++N+ Q R++K LP+KF ILDKYE+D +++
Sbjct: 184 YEFLNKTQQKNINVPIQAGIMPVVNKKQIERIVKI-SGATLPKKFMKILDKYEYDKKAME 242
Query: 259 AAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLF 302
AG+AYAV+QIVDLV+ V G+HLYTMNN AR I E+T S+F
Sbjct: 243 DAGIAYAVEQIVDLVSSGVKGIHLYTMNNPYIARKIIESTKSIF 286
>gi|106893157|ref|ZP_01360283.1| 5,10-methylenetetrahydrofolate reductase [Clostridium sp. OhILAs]
gi|106775466|gb|EAT32024.1| 5,10-methylenetetrahydrofolate reductase [Clostridium sp. OhILAs]
Length = 298
Score = 216 bits (549), Expect = 2e-54, Method: Composition-based stats.
Identities = 120/277 (43%), Positives = 162/277 (58%), Gaps = 2/277 (0%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
SFEVFPP I L+ ++ P +ISVT T +A I+N I
Sbjct: 14 FSFEVFPPKVTSPIGSIYDTLEGLQDLKPDYISVTYGAGGNGNDNRTGEIAAIIKNKYGI 73
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
+AHL I + E+ L+EL GV+ +LALRGDI G E + + + DLI I+
Sbjct: 74 EALAHLTCIGSTLEQTKGVLQELRDKGVHNVLALRGDIPEGFEGKGELKNSQDLIRLIRE 133
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ N F I ACYPEGH + N DI+ LK K +AG +TQLFFDN FY+F +K
Sbjct: 134 DQGNRFGIAAACYPEGHVEGKNVDQDIEILKLKEEAGADHAITQLFFDNNYFYEFLNKVE 193
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
GI +PI AGIMP+ N+ Q R++ +LP KF+ I++KYEH+ E+LR AG+AYA+
Sbjct: 194 EKGIQLPIQAGIMPVTNKKQIERIV-ALSGANLPVKFKKIMEKYEHNKEALRDAGIAYAL 252
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFK 303
DQIVDL++ G+HLYTMNN AR + E+ HS+ K
Sbjct: 253 DQIVDLISTGARGIHLYTMNNPYIARSVTESIHSILK 289
>gi|116514292|ref|YP_813198.1| 5,10-methylenetetrahydrofolate reductase [Lactobacillus delbrueckii
subsp. bulgaricus ATCC BAA-365]
gi|116093607|gb|ABJ58760.1| 5,10-methylenetetrahydrofolate reductase [Lactobacillus delbrueckii
subsp. bulgaricus ATCC BAA-365]
Length = 221
Score = 216 bits (549), Expect = 2e-54, Method: Composition-based stats.
Identities = 102/207 (49%), Positives = 144/207 (69%), Gaps = 1/207 (0%)
Query: 96 IYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKAEAPNFDII 155
+Y ++E+V + L L V IL LRGD IPG +P+ DF +A DL+ F+ P+F I
Sbjct: 1 MYQTREQVLNLLDNLSEFNVKNILGLRGDKIPGKQPVGDFNHANDLVAFVHQNRPDFSIA 60
Query: 156 GACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIY 215
ACYP HP++ + DI +L+ KVDAG L++QLFFDN+ FYDFQ+K +AGI VPI
Sbjct: 61 SACYPNCHPEATGFVDDIAHLRTKVDAGADYLISQLFFDNQAFYDFQEKAEIAGIHVPIE 120
Query: 216 AGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAVDQIVDLVTQ 275
AGIMP N+ Q R+ + + LP+KF AIL++Y++ E++R AG+A+AVDQI+DLV++
Sbjct: 121 AGIMPCTNKKQIERITQI-TGVPLPKKFSAILNRYQNSKEAMREAGIAFAVDQIIDLVSE 179
Query: 276 DVAGVHLYTMNNAETARHIYEATHSLF 302
V G+HLYTMN+A+ A I+ AT S+F
Sbjct: 180 GVDGIHLYTMNHADIAERIWNATKSVF 206
>gi|154499971|ref|ZP_02038009.1| hypothetical protein BACCAP_03628 [Bacteroides capillosus ATCC
29799]
gi|150271569|gb|EDM98826.1| hypothetical protein BACCAP_03628 [Bacteroides capillosus ATCC
29799]
Length = 286
Score = 215 bits (548), Expect = 3e-54, Method: Composition-based stats.
Identities = 115/288 (39%), Positives = 167/288 (57%), Gaps = 3/288 (1%)
Query: 16 KKVKLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTV 75
K + +++ +LSFEVFPP + E + A ++ P F+SVT + TV
Sbjct: 2 KIIDILSQDKVTLSFEVFPPKTSDSYESVAKATQEIAALKPDFMSVTYGAGG-GTSDYTV 60
Query: 76 PLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDF 135
+A I++ + +AHL ++E V L +L G++ +LALRGDI G P D+
Sbjct: 61 GIAAGIRDKYGVEPLAHLTCASSTREHVHQVLGKLKESGISNVLALRGDIPEGGAPAHDY 120
Query: 136 RYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDN 195
+A +L+ IKA +F + GACYPEGHP+SP + SDI LK KV+AGC L TQ+FFDN
Sbjct: 121 HHAAELVREIKASG-DFCVGGACYPEGHPESPTKASDIDYLKAKVEAGCEFLTTQMFFDN 179
Query: 196 ERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPE 255
Y+F + GI VP+ AGIMP+ N Q R+ K +LP KF+AI+DK+ +P
Sbjct: 180 NILYNFLYRIREKGITVPVVAGIMPVTNGKQMARICKL-SGTYLPEKFKAIVDKFGENPA 238
Query: 256 SLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFK 303
++R AG+AYA QI+DL+ V +H+Y+MN E A I + + K
Sbjct: 239 AMRQAGVAYAAGQIIDLIANGVNHIHIYSMNKPEIAAGIQASLSEVLK 286
>gi|148322742|gb|EDK87992.1| 5,10-methylenetetrahydrofolate reductase (NAD(P)H) [Fusobacterium
nucleatum subsp. polymorphum ATCC 10953]
Length = 288
Score = 215 bits (548), Expect = 3e-54, Method: Composition-based stats.
Identities = 123/285 (43%), Positives = 176/285 (61%), Gaps = 5/285 (1%)
Query: 16 KKVKLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTV 75
K + S++ + SFEVFPPN VG E++ LD + P +ISVT N K TV
Sbjct: 2 KIADIYKSKSLTTSFEVFPPNDKVGLEQVYNCLDVLSLEKPDYISVTYGAGG-NTKGRTV 60
Query: 76 PLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVE-PLKD 134
+A+ I++ + ++AHL I KE++ L +L+ + ILALRGD E + D
Sbjct: 61 EIANRIKSQNGVESVAHLTCIGAKKEEIDRVLEDLEKNNIENILALRGDYPVDRELEIGD 120
Query: 135 FRYATDLIEFI-KAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFF 193
F YA DLI +I + + F I A Y EGH ++ N + D+ +LK+KV+AG L++Q+F
Sbjct: 121 FNYAKDLINYIHEKKGDKFSIGAAYYVEGHRET-NDLLDLFHLKEKVNAGVDFLISQIFL 179
Query: 194 DNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHD 253
DNE FY F+DK I+VP+ AGIMP+ N Q ++ C + +P+KF IL+KYE +
Sbjct: 180 DNEFFYSFRDKLEKLQINVPLVAGIMPVTNAKQIKKITSLC-SCTIPKKFLKILEKYEDN 238
Query: 254 PESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEAT 298
P +LR AGLAYA++Q+VDLV D+ G+HLYTMN ETA+ I +AT
Sbjct: 239 PSALREAGLAYAIEQVVDLVASDINGIHLYTMNRPETAKKIIDAT 283
>gi|153853053|ref|ZP_01994462.1| hypothetical protein DORLON_00447 [Dorea longicatena DSM 13814]
gi|149753839|gb|EDM63770.1| hypothetical protein DORLON_00447 [Dorea longicatena DSM 13814]
Length = 289
Score = 207 bits (528), Expect = 6e-52, Method: Composition-based stats.
Identities = 114/277 (41%), Positives = 171/277 (61%), Gaps = 5/277 (1%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLAD 79
++ +TP LSFEVFPP E +L A + + P ++SVT + TV +A
Sbjct: 6 ILVEKTPHLSFEVFPPKTDAAYEGVLKATEAIAELKPSYMSVTYGAGG-GTSKNTVKIAS 64
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVE-PLKD-FRY 137
HI++ +P++AHL + +KE+V + +L A G+ ILALRGDI E PL + ++Y
Sbjct: 65 HIKDKYNVPSLAHLTCVSSTKEEVHQVIDQLKAAGIENILALRGDIPQESEFPLPNHYQY 124
Query: 138 ATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNER 197
A +LIE IK++ +F I ACYPEGH +S ++ DI +LK+KVD G L TQ+FFDN
Sbjct: 125 AYELIEDIKSQG-DFCIGAACYPEGHVESEHKKDDIAHLKQKVDCGVDFLTTQMFFDNNI 183
Query: 198 FYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESL 257
Y+F + G+ VP+ GIMP+ N NQ R+L + +LP +F+AI+D++ +P+++
Sbjct: 184 LYNFLYRAREKGVTVPVIPGIMPVTNANQVKRIL-SMSGTNLPERFKAIVDRFGDNPKAM 242
Query: 258 RAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHI 294
+ AG+AYA DQI+DL + VH+Y+MN E A I
Sbjct: 243 QQAGIAYATDQIIDLFANGINHVHVYSMNKPEVAAAI 279
>gi|121535729|ref|ZP_01667532.1| 5,10-methylenetetrahydrofolate reductase [Thermosinus
carboxydivorans Nor1]
gi|121305694|gb|EAX46633.1| 5,10-methylenetetrahydrofolate reductase [Thermosinus
carboxydivorans Nor1]
Length = 285
Score = 203 bits (517), Expect = 1e-50, Method: Composition-based stats.
Identities = 114/281 (40%), Positives = 158/281 (56%), Gaps = 4/281 (1%)
Query: 19 KLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLA 78
+L + P +SFE+FPP P E I +++++ P FISVT + + T+ +A
Sbjct: 5 QLFAQKRPVVSFEIFPPKPDSPLESIFDCIEELQALKPDFISVTYGAAG-STRGRTLEVA 63
Query: 79 DHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRY- 137
HIQ+D IP + HL + + E + L E A G+ ILALRGD P P Y
Sbjct: 64 RHIQHDHGIPALGHLTCVGATAETIQAILHEFAAHGIENILALRGDP-PKNAPFPPTPYR 122
Query: 138 ATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNER 197
A DLI I+ + + + A YPEGH +SP++ D++ LK+KVD G L+TQ+FFDN
Sbjct: 123 AKDLIRLIRQQRRSCSVAAAAYPEGHLESPSREDDLRFLKEKVDTGVDFLITQIFFDNAI 182
Query: 198 FYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESL 257
Y F + GIDVP+ AGIMP+ +R Q R+ C LP R +++KY HD E++
Sbjct: 183 LYRFLEDARALGIDVPVMAGIMPVFSRPQVERICSLC-GATLPPALRKLMEKYGHDKEAM 241
Query: 258 RAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEAT 298
AGL YA QI DL+ D+ GVHLYTMN AR + T
Sbjct: 242 EQAGLEYASRQIADLLAHDIDGVHLYTMNRPHLARTLVRNT 282
>gi|106887797|ref|ZP_01355076.1| 5,10-methylenetetrahydrofolate reductase [Clostridium
phytofermentans ISDg]
gi|106764691|gb|EAT21491.1| 5,10-methylenetetrahydrofolate reductase [Clostridium
phytofermentans ISDg]
Length = 286
Score = 203 bits (516), Expect = 1e-50, Method: Composition-based stats.
Identities = 121/275 (44%), Positives = 166/275 (60%), Gaps = 2/275 (0%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
S EVFPP E I L ++ P FISVT TT +A +IQ++ I
Sbjct: 14 FSLEVFPPKKDSPVESIYRVLGELTKLNPDFISVTYGAGGNAADHTTCDIASYIQSNYGI 73
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
+ HL + +KE + TL L + G+ ILALRGD P +EP KDF YA++L+E+IK
Sbjct: 74 DALTHLTCVNSTKEDMDTTLEYLKSQGIMNILALRGDRNPEIEPKKDFTYASNLVEYIKT 133
Query: 148 EAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTL 207
+ +F + GACYPE H ++ + +++ LK KVD G L++QLFFDN+ F++F +K
Sbjct: 134 KG-DFHLSGACYPEIHIEASSMEENLEYLKYKVDCGADHLISQLFFDNDYFFNFLEKARN 192
Query: 208 AGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAVD 267
GI VPI AGIMP++N+ Q R++ C +P K IL +YEH E+LR AG+AYAV+
Sbjct: 193 KGITVPIEAGIMPVVNKKQIERMVTMC-GASIPSKLAKILQRYEHQEEALRDAGIAYAVE 251
Query: 268 QIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLF 302
QI+ LV V G+HLYTMNNA A I+EA L
Sbjct: 252 QIMHLVASGVDGIHLYTMNNAYIATKIHEAIFRLL 286
>gi|154502468|ref|ZP_02039528.1| hypothetical protein RUMGNA_00281 [Ruminococcus gnavus ATCC 29149]
gi|153796864|gb|EDN79284.1| hypothetical protein RUMGNA_00281 [Ruminococcus gnavus ATCC 29149]
Length = 289
Score = 198 bits (503), Expect = 4e-49, Method: Composition-based stats.
Identities = 112/271 (41%), Positives = 163/271 (60%), Gaps = 9/271 (3%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
+SFE+FPP G +K++ A ++M G P FISVT + T +A +I++DL +
Sbjct: 14 ISFEIFPPKTDAGYDKVIRAAEEMAGLKPEFISVTYGAGG-GTSKNTAKIASYIKHDLHV 72
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPG-VEPLKD-FRYATDLIEFI 145
++AHL +K++V + L G+ ILALRGDI V P +D F YA L+E I
Sbjct: 73 ESLAHLTCASSTKDEVRSVIASLKEQGIENILALRGDISEDMVFPSEDRFHYAYQLVEEI 132
Query: 146 KAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKC 205
+ +F I ACYPEGH ++ ++ DI+ LK+KVD+G L TQ+FFDN+ Y+F +
Sbjct: 133 RRHG-DFCIGAACYPEGHVENEHKEDDIKYLKQKVDSGVDFLTTQMFFDNDIHYNFLYRI 191
Query: 206 TLAGIDVPIYAGIMPILNRNQALRLLKTCE--NIHLPRKFRAILDKYEHDPESLRAAGLA 263
AGI VP+ GIMPI + Q R +CE PR+F+AILD++ P+++ AG+A
Sbjct: 192 REAGITVPVLPGIMPITSARQMKR---SCELSGTVFPRRFQAILDRFGDSPKAMEQAGIA 248
Query: 264 YAVDQIVDLVTQDVAGVHLYTMNNAETARHI 294
YA DQI+DL+ V +H+Y+MN E A I
Sbjct: 249 YATDQIIDLLANGVKNIHIYSMNRPEVAAAI 279
>gi|153814714|ref|ZP_01967382.1| hypothetical protein RUMTOR_00929 [Ruminococcus torques ATCC 27756]
gi|145847745|gb|EDK24663.1| hypothetical protein RUMTOR_00929 [Ruminococcus torques ATCC 27756]
Length = 289
Score = 197 bits (502), Expect = 5e-49, Method: Composition-based stats.
Identities = 113/279 (40%), Positives = 162/279 (58%), Gaps = 7/279 (2%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
+SFEVFPP G EK++ A D M P FISVT + T +A HI++DL +
Sbjct: 14 ISFEVFPPKTDAGFEKVIAATDAMAKLNPAFISVTYGAGG-GTSKNTAKIASHIKDDLGV 72
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKD---FRYATDLIEF 144
++AHL + E+V D + L G+ ILALRGDI G+ P + FRYA +LIE
Sbjct: 73 VSLAHLTCASSTIEEVRDVIENLKENGIENILALRGDIPEGM-PFPNGNRFRYAYELIEE 131
Query: 145 IKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDK 204
I+ +F I ACYPEGH ++ ++ DI+ LK+KVD+G L TQ+FFDN+ Y+F +
Sbjct: 132 IRKHG-DFCIGAACYPEGHVENEHKAEDIRYLKQKVDSGVDFLTTQMFFDNDIHYNFLYR 190
Query: 205 CTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAY 264
AGI+VP+ GIMP+ + Q R + + PR+F A+LD++ ++ AG+AY
Sbjct: 191 IREAGINVPVLPGIMPMTSEKQMKRSQELSGTV-FPRRFLALLDRFGSSAAAMEQAGIAY 249
Query: 265 AVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFK 303
A DQI+DL++ V +H+YTMN A I + K
Sbjct: 250 ATDQIIDLLSNGVNNIHIYTMNKPHVAAAIMNNLSEIIK 288
>gi|51245464|ref|YP_065348.1| similar to 5,10-methylenetetrahydrofolate reductase [Desulfotalea
psychrophila LSv54]
gi|50876501|emb|CAG36341.1| related to 5,10-methylenetetrahydrofolate reductase [Desulfotalea
psychrophila LSv54]
Length = 296
Score = 195 bits (496), Expect = 2e-48, Method: Composition-based stats.
Identities = 100/282 (35%), Positives = 163/282 (57%), Gaps = 6/282 (2%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLAD 79
L+ +P+ SFE FPP G E++L L + AP +IS+T + +E T L
Sbjct: 6 LLEHYSPTFSFEFFPPKNKEGEERLLQTLKQLIPLAPSYISITYGAGG-STREKTHDLVL 64
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGD----IIPGVEPLKDF 135
I+ + + ++HL + S+ ++ L+ D G++ ILAL+GD E + DF
Sbjct: 65 RIRRETNLTVVSHLTCVGSSRAEILRILKRYDEAGIHNILALKGDPPAPTDDAAETVDDF 124
Query: 136 RYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDN 195
YA DL+ FIK P+ + A +PEGHP++PN++ +I++L++KV+ G +VTQLF+DN
Sbjct: 125 LYAADLVGFIKRHFPHMCVGVAGFPEGHPETPNRLQEIEHLRQKVEQGADYIVTQLFYDN 184
Query: 196 ERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPE 255
FYDF ++C AGI VPI AGIMP+ ++ +R + +P K I+ + E+D
Sbjct: 185 HDFYDFSERCLQAGITVPIVAGIMPVASKKGLIRTAELAAGARIPAKLLKIVQRAEND-T 243
Query: 256 SLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEA 297
+R G+ +A +Q+ DL+ Q V G+ +T+N + R IY++
Sbjct: 244 MVRKVGIHWATEQVRDLIDQHVRGIQFFTLNTSTATREIYDS 285
>gi|114565935|ref|YP_753089.1| 5,10-methylenetetrahydrofolate reductase [Syntrophomonas wolfei
subsp. wolfei str. Goettingen]
gi|114336870|gb|ABI67718.1| 5,10-methylenetetrahydrofolate reductase [Syntrophomonas wolfei
subsp. wolfei str. Goettingen]
Length = 295
Score = 195 bits (496), Expect = 3e-48, Method: Composition-based stats.
Identities = 115/290 (39%), Positives = 162/290 (55%), Gaps = 12/290 (4%)
Query: 18 VKLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPL 77
++L + P LS E+FPP A E + + ++K P +ISVT N +E TV +
Sbjct: 4 IELYRQKAPLLSLEIFPPRMAYPLESVFDTVQELKRLNPAYISVTYGAGGSN-RERTVEI 62
Query: 78 ADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFR- 136
A ++ + I AHL I +E + + L L+ G+ I+ALRGDI P EP DFR
Sbjct: 63 AARVKKEYGIEAQAHLTCIGHRQEDIKNILARLNREGICNIMALRGDI-PEDEPEFDFRR 121
Query: 137 ----YATDLIEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQL 191
YA +LI I+A +F I A +PEGHP+ P DI +LK KVD G L+TQL
Sbjct: 122 QEYHYAFELIRDIRAAYGDSFGIAAAAHPEGHPECPRLKDDIFHLKNKVDNGVDFLITQL 181
Query: 192 FFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYE 251
FFDN F+DF ++C GI+ P+ GIMP+LN Q R++ C +P ++DKYE
Sbjct: 182 FFDNRIFFDFWERCQAMGINCPVIPGIMPVLNAGQIKRMIYLC-GASMPAGLLKLVDKYE 240
Query: 252 HDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
+P + AG+ YA QI +L+ VAGVHLY+MN R I E +++
Sbjct: 241 KEPVDMEKAGIDYASQQIKELLENAVAGVHLYSMNK---PRQISEIVYNI 287
>gi|115379397|ref|ZP_01466500.1| 5,10-methylenetetrahydrofolate reductase [Stigmatella aurantiaca
DW4/3-1]
gi|115363584|gb|EAU62716.1| 5,10-methylenetetrahydrofolate reductase [Stigmatella aurantiaca
DW4/3-1]
Length = 327
Score = 195 bits (496), Expect = 3e-48, Method: Composition-based stats.
Identities = 102/284 (35%), Positives = 164/284 (57%), Gaps = 6/284 (2%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADH 80
+ P SFE FPP G E +L ++++ P F+SVT + +E T+ L
Sbjct: 44 LNPSNPCFSFEFFPPKTDEGTENLLKTVEELAPLEPGFVSVTYGAGG-STREKTLGLVTR 102
Query: 81 IQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK----DFR 136
I+ I ++AHL + +++++ + L++L+A ++ +L LRGD G FR
Sbjct: 103 IKQTTGIESMAHLTCVGHTRDELREVLQQLEAAKLDNVLVLRGDPPRGQTTFAPTPGGFR 162
Query: 137 YATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNE 196
YA++L+EFI+ E NF + GACYPEGH ++ ++ D+Q+LK KVDAG ++TQLFFDN
Sbjct: 163 YASELVEFIREEDFNFCVGGACYPEGHVETESRDEDLQHLKAKVDAGLDFIITQLFFDNA 222
Query: 197 RFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPES 256
++DF ++ GI+VPI GIMPI N Q R + C +P + LD+ + P++
Sbjct: 223 FYFDFVERARRVGINVPIVPGIMPITNVEQVQRFTRLC-GATVPMRLGLQLDRVKDQPDA 281
Query: 257 LRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHS 300
+ G+A+A Q ++L+++ V G+H YT+N + R I A S
Sbjct: 282 VVQLGVAHATVQCMELLSRGVPGIHFYTLNKSPATRMILGALRS 325
>gi|108760527|ref|YP_631248.1| 5,10-methylenetetrahydrofolate reductase [Myxococcus xanthus DK
1622]
gi|108464407|gb|ABF89592.1| 5,10-methylenetetrahydrofolate reductase [Myxococcus xanthus DK
1622]
Length = 290
Score = 192 bits (488), Expect = 2e-47, Method: Composition-based stats.
Identities = 107/276 (38%), Positives = 158/276 (57%), Gaps = 6/276 (2%)
Query: 26 PSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDL 85
P SFE FPP G +L AL+D+ P F+SVT + + TV L I+ +
Sbjct: 12 PCFSFEFFPPRTDEGEANLLKALEDLATLQPGFVSVTEGAGG-STRAKTVELVLRIKQEA 70
Query: 86 AIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPG---VEPLKD-FRYATDL 141
I +AHL S ++ L L A V+ +L LRGD G EP FRYA+++
Sbjct: 71 GIEAMAHLTCGGHSPAELRTVLERLSAAKVDNVLVLRGDPPKGQTVFEPAPGGFRYASEM 130
Query: 142 IEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDF 201
+ FI+ E NF + GACYPEGH ++P++ D+++LK KVDAG +VTQLFFDN ++DF
Sbjct: 131 VRFIREEDFNFCLGGACYPEGHVETPSRDDDLRHLKAKVDAGLDFVVTQLFFDNAFYFDF 190
Query: 202 QDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAG 261
++ AGI+VPI GIMPI N Q R + C +P + L++ + +PE++ G
Sbjct: 191 VERARRAGINVPIVPGIMPITNYEQIQRFTRLC-GATVPMRLALQLERVKDNPEAMAQLG 249
Query: 262 LAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEA 297
+A+A Q ++L+++ V G+H YT+N + R I A
Sbjct: 250 VAHATVQCMELLSRGVPGIHFYTLNKSPATRMIVSA 285
>gi|95929439|ref|ZP_01312182.1| 5,10-methylenetetrahydrofolate reductase [Desulfuromonas
acetoxidans DSM 684]
gi|95134555|gb|EAT16211.1| 5,10-methylenetetrahydrofolate reductase [Desulfuromonas
acetoxidans DSM 684]
Length = 289
Score = 192 bits (487), Expect = 3e-47, Method: Composition-based stats.
Identities = 106/277 (38%), Positives = 155/277 (55%), Gaps = 14/277 (5%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
SLSFE FPP VG E++ + ++ AP +SVT + + T L I N+
Sbjct: 13 SLSFEFFPPKTVVGGERLFDNIAELAPLAPSSVSVTYGAGG-STRSQTHDLVLRIHNETG 71
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVE------PLKDFRYATD 140
+ + H + +++ VA L E + G+ +LALRGD P ++ P+ F +A D
Sbjct: 72 VTVVPHQTCVAATRDDVAMILAEYEQNGIENVLALRGD--PPLDDPDWTPPVNGFAHAID 129
Query: 141 LIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
L++FI+ P F I A +PEGHP+ PN++ +I LK+KVDAG +VTQLFFDN FYD
Sbjct: 130 LVKFIRERFPGFSIGVAGFPEGHPEMPNRLLEIDYLKQKVDAGADYIVTQLFFDNRDFYD 189
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKF--RAILDKYEHDPESLR 258
F D+C LAGI+VPI AGIMP+ R +R+ + P R E D E +
Sbjct: 190 FCDRCCLAGIEVPIIAGIMPLRTRKGMMRMAELAAGARFPAPLLRRVTEADSEEDVEQI- 248
Query: 259 AAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
G+ +A++Q+ DLV V+G+H YT+N+A I+
Sbjct: 249 --GIDWAIEQVKDLVAHQVSGIHFYTLNSATATCEIF 283
>gi|68552087|ref|ZP_00591479.1| 5,10-methylenetetrahydrofolate reductase [Prosthecochloris
aestuarii DSM 271]
gi|68240902|gb|EAN23171.1| 5,10-methylenetetrahydrofolate reductase [Prosthecochloris
aestuarii DSM 271]
Length = 296
Score = 189 bits (481), Expect = 2e-46, Method: Composition-based stats.
Identities = 99/281 (35%), Positives = 161/281 (57%), Gaps = 8/281 (2%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLAD 79
L ++ P SFE FPP +++ + ++ P ++SVT + + T L
Sbjct: 7 LSSTDNPIFSFEFFPPKKNDDWDRLFRTISELIPFNPSYVSVTYGAGG-STRTRTHDLVT 65
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGV----EPLKDF 135
I+ + + ++HL I +K++++D L + G+ +LALRGD+ PG E KDF
Sbjct: 66 KIRKETGLTVVSHLTCICSTKDEISDILSTYENNGITNVLALRGDLPPGTTSYSEATKDF 125
Query: 136 RYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDN 195
+A DL+ FIK P+F I A +PEGHP +PN++ +I LK+KVDAG +VTQLFFDN
Sbjct: 126 PHAIDLVRFIKTNFPSFGIGVAGFPEGHPQTPNRLDEITYLKEKVDAGADYIVTQLFFDN 185
Query: 196 ERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRK-FRAILDKYEHDP 254
++DF D+C L GI VPI GIMP+ + +R+ + +P + + +++ D
Sbjct: 186 RDYFDFVDRCALEGITVPIIPGIMPVTTKKGLIRMSELALGARIPAELLKEVIEA--PDD 243
Query: 255 ESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
+S+ AG+ +A Q+ +L+ + G+H YT+N+AE R I+
Sbjct: 244 QSVAEAGIRWATKQVRELIDHHIKGIHFYTLNHAEATRMIF 284
>gi|139438198|ref|ZP_01771751.1| Hypothetical protein COLAER_00740 [Collinsella aerofaciens ATCC
25986]
gi|133776395|gb|EBA40215.1| Hypothetical protein COLAER_00740 [Collinsella aerofaciens ATCC
25986]
Length = 290
Score = 186 bits (473), Expect = 1e-45, Method: Composition-based stats.
Identities = 113/277 (40%), Positives = 151/277 (54%), Gaps = 9/277 (3%)
Query: 25 TPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQND 84
T +SFE+FPP + + ++ +P F+SVT S T P+A I ++
Sbjct: 15 TAPISFEMFPPKGELTLDTAREVAGNLCKLSPSFVSVTCSAGGSGNGAATAPIAHMITSE 74
Query: 85 LAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGV----EPLKDFRYATD 140
P++AHL + S +A + E GV ILALRGD+ G +P D+ YA D
Sbjct: 75 FDTPSVAHLTCVGRSHADIAAKIDEYRTAGVENILALRGDLPAGATEDDKPASDYAYARD 134
Query: 141 LI-EFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFY 199
LI E + A F + A YPEGH + +++LK+K DAG S VTQLFFDNE FY
Sbjct: 135 LIPELVDA---GFCVGAAAYPEGHIACEDLNLSVEHLKQKQDAGASFFVTQLFFDNECFY 191
Query: 200 DFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRA 259
F++ AGI VPI AGIMP + ++Q R++ C LP IL KYE+DPESL+A
Sbjct: 192 RFRELADKAGITVPITAGIMPFMGKSQISRMVFMC-GASLPSPVIKILAKYENDPESLQA 250
Query: 260 AGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
AG+ YA Q+ DL G+HLYTMN A I E
Sbjct: 251 AGVDYAARQLCDLKEHGADGLHLYTMNRPAIAATIME 287
>gi|150391113|ref|YP_001321162.1| Methylenetetrahydrofolate reductase (NAD(P)H) [Alkaliphilus
metalliredigens QYMF]
gi|149950975|gb|ABR49503.1| Methylenetetrahydrofolate reductase (NAD(P)H) [Alkaliphilus
metalliredigens QYMF]
Length = 294
Score = 185 bits (470), Expect = 3e-45, Method: Composition-based stats.
Identities = 108/281 (38%), Positives = 155/281 (55%), Gaps = 5/281 (1%)
Query: 16 KKVKLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTV 75
K KL + P +SFE+FPP + I ALD + P FISVT T+
Sbjct: 2 KITKLFNDKRPVISFEIFPPKKELPISSIYGALDGLADLNPDFISVTYGAGGTG-SNKTI 60
Query: 76 PLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGV--EPLK 133
+A I+N I +AHL I +KE + ++ L + +LALRGD+
Sbjct: 61 EIASIIKNKYEIEALAHLTCITSNKEVIQQNIKALQENNLENVLALRGDVPSDFIRREEN 120
Query: 134 DFRYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFF 193
++Y DLI+ +K +FDI A YPEGH + + D+Q LK+K AG + LV+QLFF
Sbjct: 121 QYQYGVDLIKELKGYG-DFDIGAAVYPEGHIECDDVEKDLQYLKEKEAAGANFLVSQLFF 179
Query: 194 DNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHD 253
DNE FY F +K I+ + AG+MPIL++ Q +++ C LP K ++ KYEH
Sbjct: 180 DNEIFYGFLEKLKAYKIESKVLAGVMPILSKKQVEKMIFMC-GASLPAKVIRLVSKYEHQ 238
Query: 254 PESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHI 294
PE LR AG+ YA +Q+ DL+ +V G+H+YTMN + A+ I
Sbjct: 239 PELLRQAGIEYAAEQVADLIANEVDGIHIYTMNQPDIAKGI 279
>gi|68549543|ref|ZP_00589006.1| 5,10-methylenetetrahydrofolate reductase [Pelodictyon
phaeoclathratiforme BU-1]
gi|68243631|gb|EAN25829.1| 5,10-methylenetetrahydrofolate reductase [Pelodictyon
phaeoclathratiforme BU-1]
Length = 289
Score = 183 bits (464), Expect = 1e-44, Method: Composition-based stats.
Identities = 100/284 (35%), Positives = 153/284 (53%), Gaps = 6/284 (2%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLAD 79
L ++ P SFE FPP E + + + ++SVT + + T L
Sbjct: 7 LNSAAKPVFSFEFFPPKKDEEWETLFETIAALSPLHASYVSVTYGAGG-STRSRTHNLVT 65
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGV----EPLKDF 135
IQ + + ++HL I +E+ LR G+N +LALRGD G + +KDF
Sbjct: 66 KIQKETGLTVVSHLTCICSDQEETGAILRNYQEHGINNVLALRGDKPAGTTSMADAIKDF 125
Query: 136 RYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDN 195
YA DL+ FIK E P+F I A +PEGHP++PN++ +I+ LK+KVDAG +VTQLFFDN
Sbjct: 126 PYAIDLVRFIKKEYPDFGIGVAGFPEGHPETPNRMKEIEYLKEKVDAGADYIVTQLFFDN 185
Query: 196 ERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPE 255
++DF ++C L GI VPI GIMPI R +R+ + +P + +D E
Sbjct: 186 HDYFDFVERCALGGITVPIIPGIMPITTRKGMIRMSELALGARVPAALLKKVLTAANDDE 245
Query: 256 SLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATH 299
+ + G+ +A +Q+ +L+ + G+H YT+N A+ I+ H
Sbjct: 246 -VASVGIEWATNQVQELIDHHIKGIHFYTLNMADATLKIFNNIH 288
>gi|125972623|ref|YP_001036533.1| 5,10-methylenetetrahydrofolate reductase [Clostridium thermocellum
ATCC 27405]
gi|125712848|gb|ABN51340.1| 5,10-methylenetetrahydrofolate reductase [Clostridium thermocellum
ATCC 27405]
Length = 291
Score = 182 bits (463), Expect = 2e-44, Method: Composition-based stats.
Identities = 114/283 (40%), Positives = 153/283 (54%), Gaps = 9/283 (3%)
Query: 18 VKLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPL 77
V L + P +SFE+FPP E I L+ K P FISVT + K+ T+ +
Sbjct: 4 VDLFKKKKPVISFEIFPPKLDTPIESIFGTLEQFKELKPDFISVTYGAGG-SAKDRTIEI 62
Query: 78 ADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDF-- 135
A I+N+ I ++AHL + SKE++ L + + ILALRGD P +P DF
Sbjct: 63 ASKIKNEYGIESMAHLTCVGHSKEEIDALLTSMREHNLENILALRGDP-PANQPDFDFSN 121
Query: 136 ---RYATDLIEFIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQL 191
+YA +LI ++ + N F I A Y EGH +S D+ LK+KVD G LVTQL
Sbjct: 122 NAFKYANELIAHVRKQNRNDFCIAAAAYVEGHVNSKRLKDDLLYLKQKVDTGVDFLVTQL 181
Query: 192 FFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYE 251
FFDN FYDF DK GI PI GIMPI +Q R+ C +P K ++DKY
Sbjct: 182 FFDNRLFYDFLDKTASIGITCPITPGIMPIFKADQIKRITYLC-GASIPAKLVIMMDKYG 240
Query: 252 HDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHI 294
+ E +R AG+ YA +QI DL+ V G+HL TMN ++ R I
Sbjct: 241 DNDEDMRKAGIEYASNQIRDLIDNGVDGIHLLTMNRPKSTREI 283
>gi|156863259|gb|EDO56690.1| hypothetical protein CLOL250_02378 [Clostridium sp. L2-50]
Length = 289
Score = 182 bits (461), Expect = 3e-44, Method: Composition-based stats.
Identities = 111/277 (40%), Positives = 162/277 (58%), Gaps = 5/277 (1%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLAD 79
++ + +LSFEVFPP + A + P ++SVT + K T+ LA+
Sbjct: 6 IIGQEKATLSFEVFPPKKDTDFASVEAAALGIAALRPSYMSVTYGAGG-STKGHTIKLAN 64
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGV--EPLKDFRY 137
IQ +PTIAHL + +K+ + L E+ G+ ILALRGDI + DF +
Sbjct: 65 EIQEKYGVPTIAHLTCVCANKDSIRTALSEMKNAGIENILALRGDIPKNYDGQVFTDFAH 124
Query: 138 ATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNER 197
A++L++ IK E+ +F + GACYPE HPDS N+ DI NLKKKV+AGC L TQ+FFDN
Sbjct: 125 ASELVKLIK-ESGDFCVGGACYPEVHPDSANKQDDIANLKKKVEAGCEYLTTQMFFDNNI 183
Query: 198 FYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESL 257
F++F + AGI VP+ GIMPI R Q +K ++P +F+ I+D++ ++
Sbjct: 184 FFNFMYRIREAGITVPVIPGIMPITKRVQVKNAVKL-SGCNVPERFKNIVDRFGDTEAAM 242
Query: 258 RAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHI 294
+ AG+AYA DQI+DL+ V +H+Y+MN E A I
Sbjct: 243 KQAGIAYATDQIIDLLANGVKHIHVYSMNKPEVAAGI 279
>gi|145219514|ref|YP_001130223.1| 5,10-methylenetetrahydrofolate reductase [Prosthecochloris
vibrioformis DSM 265]
gi|145205678|gb|ABP36721.1| 5,10-methylenetetrahydrofolate reductase [Prosthecochloris
vibrioformis DSM 265]
Length = 289
Score = 181 bits (459), Expect = 5e-44, Method: Composition-based stats.
Identities = 98/285 (34%), Positives = 153/285 (53%), Gaps = 6/285 (2%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLAD 79
L T+ P SFE FPP E + + + P ++SVT + + T L
Sbjct: 7 LNTAHKPVFSFEFFPPKKDADWETLFETITALSPLNPSYVSVTYGAGG-STRTRTHDLVT 65
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPL----KDF 135
IQ + + ++HL I + + + L + G+N +LALRGD G E + KDF
Sbjct: 66 RIQKETGLSVVSHLTCIASTSGETGEILENYQSHGINNVLALRGDKPTGTESIADAVKDF 125
Query: 136 RYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDN 195
+A DL+ FIK P+ + A +PEGHP++PN++ +I+ LK KVDAG +VTQLFFDN
Sbjct: 126 PHAIDLVRFIKNNHPDIGVGVAGFPEGHPETPNRLQEIEYLKAKVDAGADYIVTQLFFDN 185
Query: 196 ERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPE 255
++DF D+C LAGI VPI GIMP+ + R+ + +P + E+D +
Sbjct: 186 RDYFDFVDRCRLAGISVPIIPGIMPVTSTKGMTRMSELALGARIPAPLLKKVLGAENDAQ 245
Query: 256 SLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHS 300
+ + G+ +A +Q+ +L+ + G+H YT+N A I++ HS
Sbjct: 246 -VASIGIEWATNQVQELIDNQIRGIHFYTLNMATATLEIFQNLHS 289
>gi|153005527|ref|YP_001379852.1| 5,10-methylenetetrahydrofolate reductase [Anaeromyxobacter sp.
Fw109-5]
gi|152029100|gb|ABS26868.1| 5,10-methylenetetrahydrofolate reductase [Anaeromyxobacter sp.
Fw109-5]
Length = 300
Score = 180 bits (456), Expect = 1e-43, Method: Composition-based stats.
Identities = 100/278 (35%), Positives = 154/278 (55%), Gaps = 8/278 (2%)
Query: 26 PSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDL 85
P SFE FPP G ++ ++ ++ AP ++SVT + ++ T+ L ++ D
Sbjct: 16 PVFSFEFFPPKTDDGVRQLFETVEALRPLAPAYVSVTYGAGG-STRQRTLELVKRLKRDT 74
Query: 86 AIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPL----KDFRYATDL 141
+ +AHL + S+E++A L EL G+ +LALRGD G + FRYA++L
Sbjct: 75 EVEAMAHLTCVGASREELAAVLDELAEAGIQNVLALRGDPPRGETSFSPHPEGFRYASEL 134
Query: 142 IEFIKA--EAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFY 199
+ FI++ E F + A YPEGH ++ + +D+ NLK KV+AG LVTQLFFDN +++
Sbjct: 135 VAFIRSRPERWRFCLGAAAYPEGHVETRDLAADLANLKLKVEAGADFLVTQLFFDNAQYF 194
Query: 200 DFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRA 259
F ++ AGI +PI GIMP N +Q R C +P + RA ++ DP+S R
Sbjct: 195 RFVERARAAGIALPIIPGIMPFTNVDQTERFTAMC-GAAIPPRLRAAMEVRREDPDSARD 253
Query: 260 AGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEA 297
G+AYA Q +L+ G+H YT+N + + R I A
Sbjct: 254 LGVAYATLQCAELLRGGAPGIHFYTLNRSTSTRAIVAA 291
>gi|53802580|ref|YP_112676.1| 5,10-methylenetetrahydrofolate reductase [Methylococcus capsulatus
str. Bath]
gi|53756341|gb|AAU90632.1| 5,10-methylenetetrahydrofolate reductase [Methylococcus capsulatus
str. Bath]
Length = 289
Score = 179 bits (453), Expect = 3e-43, Method: Composition-based stats.
Identities = 98/271 (36%), Positives = 143/271 (52%), Gaps = 3/271 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
SFE FPP E + L + P F SVT + +E T A IQ I
Sbjct: 15 FSFEFFPPKTEEATENLRRTLTKLAPLKPRFCSVTFGAGG-STREKTFETALEIQQTTGI 73
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
HL I ++ + + L + G+ I+ALRGD+ G+ +FR+A +L+EFI++
Sbjct: 74 ECAPHLSCIASTRRSIREILEAYRSHGIRHIVALRGDMPSGMLSAGEFRHANELVEFIRS 133
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E N F I ACYPE HP + + SD++N K+KVDAG S +TQ F++ E ++ F D C
Sbjct: 134 ETGNHFHIEVACYPEVHPQAASAESDLKNFKRKVDAGADSAITQYFYNPEAYFRFVDDCE 193
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
GID+PI GIMPI N +Q +R C +PR R L+ + D +++R GL
Sbjct: 194 RLGIDIPIVPGIMPITNHSQLVRFSDLC-GADIPRWIRKRLEAFGDDRKAIRTFGLEVVT 252
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEA 297
+ L+ Q G+H YT+N AE +++A
Sbjct: 253 ELCRRLLEQGAPGLHFYTLNRAEACLEVWKA 283
>gi|78189075|ref|YP_379413.1| 5,10-methylenetetrahydrofolate reductase [Chlorobium
chlorochromatii CaD3]
gi|78171274|gb|ABB28370.1| 5,10-methylenetetrahydrofolate reductase [Chlorobium
chlorochromatii CaD3]
Length = 289
Score = 178 bits (452), Expect = 3e-43, Method: Composition-based stats.
Identities = 98/280 (35%), Positives = 151/280 (53%), Gaps = 6/280 (2%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLAD 79
L + P SFE FPP + + + + P ++SVT + + T L
Sbjct: 7 LSAANNPVFSFEFFPPKKDEEWDTLFKTIAALSPLHPSYVSVTYGAGG-STRSRTHNLVT 65
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGV----EPLKDF 135
IQ + + ++HL I + LR G+N +LALRGD GV E +KDF
Sbjct: 66 RIQQETGLTVVSHLTCISSEESDTEAILRNYQENGINNVLALRGDKPTGVATLQEAIKDF 125
Query: 136 RYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDN 195
+A DL+ FIK P+F + A +PEGHP++PN++ +I+ LK KVDAG +VTQLFFDN
Sbjct: 126 PHAIDLVRFIKRNFPDFGVGVAGFPEGHPETPNRMQEIEYLKAKVDAGADYIVTQLFFDN 185
Query: 196 ERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPE 255
++DF ++C LAGI VP+ GIMPI + +R+ + +P + E+D +
Sbjct: 186 RDYFDFVERCQLAGITVPVIPGIMPIATKKGMIRMSELALGSRIPAPLIKQVLAAENDSD 245
Query: 256 SLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
+ A G+ +A Q+ +L+ Q + G+H YT+N A+ I+
Sbjct: 246 -VAAIGIEWATAQVQELINQHIRGIHFYTLNMADATLKIF 284
>gi|15606607|ref|NP_213987.1| 5,10-methylenetetrahydrofolate reductase [Aquifex aeolicus VF5]
gi|6016544|sp|O67422|METF_AQUAE 5,10-methylenetetrahydrofolate reductase
gi|2983832|gb|AAC07387.1| 5,10-methylenetetrahydrofolate reductase [Aquifex aeolicus VF5]
Length = 296
Score = 177 bits (449), Expect = 7e-43, Method: Composition-based stats.
Identities = 98/276 (35%), Positives = 155/276 (56%), Gaps = 7/276 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
S+SFE FPP G ++ + ++ P F+SVT + ++ T + I +
Sbjct: 13 SISFEFFPPKTEEGERQLFETIRKLEKLNPTFVSVTYGAGG-STRDRTRNIVQKIHEETN 71
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDI---IPGVEPLKDF-RYATDLI 142
+ +AHL I ++E++ D L++ +G+ ILALRGD+ P P K +YA +L+
Sbjct: 72 LTVMAHLTCIAHTREELIDILQDYKNIGIENILALRGDVPRDKPDWRPPKGACKYAKELV 131
Query: 143 EFIKAEAPNFDIIG-ACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDF 201
E I+ E ++ IG A YPEGHP+SPN +++ K+KV+AG +TQ+FF N+ +Y F
Sbjct: 132 ELIRKEFGDWFSIGVASYPEGHPESPNLEWEVKYFKEKVEAGADFSITQMFFVNDYYYRF 191
Query: 202 QDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAG 261
+ C AGID+ I GIMPI N Q + C +P+ L+K E PE ++ G
Sbjct: 192 VEMCKNAGIDISIIPGIMPITNFKQIRKFASLC-GATIPQSLIEKLEKVEDKPEEVKKIG 250
Query: 262 LAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEA 297
+ +A++Q +DL+ V G+H YT+N ++ IYEA
Sbjct: 251 IEFAINQCLDLIEHGVPGLHFYTLNKSDATLKIYEA 286
>gi|77919330|ref|YP_357145.1| 5,10-methylenetetrahydrofolate reductase [Pelobacter carbinolicus
DSM 2380]
gi|77545413|gb|ABA88975.1| 5,10-methylenetetrahydrofolate reductase [Pelobacter carbinolicus
DSM 2380]
Length = 301
Score = 176 bits (447), Expect = 1e-42, Method: Composition-based stats.
Identities = 99/283 (34%), Positives = 151/283 (53%), Gaps = 15/283 (5%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
+ SFE FPP E++ + ++ PHF SVT + +E T L I +
Sbjct: 13 TFSFEFFPPKTDKAAERLYETIRQLESLHPHFTSVTYGAGG-STRERTHDLVMRIHESSS 71
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKD-----FRYATDL 141
+ I HL + ++++ L+ G++ ILAL GD P + P D F +A DL
Sbjct: 72 LDPIPHLTCVSSPEQEIHQILKRYAEAGISNILALAGDPPPDM-PHYDRSQDAFPHAADL 130
Query: 142 IEFIKA--------EAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFF 193
+ FI+ + F I A +PEGHP +PN++ ++ LK KVD G + TQLFF
Sbjct: 131 VRFIRKFNDEGLHPDKRGFGIGVAGFPEGHPTTPNRLLEMDYLKAKVDEGADYICTQLFF 190
Query: 194 DNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHD 253
DN FYDF+++C LAGI +PI AGIMPI + R+ + P +D+ + D
Sbjct: 191 DNRDFYDFRERCELAGISIPIIAGIMPIASVEGMKRMAELAAGARFPAPLLRAVDRCQDD 250
Query: 254 PESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
PES+R G+ +A +Q DL+ +V G+H YT+NN++ R I++
Sbjct: 251 PESVRRIGIHWATEQCRDLLDNEVRGIHFYTLNNSDATRQIFQ 293
>gi|119357520|ref|YP_912164.1| 5,10-methylenetetrahydrofolate reductase [Chlorobium
phaeobacteroides DSM 266]
gi|119354869|gb|ABL65740.1| 5,10-methylenetetrahydrofolate reductase [Chlorobium
phaeobacteroides DSM 266]
Length = 289
Score = 176 bits (445), Expect = 2e-42, Method: Composition-based stats.
Identities = 95/280 (33%), Positives = 149/280 (53%), Gaps = 6/280 (2%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLAD 79
L ++ P SFE FPP + + + P ++SVT + + T L
Sbjct: 7 LNSTSEPVFSFEFFPPKKEEEWNTLFATIASLTSLNPSYVSVTYGAGG-STRSKTHDLVT 65
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGV----EPLKDF 135
IQ + I ++HL + +E+ + L G+N +LALRGD GV E +KDF
Sbjct: 66 RIQKETGITVVSHLTCVCSDREETSSILENYLENGINNVLALRGDKPQGVATLAEAIKDF 125
Query: 136 RYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDN 195
+A DLI FIK P I A +PEGHP++PN++ +I LK+K+DAG +VTQLFFDN
Sbjct: 126 EHAADLIRFIKIRFPAIGIGVAGFPEGHPETPNRLKEIDYLKEKIDAGADYIVTQLFFDN 185
Query: 196 ERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPE 255
++D+ ++C +AGI VPI AGIMP+ + +R+ + +P + + + D
Sbjct: 186 RDYFDYVERCAIAGITVPIIAGIMPVSTKKGMIRMSELALGARIPAPLLKQVLESDSD-R 244
Query: 256 SLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
+ G+ +A Q+ +L+ Q G+H YT+N A+ I+
Sbjct: 245 DVAEIGIDWATRQVQELIDQQCKGIHFYTLNLADATLKIF 284
>gi|21674190|ref|NP_662255.1| 5,10-methylenetetrahydrofolate reductase [Chlorobium tepidum TLS]
gi|21647353|gb|AAM72597.1| 5,10-methylenetetrahydrofolate reductase [Chlorobium tepidum TLS]
Length = 290
Score = 176 bits (445), Expect = 2e-42, Method: Composition-based stats.
Identities = 97/275 (35%), Positives = 153/275 (55%), Gaps = 8/275 (2%)
Query: 26 PSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDL 85
P S E FPP +K+ + ++ P ++SVT + +E T L IQ +
Sbjct: 13 PVFSLEFFPPKKQDDWDKLFETISNLFPLDPSYVSVTYGAGG-STRERTHNLVTRIQQET 71
Query: 86 AIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGD----IIPGVEPLKDFRYATDL 141
+ ++HL I K ++ L+ G+ +LALRGD I E KDF +A DL
Sbjct: 72 GLTVVSHLTCIGAEKSEIESVLQNYREHGITNVLALRGDKPADITTLEEATKDFPHAIDL 131
Query: 142 IEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDF 201
++FIK P I A +PEGHP++PN++ +++ LK+KVDAG +VTQLFFDN ++D+
Sbjct: 132 VKFIKENFPEMGIGVAGFPEGHPETPNRMKELEFLKEKVDAGADYIVTQLFFDNHDYFDY 191
Query: 202 QDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRK-FRAILDKYEHDPESLRAA 260
++C LAGI VPI GIMPI+++ +R+ + +P K R +L+ D + +
Sbjct: 192 VERCELAGITVPIIPGIMPIMSKKGMIRMCELALGSRIPSKLLRKVLEA--ADDKEVAEI 249
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
G+ +A +Q+ +L+ V GVH YT+N +E I+
Sbjct: 250 GVEWATNQVQELLDHKVKGVHFYTLNLSEATLKIF 284
>gi|67919462|ref|ZP_00513039.1| 5,10-methylenetetrahydrofolate reductase [Chlorobium limicola DSM
245]
gi|67782934|gb|EAM42336.1| 5,10-methylenetetrahydrofolate reductase [Chlorobium limicola DSM
245]
Length = 290
Score = 174 bits (442), Expect = 5e-42, Method: Composition-based stats.
Identities = 98/282 (34%), Positives = 152/282 (53%), Gaps = 10/282 (3%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLAD 79
L ++ P SFE FPP E + + ++ P ++SVT + + T L
Sbjct: 7 LNSASEPVFSFEFFPPKKDEDWETLFETIANLNHLHPSYVSVTYGAGG-STRSRTHDLVT 65
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGV----EPLKDF 135
IQ + + ++HL I +E A L G+ +LALRGD G+ + +KDF
Sbjct: 66 KIQKETGLTVVSHLTCICSDREDTASILENYLEHGITNVLALRGDKPAGIATLNDAIKDF 125
Query: 136 RYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDN 195
+A DLI FIK P I A +PEGHP++PN++ +I+ LK+K+DAG +VTQLFFDN
Sbjct: 126 PHAIDLIRFIKTNYPAIGIGVAGFPEGHPETPNRLKEIEYLKEKIDAGADYIVTQLFFDN 185
Query: 196 ERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPE 255
++DF D+C +AGI VP+ AGIMP+ + +R+ + +P +L + H
Sbjct: 186 RDYFDFVDRCRIAGITVPVIAGIMPVSTKKGMIRMSELALGARIP---APLLKQVLHARN 242
Query: 256 SLRAA--GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
+ A G+ +A Q+ +L+ + V GVH YT+N A+ I+
Sbjct: 243 DVDVAKIGIDWATAQVQELIERQVKGVHFYTLNLADATLKIF 284
>gi|91774547|ref|YP_544303.1| 5,10-methylenetetrahydrofolate reductase [Methylobacillus
flagellatus KT]
gi|91708534|gb|ABE48462.1| 5,10-methylenetetrahydrofolate reductase [Methylobacillus
flagellatus KT]
Length = 280
Score = 172 bits (437), Expect = 2e-41, Method: Composition-based stats.
Identities = 100/272 (36%), Positives = 143/272 (52%), Gaps = 4/272 (1%)
Query: 26 PSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDL 85
P++SFE FPP A G K+ +A D + P F SVT + ++ T+ IQ
Sbjct: 5 PTISFEFFPPKTAEGMAKLRVARDQLAAFNPKFFSVTFGAGG-STRDRTLETVIDIQQ-A 62
Query: 86 AIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFI 145
HL I K ++ L + G+ R++ALRGDI G DFRYA++L+ FI
Sbjct: 63 GYEGAPHLSCISADKAEIRTLLTQYKTQGIKRLVALRGDIPSGEVSTGDFRYASELVAFI 122
Query: 146 KAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDK 204
+ E + F+I A YPE HP+S + +DI++ K+KVDAG +S +TQ F++ + ++ F D+
Sbjct: 123 REETGDWFEIEVAAYPEFHPESSSPSADIRHFKQKVDAGANSAITQYFYNADAYFRFVDQ 182
Query: 205 CTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAY 264
C + +D+PI G+MPI N Q R C +PR R L Y D SLRA G
Sbjct: 183 CEKSAVDIPIVPGVMPIYNFTQLARFSSVC-GAEIPRWLRLRLQDYGDDLASLRAFGTEV 241
Query: 265 AVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
D L+ G+H YT+N A T I E
Sbjct: 242 VEDLCEQLLAGGAPGLHFYTLNQAGTIASILE 273
>gi|149174500|ref|ZP_01853126.1| 5,10-methylenetetrahydrofolate reductase [Planctomyces maris DSM
8797]
gi|148846610|gb|EDL60947.1| 5,10-methylenetetrahydrofolate reductase [Planctomyces maris DSM
8797]
Length = 297
Score = 172 bits (436), Expect = 2e-41, Method: Composition-based stats.
Identities = 95/283 (33%), Positives = 148/283 (52%), Gaps = 6/283 (2%)
Query: 19 KLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLA 78
+L T LS E+FPP G+ ++ L+++ P F+S T K T + L
Sbjct: 5 ELYQGGTFGLSVEIFPPRNESGDAELFKTLEELVRYQPAFVSCTYGAGGSTSKRT-IELC 63
Query: 79 DHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPL----KD 134
IQN L AH + ++E++ + L+ G+ I+ALRGD G E
Sbjct: 64 ALIQNQLHNTATAHFTCVNSTREELVEWLQNAVDAGITNIMALRGDPPAGQETFVPADGG 123
Query: 135 FRYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFD 194
+YA +L+ I+ P+ I A YPE HP++ + D+ NLK+KVDAG ++ TQLFF+
Sbjct: 124 LKYANELVSLIRKHFPDMGIGVAGYPECHPEASDAEVDLTNLKRKVDAGADAIYTQLFFN 183
Query: 195 NERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDP 254
NE FY F+++C AGID PI GIMPI + R++ C + P L+ + D
Sbjct: 184 NEHFYQFRERCLKAGIDRPIVPGIMPITEYRRIQRIMSMCSS-EFPADLVGQLEAAQDDL 242
Query: 255 ESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEA 297
E+ G+ YA+ Q L+ + V G+H Y +N ++ + I++A
Sbjct: 243 EAQFEIGVEYAIRQCEQLIKEGVPGIHFYVLNRSQACKRIFDA 285
>gi|46199958|ref|YP_005625.1| methylenetetrahydrofolate reductase [Thermus thermophilus HB27]
gi|55980296|ref|YP_143593.1| 5,10-methylenetetrahydrofolate reductase [Thermus thermophilus HB8]
gi|42543913|pdb|1V93|A Chain A, 5,10-Methylenetetrahydrofolate Reductase From Thermus
Thermophilus Hb8
gi|46197585|gb|AAS81998.1| methylenetetrahydrofolate reductase [Thermus thermophilus HB27]
gi|55771709|dbj|BAD70150.1| 5,10-methylenetetrahydrofolate reductase [Thermus thermophilus HB8]
Length = 296
Score = 172 bits (435), Expect = 3e-41, Method: Composition-based stats.
Identities = 97/282 (34%), Positives = 153/282 (54%), Gaps = 8/282 (2%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLAD 79
L + P SFE FPP G E + L+++K P F+S+T + +E +V A
Sbjct: 7 LKARRGPLFSFEFFPPKDPEGEEALFRTLEELKAFRPAFVSITYGAMG-STRERSVAWAQ 65
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK----DF 135
IQ+ L + +AHL S+++VA+ L GV +LALRGD G + F
Sbjct: 66 RIQS-LGLNPLAHLTVAGQSRKEVAEVLHRFVESGVENLLALRGDPPRGERVFRPHPEGF 124
Query: 136 RYATDLIEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFD 194
RYA +L+ I+ + GA YPEGHP+S + +D+++ K KV+AG +TQLFF+
Sbjct: 125 RYAAELVALIRERYGDRVSVGGAAYPEGHPESESLEADLRHFKAKVEAGLDFAITQLFFN 184
Query: 195 NERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDP 254
N ++ F ++ AGI +PI GIMP+ + Q R + C +P A L++++ DP
Sbjct: 185 NAHYFGFLERARRAGIGIPILPGIMPVTSYRQLRRFTEVC-GASIPGPLLAKLERHQDDP 243
Query: 255 ESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
+++ G+ +AV Q+ +L+ V GVH YT+N + R + E
Sbjct: 244 KAVLEIGVEHAVRQVAELLEAGVEGVHFYTLNKSPATRMVLE 285
>gi|24217063|ref|NP_714546.1| 5,10-methylenetetrahydrofolate reductase [Leptospira interrogans
serovar Lai str. 56601]
gi|24202085|gb|AAN51561.1|AE011589_2 5,10-methylenetetrahydrofolate reductase [Leptospira interrogans
serovar Lai str. 56601]
Length = 310
Score = 170 bits (431), Expect = 8e-41, Method: Composition-based stats.
Identities = 96/279 (34%), Positives = 150/279 (53%), Gaps = 10/279 (3%)
Query: 22 TSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHI 81
+++ P SFE FPP G+ K++ + ++ P F++VT + ++ TV + I
Sbjct: 27 SAKGPVYSFEFFPPKTPEGDSKLMETVKELSLLNPDFVTVTYGAGG-STRDKTVQILSQI 85
Query: 82 QNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKD----FRY 137
D + PT++H + +K ++ +TL+ + + G+ ++ALRGD G K F
Sbjct: 86 SKDYSFPTVSHFTCVGANKNQILETLKGIRSSGILNLMALRGDPPKGEGEFKKVENGFGN 145
Query: 138 ATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNER 197
AT+L+ FI++E +F I G CYPE HP++ D++NLK KVDAG LV+QLFF N
Sbjct: 146 ATELVSFIRSEKLDFCIGGGCYPEKHPNAKTLEEDVENLKLKVDAGTDFLVSQLFFVNSI 205
Query: 198 FYDFQDKCTLAGIDVPIYAGIMPILNRNQA--LRLLKTCENIHLPRKFRAILDKYEHDPE 255
F +F + GI VP+ GIMPI + +Q R + CE P L + EH PE
Sbjct: 206 FENFLNLVRKVGIQVPVIPGIMPITSFSQIDRFRSMAGCE---FPSSLIQDLQEVEHRPE 262
Query: 256 SLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHI 294
L ++V Q +L+ V G+HLYT+N + + I
Sbjct: 263 EFYRRSLNFSVKQCRELLAMGVPGIHLYTLNQSHASYDI 301
>gi|45655587|ref|YP_003396.1| 5,10 methylene tetrahydrofolate reductase [Leptospira interrogans
serovar Copenhageni str. Fiocruz L1-130]
gi|45602558|gb|AAS72033.1| 5,10 methylene tetrahydrofolate reductase [Leptospira interrogans
serovar Copenhageni str. Fiocruz L1-130]
Length = 310
Score = 170 bits (431), Expect = 9e-41, Method: Composition-based stats.
Identities = 96/279 (34%), Positives = 150/279 (53%), Gaps = 10/279 (3%)
Query: 22 TSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHI 81
+++ P SFE FPP G+ K++ + ++ P F++VT + ++ TV + I
Sbjct: 27 SAKGPVYSFEFFPPKTPEGDSKLMETVKELSLLNPDFVTVTYGAGG-STRDKTVQILSQI 85
Query: 82 QNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKD----FRY 137
D + PT++H + +K ++ +TL+ + + G+ ++ALRGD G K F
Sbjct: 86 SKDYSFPTVSHFTCVGANKNQILETLKGIRSSGILNLMALRGDPPKGEGEFKKVENGFGN 145
Query: 138 ATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNER 197
AT+L+ FI++E +F I G CYPE HP++ D++NLK KVDAG LV+QLFF N
Sbjct: 146 ATELVSFIRSEKLDFCIGGGCYPEKHPNAKTLEEDVENLKLKVDAGTDFLVSQLFFVNSI 205
Query: 198 FYDFQDKCTLAGIDVPIYAGIMPILNRNQA--LRLLKTCENIHLPRKFRAILDKYEHDPE 255
F +F + GI VP+ GIMPI + +Q R + CE P L + EH PE
Sbjct: 206 FENFLNLVRKVGIQVPVIPGIMPITSFSQIDRFRSMAGCE---FPSSLIQDLQEVEHRPE 262
Query: 256 SLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHI 294
L ++V Q +L+ V G+HLYT+N + + I
Sbjct: 263 EFYRRSLNFSVKQCRELLAMGVPGIHLYTLNQSHASYDI 301
>gi|7582424|gb|AAF64321.1|AF253051_1 5,10 methylene tetrahydrofolate reductase [Leptospira interrogans]
Length = 293
Score = 170 bits (431), Expect = 9e-41, Method: Composition-based stats.
Identities = 96/279 (34%), Positives = 150/279 (53%), Gaps = 10/279 (3%)
Query: 22 TSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHI 81
+++ P SFE FPP G+ K++ + ++ P F++VT + ++ TV + I
Sbjct: 10 SAKGPVYSFEFFPPKTPEGDSKLMETVKELSLLNPDFVTVTYGAGG-STRDKTVQILSQI 68
Query: 82 QNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKD----FRY 137
D + PT++H + +K ++ +TL+ + + G+ ++ALRGD G K F
Sbjct: 69 SKDYSFPTVSHFTCVGANKNQILETLKGIRSSGILNLMALRGDPPKGEGEFKKVENGFGN 128
Query: 138 ATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNER 197
AT+L+ FI++E +F I G CYPE HP++ D++NLK KVDAG LV+QLFF N
Sbjct: 129 ATELVSFIRSEKLDFCIGGGCYPEKHPNAKTLEEDVENLKLKVDAGTDFLVSQLFFVNSI 188
Query: 198 FYDFQDKCTLAGIDVPIYAGIMPILNRNQA--LRLLKTCENIHLPRKFRAILDKYEHDPE 255
F +F + GI VP+ GIMPI + +Q R + CE P L + EH PE
Sbjct: 189 FENFLNLVRKVGIQVPVIPGIMPITSFSQIDRFRSMAGCE---FPSSLIQDLQEVEHRPE 245
Query: 256 SLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHI 294
L ++V Q +L+ V G+HLYT+N + + I
Sbjct: 246 EFYRRSLNFSVKQCRELLAMGVPGIHLYTLNQSHASYDI 284
>gi|119475425|ref|ZP_01615778.1| 5,10-methylenetetrahydrofolate reductase [marine gamma
proteobacterium HTCC2143]
gi|119451628|gb|EAW32861.1| 5,10-methylenetetrahydrofolate reductase [marine gamma
proteobacterium HTCC2143]
Length = 276
Score = 169 bits (429), Expect = 1e-40, Method: Composition-based stats.
Identities = 97/273 (35%), Positives = 147/273 (53%), Gaps = 11/273 (4%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVT---ASNNKYNIKETTVPLADHIQND 84
SFE FPP G EK+ L ++ P F SVT + + N K+T + + N
Sbjct: 7 FSFEFFPPKTDAGKEKLKLVSAELNALGPDFFSVTYGAGGSTRANTKDTVISM-----NA 61
Query: 85 LAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEF 144
I T+ HL ++ + D LRE A G++RI+ALRGD+ G+ + YA +L++F
Sbjct: 62 AGISTVPHLSFGNDDEQVILDLLREYKAAGISRIVALRGDVPSGMGAQR-LIYAEELVQF 120
Query: 145 IKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQD 203
I+ +F + A YPE HPD+ +DI+ LK+K DAG +S +TQ F++ E ++ F +
Sbjct: 121 IRDHTGDHFQLEVAAYPEVHPDAKGPENDIEFLKRKFDAGANSAITQYFYNVEAYFYFVE 180
Query: 204 KCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLA 263
+C GID PIY GIMPI N + R K+C +PR L+ + +D ES++ G+
Sbjct: 181 QCQKNGIDRPIYPGIMPITNYHNLARFSKSC-GAEIPRWICQRLESFGNDSESVQEFGIE 239
Query: 264 YAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ + G+H YTMN E R I++
Sbjct: 240 VVTQLCQRLLAEGAPGIHFYTMNQVEPNRQIWK 272
>gi|86159098|ref|YP_465883.1| 5,10-methylenetetrahydrofolate reductase [Anaeromyxobacter
dehalogenans 2CP-C]
gi|85775609|gb|ABC82446.1| 5,10-methylenetetrahydrofolate reductase [Anaeromyxobacter
dehalogenans 2CP-C]
Length = 300
Score = 169 bits (428), Expect = 2e-40, Method: Composition-based stats.
Identities = 95/278 (34%), Positives = 149/278 (53%), Gaps = 8/278 (2%)
Query: 26 PSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDL 85
P SFE FPP G + ++ ++ P ++SVT + + T+ L ++ D
Sbjct: 16 PIFSFEFFPPKTDDGVRGLFETVEALRPLGPAYVSVTYGAGG-STRAKTIDLVKRLKRDA 74
Query: 86 AIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVE---PLKD-FRYATDL 141
+ +AH+ + S+E++A L E+ G+ +LALRGD G P D F +A++L
Sbjct: 75 EVEAMAHVTCVGASREEIAAVLDEVADAGIQNVLALRGDAPRGQSAFVPHPDGFTHASEL 134
Query: 142 IEFIKA--EAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFY 199
+ FI++ E F + A YPEGH ++ + D++NLK KV+AG LVTQLFF+N ++
Sbjct: 135 VAFIRSRPERWRFCVGAAAYPEGHVETRDLAQDLRNLKLKVEAGTDFLVTQLFFENAHYF 194
Query: 200 DFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRA 259
F ++ AG++VP+ GIMP N Q R C +P RA ++ DP+ R
Sbjct: 195 RFVERARAAGVEVPVVPGIMPFTNVEQVERFTAMC-GAAIPPPLRAAMEVRRADPDGARE 253
Query: 260 AGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEA 297
G+AYA Q DL+ + G+H YT+N + + R I A
Sbjct: 254 LGVAYATLQCADLLRRGAPGIHFYTLNRSPSTRAIVAA 291
>gi|134300036|ref|YP_001113532.1| 5,10-methylenetetrahydrofolate reductase [Desulfotomaculum reducens
MI-1]
gi|134052736|gb|ABO50707.1| 5,10-methylenetetrahydrofolate reductase [Desulfotomaculum reducens
MI-1]
Length = 288
Score = 168 bits (426), Expect = 3e-40, Method: Composition-based stats.
Identities = 101/279 (36%), Positives = 143/279 (51%), Gaps = 7/279 (2%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLAD 79
L SQ P +SFE+FPP E I L+ + P FISVT + ++ T +A
Sbjct: 6 LYQSQNPVISFEIFPPKSTSPVETIYETLEGLIKLEPGFISVTYGAGGSS-RDRTKEIAA 64
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPL----KDF 135
I+N I +AHL + + ++ L EL + +LALRGD + DF
Sbjct: 65 TIKNRYKIEALAHLTCVGQAVNEIDQILNELQEENIENVLALRGDPPADAQNYDFSDSDF 124
Query: 136 RYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDN 195
+YA+DL+ IK + N + A YPEGH D+ LK KVD G L++QLFFDN
Sbjct: 125 KYASDLVRHIK-NSSNVCVAAAAYPEGHAHCRRLSDDLNWLKYKVDQGVDFLISQLFFDN 183
Query: 196 ERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPE 255
FY+F + I P+ AGI+P+LN Q R++ C +P K ++DKY + E
Sbjct: 184 RIFYNFLENALRVNIHCPVVAGILPVLNAKQIKRIISLC-GASMPAKLLMLVDKYGDNAE 242
Query: 256 SLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHI 294
+ AG+ YA Q+ DL+ V G+HLYTMN + I
Sbjct: 243 DMEKAGIEYASQQVRDLLESGVDGIHLYTMNKPQQVTEI 281
>gi|83746006|ref|ZP_00943062.1| Methylenetetrahydrofolate reductase [Ralstonia solanacearum UW551]
gi|83727400|gb|EAP74522.1| Methylenetetrahydrofolate reductase [Ralstonia solanacearum UW551]
Length = 276
Score = 168 bits (425), Expect = 4e-40, Method: Composition-based stats.
Identities = 98/274 (35%), Positives = 143/274 (52%), Gaps = 4/274 (1%)
Query: 24 QTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQN 83
Q SFE FPP A G EK+ + P FISVT ++ T+ IQ
Sbjct: 2 QDRQFSFEFFPPKTAEGAEKLRNTRAQLSPLKPRFISVTFGAGG-TTQQGTLDAVVEIQR 60
Query: 84 DLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIE 143
+ I HL + S+E + D L A G+ R++ALRGD+ G+ + +FR+A +L+E
Sbjct: 61 E-GIEAAPHLSCVGSSRESIRDILDTYRANGIRRLVALRGDLPSGMGEIGEFRFANELVE 119
Query: 144 FIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
FI+ E + F I A YPE HP + + D++N +KV AG +S +TQ FF+ + ++ F
Sbjct: 120 FIRKEMNDTFHIEVAAYPEYHPQARSSRQDLENFARKVKAGANSAITQYFFNADAYFQFV 179
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D G+DVPI GIMPI N +Q +R + C +PR L+ + D ES+RA GL
Sbjct: 180 DDARKLGVDVPIVPGIMPITNSSQLMRFSEMC-GAEIPRWIAKRLESFGDDRESIRAFGL 238
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ G+H YT+N A R I++
Sbjct: 239 DVVTALCDRLLAGGAPGLHFYTLNAAGATRAIWQ 272
>gi|82703654|ref|YP_413220.1| 5,10-methylenetetrahydrofolate reductase [Nitrosospira multiformis
ATCC 25196]
gi|82411719|gb|ABB75828.1| 5,10-methylenetetrahydrofolate reductase [Nitrosospira multiformis
ATCC 25196]
Length = 281
Score = 168 bits (425), Expect = 4e-40, Method: Composition-based stats.
Identities = 98/282 (34%), Positives = 147/282 (52%), Gaps = 11/282 (3%)
Query: 21 MTSQ---TPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPL 77
M SQ P+ SFE FPP A G EK+ + P F SVT + ++ T+
Sbjct: 1 MESQKKFVPTFSFEFFPPQTAEGIEKLRATRSQLAQLKPKFFSVTFGAGG-STRDRTLET 59
Query: 78 ADHIQND--LAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDF 135
IQ + +A P HL I ++E + L + + G+ ++ALRGD+ G+ +F
Sbjct: 60 VLEIQAEGLIAAP---HLSCIGATRENIRAMLEQYRSSGIRHLIALRGDLPSGMAQGGEF 116
Query: 136 RYATDLIEFIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFD 194
RYA +L+ FI+ E N F I A YPE HP + D++N K+K++AG S +TQ F++
Sbjct: 117 RYANELVAFIRREYGNAFHIDVASYPEYHPQARTAQEDLRNFKRKIEAGADSAITQYFYN 176
Query: 195 NERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDP 254
+ ++DF D C GI++P+ GIMPI +Q R TC +PR R L+ Y D
Sbjct: 177 ADAYFDFVDSCEAMGINIPVVPGIMPINRFSQLARFSDTC-GAEIPRWIRKRLEGYGDDT 235
Query: 255 ESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
S+RA GL D L+ G+H YT+N+A +++
Sbjct: 236 ASIRAFGLDVVTDLCARLLNAGAPGLHFYTLNSAGLTTTVWQ 277
>gi|149918735|ref|ZP_01907222.1| 5,10-methylenetetrahydrofolate reductase [Plesiocystis pacifica
SIR-1]
gi|149820336|gb|EDM79752.1| 5,10-methylenetetrahydrofolate reductase [Plesiocystis pacifica
SIR-1]
Length = 310
Score = 167 bits (424), Expect = 5e-40, Method: Composition-based stats.
Identities = 102/297 (34%), Positives = 155/297 (52%), Gaps = 23/297 (7%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADH 80
++ + P SFE FPP G + +L+ ++ P F+SVT + +E TV L
Sbjct: 7 LSHKRPVFSFEFFPPKHEKGERVLWRSLEQLRTLEPDFVSVTYGAGG-STRERTVELVAR 65
Query: 81 IQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKD----FR 136
I+ +L I +AHL + +++++A + L A V+ ILALRGD G + FR
Sbjct: 66 IKTELGIEPMAHLTCVGSTRDELARVVERLLAADVHNILALRGDPPKGETEFQHTPGGFR 125
Query: 137 YATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNE 196
YA++L +++ P I ACYPE HP++ + +D+ LK KVDAG L+TQLFFDN
Sbjct: 126 YASELTAWLRESWPELCIGAACYPEVHPEASDAEADLAALKTKVDAGVDFLITQLFFDNA 185
Query: 197 RFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILD---KYEHD 253
+++F+++ AGI+VPI GIMP+ N Q R K C +P + LD E
Sbjct: 186 AYFEFENRARGAGIEVPIIPGIMPVTNIKQIRRFTKMC-GATIPPLLQHRLDDIASAEGG 244
Query: 254 PESLRA--AGLAYAVDQIVDLV------------TQDVAGVHLYTMNNAETARHIYE 296
P + AG++YA Q L+ T V G+H YT+N + R ++E
Sbjct: 245 PHAHEVFWAGVSYAAHQCRGLLDPGRGAMPFGARTPGVHGIHFYTLNRSPATRALFE 301
>gi|116329561|ref|YP_799280.1| 5,10-methylenetetrahydrofolate reductase [Leptospira borgpetersenii
serovar Hardjo-bovis L550]
gi|116332450|ref|YP_802167.1| 5,10-methylenetetrahydrofolate reductase [Leptospira borgpetersenii
serovar Hardjo-bovis JB197]
gi|116122454|gb|ABJ80347.1| 5,10-methylenetetrahydrofolate reductase [Leptospira borgpetersenii
serovar Hardjo-bovis L550]
gi|116127317|gb|ABJ77409.1| 5,10-methylenetetrahydrofolate reductase [Leptospira borgpetersenii
serovar Hardjo-bovis JB197]
Length = 290
Score = 165 bits (418), Expect = 3e-39, Method: Composition-based stats.
Identities = 91/277 (32%), Positives = 150/277 (54%), Gaps = 6/277 (2%)
Query: 22 TSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHI 81
+++ P SFE FPP G+ K++ + ++ P F++VT + ++ T + I
Sbjct: 10 SAKGPVYSFEFFPPKTQDGDLKLMGTVKELARLDPDFVTVTYGAGG-STRDKTAQILSEI 68
Query: 82 QNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKD----FRY 137
+ + PT++H + +++++ TL+E+ + G+ ++ALRGD G K F
Sbjct: 69 SKNYSFPTVSHFTCVGANQDQIFKTLKEIRSSGIVNLMALRGDPPKGEGKFKKTEGGFEN 128
Query: 138 ATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNER 197
AT+LI FI++E +F I G CYPE HP++ + D++NLK+KVDAG LV+QLFF N
Sbjct: 129 ATELISFIRSEKLDFCIGGGCYPEKHPNAKSLEEDVRNLKRKVDAGTDFLVSQLFFVNSI 188
Query: 198 FYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESL 257
F +F + A I P+ GIMPI + +Q R ++ P L + EH PE
Sbjct: 189 FENFLNLVRKADIRAPVIPGIMPITSFSQIER-FRSIAGCEFPSSLIEDLQEVEHRPEEF 247
Query: 258 RAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHI 294
L +++ Q +L+ V G+HLYT+N + + I
Sbjct: 248 YRRSLNFSIKQCRELLAMGVPGIHLYTLNQSHASYDI 284
>gi|153885348|ref|ZP_02006505.1| 5,10-methylenetetrahydrofolate reductase [Ralstonia pickettii 12D]
gi|151578248|gb|EDN42647.1| 5,10-methylenetetrahydrofolate reductase [Ralstonia pickettii 12D]
Length = 276
Score = 165 bits (417), Expect = 4e-39, Method: Composition-based stats.
Identities = 98/274 (35%), Positives = 140/274 (51%), Gaps = 4/274 (1%)
Query: 24 QTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQN 83
Q SFE FPP A G EK+ + P FISVT ++ T+ IQ
Sbjct: 2 QDRQFSFEFFPPKTAEGAEKLRNTRAQLSPLKPRFISVTFGAGG-TTQQGTLDAVVEIQR 60
Query: 84 DLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIE 143
+ I HL + S+E + L G+ RI+ALRGD+ G+ + +FR+A +L+E
Sbjct: 61 E-GIEAAPHLSCVGSSRESIRGILNTYREHGIRRIVALRGDMPSGMGEIGEFRFANELVE 119
Query: 144 FIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
FI+ E F I A YPE HP S + D++N +KV AG S +TQ FF+ + ++ F
Sbjct: 120 FIRQETGEAFHIEVAAYPEYHPQSRSARHDLENFARKVKAGADSAITQYFFNADAYFQFV 179
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D G+DVPI GIMPI N +Q +R + C +PR L+ + D ES+RA GL
Sbjct: 180 DDARKLGVDVPIVPGIMPITNSSQLMRFSEMC-GAEVPRWIAKRLEGFGDDRESIRAFGL 238
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ G+H YT+N A + R I++
Sbjct: 239 DVVTAMCDRLLQGGAPGLHFYTLNAAGSTRAIWQ 272
>gi|17544810|ref|NP_518212.1| PROBABLE 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE OXIDOREDUCTASE
PROTEIN [Ralstonia solanacearum GMI1000]
gi|17427099|emb|CAD13619.1| probable 5,10-methylenetetrahydrofolate reductase oxidoreductase
protein [Ralstonia solanacearum]
Length = 276
Score = 164 bits (415), Expect = 6e-39, Method: Composition-based stats.
Identities = 97/274 (35%), Positives = 141/274 (51%), Gaps = 4/274 (1%)
Query: 24 QTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQN 83
Q SFE FPP A G EK+ + P FISVT ++ T+ IQ
Sbjct: 2 QDRQFSFEFFPPKTAEGAEKLRNTRAQLSPLKPRFISVTFGAGG-TTQQGTLDAVVEIQR 60
Query: 84 DLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIE 143
+ I HL + S+E + L G+ RI+ALRGD+ G+ + +FR+A +L+E
Sbjct: 61 E-GIEAAPHLSCVGSSRESIRAILDTYREHGIRRIVALRGDMPSGMGEIGEFRFANELVE 119
Query: 144 FIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
FI+ E + F I A YPE HP + + D++N +KV AG +S +TQ FF+ + ++ F
Sbjct: 120 FIRKEMNDTFHIEVAAYPEYHPQARSSRQDLENFARKVKAGANSAITQYFFNADAYFQFV 179
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D G+DVPI GIMPI N +Q +R + C +PR L+ + D ES+RA GL
Sbjct: 180 DDARKLGVDVPIVPGIMPITNSSQLMRFSEMC-GAEIPRWIAKRLESFGDDRESIRAFGL 238
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ G+H YT+N A R I++
Sbjct: 239 DVVTALCDRLLAGGAPGLHFYTLNAAAATRAIWQ 272
>gi|73539921|ref|YP_294441.1| 5,10-methylenetetrahydrofolate reductase [Ralstonia eutropha
JMP134]
gi|72117334|gb|AAZ59597.1| 5,10-methylenetetrahydrofolate reductase [Ralstonia eutropha
JMP134]
Length = 276
Score = 164 bits (415), Expect = 7e-39, Method: Composition-based stats.
Identities = 96/269 (35%), Positives = 144/269 (53%), Gaps = 4/269 (1%)
Query: 29 SFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAIP 88
SFE FPP A G EK+ + P +ISVT ++ T+ IQ + I
Sbjct: 7 SFEFFPPKTAEGAEKLRNTRAQLAPLNPKYISVTFGAGG-TTQQGTLDTVLEIQRE-GIE 64
Query: 89 TIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKAE 148
HL + S+E + + L++ G+ I+ALRGD+ G+ + +FRYA +L+EFI+AE
Sbjct: 65 AAPHLSCVGSSRESIREILQQYRDGGIRHIVALRGDMPSGMGEIGEFRYANELVEFIRAE 124
Query: 149 APN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTL 207
+ F I A YPE HP + + D++N +KV AG +S +TQ FF+ + ++ F D
Sbjct: 125 TGDWFQIEVAAYPEYHPQAKSPRHDLENFVRKVKAGANSAITQYFFNADAYFRFVDDARA 184
Query: 208 AGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAVD 267
G+DVPI GIMPI N +Q +R C + +PR L+ + D ES+RA GL
Sbjct: 185 MGVDVPIVPGIMPITNYSQLMRFSDMCGS-EVPRWVAKRLESFGDDRESIRAFGLDVVTA 243
Query: 268 QIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ V G+H YT+N A + I++
Sbjct: 244 LCERLLAGGVPGLHFYTLNAAGATKAIWQ 272
>gi|121528677|ref|ZP_01661290.1| putative 5,10-methylenetetrahydrofolate reductase oxidoreductase
protein [Ralstonia pickettii 12J]
gi|121303981|gb|EAX44946.1| putative 5,10-methylenetetrahydrofolate reductase oxidoreductase
protein [Ralstonia pickettii 12J]
Length = 276
Score = 164 bits (414), Expect = 9e-39, Method: Composition-based stats.
Identities = 97/274 (35%), Positives = 140/274 (51%), Gaps = 4/274 (1%)
Query: 24 QTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQN 83
Q SFE FPP A G EK+ + P FISVT ++ T+ IQ
Sbjct: 2 QDRQFSFEFFPPKTAEGAEKLRNTRAQLSPLKPRFISVTFGAGG-TTQQGTLDAVVEIQR 60
Query: 84 DLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIE 143
+ I HL + S+E + L G+ RI+ALRGD+ G+ + +FR+A +L+E
Sbjct: 61 E-GIEAAPHLSCVGSSRESIRGILNTYREHGIRRIVALRGDMPSGMGEIGEFRFANELVE 119
Query: 144 FIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
FI+ E F I A YPE HP S + D++N +KV +G S +TQ FF+ + ++ F
Sbjct: 120 FIRQETGEAFHIEVAAYPEYHPQSRSARHDLENFARKVKSGADSAITQYFFNADAYFQFV 179
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D G+DVPI GIMPI N +Q +R + C +PR L+ + D ES+RA GL
Sbjct: 180 DDARKLGVDVPIVPGIMPITNSSQLMRFSEMC-GAEVPRWIAKRLEGFGDDRESIRAFGL 238
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ G+H YT+N A + R I++
Sbjct: 239 DVVTAMCDRLLQGGAPGLHFYTLNAAGSTRAIWQ 272
>gi|91792004|ref|YP_561655.1| 5,10-methylenetetrahydrofolate reductase [Shewanella denitrificans
OS217]
gi|91714006|gb|ABE53932.1| 5,10-methylenetetrahydrofolate reductase [Shewanella denitrificans
OS217]
Length = 298
Score = 163 bits (412), Expect = 1e-38, Method: Composition-based stats.
Identities = 96/275 (34%), Positives = 150/275 (54%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP+ + + ++ ++ P F+SVT N +++ T + + IQ +
Sbjct: 24 NVSFEFFPPSTPEMEQLLWSSVRRLEPLKPKFVSVTYGANS-GVRDRTHSVIERIQQETQ 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL + S E++ D ++ G+ I+ALRGD+ P +P K R+A DL+ ++
Sbjct: 83 LVAAPHLTLVDASDEELVDLAKQYWQSGIRDIVALRGDL-PAGQP-KPTRFAADLVRLLR 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ A +FDI A YPEGHPD+ N +D+ NLK+K+DAG + +TQ FFD E + F+D+C
Sbjct: 141 SVA-DFDISVAAYPEGHPDARNAQADLINLKRKIDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N Q L+ N+ LP+ E DP + + G A+
Sbjct: 200 TAGIDVEIIPGILPVTNFTQ-LKRFAAMTNVALPQWLHQQFSGLEDDPATRQLVGANVAI 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE Y H+L
Sbjct: 259 DMVKVLSREGVKDFHFYTLNRAELT---YAICHTL 290
>gi|113866277|ref|YP_724766.1| 5,10-Methylenetetrahydrofolate reductase [Ralstonia eutropha H16]
gi|113525053|emb|CAJ91398.1| 5,10-Methylenetetrahydrofolate reductase [Ralstonia eutropha H16]
Length = 276
Score = 163 bits (412), Expect = 2e-38, Method: Composition-based stats.
Identities = 95/274 (34%), Positives = 145/274 (52%), Gaps = 4/274 (1%)
Query: 24 QTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQN 83
Q SFE FPP A G EK+ + P +ISVT ++ T+ IQ
Sbjct: 2 QDRYFSFEFFPPKTAEGTEKLRNTRAQLAPLKPKYISVTFGAGG-TTQQGTLDAVLEIQR 60
Query: 84 DLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIE 143
+ I HL + S+E + L++ G+ I+ALRGD+ G+ + +FRYA +L+E
Sbjct: 61 E-GIEAAPHLSCVGSSRESIRAILQQYRDGGIRHIVALRGDMPSGMGEIGEFRYANELVE 119
Query: 144 FIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
FI+AE + F+I A YPE HP + + D++N +KV AG +S +TQ F++ + ++ F
Sbjct: 120 FIRAETGDWFNIEVAAYPEYHPQAKSPRHDLENFVRKVKAGANSAITQYFYNADAYFRFV 179
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D G++VPI GIMPI N Q +R ++C +PR L+ + D ES+RA GL
Sbjct: 180 DDVRATGLEVPIVPGIMPITNYTQLMRFSESC-GAEVPRWVAKRLESFGDDRESIRAFGL 238
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ V G+H YT+N A + I++
Sbjct: 239 DVVTALCERLLAAGVPGLHFYTLNAAGATKAIWQ 272
>gi|91785597|ref|YP_560803.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia xenovorans
LB400]
gi|91689551|gb|ABE32751.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia xenovorans
LB400]
Length = 276
Score = 162 bits (410), Expect = 2e-38, Method: Composition-based stats.
Identities = 98/273 (35%), Positives = 142/273 (52%), Gaps = 10/273 (3%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVT---ASNNKYNIKETTVPLADHIQND 84
LSFE FPP G +K+ + P F+SVT + + +T V +A
Sbjct: 6 LSFEFFPPKTQEGVDKLRATRAQLATLKPKFVSVTFGAGGSTQQGTLDTVVDMAKE---- 61
Query: 85 LAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEF 144
+ H+ I SKE + L E A G+ I+ALRGD+ G+ + + RYA++L+ F
Sbjct: 62 -GLEAAPHVSCIGSSKESLRAILNEYRAHGIRHIVALRGDLPSGMGEVGELRYASELVSF 120
Query: 145 IKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQD 203
I+AE + F I A YPE HP S + D++N +KV AG +S +TQ FF+ + ++ F D
Sbjct: 121 IRAEFGDWFCIEVAGYPEYHPQSRSPRQDLENFARKVKAGANSAITQYFFNADAYFRFVD 180
Query: 204 KCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLA 263
G+DVPI GIMPI N +Q +R + C +PR L+ + D ES+RA GL
Sbjct: 181 DARKLGVDVPIVPGIMPITNFSQLMRFSEMC-GAEVPRWIARRLESFGDDRESIRAFGLD 239
Query: 264 YAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
D L+ V G+H YT+N A + I E
Sbjct: 240 VVTDLCRRLIDAKVPGLHFYTLNGAAATKAICE 272
>gi|50123164|ref|YP_052331.1| 5,10-methylenetetrahydrofolate reductase [Erwinia carotovora subsp.
atroseptica SCRI1043]
gi|49613690|emb|CAG77141.1| 5,10-methylenetetrahydrofolate reductase [Erwinia carotovora subsp.
atroseptica SCRI1043]
Length = 298
Score = 162 bits (410), Expect = 2e-38, Method: Composition-based stats.
Identities = 95/275 (34%), Positives = 149/275 (54%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + E + ++D + P F+SVT N ++ T + I+
Sbjct: 24 NVSFEFFPPRTSDMEETLWNSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIKTIKERTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I S+E++ + ++ G+ I+ALRGD+ P E K YA DL+ +K
Sbjct: 83 LEAAPHLTCIDASREQLREIAQDYWQSGIRHIVALRGDLPP--EGGKPEMYAADLVSLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E +FDI A YPE HP++ + +D+ NLK K+DAG + +TQ FFD E + F+D+C
Sbjct: 141 -EVGDFDISVAAYPEVHPEAKSAQADLINLKHKIDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
GIDV I GI+P+ N Q L+ T N+ +P ++ D ++DPE+ + G + A+
Sbjct: 200 ATGIDVEIVPGILPVSNFKQ-LQRFATMTNVRVPNWMTSVFDGLDNDPETRKMVGASIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAELS---YAICHTL 290
>gi|94309117|ref|YP_582327.1| 5,10-methylenetetrahydrofolate reductase [Ralstonia metallidurans
CH34]
gi|93352969|gb|ABF07058.1| 5,10-methylenetetrahydrofolate reductase [Ralstonia metallidurans
CH34]
Length = 276
Score = 162 bits (410), Expect = 3e-38, Method: Composition-based stats.
Identities = 93/270 (34%), Positives = 143/270 (52%), Gaps = 4/270 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
SFE FPP A G EK+ + P +ISVT ++ T+ IQ + I
Sbjct: 6 FSFEFFPPKTAEGAEKLRNTRAQLAPLQPKYISVTFGAGG-TTQQGTLDAVLEIQRE-GI 63
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
HL + +++ + L+ G+ I+ALRGD+ G+ + +FRYA +L+EFI+A
Sbjct: 64 EAAPHLSCVGSTRDSIRQILQTYRDGGIRHIVALRGDMPSGMGEIGEFRYANELVEFIRA 123
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E + F+I A YPE HP + + D++N +KV AG S +TQ FF+ + ++ F D
Sbjct: 124 ETGDWFNIEVAAYPEYHPQARSPRHDLENFVRKVKAGADSAITQYFFNADAYFRFVDDVR 183
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G++VPI GIMPI N +Q +R + C +PR L+ + D E++RA GL
Sbjct: 184 AMGVEVPIVPGIMPITNYSQLMRFSEMC-GAEVPRWVAKRLESFGDDKEAIRAFGLDVVT 242
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
D L+ V G+H YT+N A + I++
Sbjct: 243 DLCTRLLEAGVPGLHFYTLNAAGATKAIWQ 272
>gi|67939413|ref|ZP_00531915.1| 5,10-methylenetetrahydrofolate reductase [Chlorobium
phaeobacteroides BS1]
gi|67914365|gb|EAM63711.1| 5,10-methylenetetrahydrofolate reductase [Chlorobium
phaeobacteroides BS1]
Length = 293
Score = 162 bits (409), Expect = 3e-38, Method: Composition-based stats.
Identities = 100/282 (35%), Positives = 154/282 (54%), Gaps = 10/282 (3%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLAD 79
L ++ P SFE FPP K+ + ++ P ++SVT + + T L
Sbjct: 7 LNSATGPVFSFEFFPPKKTEDWGKLFHTISELIPFNPSYVSVTYGAGG-STRSRTHDLVT 65
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGV----EPLKDF 135
IQ + + ++HL I K+ VA+ L + G+ +LALRGD+ PG E KDF
Sbjct: 66 KIQRETGLTVVSHLTCICSGKKDVAEILEDYRTQGITNVLALRGDLPPGSTSYEEATKDF 125
Query: 136 RYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDN 195
+A DL++FI P + A +PEGHP +PN++ +I+ LK KVD G +VTQ+FFDN
Sbjct: 126 PHAVDLVKFIVENFPEIGVGVAGFPEGHPQTPNRLKEIEYLKAKVDQGADYIVTQMFFDN 185
Query: 196 ERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDP- 254
F+DF +C+LAGI+VPI GIMP+ + +++ + +P A+L K P
Sbjct: 186 RDFFDFVGRCSLAGINVPIIPGIMPVTTKKGLIKMSELALGARIP---AALLKKVLEAPN 242
Query: 255 -ESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
E + G+ +A +Q +L+ + G+H YT+NNAE R I+
Sbjct: 243 DEEVAKTGIEWATEQTRELIENHIRGIHFYTLNNAEATRKIF 284
>gi|59712916|ref|YP_205692.1| 5,10-methylenetetrahydrofolate reductase [Vibrio fischeri ES114]
gi|59481017|gb|AAW86804.1| methylenetetrahydrofolate reductase [Vibrio fischeri ES114]
Length = 295
Score = 161 bits (408), Expect = 4e-38, Method: Composition-based stats.
Identities = 98/275 (35%), Positives = 149/275 (54%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP+ E + ++ +K P F+SVT N ++ T + I+
Sbjct: 24 NVSFEFFPPSSEKMEETLWNSIHRLKTLKPKFVSVTYGANSGE-RDRTHSIIKEIKEQTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I S+ ++ D + A G+ I+ALRGDI PG + YA+DL+E +K
Sbjct: 83 LIAAPHLTCIDASRSELIDIANDYWANGIKDIVALRGDIPPGGGAPE--MYASDLVELLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
++ +FDI A +PE HP++ + +D+ NLK+KVDAG S +TQ FFD E + F+D+C
Sbjct: 141 SQH-DFDISVAAFPEVHPEAKSAQADLLNLKRKVDAGASRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA R K N+ +P + + DP + + G ++A+
Sbjct: 200 SAGIDVEIIPGILPVSNFKQASRFAKM-NNVKIPGWMAQQFEGLDDDPVTRQMVGASHAI 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D L + V H YT+N AE H Y H+L
Sbjct: 259 DMTRILSREGVKDFHFYTLNRAE---HTYALCHTL 290
>gi|94501839|ref|ZP_01308351.1| 5,10-methylenetetrahydrofolate reductase [Oceanobacter sp. RED65]
gi|94426060|gb|EAT11056.1| 5,10-methylenetetrahydrofolate reductase [Oceanobacter sp. RED65]
Length = 278
Score = 161 bits (407), Expect = 5e-38, Method: Composition-based stats.
Identities = 95/271 (35%), Positives = 144/271 (53%), Gaps = 5/271 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
LSFE FP G +K+ D + P F SVT + ++ T+ + + N + +
Sbjct: 6 LSFEFFPTKTEEGTKKLYATRDKLAELKPDFFSVTFGAGG-STRDHTMDVVTKM-NGMGV 63
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVE-PLKDFRYATDLIEFIK 146
T HL I SK+++ L V RI+ALRGD+ G+ + +YA +L+E IK
Sbjct: 64 GTAPHLSCIGQSKDEIKQLLSTYADNKVERIVALRGDLPSGMAVSSGELKYANELVELIK 123
Query: 147 AE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKC 205
E F + A YPE HP +PN +D++N K+KV+AG S +TQ FF+ + ++ + D+C
Sbjct: 124 QEHGDQFHLEVAAYPEMHPQAPNFEADLENFKRKVEAGADSAITQYFFNPDSYFYYVDRC 183
Query: 206 TLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYA 265
GI++PI GIMPI N ++ R C +PR R L+ Y D ES++ G
Sbjct: 184 MEMGIEIPIVPGIMPITNYSKLARFSDAC-GAEIPRWIRKQLEAYGDDVESIQKFGEEVV 242
Query: 266 VDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
DLV DV G+H YT+N A+ +I++
Sbjct: 243 TQMCEDLVENDVPGLHFYTLNQADPCINIWK 273
>gi|83644379|ref|YP_432814.1| 5,10-methylenetetrahydrofolate reductase [Hahella chejuensis KCTC
2396]
gi|83632422|gb|ABC28389.1| 5,10-methylenetetrahydrofolate reductase [Hahella chejuensis KCTC
2396]
Length = 287
Score = 161 bits (407), Expect = 6e-38, Method: Composition-based stats.
Identities = 97/282 (34%), Positives = 145/282 (51%), Gaps = 11/282 (3%)
Query: 21 MTSQTP---SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVP- 76
M SQT SFE FPP G EK+ + D + P F SVT + +E T+
Sbjct: 1 MESQTQFKRRFSFEFFPPKTPEGMEKLQVVRDKLAKRKPDFFSVTYGAGG-STRERTIDT 59
Query: 77 -LADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDF 135
L H Q I T HL I +KE + + L + G+ RI+ALRGD+ G+ +
Sbjct: 60 VLTLHRQ---GISTAPHLSCIGATKESIGELLDLYRSNGIQRIVALRGDLPSGMGAPGEL 116
Query: 136 RYATDLIEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFD 194
RYA +L+ +I+ +F I A YPE HP + N +D+ N ++KV+AG +S +TQ FF+
Sbjct: 117 RYANELVSYIRERTGDHFSIEVAAYPEFHPQAQNAEADLNNFRRKVEAGATSAITQYFFN 176
Query: 195 NERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDP 254
+ ++ F ++C AG+++PI GIMPI N + R C +PR R L+ Y D
Sbjct: 177 ADSYFYFVERCEKAGLNLPIVPGIMPITNYSNLARFSDMC-GAEIPRWVRKQLEAYGDDS 235
Query: 255 ESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
S+R G L+ G+H YT+N AE + +++
Sbjct: 236 ASIRKFGEEVVTRLCERLLAAGAPGIHFYTLNQAEPSLAVWD 277
>gi|117621243|ref|YP_858383.1| 5,10-methylenetetrahydrofolate reductase [Aeromonas hydrophila
subsp. hydrophila ATCC 7966]
gi|117562650|gb|ABK39598.1| 5,10-methylenetetrahydrofolate reductase [Aeromonas hydrophila
subsp. hydrophila ATCC 7966]
Length = 298
Score = 161 bits (407), Expect = 6e-38, Method: Composition-based stats.
Identities = 97/275 (35%), Positives = 146/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
S+SFE FPPN + +++ +K P F+SVT N ++ T + I+
Sbjct: 24 SVSFEFFPPNSEGMENTLWQSIERLKVLEPKFVSVTYGANS-GTRDRTHKVIKDIKERTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I S++++ R+ G+ I+ALRGD+ G+E K YATDL+ +K
Sbjct: 83 LIAAPHLTCIDASRDELRTIARDYWNSGIRHIVALRGDLPQGLE--KPEMYATDLVALLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
AEA +FDI A YPEGHP++ + SD+ NLK+K+DAG + +TQ FFD E + F+D+C
Sbjct: 141 AEA-DFDISVAAYPEGHPEARSAQSDLLNLKRKIDAGANRAITQFFFDVETYLRFRDRCA 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
GID I GI+P+ N Q L N+ +PR + + D + G + A+
Sbjct: 200 AIGIDAEIVPGILPVSNY-QTLAKFAGFTNVKIPRWMHQRFEGLDDDQMTRNMVGASIAI 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
DQ+ L + V H YT+N +E Y H+L
Sbjct: 259 DQVRVLSQEGVKDFHFYTLNRSELT---YAICHTL 290
>gi|118032263|ref|ZP_01503713.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia phymatum
STM815]
gi|117981948|gb|EAU96336.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia phymatum
STM815]
Length = 276
Score = 160 bits (405), Expect = 9e-38, Method: Composition-based stats.
Identities = 100/271 (36%), Positives = 144/271 (53%), Gaps = 6/271 (2%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDL-A 86
LSFE FPP G EK+ + P F+SVT + T + D ++ L A
Sbjct: 6 LSFEFFPPKTQEGLEKLRATRAQLLPLKPKFVSVTFGAGGSTQQGTLDTVLDMAKDGLEA 65
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
P HL I SKE + L E + G+ I+ALRGD+ G+ + + RYA++L+ FI+
Sbjct: 66 AP---HLSCIGSSKESLRAILNEYRSHGIRHIVALRGDLPSGMGEVGELRYASELVSFIR 122
Query: 147 AEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKC 205
AE + F I A YPE HP S + D++N +KV AG +S +TQ FF+ + ++ F +
Sbjct: 123 AEFGDWFCIEVAAYPEYHPQSRSPKHDLENFARKVKAGANSAITQYFFNADAYFRFVEDA 182
Query: 206 TLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYA 265
G+DVPI GIMPI N +Q +R + C +PR L+ + D ES+RA GL
Sbjct: 183 QKLGVDVPIVPGIMPITNFSQLMRFSEMC-GAEVPRWVARRLESFGDDRESIRAFGLDVV 241
Query: 266 VDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
+ LV V G+H YT+N A ++ I E
Sbjct: 242 TNLCRRLVDAKVPGLHFYTLNGAAASKAICE 272
>gi|37528569|ref|NP_931914.1| 5,10-methylenetetrahydrofolate reductase [Photorhabdus luminescens
subsp. laumondii TTO1]
gi|36788007|emb|CAE17126.1| 5,10-methylenetetrahydrofolate reductase [Photorhabdus luminescens
subsp. laumondii TTO1]
Length = 294
Score = 160 bits (405), Expect = 1e-37, Method: Composition-based stats.
Identities = 94/274 (34%), Positives = 147/274 (53%), Gaps = 8/274 (2%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
+SFE FPP A + + +++ + P F+SVT N ++ T + I+ +
Sbjct: 25 VSFEFFPPRTAEMEKTLWKSINRLSTLKPKFVSVTYGANSGE-RDRTHSIIKGIKEQTGL 83
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
HL I S++++ + R+ G+ I+ALRGD+ E K Y +DL+E +K
Sbjct: 84 EAAPHLTCIDASRDELCEIARDYWKNGIRHIVALRGDLPENSEKPK--MYGSDLVELLKK 141
Query: 148 EAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTL 207
EA +FDI A YPE HP++ + +D+ +LK+K+DAG + +TQ FFD E + F+D+C
Sbjct: 142 EA-DFDISVAAYPEVHPEAKSSQADLISLKRKIDAGANRAITQFFFDVESYLRFRDRCVT 200
Query: 208 AGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAVD 267
AGIDV I GI+P+ N Q L+ N+ +P + D + DPES G + A+D
Sbjct: 201 AGIDVEIVPGILPVSNFRQ-LKRFAVMTNVRIPSWMTRMFDGLDDDPESANLVGASIAMD 259
Query: 268 QIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
+ L + V H YT+N AE + Y H+L
Sbjct: 260 MVKILSREGVKDFHFYTLNRAELS---YAICHTL 290
>gi|114771528|ref|ZP_01448938.1| 5,10-methylenetetrahydrofolate reductase [alpha proteobacterium
HTCC2255]
Length = 293
Score = 160 bits (404), Expect = 1e-37, Method: Composition-based stats.
Identities = 94/271 (34%), Positives = 151/271 (55%), Gaps = 10/271 (3%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPPN + +++ + P ++SVT N ++ T + IQ+DL
Sbjct: 22 NVSFEFFPPNSDKMESMLWKSVERLAPLKPEYMSVTYGANSGE-RDKTHGVVKRIQHDLG 80
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+P + HL + SKE++ + +E G+ RI+ALRGD+ PG++ K YA+DL+ +K
Sbjct: 81 VPAVPHLTCVDASKEELIEIAKEYWNNGIRRIVALRGDLPPGMD--KPDMYASDLVTILK 138
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ +FDI A YPE HP++PN D+ NLK+K +AG + +TQ FFD + F+D+
Sbjct: 139 -DVADFDISVAAYPEKHPEAPNDQFDLLNLKRKAEAGANEAITQFFFDTSHYLRFRDRAA 197
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLR---AAGLA 263
AGID+ I GI+P+ N Q L N+H+P + D + + ++ R AA +
Sbjct: 198 AAGIDIDIVPGILPVTNY-QTLVKFAGFTNVHVPNWLHKMYDGLDENDQTTRNLLAANI- 255
Query: 264 YAVDQIVDLVTQDVAGVHLYTMNNAETARHI 294
A+DQ+ L + V H YT+N +E + I
Sbjct: 256 -AMDQVKVLAREGVKHFHFYTLNRSELSYAI 285
>gi|34496421|ref|NP_900636.1| 5,10-methylenetetrahydrofolate reductase [Chromobacterium violaceum
ATCC 12472]
gi|34102274|gb|AAQ58640.1| 5,10-methylenetetrahydrofolate reductase [Chromobacterium violaceum
ATCC 12472]
Length = 278
Score = 160 bits (404), Expect = 1e-37, Method: Composition-based stats.
Identities = 100/278 (35%), Positives = 140/278 (50%), Gaps = 9/278 (3%)
Query: 23 SQTP-SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVT--ASNNKYNIKETTVPLAD 79
+QTP + SFE FPP G K+ + P F SVT A + +TV L
Sbjct: 2 TQTPRTFSFEFFPPKTPEGVAKLRTTRQQLAQFKPQFFSVTFGAGGTTRDGTLSTV-LEI 60
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYAT 139
H + A P HL I ++E +A L E G+ ++ALRGDI G+ +FRYA
Sbjct: 61 HSEGQAAAP---HLSCIGSTRENIAAILNEYRGNGIRHLVALRGDIPSGMVAAGEFRYAN 117
Query: 140 DLIEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERF 198
+L+EFI+AE +F I A YPE HP + + D+ N +KV AG S +TQ FF+ + +
Sbjct: 118 ELVEFIRAEHGDHFHIEVAAYPEFHPQARSAEDDLANFVRKVRAGADSAMTQYFFNADSY 177
Query: 199 YDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLR 258
+ F D+ G+D+PI GIMPI N Q R C +PR R + Y D S+R
Sbjct: 178 FRFVDEVRARGVDIPIVPGIMPISNFGQLCRFSDMC-GAEVPRWLRLRMQSYYDDTASIR 236
Query: 259 AAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
A GL + L+ G+H YT+N A I++
Sbjct: 237 ALGLDVVTELCDRLLQGGAPGLHFYTLNQAGLVSTIWQ 274
>gi|152988219|ref|YP_001345925.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas aeruginosa
PA7]
gi|150963377|gb|ABR85402.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas aeruginosa
PA7]
Length = 282
Score = 159 bits (403), Expect = 2e-37, Method: Composition-based stats.
Identities = 92/278 (33%), Positives = 146/278 (52%), Gaps = 4/278 (1%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADH 80
M+ SFE FP G+EK+L ++ G P F S T + ++ T+
Sbjct: 1 MSQSERRFSFEFFPAKTEAGHEKLLATARNLAGYKPDFFSCTYGAGG-STRDRTLHTVLQ 59
Query: 81 IQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK-DFRYAT 139
+ ++ +PT HL + SK ++ + L + A G+ RI+ALRGD+ G+ + RYA
Sbjct: 60 LDGEVKVPTAPHLSCVGDSKAELRELLGQYRAAGIRRIVALRGDLPSGMGMASGELRYAN 119
Query: 140 DLIEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERF 198
+L+EFI+AE +F I A YPE HP + + D+ N +KV AG SS +TQ FF+ + +
Sbjct: 120 ELVEFIRAETGDHFHIEVAAYPEVHPQARSFEDDLANFVRKVKAGASSAITQYFFNADAY 179
Query: 199 YDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLR 258
+ F ++ G+D+P+ GIMPI N ++ R C LPR R L+ Y D S++
Sbjct: 180 FYFVERVAKLGVDIPVVPGIMPITNYSKLARFSDAC-GAELPRWIRKQLEAYGDDSRSIQ 238
Query: 259 AAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
A G + L+ G+H YT+N A+ + I++
Sbjct: 239 AFGEQVISEMCERLLQGGAPGLHFYTLNQADPSLAIWK 276
>gi|78486163|ref|YP_392088.1| 5,10-methylenetetrahydrofolate reductase [Thiomicrospira crunogena
XCL-2]
gi|78364449|gb|ABB42414.1| 5,10-methylenetetrahydrofolate reductase [Thiomicrospira crunogena
XCL-2]
Length = 285
Score = 159 bits (403), Expect = 2e-37, Method: Composition-based stats.
Identities = 99/290 (34%), Positives = 145/290 (50%), Gaps = 14/290 (4%)
Query: 9 SQQKSKTKKVKLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKY 68
SQQK + K LS E FPP G EK+ ++++ P ++SVT
Sbjct: 3 SQQKYEQK-----------LSLEFFPPRTDKGVEKLQTVIEELGTIHPEYMSVTYGAGG- 50
Query: 69 NIKETTVPLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPG 128
+ T+ ++IQ HL I S+E V D L +A+G+ RI+ALRGD+ G
Sbjct: 51 TTQNRTIETVEYIQTQTEFDAAPHLTCIGASEESVLDLLDRYEAMGIKRIVALRGDLPSG 110
Query: 129 VEPLKDFRYATDLIEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSL 187
+ +F+YA+DLI FI+ E F + A YPE HP + N I+ K KVD G S
Sbjct: 111 MMDPGEFKYASDLIAFIRQERGDTFKLEVAAYPETHPQARNCDIGIKWFKHKVDQGADSA 170
Query: 188 VTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAIL 247
+TQ F++ + + F D C +GID+PI GIMPI N +R + C +PR + L
Sbjct: 171 ITQYFYNVDSYLYFIDNCERSGIDLPIVPGIMPITNYENLIRFSEGC-GAEVPRWLKCRL 229
Query: 248 DKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEA 297
+ + D ESL+A G + L+ G+H Y+MN + +I A
Sbjct: 230 ESFGDDTESLKAFGEDVVTELSQRLLDAGAPGLHFYSMNQSAPTLNIVNA 279
>gi|118040259|ref|ZP_01511655.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia phytofirmans
PsJN]
gi|117989428|gb|EAV03730.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia phytofirmans
PsJN]
Length = 276
Score = 159 bits (402), Expect = 2e-37, Method: Composition-based stats.
Identities = 98/273 (35%), Positives = 141/273 (51%), Gaps = 10/273 (3%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVT---ASNNKYNIKETTVPLADHIQND 84
LSFE FPP G +K+ + P F+SVT + + +T V +A
Sbjct: 6 LSFEFFPPKTQEGVDKLRATRAQLVTLKPKFMSVTFGAGGSTQQGTLDTVVEMAKE---- 61
Query: 85 LAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEF 144
+ H+ I SKE + L E A G+ I+ALRGD+ G+ + + RYA++L+ F
Sbjct: 62 -GLEAAPHVSCIGSSKESLRAILTEYRAHGIRHIVALRGDLPSGMGEVGELRYASELVSF 120
Query: 145 IKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQD 203
I+AE + F I A YPE HP S + D+ N +KV AG +S +TQ FF+ + ++ F D
Sbjct: 121 IRAEFGDWFWIEVAGYPEYHPQSRSPRHDLDNFARKVKAGANSAITQYFFNADAYFRFVD 180
Query: 204 KCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLA 263
G+DVPI GIMPI N +Q +R + C +PR L+ + D ES+RA GL
Sbjct: 181 DARKLGVDVPIVPGIMPITNFSQLMRFSEMC-GAEVPRWIARRLESFGDDRESIRAFGLD 239
Query: 264 YAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
D L+ V G+H YT+N A + I E
Sbjct: 240 VVTDLCGRLIDVKVPGLHFYTLNGAAATKAICE 272
>gi|116618884|ref|YP_819255.1| 5,10-methylenetetrahydrofolate reductase [Leuconostoc mesenteroides
subsp. mesenteroides ATCC 8293]
gi|116097731|gb|ABJ62882.1| 5,10-methylenetetrahydrofolate reductase [Leuconostoc mesenteroides
subsp. mesenteroides ATCC 8293]
Length = 297
Score = 159 bits (401), Expect = 3e-37, Method: Composition-based stats.
Identities = 103/284 (36%), Positives = 150/284 (52%), Gaps = 22/284 (7%)
Query: 26 PSLSFEVFPPNPAVGNEKILLALDDM--KGSAPHFISVTASNNKYNIKETTVPLADHIQN 83
P LSFE+FPP G + L ++ K + +ISVT + + T +A++I+
Sbjct: 14 PVLSFEIFPPKTEDGLHALYKTLQEVNPKETGVDYISVTYGAGGGSNHKRTKEIAEYIER 73
Query: 84 DLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDF-----RYA 138
+ I + +L I + + L ++ GV I ALRGD P KD+ +A
Sbjct: 74 NCGITALHNLTGINQTPSSLKGNLEKISVAGVENIFALRGDT-----PTKDYVNEYYPFA 128
Query: 139 TDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERF 198
DLI+ IK + FDI A YPEGH D+P + +K+KV +G L++QLFFDN F
Sbjct: 129 KDLIKEIKKDG-RFDIGAAIYPEGHVDNPTTGISVTGVKEKVISGTEFLISQLFFDNGVF 187
Query: 199 YDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLR 258
Y+ Q+ I VP+ AGI+PI++R Q R+ + LP + I+ KYE PE+L+
Sbjct: 188 YNMQEALKENYIKVPVSAGILPIISRAQVERITYMIGS-SLPARLAKIVHKYEDQPEALQ 246
Query: 259 AAGLAYAVDQIVDLVTQDVAGVHLYTMNN--------AETARHI 294
AG+ YA++QI DL+ V G+HLY MN E RHI
Sbjct: 247 QAGIEYALEQIHDLLDHGVDGIHLYAMNQPNVLKIMLPEINRHI 290
>gi|46579410|ref|YP_010218.1| 5,10-methylenetetrahydrofolate reductase [Desulfovibrio vulgaris
subsp. vulgaris str. Hildenborough]
gi|120603035|ref|YP_967435.1| 5,10-methylenetetrahydrofolate reductase [Desulfovibrio vulgaris
subsp. vulgaris DP4]
gi|46448824|gb|AAS95477.1| 5,10-methylenetetrahydrofolate reductase [Desulfovibrio vulgaris
subsp. vulgaris str. Hildenborough]
gi|120563264|gb|ABM29008.1| 5,10-methylenetetrahydrofolate reductase [Desulfovibrio vulgaris
subsp. vulgaris DP4]
Length = 291
Score = 158 bits (400), Expect = 4e-37, Method: Composition-based stats.
Identities = 94/281 (33%), Positives = 148/281 (52%), Gaps = 7/281 (2%)
Query: 26 PSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDL 85
P S E FPP ++ +K P F SVT ++ T+ + H++N L
Sbjct: 13 PFYSLEFFPPKEREQWPAFFATVERLKAMDPVFASVTYGAGG-GTQDNTLDITAHLKNAL 71
Query: 86 AIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVE---PLKDFRYATDLI 142
+ +AHL + ++E++A L L GV +LALRGD G + +FRYA+DL+
Sbjct: 72 GLEPMAHLTCVGATRERIAGFLARLREQGVENVLALRGDPPRGQQVDWETAEFRYASDLV 131
Query: 143 EFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
F++ E P F I A YP HP+S + DI + +K+ AG +VTQLFFD ++ F
Sbjct: 132 RFVRNEFPEFGIGVAGYPAAHPESVSFSQDIAHTCQKIHAGADFVVTQLFFDVREYFAFI 191
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEH--DPESLRAA 260
++ G++ P+ GI+PI + R+L C ++P K L++ + E++R A
Sbjct: 192 ERLKECGVEKPVLPGILPIQSLESIKRILALC-GANIPGKLYLELEEADARGGAEAVREA 250
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
G+A+AV QI L+ G+HLYT+N A+ I +A +L
Sbjct: 251 GIAFAVRQIRSLIDGGAPGIHLYTLNKADMCLQIRDAVGAL 291
>gi|148977254|ref|ZP_01813881.1| 5,10-methylenetetrahydrofolate reductase [Vibrionales bacterium
SWAT-3]
gi|145963536|gb|EDK28799.1| 5,10-methylenetetrahydrofolate reductase [Vibrionales bacterium
SWAT-3]
Length = 299
Score = 158 bits (400), Expect = 4e-37, Method: Composition-based stats.
Identities = 97/279 (34%), Positives = 148/279 (53%), Gaps = 8/279 (2%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
S ++SFE FPP+ E + ++ +K P F+SVT N ++ T + I+
Sbjct: 20 SDNINVSFEFFPPSSEKMEETLWNSVHRLKTLQPKFVSVTYGANSGE-RDRTHSIIKEIK 78
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLI 142
N + HL I S+E++ + A G+ I+ALRGDI PG + YA+DL+
Sbjct: 79 NQTGLVAAPHLTCIDASREELIQIADDYWANGIESIVALRGDIPPGGGAPE--MYASDLV 136
Query: 143 EFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
E +K+ +FDI A +PE HP++ + SD+ NLK+KVDAG + +TQ FFD E + F+
Sbjct: 137 ELLKSRH-DFDISVAAFPEVHPEAKSAQSDLINLKRKVDAGANRAITQFFFDVESYLRFR 195
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D+C AG+DV I GI+P+ N QA R N+ +P + + DP + + G
Sbjct: 196 DRCVAAGVDVEIVPGILPVSNFKQASR-FAAMNNVKVPGWMAKQFEGLDDDPTTRQLVGA 254
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
+ A+D + L + V H YT+N AE Y H+L
Sbjct: 255 SQAIDMVRTLSREGVKDFHFYTLNRAEMT---YALCHTL 290
>gi|6016545|sp|P71319|METF_PECCC 5,10-methylenetetrahydrofolate reductase
gi|3851176|gb|AAC72242.1| 5,10-methylenetetrahydrofolate reductase [Pectobacterium
carotovorum]
Length = 298
Score = 158 bits (399), Expect = 5e-37, Method: Composition-based stats.
Identities = 94/275 (34%), Positives = 147/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + E + ++D + P F+SVT N ++ T + I+
Sbjct: 24 NVSFEFFPPRTSDMEETLWSSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIKTIKERTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I S+E++ + ++ G+ I+ALRGD+ E K YA DL+ +K
Sbjct: 83 LEAAPHLTCIDASREQLREIAQDYWESGIRHIVALRGDLPQ--EGGKPDMYAADLVSLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E +FDI A YPE HP++ + +D+ NLK K+DAG + +TQ FFD E + F+D+C
Sbjct: 141 -EVGDFDISVAAYPEVHPEAKSAQADLINLKHKIDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
GIDV I GI+P+ N Q L+ T N+ +P + D ++DPE+ + G + A+
Sbjct: 200 ATGIDVEIVPGILPVSNFKQ-LQKFATMTNVRVPNWMTTMFDGLDNDPETRKMVGASIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAELS---YAICHTL 290
>gi|78187206|ref|YP_375249.1| 5,10-methylenetetrahydrofolate reductase [Pelodictyon luteolum DSM
273]
gi|78167108|gb|ABB24206.1| 5,10-methylenetetrahydrofolate reductase [Pelodictyon luteolum DSM
273]
Length = 289
Score = 158 bits (399), Expect = 5e-37, Method: Composition-based stats.
Identities = 103/285 (36%), Positives = 159/285 (55%), Gaps = 6/285 (2%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLAD 79
L T++ P SFE FPP E + + + P ++SVT + + T L
Sbjct: 7 LNTAEKPVFSFEFFPPKKDEDWETLFDTIKALSPLNPSYVSVTYGAGG-STRTRTHDLVT 65
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGV----EPLKDF 135
IQ + + ++HL I S+E+ L G+N +LALRGD G E +KDF
Sbjct: 66 RIQKETGLSVVSHLTCIASSREETGIILENYRRHGINNVLALRGDKPAGAATLAEAIKDF 125
Query: 136 RYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDN 195
+A DL+ FIK+ P+F + A +PEGHP++PN++++I+ LK+KVDAG +VTQLFFDN
Sbjct: 126 PHAIDLVGFIKSNYPDFGVGVAGFPEGHPETPNRLTEIEYLKEKVDAGADYIVTQLFFDN 185
Query: 196 ERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPE 255
F+DF+D+C LAGI VPI AGIMP+ + +R+ + +P + + + E
Sbjct: 186 RDFFDFRDRCRLAGITVPIIAGIMPVTTKKGMIRMSELALGARIPAPLQEKVMAASSEGE 245
Query: 256 SLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHS 300
+ + G+ +A Q+ +LV V G+H YT+N A+ I+ H+
Sbjct: 246 -VASIGIEWATCQVQELVDNHVRGIHFYTLNMADATLRIFRNLHA 289
>gi|16416900|gb|AAL18459.1| unknown [Photorhabdus luminescens]
Length = 294
Score = 158 bits (399), Expect = 5e-37, Method: Composition-based stats.
Identities = 93/274 (33%), Positives = 146/274 (53%), Gaps = 8/274 (2%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
+SFE FPP + + +++ + P F+SVT N ++ T + I+ +
Sbjct: 25 VSFEFFPPRTTEMEKTLWKSINRLSTLKPKFVSVTYGANSGE-RDRTHSIIKGIKEKTGL 83
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
HL I S++++ + R+ G+ I+ALRGD+ E K Y +DL+E +K
Sbjct: 84 EAAPHLTCIDASRDELCEIARDYWKNGIRHIVALRGDLPENGEKPK--MYGSDLVELLKK 141
Query: 148 EAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTL 207
EA +FDI A YPE HP++ + +D+ +LK+K+DAG + +TQ FFD E + F+D+C
Sbjct: 142 EA-DFDISVAAYPEVHPEAKSSQADLISLKRKIDAGANRAITQFFFDVESYLRFRDRCVA 200
Query: 208 AGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAVD 267
AGIDV I GI+P+ N Q L+ N+ +P + D + DPES G + A+D
Sbjct: 201 AGIDVEIVPGILPVSNFRQ-LKRFAVMTNVRIPSWMTRMFDGLDDDPESANLVGASIAMD 259
Query: 268 QIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
+ L + V H YT+N AE + Y H+L
Sbjct: 260 MVKILSREGVKDFHFYTLNRAELS---YAICHTL 290
>gi|32474881|ref|NP_867875.1| 5,10-methylenetetrahydrofolate reductase [Rhodopirellula baltica SH
1]
gi|32445421|emb|CAD75422.1| 5,10-methylenetetrahydrofolate reductase [Rhodopirellula baltica SH
1]
Length = 294
Score = 157 bits (398), Expect = 6e-37, Method: Composition-based stats.
Identities = 86/275 (31%), Positives = 149/275 (54%), Gaps = 7/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE+FPP + G E + ++ + P + + T + + TT+ + ++
Sbjct: 17 AISFELFPPKTSEGVELLCKNVERLMQFGPKYFTCTYGAGGSS-QGTTLEVLQKVKQITK 75
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK----DFRYATDLI 142
+P +HL + + +++ L E +GV+ I+ALRGD G + +YA +L+
Sbjct: 76 LPVASHLTCVGSTVKELEAYLTEAGRIGVDYIVALRGDPPKGTTQFEVTEGGLKYANELV 135
Query: 143 EFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
E I+ + I A YPE H ++ + +D+ NLK+KVDAG ++TQLF+DN+ FY F+
Sbjct: 136 ELIRGRFGDLGIAVAGYPETHQEAVDFQTDLTNLKRKVDAGADIVITQLFYDNDDFYRFR 195
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D C GI+VPI GI+P+ N QA R+ C+ +P+ + + + + D + R G+
Sbjct: 196 DACEKVGIEVPIVPGILPVTNFKQAKRIASMCKAA-IPQSLESAMTEADDDQDQFR-VGV 253
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEA 297
+A Q +DLV V G+H Y +N +E A + +
Sbjct: 254 EHARQQTIDLVNNGVPGIHYYVLNKSEAAAELLDG 288
>gi|120555954|ref|YP_960305.1| 5,10-methylenetetrahydrofolate reductase [Marinobacter aquaeolei
VT8]
gi|120325803|gb|ABM20118.1| 5,10-methylenetetrahydrofolate reductase [Marinobacter aquaeolei
VT8]
Length = 289
Score = 157 bits (397), Expect = 7e-37, Method: Composition-based stats.
Identities = 91/273 (33%), Positives = 143/273 (52%), Gaps = 10/273 (3%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVT---ASNNKYNIKETTVPLADHIQND 84
SFE FPP G EK+ + + P F SVT + + ET + L H Q
Sbjct: 11 FSFEFFPPKTDQGKEKLQAVRNQLAEVNPDFFSVTFGAGGSTRDRTIETVLNL--HQQ-- 66
Query: 85 LAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEF 144
I T HL + ++E++ + L G+NRI+ALRGD+ G+ + RYA +L+EF
Sbjct: 67 -GISTAPHLSCVGGTREEIGELLDVYKENGINRIVALRGDMPSGMGASGELRYANELVEF 125
Query: 145 IKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQD 203
I+ + + F++ A YPE HP + N D++N +KV AG +S +TQ FF+ + ++ F D
Sbjct: 126 IRQHSGDHFNLEVAAYPEFHPQARNAEEDLKNFARKVQAGANSAITQYFFNADSYFYFID 185
Query: 204 KCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLA 263
+ G+ +P+ GIMPI+N + +R C +PR R L+ Y D +S+R G
Sbjct: 186 RLEQMGVTIPVVPGIMPIVNFSSLVRFSDMC-GAEIPRWIRKQLEAYGDDTDSIRKFGEE 244
Query: 264 YAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
+ L+ G+H YT+N AE + I++
Sbjct: 245 VVTEMCQKLLKAGAPGLHFYTLNQAEPSLSIWK 277
>gi|146284248|ref|YP_001174401.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas stutzeri
A1501]
gi|145572453|gb|ABP81559.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas stutzeri
A1501]
Length = 283
Score = 157 bits (397), Expect = 8e-37, Method: Composition-based stats.
Identities = 91/278 (32%), Positives = 144/278 (51%), Gaps = 4/278 (1%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLAD 79
+ +S PS+SFE FP G+EK+L + G P F S T + ++ T+
Sbjct: 1 MTSSNRPSISFEFFPTKTEAGHEKLLNVARQLAGYQPDFFSCTYGAGG-STRDRTLNTVL 59
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK-DFRYA 138
+ ++ IPT HL + +K ++ + L + G+ RI+ALRGD+ G+ + RYA
Sbjct: 60 QLDGEVKIPTAPHLSCVGDTKAQLRELLNLYKSAGIQRIVALRGDLPSGMGMASGELRYA 119
Query: 139 TDLIEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNER 197
+L+EFI+AE +F I A YPE HP + N D+ N +K AG S +TQ FF+ +
Sbjct: 120 NELVEFIRAETGDHFHIEIAAYPEMHPQARNFEDDLANFVRKAKAGADSAITQYFFNADC 179
Query: 198 FYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESL 257
++ F ++ G+ P+ GIMPI N ++ R C +PR R L+ Y D +S+
Sbjct: 180 YFYFVERVRKLGVQTPVVPGIMPITNYSKLARFSDAC-GAEIPRWVRKQLEAYGDDMQSI 238
Query: 258 RAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
+A G + L+ G+H YT+N AE + I+
Sbjct: 239 QAFGEQVITEMCQKLLAGGAPGLHFYTLNQAEPSLAIW 276
>gi|148244912|ref|YP_001219606.1| 5,10-methylenetetrahydrofolate reductase [Candidatus
Vesicomyosocius okutanii HA]
gi|146326739|dbj|BAF61882.1| 5,10-methylenetetrahydrofolate reductase [Candidatus
Vesicomyosocius okutanii HA]
Length = 273
Score = 157 bits (397), Expect = 9e-37, Method: Composition-based stats.
Identities = 93/265 (35%), Positives = 136/265 (51%), Gaps = 3/265 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
+SFE FPP G EK++ + +P + S T S ++TT+ IQ + I
Sbjct: 3 ISFEFFPPKTEQGKEKLIQVRQSLSVVSPKYFSTT-SGAGGTTQDTTLETVLDIQKNNNI 61
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
P HL I L K + + L + A+ +N I+ALRGDI + + DF YA +L+EFI++
Sbjct: 62 PATPHLSCIGLKKSNIIELLDKYKAININHIIALRGDIPSSIRNMGDFNYANELVEFIRS 121
Query: 148 E-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ NF+I A YPE HP + N SD+ + KV AG + +TQ F++ + ++ FQD
Sbjct: 122 KYNDNFNIEVAAYPEMHPQAKNIKSDLTHFVNKVKAGANGAITQYFYNADAYFRFQDDVQ 181
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
GI++PI GIMPI N + L C +P+ L YE+D ESL G
Sbjct: 182 KLGINIPITPGIMPITNYTKLLNFSNMC-GAQIPKWILERLKFYENDLESLNDFGFDVVA 240
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETA 291
+ L Q V H Y+MN E +
Sbjct: 241 NLCQTLKNQGVNSFHFYSMNLVEPS 265
>gi|77956365|ref|ZP_00820470.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Yersinia
bercovieri ATCC 43970]
Length = 294
Score = 157 bits (396), Expect = 9e-37, Method: Composition-based stats.
Identities = 92/275 (33%), Positives = 148/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + E + ++D + P F+SVT N ++ T + I+
Sbjct: 24 NVSFEFFPPRTSEMEETLWSSIDRLSTLKPKFVSVTYGANSGE-RDRTHSIIKGIKERTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL + S ++ D + + G+ I+ALRGD+ P + K YA+DL+ +K
Sbjct: 83 LEAAPHLTCVDASPTQLRDIAADYWSSGIRHIVALRGDLPP--DSGKPEMYASDLVTLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ +FDI A YPE HP++ + +D+ NLK+K+DAG + +TQ FFD E + F+D+C
Sbjct: 141 -DVGDFDISVAAYPEVHPEAKSAQADLINLKRKIDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
GIDV I GI+P+ N Q L+ T N+ +P I + ++DPE+ + G + A+
Sbjct: 200 ATGIDVEIVPGILPVSNFKQ-LQRFATMTNVRVPNWMTTIFEGLDNDPETRKMVGASVAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAELS---YAICHTL 290
>gi|78064854|ref|YP_367623.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia sp. 383]
gi|77965599|gb|ABB06979.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia sp. 383]
Length = 276
Score = 157 bits (396), Expect = 1e-36, Method: Composition-based stats.
Identities = 95/270 (35%), Positives = 142/270 (52%), Gaps = 4/270 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
LSFE FPP A G EK+ + P F+S T + ++ T+ +Q D +
Sbjct: 6 LSFEFFPPKTAEGVEKLRATRAQLLPLKPKFVSCTFGAGG-STQQGTLDTVLDMQKD-GL 63
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
HL I S++ + L + + G+ I+ALRGD+ G+ + + RYA++L+ FI+A
Sbjct: 64 EAAPHLSCIGSSRDSLRAILDQYRSYGIRHIVALRGDLPSGMGEVGELRYASELVSFIRA 123
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E + F I A YPE HP + + +D++N +KV AG +S +TQ FF+ + ++ F D
Sbjct: 124 EHGDWFHIEVAGYPEYHPQARSPKADLENFARKVKAGANSAITQYFFNADAYFRFVDDAR 183
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G+DVPI GIMPI N +Q +R + C +PR L+ + D ES+RA G
Sbjct: 184 KLGVDVPIVPGIMPITNFSQLMRFSEMC-GAEVPRWVARRLESFGDDRESIRAFGADVVT 242
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
LV V G+H YT+N A R I E
Sbjct: 243 SLCQRLVDAGVPGLHFYTLNTAAATRTICE 272
>gi|110597927|ref|ZP_01386209.1| 5,10-methylenetetrahydrofolate reductase [Chlorobium ferrooxidans
DSM 13031]
gi|110340504|gb|EAT58990.1| 5,10-methylenetetrahydrofolate reductase [Chlorobium ferrooxidans
DSM 13031]
Length = 328
Score = 157 bits (396), Expect = 1e-36, Method: Composition-based stats.
Identities = 99/279 (35%), Positives = 149/279 (53%), Gaps = 8/279 (2%)
Query: 26 PSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDL 85
P SFE FPP E + + + P ++SVT + + T L IQ +
Sbjct: 52 PVFSFEFFPPKKDEEWETLFKTIAALSPLNPSYVSVTYGAGG-STRSRTHDLVTKIQRET 110
Query: 86 AIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGV----EPLKDFRYATDL 141
+ ++HL I +E+ L+ G+N +LALRGD G E +KDF +A DL
Sbjct: 111 GLTVVSHLTCICSDREETGSILQNYRDNGINNVLALRGDKPAGTATLAEAIKDFPHAIDL 170
Query: 142 IEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDF 201
I FIK P+ + A +PEGHP++PN++ +I LK+K+DAG +VTQLFFDN F+DF
Sbjct: 171 IRFIKTNYPDIGVGVAGFPEGHPETPNRLQEIDYLKEKIDAGADYIVTQLFFDNRDFFDF 230
Query: 202 QDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKF-RAILDKYEHDPESLRAA 260
++CT+AGI VPI GIMPI R +R+ + +P + +L D + +
Sbjct: 231 VERCTIAGITVPIIPGIMPITTRKGMIRMSELALGARVPAPLMKKVLSA--SDDAGVASV 288
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATH 299
G+ +A Q+ +L+ + GVH YT+N A+ I+ H
Sbjct: 289 GIEWATMQVQELIDNHIKGVHFYTLNMADATLRIFNNLH 327
>gi|49083086|gb|AAT50943.1| PA0430 [synthetic construct]
Length = 291
Score = 157 bits (396), Expect = 1e-36, Method: Composition-based stats.
Identities = 91/282 (32%), Positives = 146/282 (51%), Gaps = 4/282 (1%)
Query: 17 KVKLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVP 76
K +M+ SFE FP G+EK+L A ++ G P F S T + ++ T+
Sbjct: 5 KEPIMSQSERRFSFEFFPAKTEAGHEKLLAAARNLAGYKPDFFSCTYGAGG-STRDRTLS 63
Query: 77 LADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK-DF 135
+ ++ +PT HL + SK ++ + L G+ RI+ALRGD+ G+ +
Sbjct: 64 TVLQLDGEVKVPTAPHLSCVGDSKAELRELLGRYREAGIRRIVALRGDLPSGMGMASGEL 123
Query: 136 RYATDLIEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFD 194
RYA +L++FI+ E +F I A YPE HP + + D+ N +KV AG SS +TQ FF+
Sbjct: 124 RYANELVDFIRTETGDHFHIEVAAYPEVHPQARSFEDDLANFVRKVKAGASSAITQYFFN 183
Query: 195 NERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDP 254
+ ++ F ++ G+D+P+ GIMPI N ++ R C LPR R L+ Y D
Sbjct: 184 ADAYFYFVERVAKLGVDIPVVPGIMPITNYSKLARFSDAC-GAELPRWIRKQLEAYGDDS 242
Query: 255 ESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
S++A G + L+ G+H YT+N A+ + I++
Sbjct: 243 RSIQAFGEQVISEMCERLLEGGAPGLHFYTLNQADPSLAIWK 284
>gi|107024376|ref|YP_622703.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia cenocepacia
AU 1054]
gi|116688298|ref|YP_833921.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia cenocepacia
HI2424]
gi|105894565|gb|ABF77730.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia cenocepacia
AU 1054]
gi|116646387|gb|ABK07028.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia cenocepacia
HI2424]
Length = 276
Score = 157 bits (396), Expect = 1e-36, Method: Composition-based stats.
Identities = 96/270 (35%), Positives = 144/270 (53%), Gaps = 4/270 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
LSFE FPP A G EK+ + P F+SVT + ++ T+ +Q D +
Sbjct: 6 LSFEFFPPKTADGVEKLRATRAQLLPLKPKFVSVTFGAGG-STQQGTLDTVLDMQKD-GL 63
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
HL I S++ + L + + G+ I+ALRGD+ G+ + + RYA++L+ FI+A
Sbjct: 64 EAAPHLSCIGSSRDSLRAILDQYRSHGIRHIVALRGDLPSGMGEVGELRYASELVSFIRA 123
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E + F I A YPE HP S + +D++N +KV AG +S +TQ FF+ + ++ F D
Sbjct: 124 EHGDWFHIEVAGYPEYHPQSRSPKADLENFARKVKAGANSAITQYFFNADAYFRFVDDAR 183
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G+DVPI GIMPI N +Q +R + C +PR L+ + D ES+RA G
Sbjct: 184 KLGVDVPIVPGIMPITNFSQLMRFSEMC-GAEVPRWVARRLESFGDDRESIRAFGADVVT 242
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
+ L+ V G+H YT+N A R I E
Sbjct: 243 NLCQRLIDAGVPGLHFYTLNLATATRTICE 272
>gi|84363502|ref|ZP_00988081.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Burkholderia
dolosa AUO158]
gi|124893500|gb|EAY67380.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia dolosa
AUO158]
Length = 276
Score = 157 bits (396), Expect = 1e-36, Method: Composition-based stats.
Identities = 96/270 (35%), Positives = 143/270 (52%), Gaps = 4/270 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
LSFE FPP A G EK+ + P F+SVT + ++ T+ +Q D +
Sbjct: 6 LSFEFFPPKTADGVEKLRATRAQLLPLKPKFVSVTFGAGG-STQQGTLDTVLDMQKD-GL 63
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
HL I S++ + L + + G+ I+ALRGD+ G+ + + RYA++L+ FI+A
Sbjct: 64 EAAPHLSCIGSSRDSLRAILDQYRSHGIRHIVALRGDLPSGMGEVGELRYASELVSFIRA 123
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E + F I A YPE HP S + +D++N +KV AG +S +TQ FF+ + ++ F D
Sbjct: 124 EHGDWFHIEVAAYPEYHPQSRSPKADLENFARKVKAGANSAITQYFFNADAYFRFVDDVR 183
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G+DVPI GIMPI N +Q +R + C +PR L+ + D ES+RA G
Sbjct: 184 KLGVDVPIVPGIMPITNFSQLMRFSEMC-GAEVPRWVARRLESFGDDRESIRAFGADVVT 242
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ V G+H YT+N A R I E
Sbjct: 243 SLCRRLLDAGVPGLHFYTLNAAAATRTICE 272
>gi|88705488|ref|ZP_01103199.1| 5,10-methylenetetrahydrofolate reductase [gamma proteobacterium KT
71]
gi|88700578|gb|EAQ97686.1| 5,10-methylenetetrahydrofolate reductase [Congregibacter litoralis
KT71]
Length = 278
Score = 157 bits (396), Expect = 1e-36, Method: Composition-based stats.
Identities = 96/274 (35%), Positives = 139/274 (50%), Gaps = 5/274 (1%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKIL-LALDDMKGSAPHFISVTASNNKYNIKETTVPLADHI 81
S++ ++SFE FP G EK+L + +++ P F SVT + ++ T + + +
Sbjct: 2 SKSAAISFEYFPAKTDAGREKLLNVTTPELQAVGPEFYSVTYGAGG-STRDNTRGIVEGL 60
Query: 82 QNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDL 141
N + HL + +A L++ A G+ R++ALRGD+ G YA +L
Sbjct: 61 -NAQGLDVAPHLSFGLDDEATIAALLQDYKAAGIKRLVALRGDLPSGAGGGARLVYANEL 119
Query: 142 IEFIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
+ FI+ N F I A YPE HP + + SDI LK K DAG S +TQ F++ E ++
Sbjct: 120 VAFIREHTGNHFHIEVAAYPEIHPQAESYESDIHYLKGKFDAGADSAITQYFYNVEAYFY 179
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
F D+C GID PIYAGIMPI N R K C +PR L+ + D ES+RA
Sbjct: 180 FLDRCAAIGIDKPIYAGIMPITNYANLARFSKNC-GAEIPRWISKRLEGFADDQESIRAF 238
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHI 294
G+ L+ D G+H YTMN A+ I
Sbjct: 239 GIDVVTQLCQTLLESDAPGIHFYTMNQAQPTLQI 272
>gi|33593993|ref|NP_881637.1| putative methylenetetrahydrofolate reductase [Bordetella pertussis
Tohama I]
gi|33594915|ref|NP_882558.1| putative methylenetetrahydrofolate reductase [Bordetella
parapertussis 12822]
gi|33599190|ref|NP_886750.1| putative methylenetetrahydrofolate reductase [Bordetella
bronchiseptica RB50]
gi|33564067|emb|CAE43335.1| putative methylenetetrahydrofolate reductase [Bordetella pertussis
Tohama I]
gi|33564991|emb|CAE39938.1| putative methylenetetrahydrofolate reductase [Bordetella
parapertussis]
gi|33575236|emb|CAE30699.1| putative methylenetetrahydrofolate reductase [Bordetella
bronchiseptica RB50]
Length = 280
Score = 156 bits (395), Expect = 1e-36, Method: Composition-based stats.
Identities = 93/285 (32%), Positives = 145/285 (50%), Gaps = 9/285 (3%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLAD 79
+ S P+ S E FPP E+++ A M P ++SVT T AD
Sbjct: 1 MTQSTAPAFSLEFFPPRDIAAQERLVRAAKQMLAIQPRYVSVTFGAGG----STRAGTAD 56
Query: 80 HIQN--DLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVE-PLKDFR 136
++ +L HL I +++++ D L GV R++ALRGD+ G+ + R
Sbjct: 57 TVRTLRNLGCDAAPHLSCIGATRDQLRDILAAYREQGVRRLVALRGDLPSGMGGDAGELR 116
Query: 137 YATDLIEFIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDN 195
YA+DL+ FI+ E + F I A YPE HP + + +D+ + KV AG + +TQ FF+
Sbjct: 117 YASDLVAFIRQETGDWFHIEVAAYPEMHPQAESPSADLAHFVNKVQAGADAAITQYFFNP 176
Query: 196 ERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPE 255
+ ++DF ++ G+ +PI GIMPI N Q +R + C +PR R L +Y D
Sbjct: 177 DAYFDFVERAQAKGVAIPIVPGIMPITNHTQLVRFSEMC-GAEIPRWIRLRLAEYGDDKA 235
Query: 256 SLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHS 300
S+RA GL + L+ GVH YT+N+AE I++A ++
Sbjct: 236 SIRAFGLDVVSELCQTLLENGAPGVHFYTLNHAEATLGIWKALNA 280
>gi|104783957|ref|YP_610455.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas entomophila
L48]
gi|95112944|emb|CAK17672.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas]
Length = 281
Score = 156 bits (395), Expect = 2e-36, Method: Composition-based stats.
Identities = 92/275 (33%), Positives = 140/275 (50%), Gaps = 4/275 (1%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
SQ SFE FP G+EK++ + P F S T + ++ T+ ++
Sbjct: 2 SQERRYSFEFFPTKTDAGHEKLMGVARQLASYNPDFFSCTYGAGG-STRDRTLNTVLQLE 60
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK-DFRYATDL 141
+++ +P HL + SK+ + L E A G+ RI+ALRGD+ G+ + RYA+DL
Sbjct: 61 SEVKVPAAPHLSCVGDSKDDLRALLAEYKAAGIKRIVALRGDLPSGMGMASGELRYASDL 120
Query: 142 IEFIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
+EFI+ E N F + A YPE HP + N D+ N KV AG S +TQ FF+ + ++
Sbjct: 121 VEFIRQETGNHFHLEVAAYPEMHPQARNFEVDLANFAHKVKAGADSAITQYFFNADSYFY 180
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
F ++ G+D+P+ GIMPI N N+ R C +PR R L+ Y D S++A
Sbjct: 181 FVERAQKLGVDIPVVPGIMPITNYNKLARFSDAC-GAEIPRWIRKQLEAYADDTASIQAF 239
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
G L+ G+H YT+N AE + I+
Sbjct: 240 GEEVITRMCEQLLQGGAPGLHFYTLNQAEPSLAIW 274
>gi|118711673|ref|ZP_01564247.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia cenocepacia
MC0-3]
gi|118651007|gb|EAV57798.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia cenocepacia
MC0-3]
Length = 276
Score = 156 bits (395), Expect = 2e-36, Method: Composition-based stats.
Identities = 96/270 (35%), Positives = 143/270 (52%), Gaps = 4/270 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
LSFE FPP A G EK+ + P F+SVT + ++ T+ +Q D +
Sbjct: 6 LSFEFFPPKTADGVEKLRATRAQLLPLKPKFVSVTFGAGG-STQQGTLDTVLDMQKD-GL 63
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
HL I S++ + L + + G+ I+ALRGD+ G+ + + RYA++L+ FI+A
Sbjct: 64 EAAPHLSCIGSSRDSLRAILDQYRSHGIRHIVALRGDLPSGMGEVGELRYASELVSFIRA 123
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E + F I A YPE HP S + +D++N +KV AG +S +TQ FF+ + ++ F D
Sbjct: 124 EHGDWFHIEVAGYPEYHPQSRSPKADLENFARKVKAGANSAITQYFFNADAYFRFVDDAR 183
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G+DVPI GIMPI N +Q +R + C +PR L+ + D ES+RA G
Sbjct: 184 KLGVDVPIVPGIMPITNFSQLMRFSEMC-GAEVPRWVARRLESFGDDRESIRAFGADVVT 242
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ V G+H YT+N A R I E
Sbjct: 243 SLCQRLIDAGVPGLHFYTLNLATATRTICE 272
>gi|118594099|ref|ZP_01551446.1| metF; 5,10-methylenetetrahydrofolate reductase oxidoreductase
protein [Methylophilales bacterium HTCC2181]
gi|118439877|gb|EAV46504.1| metF; 5,10-methylenetetrahydrofolate reductase oxidoreductase
protein [Methylophilales bacterium HTCC2181]
Length = 277
Score = 156 bits (394), Expect = 2e-36, Method: Composition-based stats.
Identities = 91/264 (34%), Positives = 141/264 (53%), Gaps = 4/264 (1%)
Query: 26 PSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDL 85
P +SFE FPP G + + L + ++ P F SVT + KE T+ I+ L
Sbjct: 5 PPISFEFFPPRNEEGMQNLELVIKNLNLFDPDFYSVTFGAGG-STKEKTLETVLKIKG-L 62
Query: 86 AIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFI 145
+ H+ I SK++++ L+ + +N+I+ALRGD G DF+YA +L+ FI
Sbjct: 63 GSSAVPHISCISSSKKEISQVLKAYQSHNINQIVALRGDNPSGAVNYGDFKYANELVNFI 122
Query: 146 KAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDK 204
+ E +F I A YPE HP++ + D+ N K+K+DAG S +TQ FF+ + ++ F ++
Sbjct: 123 REETGDHFLIEVAAYPEFHPEALSAKDDMDNFKRKIDAGASGAITQFFFNVDAYFKFMEE 182
Query: 205 CTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAY 264
C I++PI GIMPI N Q R C + +PR + L+ Y D ESLR+ G+
Sbjct: 183 CQKRSINIPIVPGIMPIYNIKQLSRFSANCGS-EIPRWLKMKLEDYGDDLESLRSYGIDV 241
Query: 265 AVDQIVDLVTQDVAGVHLYTMNNA 288
+ L+ V VH YT+N +
Sbjct: 242 ITELCETLIQYGVPSVHFYTLNQS 265
>gi|71905825|ref|YP_283412.1| 5,10-methylenetetrahydrofolate reductase [Dechloromonas aromatica
RCB]
gi|71845446|gb|AAZ44942.1| 5,10-methylenetetrahydrofolate reductase [Dechloromonas aromatica
RCB]
Length = 274
Score = 156 bits (394), Expect = 2e-36, Method: Composition-based stats.
Identities = 89/270 (32%), Positives = 135/270 (50%), Gaps = 4/270 (1%)
Query: 26 PSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDL 85
P +S E FPP G EK+ ++ PHF SVT + +E T + I +
Sbjct: 3 PEISIEFFPPQTPEGIEKLRTVRAELAKLNPHFFSVTYGAGG-STRERTFAVVKEIAAE- 60
Query: 86 AIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFI 145
HL I ++E + + L E + G+ R +ALRGD+ G+ +FRYA +L+EFI
Sbjct: 61 GFDAAPHLSCIGSTRESIREILAEYKSAGIKRTVALRGDLPSGMAEAGEFRYANELVEFI 120
Query: 146 KAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDK 204
+AE + F I A YPE HP + + D++ +KV AG +S +TQ F++ + ++ F D+
Sbjct: 121 RAETGDWFSIEVAAYPEWHPQARSPKDDLEAFARKVKAGANSAITQYFYNADAYFHFVDE 180
Query: 205 CTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAY 264
G+DVPI GIMPI + R C +PR R + + D +S+RA GL
Sbjct: 181 AKALGVDVPIIPGIMPIAGFTKLARFSDAC-GADIPRWMRKKFESFGDDADSIRAFGLDV 239
Query: 265 AVDQIVDLVTQDVAGVHLYTMNNAETARHI 294
+ L+ G+H Y MN + I
Sbjct: 240 VTELCERLLKGGAPGLHFYAMNQSALTTEI 269
>gi|113971767|ref|YP_735560.1| 5,10-methylenetetrahydrofolate reductase [Shewanella sp. MR-4]
gi|114046024|ref|YP_736574.1| 5,10-methylenetetrahydrofolate reductase [Shewanella sp. MR-7]
gi|117922048|ref|YP_871240.1| 5,10-methylenetetrahydrofolate reductase [Shewanella sp. ANA-3]
gi|113886451|gb|ABI40503.1| 5,10-methylenetetrahydrofolate reductase [Shewanella sp. MR-4]
gi|113887466|gb|ABI41517.1| 5,10-methylenetetrahydrofolate reductase [Shewanella sp. MR-7]
gi|117614380|gb|ABK49834.1| 5,10-methylenetetrahydrofolate reductase [Shewanella sp. ANA-3]
Length = 297
Score = 156 bits (394), Expect = 2e-36, Method: Composition-based stats.
Identities = 96/275 (34%), Positives = 147/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP+ + + ++ ++ P F+SVT N +++ T + + IQ +
Sbjct: 24 NVSFEFFPPSTPEMEQILWNSIRRLEPLNPKFVSVTYGANS-GVRDRTHGVIERIQKETN 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL + S E++ D + G+ I+ALRGD+ P P K R+A DL+ ++
Sbjct: 83 LVAAPHLTLVDASDEELLDLAKHYWKSGIRDIVALRGDL-PAGSP-KPTRFAADLVRLLR 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ A +FDI A YPE HPD+ N +D+ NLK+K+DAG S +TQ FFD E + F+D+C
Sbjct: 141 SVA-DFDISVAAYPEVHPDAANAQADLINLKRKIDAGASRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N Q L+ N+ LP D E+D + + G A+
Sbjct: 200 AAGIDVEIVPGILPVTNFTQ-LKRFAGMTNVSLPSWLHKQFDGLENDAGTRQLVGANVAI 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE Y H+L
Sbjct: 259 DMVKVLSREGVKDFHFYTLNRAELT---YAICHTL 290
>gi|126358338|ref|ZP_01715337.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas putida GB-1]
gi|126317103|gb|EAZ68024.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas putida GB-1]
Length = 281
Score = 156 bits (394), Expect = 2e-36, Method: Composition-based stats.
Identities = 92/275 (33%), Positives = 142/275 (51%), Gaps = 4/275 (1%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
SQ SFE FP G+EK++ + P F S T + ++ T+ ++
Sbjct: 2 SQERRYSFEFFPTKTDAGHEKLMGVARQLATYNPDFFSCTYGAGG-STRDRTLNTVLQLE 60
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK-DFRYATDL 141
N++ +P HL + SK+ + L E A G+ RI+ALRGD+ G+ + RYA+DL
Sbjct: 61 NEVKVPAAPHLSCVGDSKDDLRALLAEYKAAGIKRIVALRGDLPSGMGMASGELRYASDL 120
Query: 142 IEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
+EFI+ E A +F + A YPE HP + N +D+ N KV AG S +TQ FF+ + ++
Sbjct: 121 VEFIRQETADHFHLEVAAYPEMHPQARNFETDLANFVHKVKAGADSAITQYFFNADSYFY 180
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
F ++ G+D+P+ GIMPI N ++ R C +PR R L+ Y D S++A
Sbjct: 181 FVERAQKLGVDIPVVPGIMPITNYSKLARFSDAC-GAEIPRWIRKQLEAYADDTASIQAF 239
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
G L+ G+H YT+N AE + I+
Sbjct: 240 GEEVITRMCEQLLQGGAPGLHFYTLNQAEPSLAIW 274
>gi|134294350|ref|YP_001118085.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia
vietnamiensis G4]
gi|134137507|gb|ABO53250.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia
vietnamiensis G4]
Length = 276
Score = 156 bits (394), Expect = 2e-36, Method: Composition-based stats.
Identities = 95/270 (35%), Positives = 143/270 (52%), Gaps = 4/270 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
LSFE FPP A G EK+ + P F+SVT + ++ T+ +Q D +
Sbjct: 6 LSFEFFPPKTADGVEKLRATRAQLLPLKPKFVSVTFGAGG-STQQGTLDTVLDMQKD-GL 63
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
HL I S++ + L + + G+ I+ALRGD+ G+ + + RYA++L+ FI+A
Sbjct: 64 EAAPHLSCIGSSRDSLRAILDQYRSHGIRHIVALRGDLPSGMGEVGELRYASELVSFIRA 123
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E + F I A YPE HP S + +D+QN +KV AG +S +TQ FF+ + ++ F D
Sbjct: 124 EHGDWFHIEVAGYPEYHPQSRSPAADLQNFARKVKAGANSAITQYFFNADAYFRFVDDAR 183
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G+DVPI GIMPI N +Q +R + C +PR L+ + D +++RA G
Sbjct: 184 KLGVDVPIVPGIMPITNFSQLMRFSEMC-GAEVPRWVARRLESFGDDRDAIRAFGADVVT 242
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ V G+H YT+N A R I E
Sbjct: 243 GLCQRLIDAGVPGLHFYTLNAAAATRTICE 272
>gi|127511456|ref|YP_001092653.1| 5,10-methylenetetrahydrofolate reductase [Shewanella loihica PV-4]
gi|126636751|gb|ABO22394.1| 5,10-methylenetetrahydrofolate reductase [Shewanella loihica PV-4]
Length = 296
Score = 156 bits (394), Expect = 2e-36, Method: Composition-based stats.
Identities = 95/275 (34%), Positives = 146/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + ++ ++ P F+SVT N +++ T + + IQ +
Sbjct: 24 NVSFEFFPPATPEMETILWNSIRRLEPLKPKFVSVTYGANS-GVRDRTHGVIERIQKETD 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL + S E++ + + G+ I+ALRGD+ P P K R+A DL+ +K
Sbjct: 83 LVAAPHLTLVDASDEELVELAKHYWNSGIRDIVALRGDL-PAGSP-KPTRFANDLVRLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ A +FDI A YPE HPD+PN +D+ NLKKK+DAG + +TQ FFD E + F+D+C
Sbjct: 141 SVA-DFDISVAAYPEVHPDAPNAQADLINLKKKIDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N Q L+ N+ +P + + DP + + G A+
Sbjct: 200 AAGIDVEIVPGILPVTNFTQ-LKRFAGMTNVSIPSWLHKQFEGLDDDPSTRQMVGANVAI 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE Y H+L
Sbjct: 259 DMVKVLSREGVKDFHFYTLNRAELT---YAICHTL 290
>gi|74318535|ref|YP_316275.1| 5,10-methylenetetrahydrofolate reductase (FADH) [Thiobacillus
denitrificans ATCC 25259]
gi|74058030|gb|AAZ98470.1| 5,10-methylenetetrahydrofolate reductase (FADH) [Thiobacillus
denitrificans ATCC 25259]
Length = 276
Score = 156 bits (394), Expect = 2e-36, Method: Composition-based stats.
Identities = 97/277 (35%), Positives = 138/277 (49%), Gaps = 6/277 (2%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADH 80
MT +T SFE FPP A G EK+ + P F SVT + ++ T+
Sbjct: 1 MTERT--FSFEFFPPKTAEGVEKLRATRKQLAQLHPKFFSVTFGAGG-STRDRTLETVRE 57
Query: 81 IQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATD 140
IQ D HL I + + + D L E G+ ++ALRGD+ G +F YA +
Sbjct: 58 IQAD-GSEAAPHLSCIGSTADNLRDILGEYKNQGIRHLVALRGDLPSGTFDAGEFNYANE 116
Query: 141 LIEFIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFY 199
L+ FI+ E + F+I A YPE HP + + D+ N K+KVDAG ++ +TQ FF+ + ++
Sbjct: 117 LVAFIRKETGDWFEIEVAAYPEVHPQARSYGEDLANFKRKVDAGANAAITQYFFNADAYF 176
Query: 200 DFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRA 259
F D G+ +PI GIMPI N Q R C +PR R L+ Y D S+RA
Sbjct: 177 RFVDDARALGVSIPIVPGIMPIGNYVQLARFSDAC-GAEIPRWLRKKLESYGDDLTSIRA 235
Query: 260 AGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
GL D L+ G+H YTMN A + I++
Sbjct: 236 FGLDVVTDLCDRLLAGGAPGLHFYTMNQAGPSTTIWQ 272
>gi|121603404|ref|YP_980733.1| 5,10-methylenetetrahydrofolate reductase [Polaromonas
naphthalenivorans CJ2]
gi|120592373|gb|ABM35812.1| 5,10-methylenetetrahydrofolate reductase [Polaromonas
naphthalenivorans CJ2]
Length = 276
Score = 155 bits (393), Expect = 2e-36, Method: Composition-based stats.
Identities = 93/268 (34%), Positives = 134/268 (50%), Gaps = 4/268 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
+SFE FPP G +K+ L + P F SVT + +E T IQ + +
Sbjct: 5 VSFEFFPPKTPEGADKLRLTRQALYAHLPEFCSVTFGAGG-STQEGTFSTVKAIQEE-GV 62
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
+H + +K V + L L A+GV R++ALRGD+ G +F YA+DL+ FI+A
Sbjct: 63 AAASHFSCVGATKSTVREQLGALRAMGVKRLVALRGDLPSGYGMGGEFHYASDLVAFIRA 122
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E + F I A YPE HP + + +D+ KV AG +S +TQ FF+ + ++ F D
Sbjct: 123 ETGDAFHIEVAAYPEIHPQAKSADADLNAFATKVRAGANSAITQYFFNADAYFRFVDDVR 182
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G++VP+ GIMPI + Q +R C +PR R L Y D S+++ GL
Sbjct: 183 RLGVEVPVVPGIMPITSSTQLMRFSDAC-GAEIPRWIRLRLQGYGDDTASIKSFGLDVIT 241
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHI 294
D L V G+H YTMN A I
Sbjct: 242 DLCGQLCAAGVPGIHFYTMNQAAATTEI 269
>gi|77960049|ref|ZP_00823947.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Yersinia
mollaretii ATCC 43969]
Length = 294
Score = 155 bits (393), Expect = 2e-36, Method: Composition-based stats.
Identities = 92/275 (33%), Positives = 147/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + E + ++D + P F+SVT N ++ T + I+
Sbjct: 24 NVSFEFFPPRTSEMEETLWSSIDRLSTLKPKFVSVTYGANSGE-RDRTHSIIKGIKERTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL + S ++ D + G+ I+ALRGD+ P + K YA+DL+ +K
Sbjct: 83 LEAAPHLTCVDASPTQLRDIAADYWNSGIRHIVALRGDLPP--DSGKPEMYASDLVTLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ +FDI A YPE HP++ + +D+ NLK+K+DAG + +TQ FFD E + F+D+C
Sbjct: 141 -DVGDFDISVAAYPEVHPEAKSAQADLINLKRKIDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
GIDV I GI+P+ N Q L+ T N+ +P I + ++DPE+ + G + A+
Sbjct: 200 ATGIDVEIVPGILPVSNFKQ-LQRFATMTNVRVPNWMTTIFEGLDNDPETRKMVGASVAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAELS---YAICHTL 290
>gi|126642375|ref|YP_001085359.1| 510-methylenetetrahydrofolate reductase [Acinetobacter baumannii
ATCC 17978]
gi|126388259|gb|ABO12757.1| 510-methylenetetrahydrofolate reductase [Acinetobacter baumannii
ATCC 17978]
Length = 296
Score = 155 bits (393), Expect = 2e-36, Method: Composition-based stats.
Identities = 94/275 (34%), Positives = 140/275 (50%), Gaps = 5/275 (1%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADH 80
MT +TP +SFE FPP G EK+ + +++ P F S+T + T + D
Sbjct: 19 MTKRTP-ISFEFFPPKTDAGAEKLRIVHQELQQLNPEFFSITYGAGGSTRERTLAAIEDF 77
Query: 81 IQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATD 140
N P HL I K ++A+ L A G++RI+ALRGD+ G L + YA D
Sbjct: 78 --NGKGTPVAPHLSCIGDDKTRIAELLDLYKAQGIDRIVALRGDLPSGQVGLGELPYAQD 135
Query: 141 LIEFIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFY 199
L+ FI+ + + F I A YPE HP + + SDIQ +KV AG ++ +TQ FF+ + ++
Sbjct: 136 LVRFIREHSGDHFHIEVAAYPEMHPQAQSLDSDIQRFIEKVQAGANAGITQFFFNPDSYF 195
Query: 200 DFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRA 259
F ++ AGI++P+ GIMPI N + +R +PR R L Y D ES++A
Sbjct: 196 YFIERLEKAGINIPVAPGIMPITNASNLIRFADG-TGAEIPRWIRKQLQAYGDDSESIKA 254
Query: 260 AGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHI 294
G V L+ +H Y+MN E R +
Sbjct: 255 FGHEVVVKLCERLIAGGAPSLHFYSMNQVEPTRQL 289
>gi|77461502|ref|YP_351009.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas fluorescens
PfO-1]
gi|77385505|gb|ABA77018.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas fluorescens
PfO-1]
Length = 281
Score = 155 bits (393), Expect = 2e-36, Method: Composition-based stats.
Identities = 91/275 (33%), Positives = 140/275 (50%), Gaps = 4/275 (1%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
SQ SFE FP G+EK+L + P F S T + ++ T+ ++
Sbjct: 2 SQDRRYSFEFFPTKTDAGHEKLLATARQLATYKPDFFSCTYGAGG-STRDRTLNTVLQLE 60
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK-DFRYATDL 141
+++ IP HL + SK+ + L E A G+ RI+ALRGD+ G+ + R+A +L
Sbjct: 61 SEVKIPAAPHLSCVGDSKDDLRGLLNEYKAAGIKRIVALRGDLPSGMGMTSGELRHANEL 120
Query: 142 IEFIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
+EFI+ E N F I A YPE HP + N D+ N +K AG S +TQ FF+ + ++
Sbjct: 121 VEFIREETGNHFHIEVAAYPEMHPQARNYEDDLANFVRKARAGADSAITQYFFNADSYFY 180
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
F D+ G+D+P+ GIMPI N ++ R C +PR R L+ Y D +S++
Sbjct: 181 FVDRLQALGVDIPVVPGIMPITNYSKLARFSDAC-GAEIPRWIRKQLEAYGDDSQSIQRF 239
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
G + L+ G+H Y+MN AE + I+
Sbjct: 240 GEQVVTEMCERLLQGGAPGLHFYSMNQAEPSLAIW 274
>gi|84356259|ref|ZP_00981113.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Burkholderia
cenocepacia PC184]
gi|124871553|gb|EAY63269.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia cenocepacia
PC184]
Length = 276
Score = 155 bits (393), Expect = 2e-36, Method: Composition-based stats.
Identities = 96/270 (35%), Positives = 142/270 (52%), Gaps = 4/270 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
LSFE FPP A G EK+ + P F+SVT + ++ T+ +Q D +
Sbjct: 6 LSFEFFPPKTADGVEKLRATRAQLLPLKPKFVSVTFGAGG-STQQGTLDTVLDMQKD-GL 63
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
HL I S++ + L + + G+ I+ALRGD+ G+ + + RYA++L+ FI+A
Sbjct: 64 EAAPHLSCIGSSRDSLRAILDQYRSHGIRHIVALRGDLPSGMGEVGELRYASELVSFIRA 123
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E + F I A YPE HP S + +D++N +KV AG +S +TQ FF+ + ++ F D
Sbjct: 124 EHGDWFHIEVAGYPEYHPQSRSPKADLENFARKVKAGANSAITQYFFNADAYFRFVDDAR 183
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G+DVPI GIMPI N +Q +R + C +PR L+ + D ES+RA G
Sbjct: 184 KLGVDVPIVPGIMPITNFSQLMRFSEMC-GAEVPRWVARRLESFGDDRESIRAFGADVVT 242
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ V G H YT+N A R I E
Sbjct: 243 SLCQRLIDAGVPGPHFYTLNAATATRTICE 272
>gi|77976264|ref|ZP_00831769.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Yersinia
intermedia ATCC 29909]
Length = 294
Score = 155 bits (393), Expect = 3e-36, Method: Composition-based stats.
Identities = 93/275 (33%), Positives = 146/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + E + ++D + P F+SVT N ++ T + I+
Sbjct: 24 NVSFEFFPPRTSEMEETLWNSIDRLSTLKPKFVSVTYGANSGE-RDRTHSIIKGIKERTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I S ++ D + G+ I+ALRGD+ P K YA+DL+ +K
Sbjct: 83 LEAAPHLTCIDASPTQLRDIATDYWNSGIRHIVALRGDLPPNSG--KPEMYASDLVTLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ +FDI A YPE HP++ + +D+ NLK+K+DAG + +TQ FFD E + F+D+C
Sbjct: 141 -DVGDFDISVAAYPEVHPEAKSAQADLINLKRKIDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
GIDV I GI+P+ N Q L+ T N+ +P +I + + DPE+ + G + A+
Sbjct: 200 ATGIDVEIVPGILPVSNFKQ-LQRFATMTNVRVPHWMSSIFEGLDDDPETRKMVGASVAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAELS---YAICHTL 290
>gi|91227302|ref|ZP_01261727.1| 5,10-methylenetetrahydrofolate reductase [Vibrio alginolyticus
12G01]
gi|91188696|gb|EAS74985.1| 5,10-methylenetetrahydrofolate reductase [Vibrio alginolyticus
12G01]
Length = 300
Score = 155 bits (392), Expect = 3e-36, Method: Composition-based stats.
Identities = 97/279 (34%), Positives = 147/279 (52%), Gaps = 8/279 (2%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
S ++SFE FPP+ A E + ++ +K P F+SVT N ++ T + I+
Sbjct: 20 SDNINVSFEFFPPSSAKMEETLWNSVHRLKTLQPKFVSVTYGANSGE-RDRTHSIIKEIK 78
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLI 142
+ HL I ++E++ + + G+ I+ALRGDI PG YA+DL+
Sbjct: 79 ATTGLVAAPHLTCIDATREELINIADDYWNNGIENIVALRGDIPPGGGAPD--MYASDLV 136
Query: 143 EFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
E +K+ +FDI A +PE HP++ + SD+ NLK+KVDAG + +TQ FFD E + F+
Sbjct: 137 ELLKSRH-DFDISVAAFPEVHPEAKSAQSDLLNLKRKVDAGANRAITQFFFDVESYLRFR 195
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D+C AGIDV I GI+P+ N QA R N+ +P D + DP + + G
Sbjct: 196 DRCVAAGIDVEIVPGILPVSNFKQASRFAAQ-NNVKVPGWMSKQFDGLDDDPVTRQLVGA 254
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
+ A+D + L + V H YT+N AE Y H+L
Sbjct: 255 SQAIDMVRVLSREGVKDFHFYTLNRAEMT---YALCHTL 290
>gi|86147309|ref|ZP_01065623.1| 5,10-methylenetetrahydrofolate reductase [Vibrio sp. MED222]
gi|85834874|gb|EAQ53018.1| 5,10-methylenetetrahydrofolate reductase [Vibrio sp. MED222]
Length = 299
Score = 155 bits (392), Expect = 3e-36, Method: Composition-based stats.
Identities = 97/279 (34%), Positives = 147/279 (52%), Gaps = 8/279 (2%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
S ++SFE FPP+ E + ++ +K P F+SVT N ++ T + I+
Sbjct: 20 SDNINVSFEFFPPSSEKMEETLWNSVHRLKTLQPKFVSVTYGANSGE-RDRTHSIIKEIK 78
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLI 142
N + HL I S+E++ + A G+ I+ALRGDI P D YA+DL+
Sbjct: 79 NQTGLVAAPHLTCIDASREELIQIADDYWANGIESIVALRGDI-PAGGGAPDM-YASDLV 136
Query: 143 EFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
E +K+ +FDI A +PE HP++ + SD+ NLK+KVDAG + +TQ FFD E + F+
Sbjct: 137 ELLKSRH-DFDISVAAFPEVHPEAKSAQSDLINLKRKVDAGANRAITQFFFDVESYLRFR 195
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D+C AG+DV I GI+P+ N QA R N+ +P + + DP + + G
Sbjct: 196 DRCVAAGVDVEIVPGILPVSNFKQASR-FAAMNNVKVPGWMAKQFEGLDDDPTTRQLVGA 254
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
+ A+D + L + V H YT+N AE Y H+L
Sbjct: 255 SQAIDMVRTLSREGVKDFHFYTLNRAEMT---YALCHTL 290
>gi|84390837|ref|ZP_00991529.1| 5,10-methylenetetrahydrofolate reductase [Vibrio splendidus 12B01]
gi|84376640|gb|EAP93517.1| 5,10-methylenetetrahydrofolate reductase [Vibrio splendidus 12B01]
Length = 299
Score = 155 bits (392), Expect = 3e-36, Method: Composition-based stats.
Identities = 96/279 (34%), Positives = 147/279 (52%), Gaps = 8/279 (2%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
S ++SFE FPP+ E + ++ +K P F+SVT N ++ T + I+
Sbjct: 20 SDNINVSFEFFPPSSEKMEETLWNSVHRLKTLQPKFVSVTYGANSGE-RDRTHSIIKEIK 78
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLI 142
N + HL I S+E++ + A G+ I+ALRGDI G + YA+DL+
Sbjct: 79 NQTGLVAAPHLTCIDASREELIQIADDYWANGIESIVALRGDIPAGGGAPE--MYASDLV 136
Query: 143 EFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
E +K+ +FDI A +PE HP++ + SD+ NLK+KVDAG + +TQ FFD E + F+
Sbjct: 137 ELLKSRH-DFDISVAAFPEVHPEAKSAQSDLINLKRKVDAGANRAITQFFFDVESYLRFR 195
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D+C AG+DV I GI+P+ N QA R N+ +P + + DP + + G
Sbjct: 196 DRCVAAGVDVEIVPGILPVSNFKQASR-FAAMNNVKVPGWMAKQFEGLDDDPTTRQLVGA 254
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
+ A+D + L + V H YT+N AE Y H+L
Sbjct: 255 SQAIDMVRTLSREGVKDFHFYTLNRAEMT---YALCHTL 290
>gi|118720061|ref|ZP_01572589.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia multivorans
ATCC 17616]
gi|118656743|gb|EAV63495.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia multivorans
ATCC 17616]
Length = 276
Score = 155 bits (392), Expect = 3e-36, Method: Composition-based stats.
Identities = 94/270 (34%), Positives = 143/270 (52%), Gaps = 4/270 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
LSFE FPP A G EK+ + P F+SVT + ++ T+ +Q D +
Sbjct: 6 LSFEFFPPKTADGVEKLRATRAQLLPLKPKFVSVTFGAGG-STQQGTLDTVLDMQKD-GL 63
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
HL I S++ + L + + G+ I+ALRGD+ G+ + + RYA++L+ FI+A
Sbjct: 64 DAAPHLSCIGSSRDSLRAILDQYRSCGIRHIVALRGDLPSGMGSVGELRYASELVSFIRA 123
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E + F I A YPE HP + + +D++N +KV AG +S +TQ FF+ + ++ F D
Sbjct: 124 EHGDWFHIEVAGYPEYHPQARSPKADLENFARKVKAGANSAITQYFFNADAYFRFVDDVR 183
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G+DVPI GIMPI N +Q +R + C +PR L+ + D ES+RA G
Sbjct: 184 KLGVDVPIVPGIMPITNFSQLMRFSEMC-GAEVPRWVARRLESFGDDRESIRAFGADVVT 242
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ V G+H YT+N A + I E
Sbjct: 243 GLCQRLIDAGVPGLHFYTLNAAAATKAICE 272
>gi|152999088|ref|YP_001364769.1| 5,10-methylenetetrahydrofolate reductase [Shewanella baltica OS185]
gi|151363706|gb|ABS06706.1| 5,10-methylenetetrahydrofolate reductase [Shewanella baltica OS185]
Length = 295
Score = 155 bits (391), Expect = 4e-36, Method: Composition-based stats.
Identities = 95/275 (34%), Positives = 147/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP+ + + ++ ++ P F+SVT N +++ T + + IQ +
Sbjct: 24 NVSFEFFPPSTPEMEQILWNSIRRLEPLNPKFVSVTYGANS-GVRDRTHGVIERIQQETD 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL + S E++ + + G+ I+ALRGD+ P P K R+A DL+ ++
Sbjct: 83 LVAAPHLTLVDASDEELLELAKHYWKSGIRDIVALRGDL-PAGSP-KPTRFAVDLVRLLR 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ A +FDI A YPE HPD+ N +D+ NLK+K+DAG S +TQ FFD E + F+D+C
Sbjct: 141 SVA-DFDISVAAYPEVHPDASNAQADLINLKRKIDAGASRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N Q L+ N+ LP D E+D + + G A+
Sbjct: 200 AAGIDVEIVPGILPVTNFTQ-LKRFAGMTNVSLPNWLHKQFDGLENDAGTRQLVGANVAI 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE Y H+L
Sbjct: 259 DMVKVLSREGVKDFHFYTLNRAELT---YAICHTL 290
>gi|24375541|ref|NP_719584.1| 5,10-methylenetetrahydrofolate reductase [Shewanella oneidensis
MR-1]
gi|24350417|gb|AAN57028.1|AE015836_10 5,10-methylenetetrahydrofolate reductase [Shewanella oneidensis
MR-1]
Length = 297
Score = 155 bits (391), Expect = 4e-36, Method: Composition-based stats.
Identities = 95/275 (34%), Positives = 147/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP+ + + ++ ++ P F+SVT N +++ T + + IQ +
Sbjct: 24 NVSFEFFPPSTPEMEQILWNSIRRLEPLNPKFVSVTYGANS-GVRDRTHGVIERIQQETN 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL + S E++ + + G+ I+ALRGD+ P P K R+A DL+ ++
Sbjct: 83 LVAAPHLTLVDASDEELLELAKHYWKSGIRDIVALRGDL-PAGSP-KPTRFAVDLVRLLR 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ A +FDI A YPE HPD+ N +D+ NLK+K+DAG S +TQ FFD E + F+D+C
Sbjct: 141 SVA-DFDISVAAYPEVHPDAANAQADLINLKRKIDAGASRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N Q L+ N+ LP D E+D + + G A+
Sbjct: 200 AAGIDVEIVPGILPVTNFTQ-LKRFAGMTNVSLPSWLHKQFDGLENDAGTRQLVGANVAI 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE Y H+L
Sbjct: 259 DMVKVLSREGVKDFHFYTLNRAELT---YAICHTL 290
>gi|15595627|ref|NP_249121.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas aeruginosa
PAO1]
gi|84318650|ref|ZP_00967071.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Pseudomonas
aeruginosa C3719]
gi|84324517|ref|ZP_00972575.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Pseudomonas
aeruginosa 2192]
gi|107099416|ref|ZP_01363334.1| hypothetical protein PaerPA_01000428 [Pseudomonas aeruginosa PACS2]
gi|116054161|ref|YP_788604.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas aeruginosa
UCBPP-PA14]
gi|9946287|gb|AAG03819.1|AE004480_3 5,10-methylenetetrahydrofolate reductase [Pseudomonas aeruginosa
PAO1]
gi|115589382|gb|ABJ15397.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas aeruginosa
UCBPP-PA14]
gi|126169268|gb|EAZ54779.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas aeruginosa
C3719]
gi|126196906|gb|EAZ60969.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas aeruginosa
2192]
Length = 290
Score = 155 bits (391), Expect = 4e-36, Method: Composition-based stats.
Identities = 90/282 (31%), Positives = 145/282 (51%), Gaps = 4/282 (1%)
Query: 17 KVKLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVP 76
K +M+ SFE FP G+EK+L ++ G P F S T + ++ T+
Sbjct: 5 KEPIMSQSERRFSFEFFPAKTEAGHEKLLATARNLAGYKPDFFSCTYGAGG-STRDRTLS 63
Query: 77 LADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK-DF 135
+ ++ +PT HL + SK ++ + L G+ RI+ALRGD+ G+ +
Sbjct: 64 TVLQLDGEVKVPTAPHLSCVGDSKAELRELLGRYREAGIRRIVALRGDLPSGMGMASGEL 123
Query: 136 RYATDLIEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFD 194
RYA +L++FI+ E +F I A YPE HP + + D+ N +KV AG SS +TQ FF+
Sbjct: 124 RYANELVDFIRTETGDHFHIEVAAYPEVHPQARSFEDDLANFVRKVKAGASSAITQYFFN 183
Query: 195 NERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDP 254
+ ++ F ++ G+D+P+ GIMPI N ++ R C LPR R L+ Y D
Sbjct: 184 ADAYFYFVERVAKLGVDIPVVPGIMPITNYSKLARFSDAC-GAELPRWIRKQLEAYGDDS 242
Query: 255 ESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
S++A G + L+ G+H YT+N A+ + I++
Sbjct: 243 RSIQAFGEQVISEMCERLLEGGAPGLHFYTLNQADPSLAIWK 284
>gi|118593283|ref|ZP_01550668.1| Methylenetetrahydrofolate reductase:5,10-methylenetetrahydrofolate
reductase [Stappia aggregata IAM 12614]
gi|118434174|gb|EAV40830.1| Methylenetetrahydrofolate reductase:5,10-methylenetetrahydrofolate
reductase [Stappia aggregata IAM 12614]
Length = 304
Score = 155 bits (391), Expect = 4e-36, Method: Composition-based stats.
Identities = 90/267 (33%), Positives = 145/267 (54%), Gaps = 10/267 (3%)
Query: 29 SFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAIP 88
SFE FPP E + + + +P F+SVT + +E T + I + +
Sbjct: 20 SFEFFPPKSDKMAETLWQTVQRLAPLSPSFVSVTYGAGG-STRERTHRTVERILKETELA 78
Query: 89 TIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGV------EPLKDFRYATDLI 142
AHL + ++ ++ +++ +GV ++ALRGD + G+ P + + YA+DL+
Sbjct: 79 PAAHLTCVGAARSEIDTIVKDYWDLGVRHLVALRGDPLDGIGSRYVPHP-EGYAYASDLV 137
Query: 143 EFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
E +K A NFDI + YPE HP+S N +I NLK+KVDAG ++TQ FFDN+ F D+
Sbjct: 138 EGVKKIA-NFDISVSGYPERHPESGNWQKEIDNLKRKVDAGADRIITQYFFDNDLFDDYL 196
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D+ AGI++P+ GI+PI N Q + C +P+ +DPE+ + G+
Sbjct: 197 DRIAAAGINIPVIPGILPIHNFEQTMVFSAKC-GTSIPQWLARRFAGLSNDPETRKLVGV 255
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAE 289
+ A +Q++DLV + + H YTMN A+
Sbjct: 256 SVACEQVMDLVDRGINDFHFYTMNRAD 282
>gi|16120462|ref|NP_403775.1| 5,10-methylenetetrahydrofolate reductase [Yersinia pestis CO92]
gi|22124221|ref|NP_667644.1| 5,10-methylenetetrahydrofolate reductase [Yersinia pestis KIM]
gi|45439982|ref|NP_991521.1| 5,10-methylenetetrahydrofolate reductase [Yersinia pestis biovar
Microtus str. 91001]
gi|51594465|ref|YP_068656.1| 5,10-methylenetetrahydrofolate reductase [Yersinia
pseudotuberculosis IP 32953]
gi|77635858|ref|ZP_00797938.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Yersinia pestis
Angola]
gi|89105834|ref|ZP_01178347.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Yersinia pestis
biovar Orientalis str. IP275]
gi|108806264|ref|YP_650180.1| 5,10-methylenetetrahydrofolate reductase [Yersinia pestis Antiqua]
gi|108813897|ref|YP_649664.1| 5,10-methylenetetrahydrofolate reductase [Yersinia pestis Nepal516]
gi|145601032|ref|YP_001165108.1| 5,10-methylenetetrahydrofolate reductase [Yersinia pestis Pestoides
F]
gi|150260801|ref|ZP_01917529.1| 5,10-methylenetetrahydrofolate reductase [Yersinia pestis
CA88-4125]
gi|153950445|ref|YP_001399123.1| 5,10-methylenetetrahydrofolate reductase [Yersinia
pseudotuberculosis IP 31758]
gi|21956983|gb|AAM83895.1|AE013629_6 5,10-methylenetetrahydrofolate reductase [Yersinia pestis KIM]
gi|45434837|gb|AAS60398.1| 5,10-methylenetetrahydrofolate reductase [Yersinia pestis biovar
Microtus str. 91001]
gi|51587747|emb|CAH19347.1| 5,10-methylenetetrahydrofolate reductase [Yersinia
pseudotuberculosis IP 32953]
gi|108777545|gb|ABG20064.1| 5,10-methylenetetrahydrofolate reductase [Yersinia pestis Nepal516]
gi|108778177|gb|ABG12235.1| 5,10-methylenetetrahydrofolate reductase [Yersinia pestis Antiqua]
gi|115345941|emb|CAL18804.1| 5,10-methylenetetrahydrofolate reductase [Yersinia pestis CO92]
gi|145212728|gb|ABP42135.1| 5,10-methylenetetrahydrofolate reductase [Yersinia pestis Pestoides
F]
gi|149290209|gb|EDM40286.1| 5,10-methylenetetrahydrofolate reductase [Yersinia pestis
CA88-4125]
gi|152961940|gb|ABS49401.1| 5,10-methylenetetrahydrofolate reductase [Yersinia
pseudotuberculosis IP 31758]
Length = 294
Score = 155 bits (391), Expect = 4e-36, Method: Composition-based stats.
Identities = 93/275 (33%), Positives = 146/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I+
Sbjct: 24 NVSFEFFPPRTSEMEDTLWSSIDRLSTLKPKFVSVTYGANSGE-RDRTHSIIKGIKERTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I S ++ D + G+ I+ALRGD+ P K YA DL+ +K
Sbjct: 83 LEAAPHLTCIDASPTQLRDIAIDYWNSGIRHIVALRGDLPPNSG--KPEMYACDLVGLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ +FDI A YPE HP++ + +D+ NLK+K+DAG + +TQ FFD E + F+D+C
Sbjct: 141 -DVGDFDISVAAYPEIHPEAKSAQADLINLKRKIDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
GIDV I GI+P+ N Q L+ T N+ +P +I D ++DPE+ + G + A+
Sbjct: 200 ATGIDVEIVPGILPVSNFKQ-LQRFATMTNVRVPNWMTSIFDGLDNDPETRKMVGASVAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAELS---YAICHTL 290
>gi|115421264|emb|CAJ47769.1| 5,10-methylenetetrahydrofolate reductase [Bordetella avium 197N]
Length = 280
Score = 155 bits (391), Expect = 4e-36, Method: Composition-based stats.
Identities = 91/282 (32%), Positives = 143/282 (50%), Gaps = 11/282 (3%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVT---ASNNKYNIKETTVP 76
+ S +P++S E FPP E+++ A M P ++SVT + + +ET
Sbjct: 1 MTDSTSPAISLEFFPPRDIAAQERLVRAAKQMLAVQPSYVSVTFGAGGSTRAGTEETVRT 60
Query: 77 LADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVE-PLKDF 135
L + L HL I S+E++ L GV R++ALRGD+ G+ +
Sbjct: 61 LTN-----LGCDAAPHLSCIGSSREQLRSILDHYREAGVRRVVALRGDLPSGMGGDAGEL 115
Query: 136 RYATDLIEFIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFD 194
R+A DL+ FI+ E + F I A YPE HP + + +D+ + KV AG ++ +TQ FF+
Sbjct: 116 RHAVDLVRFIREETGDWFHIEVAAYPEMHPQATSPTADLGHFVSKVQAGANAAITQYFFN 175
Query: 195 NERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDP 254
+ ++DF D+ G+ +PI GIMPI N +Q R + C LPR R L ++ D
Sbjct: 176 ADAYFDFVDRAQARGVTIPIVPGIMPITNYSQLSRFSEMC-GAELPRWIRLRLAEFGDDK 234
Query: 255 ESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
S+RA G+ L+ V G+H YT+N +E I++
Sbjct: 235 ASIRAFGVDVVTKLCQTLLDHGVPGLHFYTLNQSEATLSIWK 276
>gi|29655326|ref|NP_821018.1| 5,10-methylenetetrahydrofolate reductase [Coxiella burnetii RSA
493]
gi|95927833|ref|ZP_01310586.1| hypothetical protein CburR_01000414 [Coxiella burnetii RSA 331]
gi|29542598|gb|AAO91532.1| 5,10-methylenetetrahydrofolate reductase [Coxiella burnetii RSA
493]
Length = 290
Score = 155 bits (391), Expect = 4e-36, Method: Composition-based stats.
Identities = 96/290 (33%), Positives = 149/290 (51%), Gaps = 7/290 (2%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADH 80
M + SLSFE+FPP G E + ++ P + SVT N ++ T+ +
Sbjct: 1 MDASHLSLSFELFPPKTLTGFENLKSVWRTLQDKTPDYFSVTFGAGGGN-QDKTMRVVRA 59
Query: 81 IQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK--DFRYA 138
++ D I HL I LSK + D L +G+ RI+ALRGD+ P E + DF +A
Sbjct: 60 LRQDF-IEVAPHLTCIGLSKTAIFDLLNNYRLLGIKRIVALRGDL-PLEEDIAGGDFNHA 117
Query: 139 TDLIEFI-KAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNER 197
+L+ +I K F I A YPE HP++ ++N ++K+ AG + +TQ F++ +
Sbjct: 118 NELVAYIRKLTGDYFHIEVAAYPEFHPETRTVQEALKNFQQKIAAGANGAITQYFYNRDA 177
Query: 198 FYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESL 257
+++F D C GI+ PI GIMPI + ++ +R KTC +PR L+ Y++D SL
Sbjct: 178 YFNFVDACRNVGIEAPIVPGIMPISDFDKLVRFSKTCAT-EIPRWLYKRLESYKNDKASL 236
Query: 258 RAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFKHHSQ 307
+A G+ DL+ V G+H YT+N E + I E S+ Q
Sbjct: 237 KAYGVEVVTKLCEDLIAYGVPGLHFYTLNQCEPTQTIIENLQSITSFREQ 286
>gi|82546293|ref|YP_410240.1| 5,10-methylenetetrahydrofolate reductase [Shigella boydii Sb227]
gi|81247704|gb|ABB68412.1| 5,10-methylenetetrahydrofolate reductase [Shigella boydii Sb227]
Length = 296
Score = 155 bits (391), Expect = 4e-36, Method: Composition-based stats.
Identities = 96/293 (32%), Positives = 155/293 (52%), Gaps = 9/293 (3%)
Query: 9 SQQKSKTKKVKLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKY 68
SQ+ + +++ + Q ++SFE FPP + + + ++D + P F+SVT N
Sbjct: 7 SQRDALNQRLAEVQGQI-NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSG 65
Query: 69 NIKETTVPLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPG 128
++ T + I++ + HL I + +++ R+ G+ I+ALRGD+ PG
Sbjct: 66 E-RDRTHSIIKGIKDRTGLEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPG 124
Query: 129 VEPLKDFRYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLV 188
K YA+DL+ +K E +FDI A YPE HP++ + +D+ NLK+KVDAG + +
Sbjct: 125 SG--KPEMYASDLVTLLK-EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAI 181
Query: 189 TQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILD 248
TQ FFD E + F+D+C AGIDV I GI+P+ N QA + N+ +P + D
Sbjct: 182 TQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPAWMAQMFD 240
Query: 249 KYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
+ D E+ + G A+D + L + V H YT+N AE + Y H+L
Sbjct: 241 GLDDDAETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 290
>gi|83814829|ref|YP_446200.1| 5,10-methylenetetrahydrofolate reductase [Salinibacter ruber DSM
13855]
gi|83756223|gb|ABC44336.1| 5,10-methylenetetrahydrofolate reductase [Salinibacter ruber DSM
13855]
Length = 319
Score = 155 bits (391), Expect = 4e-36, Method: Composition-based stats.
Identities = 96/306 (31%), Positives = 155/306 (50%), Gaps = 35/306 (11%)
Query: 26 PSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKET------------ 73
P +S+E+ PP ++IL ++++ P FI VT+ + + K+
Sbjct: 13 PLISYEIIPPKRGGSADQILGVVEELMPYEPPFIDVTSHSAEVEYKQKDDGTWTRCVKRK 72
Query: 74 ---TVPLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGD------ 124
T+ L I+ I T+ H+ ++E+ D L EL+ +GV +LA+RGD
Sbjct: 73 RPGTIGLCAAIEARFDIDTVPHILCKGFTREETEDALIELNYLGVENVLAIRGDDNGYEK 132
Query: 125 -----------IIPGVEPLKDFRYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDI 173
+ V ++D T L + + AE +F + YPE H ++PN DI
Sbjct: 133 SISGNRSRNEYAVDLVRQIQDMNEGTYLEDLMDAEPTDFCVGVGGYPETHFEAPNLAWDI 192
Query: 174 QNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKT 233
LK++VDAG +VTQ+FFDNE F++F DKC GI+VPI G + IL R + LRLL
Sbjct: 193 MRLKEQVDAGADYIVTQMFFDNEYFFNFVDKCREVGIEVPIVPG-LKILKRKRHLRLLPK 251
Query: 234 CENIHLPRKFRAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARH 293
+ +P + A +D DP+ + G+ +A+ Q +L+ V G+H Y M++A+T +
Sbjct: 252 YFHTEIPEELAAEVDA--ADPDDVERIGVNWAIRQARELMEAGVPGIHFYIMSSADTVKK 309
Query: 294 IYEATH 299
+ E H
Sbjct: 310 VVEPMH 315
>gi|124545548|ref|ZP_01704741.1| 5,10-methylenetetrahydrofolate reductase [Shewanella putrefaciens
200]
gi|124510891|gb|EAY54958.1| 5,10-methylenetetrahydrofolate reductase [Shewanella putrefaciens
200]
Length = 295
Score = 155 bits (391), Expect = 4e-36, Method: Composition-based stats.
Identities = 95/275 (34%), Positives = 147/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP+ + + ++ ++ P F+SVT N +++ T + + IQ +
Sbjct: 24 NVSFEFFPPSTPEMEQILWNSIRRLEPLNPKFVSVTYGANS-GVRDRTHGVIERIQQETD 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL + S E++ + + G+ I+ALRGD+ P P K R+A DL+ ++
Sbjct: 83 LVAAPHLTLVDASDEELLELAKHYWKSGIRDIVALRGDL-PAGSP-KPTRFAVDLVRLLR 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ A +FDI A YPE HPD+ N +D+ NLK+K+DAG S +TQ FFD E + F+D+C
Sbjct: 141 SVA-DFDISVAAYPEVHPDASNAQADLINLKRKIDAGASRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N Q L+ N+ LP D E+D + + G A+
Sbjct: 200 AAGIDVEIVPGILPVTNFTQ-LKRFAGMTNVSLPNWLHKQFDGLENDAGTRQLVGANVAI 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE Y H+L
Sbjct: 259 DMVKVLSREGVKDFHFYTLNRAELT---YAICHTL 290
>gi|120600344|ref|YP_964918.1| 5,10-methylenetetrahydrofolate reductase [Shewanella sp. W3-18-1]
gi|146291724|ref|YP_001182148.1| 5,10-methylenetetrahydrofolate reductase [Shewanella putrefaciens
CN-32]
gi|120560437|gb|ABM26364.1| 5,10-methylenetetrahydrofolate reductase [Shewanella sp. W3-18-1]
gi|145563414|gb|ABP74349.1| 5,10-methylenetetrahydrofolate reductase [Shewanella putrefaciens
CN-32]
Length = 295
Score = 154 bits (390), Expect = 5e-36, Method: Composition-based stats.
Identities = 95/275 (34%), Positives = 147/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP+ + + ++ ++ P F+SVT N +++ T + + IQ +
Sbjct: 24 NVSFEFFPPSTPEMEQILWNSIRRLEPLNPKFVSVTYGANS-GVRDRTHGVIERIQQETD 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL + S E++ + + G+ I+ALRGD+ P P K R+A DL+ ++
Sbjct: 83 LVAAPHLTLVDASDEELLELAKHYWKSGIRDIVALRGDL-PAGSP-KPTRFAADLVRLLR 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ A +FDI A YPE HPD+ N +D+ NLK+K+DAG S +TQ FFD E + F+D+C
Sbjct: 141 SVA-DFDISVAAYPEVHPDASNAQADLINLKRKIDAGASRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N Q L+ N+ LP D E+D + + G A+
Sbjct: 200 AAGIDVEIVPGILPVTNFTQ-LKRFAGMTNVSLPNWLHKQFDGLENDAGTRQLVGANVAI 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE Y H+L
Sbjct: 259 DMVKVLSREGVKDFHFYTLNRAELT---YAICHTL 290
>gi|70733084|ref|YP_262857.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas fluorescens
Pf-5]
gi|68347383|gb|AAY94989.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas fluorescens
Pf-5]
Length = 288
Score = 154 bits (390), Expect = 5e-36, Method: Composition-based stats.
Identities = 92/283 (32%), Positives = 145/283 (51%), Gaps = 10/283 (3%)
Query: 21 MTSQTPSLS------FEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETT 74
M + PS+S FE FP G+EK+L + G P F S T + ++ T
Sbjct: 1 MQLEVPSMSKDRRYSFEFFPTKTDAGHEKLLATARQLAGYNPDFFSCTYGAGG-STRDRT 59
Query: 75 VPLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK- 133
V +++++ +P HL + SK+ + L++ A G+ RI+ALRGD+ G+
Sbjct: 60 VNTVLQLESEVKVPAAPHLSCVGDSKDDLRGLLQQYQAAGIKRIVALRGDLPSGMGMASG 119
Query: 134 DFRYATDLIEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLF 192
+ RYA DL+ FI+ E +F I A YPE HP + N D+ N +K +AG S +TQ F
Sbjct: 120 ELRYANDLVSFIREETGSHFHIEVAAYPEMHPQARNFEEDLVNFVRKANAGADSAITQYF 179
Query: 193 FDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEH 252
F+ + ++ F ++ G+++PI GIMPI N ++ R C +PR R L+ Y
Sbjct: 180 FNADSYFYFVERVQKMGVNIPIVPGIMPITNYSKLARFSDAC-GAEIPRWIRKQLEAYGD 238
Query: 253 DPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
D S++A G D L+ G+H YT+N A+ + I+
Sbjct: 239 DSASIQAFGEQVISDMCERLLQGGAPGLHFYTLNQADPSLAIW 281
>gi|153206974|ref|ZP_01945792.1| 5,10-methylenetetrahydrofolate reductase [Coxiella burnetii 'MSU
Goat Q177']
Length = 290
Score = 154 bits (390), Expect = 6e-36, Method: Composition-based stats.
Identities = 95/290 (32%), Positives = 150/290 (51%), Gaps = 7/290 (2%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADH 80
M + SLSFE+FPP G E + ++ P + SVT + ++ T+ +
Sbjct: 1 MDASHLSLSFELFPPKTLTGFENLKSVWRTLQDKTPDYFSVTFGAGGGS-QDKTMRVVRA 59
Query: 81 IQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK--DFRYA 138
++ D I HL I LSK ++D L +G+ RI+ALRGD+ P E + DF +A
Sbjct: 60 LRQDF-IEVAPHLTCIGLSKTAISDLLNNYRLLGIKRIVALRGDL-PLEEDIAGGDFNHA 117
Query: 139 TDLIEFI-KAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNER 197
+L+ +I K F I A YPE HP++ ++N ++K+ AG + +TQ F++ +
Sbjct: 118 NELVAYIRKLTGDYFHIKVAAYPEFHPETRTVQEALKNFQQKIAAGANGAITQYFYNRDA 177
Query: 198 FYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESL 257
+++F D C GI+ PI GIMPI + ++ +R KTC +PR L+ Y++D SL
Sbjct: 178 YFNFVDACRNVGIEAPIVPGIMPISDFDKLVRFSKTCAT-EIPRWLYKRLESYKNDKASL 236
Query: 258 RAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFKHHSQ 307
+A G+ DL+ V G+H YT+N E + I E S+ Q
Sbjct: 237 KAYGVEVVTKLCEDLIAYGVPGLHFYTLNQCEPTQTIIENLQSITSFREQ 286
>gi|119856482|ref|ZP_01637915.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas putida W619]
gi|119817441|gb|EAX20184.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas putida W619]
Length = 281
Score = 154 bits (390), Expect = 6e-36, Method: Composition-based stats.
Identities = 89/275 (32%), Positives = 142/275 (51%), Gaps = 4/275 (1%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
SQ SFE FP G+EK++ + P F S T + ++ T+ ++
Sbjct: 2 SQERRYSFEFFPTKTDAGHEKLMGVARQLAAYKPDFFSCTYGAGG-STRDRTLNTVLQLE 60
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK-DFRYATDL 141
N++ +P HL + +K+++ L E A G+ RI+ALRGD+ G+ + RYA+DL
Sbjct: 61 NEVKVPAAPHLSCVGDTKDELRALLAEYKAAGIKRIVALRGDLPSGMGMASGELRYASDL 120
Query: 142 IEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
+EFI+ E +F + A YPE HP + N +D+ N KV AG S +TQ FF+ + ++
Sbjct: 121 VEFIRQETGDHFHLEVAAYPEMHPQARNFEADLANFVHKVKAGADSAITQYFFNADSYFY 180
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
F ++ G+++P+ GIMPI N ++ R C +PR R L+ Y D S++A
Sbjct: 181 FVERAQKLGVEIPVVPGIMPITNYSKLARFSDAC-GAEIPRWIRKQLEAYADDTASIQAF 239
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
G L+ G+H YT+N AE + I+
Sbjct: 240 GEEVITRMCEQLLQGGAPGLHFYTLNQAEASLAIW 274
>gi|154706556|ref|YP_001425447.1| 5,10-methylenetetrahydrofolate reductase [Coxiella burnetii Dugway
7E9-12]
gi|154355842|gb|ABS77304.1| 5,10-methylenetetrahydrofolate reductase [Coxiella burnetii Dugway
7E9-12]
Length = 290
Score = 154 bits (390), Expect = 6e-36, Method: Composition-based stats.
Identities = 95/290 (32%), Positives = 150/290 (51%), Gaps = 7/290 (2%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADH 80
M + SLSFE+FPP G E + ++ P + SVT N ++ T+ +
Sbjct: 1 MDASHLSLSFELFPPKTLTGFENLKSVWRTLQDKTPDYFSVTFGAGGGN-QDKTMRVVRA 59
Query: 81 IQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK--DFRYA 138
++ D I HL I LSK ++D L +G+ RI+ALRGD+ P E + DF +A
Sbjct: 60 LRQDF-IEVAPHLTCIGLSKTAISDLLNNYRLLGIKRIVALRGDL-PLEEDIAGGDFNHA 117
Query: 139 TDLIEFI-KAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNER 197
+L+ +I K F I A YPE HP++ ++N ++K+ AG + +TQ F++ +
Sbjct: 118 NELVAYIRKLTGDYFHIEVAAYPEFHPETRTVQEALKNFQQKIAAGANGAITQYFYNRDA 177
Query: 198 FYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESL 257
+++F D C GI+ PI GIMPI + ++ ++ KTC +PR L+ Y++D SL
Sbjct: 178 YFNFVDACRNVGIEAPIVPGIMPISDFDKLVQFSKTCAT-EIPRWLYKRLESYKNDKASL 236
Query: 258 RAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSLFKHHSQ 307
+A G+ DL+ V G+H YT+N E + I E S+ Q
Sbjct: 237 KAYGVEVVTKLCEDLIAYGVPGLHFYTLNQCEPTQTIIENLQSITSFREQ 286
>gi|113947237|ref|ZP_01432903.1| 5,10-methylenetetrahydrofolate reductase [Shewanella baltica OS195]
gi|126175967|ref|YP_001052116.1| 5,10-methylenetetrahydrofolate reductase [Shewanella baltica OS155]
gi|149114902|ref|ZP_01841651.1| 5,10-methylenetetrahydrofolate reductase [Shewanella baltica OS223]
gi|113910345|gb|EAU28984.1| 5,10-methylenetetrahydrofolate reductase [Shewanella baltica OS195]
gi|125999172|gb|ABN63247.1| 5,10-methylenetetrahydrofolate reductase [Shewanella baltica OS155]
gi|146865351|gb|EDK50678.1| 5,10-methylenetetrahydrofolate reductase [Shewanella baltica OS223]
Length = 295
Score = 154 bits (390), Expect = 6e-36, Method: Composition-based stats.
Identities = 95/275 (34%), Positives = 147/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP+ + + ++ ++ P F+SVT N +++ T + + IQ +
Sbjct: 24 NVSFEFFPPSTPEMEQILWNSIRRLEPLNPKFVSVTYGANS-GVRDRTHGVIERIQQETD 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL + S E++ + + G+ I+ALRGD+ P P K R+A DL+ ++
Sbjct: 83 LVAAPHLTLVDASDEELLELAKHYWKSGIRDIVALRGDL-PAGSP-KPTRFAVDLVRLLR 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ A +FDI A YPE HPD+ N +D+ NLK+K+DAG S +TQ FFD E + F+D+C
Sbjct: 141 SVA-DFDISVAAYPEVHPDASNAQADLINLKRKIDAGASRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N Q L+ N+ LP D E+D + + G A+
Sbjct: 200 AAGIDVEIVPGILPVTNFTQ-LKRFAGMTNVSLPGWLHKQFDGLENDAGTRQLVGANVAI 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE Y H+L
Sbjct: 259 DMVKVLSREGVKDFHFYTLNRAELT---YAICHTL 290
>gi|16131779|ref|NP_418376.1| 5,10-methylenetetrahydrofolate reductase [Escherichia coli K12]
gi|24115235|ref|NP_709745.1| 5,10-methylenetetrahydrofolate reductase [Shigella flexneri 2a str.
301]
gi|30064766|ref|NP_838937.1| 5,10-methylenetetrahydrofolate reductase [Shigella flexneri 2a str.
2457T]
gi|74314446|ref|YP_312865.1| 5,10-methylenetetrahydrofolate reductase [Shigella sonnei Ss046]
gi|75176669|ref|ZP_00696797.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Shigella boydii
BS512]
gi|75188679|ref|ZP_00701946.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Escherichia coli
E24377A]
gi|75197814|ref|ZP_00707884.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Escherichia coli
HS]
gi|75209372|ref|ZP_00709608.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Escherichia coli
B171]
gi|75227810|ref|ZP_00714528.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Escherichia coli
B7A]
gi|75238387|ref|ZP_00722386.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Escherichia coli
E110019]
gi|75258074|ref|ZP_00729535.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Escherichia coli
E22]
gi|75513872|ref|ZP_00736225.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Escherichia coli
53638]
gi|83569790|ref|ZP_00921239.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Shigella
dysenteriae 1012]
gi|83586214|ref|ZP_00924850.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Escherichia coli
101-1]
gi|89110088|ref|AP_003868.1| 5,10-methylenetetrahydrofolate reductase [Escherichia coli W3110]
gi|110807801|ref|YP_691321.1| 5,10-methylenetetrahydrofolate reductase [Shigella flexneri 5 str.
8401]
gi|124527606|ref|ZP_01699071.1| 5,10-methylenetetrahydrofolate reductase [Escherichia coli B]
gi|84028093|sp|P0AEZ1|METF_ECOLI 5,10-methylenetetrahydrofolate reductase
gi|84028094|sp|P0AEZ2|METF_SHIFL 5,10-methylenetetrahydrofolate reductase
gi|42000|emb|CAA24747.1| unnamed protein product [Escherichia coli]
gi|305044|gb|AAB03073.1| 5,10 methylenetetrahydrofolate reductase [Escherichia coli]
gi|1790377|gb|AAC76923.1| 5,10-methylenetetrahydrofolate reductase [Escherichia coli K12]
gi|24054522|gb|AAN45452.1| 5,10-methylene-tetrahydrofolate reductase [Shigella flexneri 2a
str. 301]
gi|30043026|gb|AAP18748.1| 5,10-methylene-tetrahydrofolate reductase [Shigella flexneri 2a
str. 2457T]
gi|73857923|gb|AAZ90630.1| 5,10-methylenetetrahydrofolate reductase [Shigella sonnei Ss046]
gi|85676119|dbj|BAE77369.1| 5,10-methylenetetrahydrofolate reductase [Escherichia coli W3110]
gi|110617349|gb|ABF06016.1| 5,10-methylenetetrahydrofolate reductase [Shigella flexneri 5 str.
8401]
gi|124501308|gb|EAY48773.1| 5,10-methylenetetrahydrofolate reductase [Escherichia coli B]
gi|157069098|gb|ABV08353.1| 5,10-methylenetetrahydrofolate reductase [Escherichia coli HS]
gi|157079280|gb|ABV18988.1| 5,10-methylenetetrahydrofolate reductase [Escherichia coli E24377A]
Length = 296
Score = 154 bits (389), Expect = 7e-36, Method: Composition-based stats.
Identities = 93/275 (33%), Positives = 146/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I++
Sbjct: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIKGIKDRTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I + +++ R+ G+ I+ALRGD+ PG K YA+DL+ +K
Sbjct: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYASDLVTLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E +FDI A YPE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+D+C
Sbjct: 141 -EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA + N+ +P + D + D E+ + G A+
Sbjct: 200 SAGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 290
>gi|75765836|pdb|1ZP3|A Chain A, E. Coli Methylenetetrahydrofolate Reductase (Oxidized)
gi|75765837|pdb|1ZP3|B Chain B, E. Coli Methylenetetrahydrofolate Reductase (Oxidized)
gi|75765838|pdb|1ZP3|C Chain C, E. Coli Methylenetetrahydrofolate Reductase (Oxidized)
gi|75765848|pdb|1ZPT|A Chain A, Escherichia Coli Methylenetetrahydrofolate Reductase
(Reduced) Complexed With Nadh, Ph 7.25
gi|75765849|pdb|1ZPT|B Chain B, Escherichia Coli Methylenetetrahydrofolate Reductase
(Reduced) Complexed With Nadh, Ph 7.25
gi|75765850|pdb|1ZPT|C Chain C, Escherichia Coli Methylenetetrahydrofolate Reductase
(Reduced) Complexed With Nadh, Ph 7.25
gi|75765878|pdb|1ZRQ|A Chain A, Escherichia Coli Methylenetetrahydrofolate Reductase
(Reduced) Complexed With Nadh, Ph 6.0
gi|75765879|pdb|1ZRQ|B Chain B, Escherichia Coli Methylenetetrahydrofolate Reductase
(Reduced) Complexed With Nadh, Ph 6.0
gi|75765880|pdb|1ZRQ|C Chain C, Escherichia Coli Methylenetetrahydrofolate Reductase
(Reduced) Complexed With Nadh, Ph 6.0
Length = 304
Score = 154 bits (389), Expect = 7e-36, Method: Composition-based stats.
Identities = 93/275 (33%), Positives = 146/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I++
Sbjct: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIKGIKDRTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I + +++ R+ G+ I+ALRGD+ PG K YA+DL+ +K
Sbjct: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYASDLVTLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E +FDI A YPE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+D+C
Sbjct: 141 -EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA + N+ +P + D + D E+ + G A+
Sbjct: 200 SAGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 290
>gi|6729702|pdb|1B5T|A Chain A, Escherichia Coli Methylenetetrahydrofolate Reductase
gi|6729703|pdb|1B5T|B Chain B, Escherichia Coli Methylenetetrahydrofolate Reductase
gi|6729704|pdb|1B5T|C Chain C, Escherichia Coli Methylenetetrahydrofolate Reductase
Length = 275
Score = 154 bits (389), Expect = 7e-36, Method: Composition-based stats.
Identities = 93/275 (33%), Positives = 146/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I++
Sbjct: 4 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIKGIKDRTG 62
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I + +++ R+ G+ I+ALRGD+ PG K YA+DL+ +K
Sbjct: 63 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYASDLVTLLK 120
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E +FDI A YPE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+D+C
Sbjct: 121 -EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 179
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA + N+ +P + D + D E+ + G A+
Sbjct: 180 SAGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 238
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 239 DMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 270
>gi|15804538|ref|NP_290578.1| 5,10-methylenetetrahydrofolate reductase [Escherichia coli O157:H7
EDL933]
gi|15834124|ref|NP_312897.1| 5,10-methylenetetrahydrofolate reductase [Escherichia coli O157:H7
str. Sakai]
gi|12518856|gb|AAG59142.1|AE005625_5 5,10-methylenetetrahydrofolate reductase [Escherichia coli O157:H7
EDL933]
gi|13364346|dbj|BAB38293.1| 5,10-methylenetetrahydrofolate reductase [Escherichia coli O157:H7
str. Sakai]
Length = 296
Score = 154 bits (389), Expect = 7e-36, Method: Composition-based stats.
Identities = 93/275 (33%), Positives = 146/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I++
Sbjct: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIKGIKDRTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I + +++ R+ G+ I+ALRGD+ PG K YA+DL+ +K
Sbjct: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYASDLVTLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E +FDI A YPE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+D+C
Sbjct: 141 -EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA + N+ +P + D + D E+ + G A+
Sbjct: 200 SAGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 290
>gi|99032263|pdb|2FMN|A Chain A, Ala177val Mutant Of E. Coli Methylenetetrahydrofolate
Reductase Complex With Ly309887
gi|99032264|pdb|2FMN|B Chain B, Ala177val Mutant Of E. Coli Methylenetetrahydrofolate
Reductase Complex With Ly309887
gi|99032265|pdb|2FMN|C Chain C, Ala177val Mutant Of E. Coli Methylenetetrahydrofolate
Reductase Complex With Ly309887
gi|99032266|pdb|2FMO|A Chain A, Ala177val Mutant Of E. Coli Methylenetetrahydrofolate
Reductase
gi|99032267|pdb|2FMO|B Chain B, Ala177val Mutant Of E. Coli Methylenetetrahydrofolate
Reductase
gi|99032268|pdb|2FMO|C Chain C, Ala177val Mutant Of E. Coli Methylenetetrahydrofolate
Reductase
Length = 304
Score = 154 bits (388), Expect = 8e-36, Method: Composition-based stats.
Identities = 93/275 (33%), Positives = 146/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I++
Sbjct: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIKGIKDRTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I + +++ R+ G+ I+ALRGD+ PG K YA+DL+ +K
Sbjct: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYASDLVTLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E +FDI A YPE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+D+C
Sbjct: 141 -EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGVNRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA + N+ +P + D + D E+ + G A+
Sbjct: 200 SAGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 290
>gi|151937691|gb|EDN56542.1| 5,10-methylenetetrahydrofolate reductase [Vibrio sp. Ex25]
Length = 309
Score = 154 bits (388), Expect = 8e-36, Method: Composition-based stats.
Identities = 96/279 (34%), Positives = 147/279 (52%), Gaps = 8/279 (2%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
S ++SFE FPP+ A E + ++ +K P F+SVT N ++ T + I+
Sbjct: 29 SDNINVSFEFFPPSSAKMEETLWNSVHRLKTLQPKFVSVTYGANSGE-RDRTHSIIKEIK 87
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLI 142
+ HL I ++E++ + + G+ I+ALRGDI PG YA+DL+
Sbjct: 88 ATTGLVAAPHLTCIDATREELINIADDYWNNGIENIVALRGDIPPGGGAPD--MYASDLV 145
Query: 143 EFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
E +K+ +FDI A +PE HP++ + SD+ NLK+KVDAG + +TQ FFD E + F+
Sbjct: 146 ELLKSRH-DFDISVAAFPEVHPEAKSAQSDLLNLKRKVDAGANRAITQFFFDVESYLRFR 204
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D+C AGIDV I GI+P+ N QA R N+ +P + + DP + + G
Sbjct: 205 DRCVAAGIDVEIVPGILPVSNFKQASRFAAQ-NNVKVPGWMSKQFEGLDDDPVTRQLVGA 263
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
+ A+D + L + V H YT+N AE Y H+L
Sbjct: 264 SQAIDMVRVLSREGVKDFHFYTLNRAEMT---YALCHTL 299
>gi|116184187|ref|ZP_01474134.1| hypothetical protein VEx2w_02003303 [Vibrio sp. Ex25]
Length = 300
Score = 154 bits (388), Expect = 9e-36, Method: Composition-based stats.
Identities = 96/279 (34%), Positives = 147/279 (52%), Gaps = 8/279 (2%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
S ++SFE FPP+ A E + ++ +K P F+SVT N ++ T + I+
Sbjct: 20 SDNINVSFEFFPPSSAKMEETLWNSVHRLKTLQPKFVSVTYGANSGE-RDRTHSIIKEIK 78
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLI 142
+ HL I ++E++ + + G+ I+ALRGDI PG YA+DL+
Sbjct: 79 ATTGLVAAPHLTCIDATREELINIADDYWNNGIENIVALRGDIPPGGGAPD--MYASDLV 136
Query: 143 EFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
E +K+ +FDI A +PE HP++ + SD+ NLK+KVDAG + +TQ FFD E + F+
Sbjct: 137 ELLKSRH-DFDISVAAFPEVHPEAKSAQSDLLNLKRKVDAGANRAITQFFFDVESYLRFR 195
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D+C AGIDV I GI+P+ N QA R N+ +P + + DP + + G
Sbjct: 196 DRCVAAGIDVEIVPGILPVSNFKQASRFAAQ-NNVKVPGWMSKQFEGLDDDPVTRQLVGA 254
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
+ A+D + L + V H YT+N AE Y H+L
Sbjct: 255 SQAIDMVRVLSREGVKDFHFYTLNRAEMT---YALCHTL 290
>gi|115350244|ref|YP_772083.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia cepacia
AMMD]
gi|115280232|gb|ABI85749.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia cepacia
AMMD]
Length = 276
Score = 154 bits (388), Expect = 9e-36, Method: Composition-based stats.
Identities = 94/270 (34%), Positives = 141/270 (52%), Gaps = 4/270 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
LSFE FPP A G EK+ + P F+SVT + ++ T+ +Q D +
Sbjct: 6 LSFEFFPPKTAEGVEKLRATRAQLLPLKPKFVSVTFGAGG-STQQGTLDTVLDMQKD-GL 63
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
HL I S+ + L + + G+ I+ALRGD+ G+ + + RYA++L+ FI+A
Sbjct: 64 EAAPHLSCIGSSRADLRAILDQYRSHGIRHIVALRGDLPSGMGAVGELRYASELVSFIRA 123
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E + F I A YPE HP + + +D++N +KV AG +S +TQ FF+ + ++ F D
Sbjct: 124 EHGDWFHIEVAGYPEYHPQARSPKADLENFARKVKAGANSAITQYFFNADAYFRFVDDAR 183
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G+DVPI GIMPI N Q +R + C +PR L+ + D +++RA G
Sbjct: 184 KLGVDVPIVPGIMPITNFTQLMRFSEMC-GAEVPRWVARRLESFGDDRDAIRAFGADVVT 242
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
LV V G+H YT+N A R I E
Sbjct: 243 SLCQRLVDAGVPGLHFYTLNTASATRTICE 272
>gi|16767371|ref|NP_462986.1| 5,10-methylenetetrahydrofolate reductase [Salmonella typhimurium
LT2]
gi|20141497|sp|P11003|METF_SALTY 5,10-methylenetetrahydrofolate reductase
gi|16422672|gb|AAL22945.1| 5,10-methylenetetrahydrofolate reductase [Salmonella typhimurium
LT2]
Length = 296
Score = 154 bits (388), Expect = 1e-35, Method: Composition-based stats.
Identities = 92/275 (33%), Positives = 146/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I+
Sbjct: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE-RDRTHSVIKGIKERTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I +++++ R+ G+ I+ALRGD+ PG K YA DL+ +K
Sbjct: 83 LEAAPHLTCIDATRDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYAADLVGLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E +FDI A YPE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+D+C
Sbjct: 141 -EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA + N+ +P + + ++D E+ + G A+
Sbjct: 200 SAGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPSWMSLMFEGLDNDAETRKLVGANIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 290
>gi|82778864|ref|YP_405213.1| 5,10-methylenetetrahydrofolate reductase [Shigella dysenteriae
Sd197]
gi|81243012|gb|ABB63722.1| 5,10-methylenetetrahydrofolate reductase [Shigella dysenteriae
Sd197]
Length = 296
Score = 153 bits (387), Expect = 1e-35, Method: Composition-based stats.
Identities = 93/275 (33%), Positives = 146/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I++
Sbjct: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIKGIKDRTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I + +++ R+ G+ I+ALRGD+ PG K YA+DL+ +K
Sbjct: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYASDLVTLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E +FDI A YPE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+D+C
Sbjct: 141 -EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA + N+ +P + D + D E+ + G A+
Sbjct: 200 PAGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 290
>gi|149375976|ref|ZP_01893742.1| 5,10-methylenetetrahydrofolate reductase [Marinobacter algicola
DG893]
gi|149359613|gb|EDM48071.1| 5,10-methylenetetrahydrofolate reductase [Marinobacter algicola
DG893]
Length = 289
Score = 153 bits (387), Expect = 1e-35, Method: Composition-based stats.
Identities = 87/270 (32%), Positives = 135/270 (50%), Gaps = 4/270 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
SFE FPP G EK+ + + P F SVT T + D + +
Sbjct: 11 FSFEFFPPKTDKGWEKLQGVRNTLAEVDPDFFSVTFGAGGSTRDRTVQTVLD--LHKRGV 68
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
T HL + +++ +A+ L G+NRI+ALRGD+ G+ + RYA +L+ FI+
Sbjct: 69 STAPHLSCVGATRDSIAELLDVYRENGINRIVALRGDMPSGMGAAGELRYANELVSFIRE 128
Query: 148 -EAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
F+I A YPE HP + D++N +KVDAG +S +TQ FF+ + ++ F D+
Sbjct: 129 YSGDTFNIEVAAYPEFHPQARTAEDDLKNFARKVDAGANSAITQYFFNADSYFYFIDRLE 188
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G+ +P+ GIMPI+N + R C +PR R L+ Y D +S+R G
Sbjct: 189 KMGVTIPVVPGIMPIVNFSNLTRFSDMC-GAEIPRWIRKQLEAYGDDSDSIRKFGEEVVT 247
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
+ L+ G+H YT+N AE + I++
Sbjct: 248 EMCAKLLAAGAPGLHFYTLNQAEPSLSIWK 277
>gi|114778670|ref|ZP_01453482.1| 5,10-methylenetetrahydrofolate reductase [Mariprofundus
ferrooxydans PV-1]
gi|114551032|gb|EAU53594.1| 5,10-methylenetetrahydrofolate reductase [Mariprofundus
ferrooxydans PV-1]
Length = 251
Score = 153 bits (387), Expect = 1e-35, Method: Composition-based stats.
Identities = 89/240 (37%), Positives = 134/240 (55%), Gaps = 8/240 (3%)
Query: 55 APHFISVTASNNKYNIKETTVPLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVG 114
+P +ISVT ++ T + I+++ + +AHL + S++++A L + A G
Sbjct: 2 SPAYISVTYGAGG-TTQDRTKGIVTRIKDETGLSPVAHLTCVGASRDELAALLADYRAAG 60
Query: 115 VNRILALRGDIIPGVEPLK----DFRYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQI 170
+ ILALRGD G++ + F YATDLI F++ E +F I A YPEGHP+S +
Sbjct: 61 IENILALRGDAPEGLDRFEAVAGGFSYATDLIAFLR-EQGDFSIACATYPEGHPESAGGV 119
Query: 171 SD-IQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALR 229
+D I+ LK K D G + VTQ FFDN+ F+ F+D C AGI +PI GIMPI N +Q +R
Sbjct: 120 ADDIRYLKLKQDNGADAAVTQYFFDNDAFFRFRDACRAAGITLPIIPGIMPIGNYDQIVR 179
Query: 230 LLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAE 289
C +P + D E+++A G+ A Q +L+ V G+H YT+N +E
Sbjct: 180 FSSMC-GASIPAWLHEQMQPIRDDLEAVKALGIELAAKQCRELLQAGVPGLHFYTLNKSE 238
>gi|114564699|ref|YP_752213.1| 5,10-methylenetetrahydrofolate reductase [Shewanella frigidimarina
NCIMB 400]
gi|114335992|gb|ABI73374.1| 5,10-methylenetetrahydrofolate reductase [Shewanella frigidimarina
NCIMB 400]
Length = 294
Score = 153 bits (386), Expect = 1e-35, Method: Composition-based stats.
Identities = 94/275 (34%), Positives = 146/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP+ E + ++ ++ P F+SVT N +++ T + + IQ +
Sbjct: 23 NVSFEFFPPSTPAMEEILWNSIRRLEPLNPKFVSVTYGANS-GVRDRTHSVIERIQKETN 81
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL + S E++ + + G+ I+ALRGD+ P P K R+A DL+ ++
Sbjct: 82 LLAAPHLTLVDASDEELVELAKHYWNSGIRDIVALRGDL-PDGSP-KPTRFANDLVRLLR 139
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ A +FDI A YPE HPD+ N +D+ NLKKK+DAG + +TQ FFD E + F+D+C
Sbjct: 140 SVA-DFDISVAAYPEVHPDARNAQADLINLKKKIDAGANRAITQFFFDVESYLRFRDRCV 198
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N Q R N+ +P + + DP + + G A+
Sbjct: 199 TAGIDVEIIPGILPVTNFKQTKRFAGM-TNVAIPHWLHRQFEGLDDDPATRQLVGANVAI 257
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE Y H+L
Sbjct: 258 DMVKVLSREGVKDFHFYTLNRAELT---YAICHTL 289
>gi|118700256|ref|ZP_01558326.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia ambifaria
MC40-6]
gi|118642394|gb|EAV49236.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia ambifaria
MC40-6]
Length = 276
Score = 153 bits (386), Expect = 1e-35, Method: Composition-based stats.
Identities = 94/270 (34%), Positives = 141/270 (52%), Gaps = 4/270 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
LSFE FPP A G EK+ + P F+SVT + ++ T+ +Q D +
Sbjct: 6 LSFEFFPPKTAEGVEKLRATRAQLLPLKPKFVSVTFGAGG-STQQGTLDTVLDMQKD-GL 63
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
HL I S+ + L + + G+ I+ALRGD+ G+ + + RYA++L+ FI+A
Sbjct: 64 EAAPHLSCIGSSRADLRAILDQYRSHGIRHIVALRGDLPSGMGAVGELRYASELVSFIRA 123
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E + F I A YPE HP + + +D++N +KV AG +S +TQ FF+ + ++ F D
Sbjct: 124 EHGDWFHIEVAGYPEYHPQARSPKADLENFARKVKAGANSAITQYFFNADAYFRFVDDAR 183
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G+DVPI GIMPI N Q +R + C +PR L+ + D +++RA G
Sbjct: 184 KLGVDVPIVPGIMPITNFTQLMRFSEMC-GAEVPRWVARRLESFGDDRDAIRAFGADVVT 242
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
LV V G+H YT+N A R I E
Sbjct: 243 SLCQRLVDAGVPGLHFYTLNAASATRTICE 272
>gi|157084464|gb|ABV14142.1| hypothetical protein CKO_03051 [Citrobacter koseri ATCC BAA-895]
Length = 296
Score = 153 bits (386), Expect = 1e-35, Method: Composition-based stats.
Identities = 92/275 (33%), Positives = 145/275 (52%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I+
Sbjct: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIKGIKERTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I +++++ ++ G+ I+ALRGD+ PG K YA DL+ +K
Sbjct: 83 LEAAPHLTCIDATRDELRTIAQDYWNNGIRHIVALRGDLPPGSG--KPDMYAADLVSLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E +FDI A YPE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+D+C
Sbjct: 141 -EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA + N+ +P + D + D E+ + G A+
Sbjct: 200 SAGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPAWMSQMFDGLDDDAETRKLVGANIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 290
>gi|148550052|ref|YP_001270154.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas putida F1]
gi|148514110|gb|ABQ80970.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas putida F1]
Length = 281
Score = 153 bits (386), Expect = 2e-35, Method: Composition-based stats.
Identities = 91/275 (33%), Positives = 142/275 (51%), Gaps = 4/275 (1%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
SQ SFE FP G+EK++ + P F S T + ++ T+ ++
Sbjct: 2 SQERRYSFEFFPTKTDAGHEKLMGVARQLATYNPDFFSCTYGAGG-STRDRTLNTVLQLE 60
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK-DFRYATDL 141
+++ IP HL + +K ++ L E A G+ RI+ALRGD+ G+ + RYA+DL
Sbjct: 61 SEVKIPAAPHLSCVGDTKAELRALLAEYKAAGIKRIVALRGDLPSGMGMASGELRYASDL 120
Query: 142 IEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
+EFI+ E A +F + A YPE HP + N +D+ N KV AG S +TQ FF+ + ++
Sbjct: 121 VEFIRQETADHFHLEVAAYPEMHPQARNFEADLANFVHKVKAGADSAITQYFFNADSYFY 180
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
F ++ G+D+P+ GIMPI N ++ R C +PR R L+ Y D S++A
Sbjct: 181 FVERAQKLGVDIPVVPGIMPITNYSKLARFSDAC-GAEIPRWIRKQLEAYADDTASIQAF 239
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
G L+ G+H YT+N AE + I+
Sbjct: 240 GEEVITRMCEQLLQGGAPGLHFYTLNQAEPSLAIW 274
>gi|47779|emb|CAA30531.1| unnamed protein product [Salmonella typhimurium]
Length = 296
Score = 153 bits (386), Expect = 2e-35, Method: Composition-based stats.
Identities = 92/275 (33%), Positives = 146/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I+
Sbjct: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE-RDRTHSVIKGIKERTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I +++++ R+ G+ I+ALRGD+ PG K YA DL+ +K
Sbjct: 83 LEAAPHLTCIDPTRDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYAADLVGLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E +FDI A YPE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+D+C
Sbjct: 141 -EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA + N+ +P + + ++D E+ + G A+
Sbjct: 200 SAGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPSWMSLMFEGLDNDAETRKLVGANIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 290
>gi|29143817|ref|NP_807159.1| 5,10-methylenetetrahydrofolate reductase [Salmonella enterica
subsp. enterica serovar Typhi Ty2]
gi|56415951|ref|YP_153026.1| 5,10-methylenetetrahydrofolate reductase [Salmonella enterica
subsp. enterica serovar Paratyphi A str. ATCC 9150]
gi|62182567|ref|YP_218984.1| 5,10-methylenetetrahydrofolate reductase [Salmonella enterica
subsp. enterica serovar Choleraesuis str. SC-B67]
gi|29139453|gb|AAO71019.1| 5,10 methylenetetrahydrofolate reductase [Salmonella enterica
subsp. enterica serovar Typhi Ty2]
gi|56130208|gb|AAV79714.1| 5,10 methylenetetrahydrofolate reductase [Salmonella enterica
subsp. enterica serovar Paratyphi A str. ATCC 9150]
gi|62130200|gb|AAX67903.1| 5,10-methylenetetrahydrofolate reductase [Salmonella enterica
subsp. enterica serovar Choleraesuis str. SC-B67]
Length = 296
Score = 153 bits (386), Expect = 2e-35, Method: Composition-based stats.
Identities = 92/275 (33%), Positives = 145/275 (52%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I+
Sbjct: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE-RDRTHSVIKGIKERTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I +++++ R+ G+ I+ALRGD+ PG K YA DL+ +K
Sbjct: 83 LEAAPHLTCIDATRDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYAADLVGLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E +FDI A YPE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+D+C
Sbjct: 141 -EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA + N+ +P + + + D E+ + G A+
Sbjct: 200 SAGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPSWMSLMFEGLDDDAETRKLVGANIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 290
>gi|75765839|pdb|1ZP4|A Chain A, Glu28gln Mutant Of E. Coli Methylenetetrahydrofolate
Reductase (Oxidized) Complex With Methyltetrahydrofolate
gi|75765840|pdb|1ZP4|B Chain B, Glu28gln Mutant Of E. Coli Methylenetetrahydrofolate
Reductase (Oxidized) Complex With Methyltetrahydrofolate
gi|75765841|pdb|1ZP4|C Chain C, Glu28gln Mutant Of E. Coli Methylenetetrahydrofolate
Reductase (Oxidized) Complex With Methyltetrahydrofolate
Length = 304
Score = 152 bits (385), Expect = 2e-35, Method: Composition-based stats.
Identities = 92/275 (33%), Positives = 146/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SF+ FPP + + + ++D + P F+SVT N ++ T + I++
Sbjct: 24 NVSFQFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIKGIKDRTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I + +++ R+ G+ I+ALRGD+ PG K YA+DL+ +K
Sbjct: 83 LEAAPHLTCIDATPDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYASDLVTLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E +FDI A YPE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+D+C
Sbjct: 141 -EVADFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA + N+ +P + D + D E+ + G A+
Sbjct: 200 SAGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 290
>gi|153835464|ref|ZP_01988131.1| 5,10-methylenetetrahydrofolate reductase [Vibrio harveyi HY01]
gi|148867989|gb|EDL67184.1| 5,10-methylenetetrahydrofolate reductase [Vibrio harveyi HY01]
Length = 300
Score = 152 bits (385), Expect = 2e-35, Method: Composition-based stats.
Identities = 96/279 (34%), Positives = 146/279 (52%), Gaps = 8/279 (2%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
S ++SFE FPP+ E + ++ +K P F+SVT N ++ T + I+
Sbjct: 20 SDNINVSFEFFPPSSEKMEETLWNSVHRLKTLQPKFVSVTYGANSGE-RDRTHSIIKEIK 78
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLI 142
+ HL I +++++ D + G+ I+ALRGDI PG YA+DL+
Sbjct: 79 AATGLVAAPHLTCIDATRDELIDIADDYWNNGIKNIVALRGDIPPGGGAPD--MYASDLV 136
Query: 143 EFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
E +KA +FDI A +PE HP++ + SD+ NLK+KVDAG + +TQ FFD E + F+
Sbjct: 137 ELLKARH-DFDISVAAFPEVHPEAKSAQSDLLNLKRKVDAGANRAITQFFFDVESYLRFR 195
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D+C AGIDV I GI+P+ N QA R N+ +P + + DP + + G
Sbjct: 196 DRCVAAGIDVEIVPGILPVSNFKQASRFAAQ-NNVKVPGWMSKQFEGLDDDPVTRQLVGA 254
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
+ A+D + L + V H YT+N AE Y H+L
Sbjct: 255 SQAIDMVRVLSREGVKDFHFYTLNRAEMT---YALCHTL 290
>gi|30248672|ref|NP_840742.1| metF; 5,10-methylenetetrahydrofolate reductase oxidoreductase
protein [Nitrosomonas europaea ATCC 19718]
gi|30180267|emb|CAD84572.1| metF; 5,10-methylenetetrahydrofolate reductase oxidoreductase
protein [Nitrosomonas europaea ATCC 19718]
Length = 281
Score = 152 bits (385), Expect = 2e-35, Method: Composition-based stats.
Identities = 92/280 (32%), Positives = 143/280 (51%), Gaps = 7/280 (2%)
Query: 21 MTSQ---TPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPL 77
M SQ TP+ SFE FPP G EK+ + P F SVT + +E T+
Sbjct: 1 MQSQKKFTPTFSFEFFPPQTPEGMEKLRATRIQLAQFNPKFFSVTFGAGG-STRERTLET 59
Query: 78 ADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRY 137
IQ + P HL I +++ + L + + G++RI+ALRGD+ G+ +FRY
Sbjct: 60 VLEIQAE-GYPVAPHLSCIGSTRDNIRSILEKYHSHGISRIVALRGDLPSGMAQAGEFRY 118
Query: 138 ATDLIEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNE 196
A +L+ FI+ E F I A YPE HP + + + D N ++KV+AG ++ +TQ F++ +
Sbjct: 119 ANELVAFIRKEFGDTFWIEVAAYPEYHPQARSALEDFTNFRRKVEAGSNAAITQFFYNVD 178
Query: 197 RFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPES 256
+ F + C A +++PI GIMPI +Q R C +PR R L+ + D S
Sbjct: 179 AYLHFVEMCEAADLNIPIVPGIMPISKFSQLARFSDGC-GAEIPRWIRRKLESFGDDIPS 237
Query: 257 LRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
++A GL L+ G+H YT+N+A I++
Sbjct: 238 IQAFGLDVVTALCARLLEAGAPGLHFYTLNSAVLPTKIWQ 277
>gi|88794556|ref|ZP_01110263.1| 5,10-methylenetetrahydrofolate reductase [Alteromonas macleodii
'Deep ecotype']
gi|88774089|gb|EAR05347.1| 5,10-methylenetetrahydrofolate reductase [Alteromonas macleodii
'Deep ecotype']
Length = 295
Score = 152 bits (385), Expect = 2e-35, Method: Composition-based stats.
Identities = 87/268 (32%), Positives = 143/268 (53%), Gaps = 6/268 (2%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
+SFE FPP + + +++ + P ++SVT N ++ T + IQ +
Sbjct: 23 VSFEFFPPKTEAMEQTLWKSVERLAPLKPSYMSVTYGANSGE-RDRTHDVVKRIQQQTGV 81
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
+ HL + S+E++ ++ G+ RI+ALRGD+ PG+E K YA+DL+ +K
Sbjct: 82 AAVPHLTCVDASREELKQIAKDYWDSGIRRIVALRGDLPPGLE--KTEMYASDLVALLK- 138
Query: 148 EAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTL 207
+ +FDI A YPE HP++PN D+ NLK+K +AG + +TQ FFD + F+D+
Sbjct: 139 DVADFDISVAAYPEKHPEAPNAQFDLLNLKRKAEAGATEAITQFFFDTSVYLRFRDRAAA 198
Query: 208 AGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLR-AAGLAYAV 266
AG+D+ + GI+P+ N Q L N+H+P + D + D ++ R G A+
Sbjct: 199 AGVDIDLVPGILPVTNY-QTLVKFAGFTNVHVPGWLHKMFDGLDADDQATRNLIGANIAM 257
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHI 294
DQ+ L + V H YT+N +E + I
Sbjct: 258 DQVKVLAKEGVKHFHFYTLNRSELSYAI 285
>gi|149189175|ref|ZP_01867462.1| 5,10-methylenetetrahydrofolate reductase [Vibrio shilonii AK1]
gi|148836929|gb|EDL53879.1| 5,10-methylenetetrahydrofolate reductase [Vibrio shilonii AK1]
Length = 296
Score = 152 bits (384), Expect = 2e-35, Method: Composition-based stats.
Identities = 94/279 (33%), Positives = 149/279 (53%), Gaps = 8/279 (2%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
S ++SFE FPP+ E + ++ +K P F+SVT N ++ T + I+
Sbjct: 20 SDNINVSFEFFPPSTPTMEETLWKSVHRLKTLQPKFVSVTYGANSGE-RDRTHSIIKEIK 78
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLI 142
++ + HL I S++++ D + + G+ I+ALRGDI P D YA+DL+
Sbjct: 79 SETGLVAAPHLTCIDASRDELIDIAEDYWSNGIKNIVALRGDI-PAGGGQPDM-YASDLV 136
Query: 143 EFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
E +K+ +FDI A +PE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+
Sbjct: 137 ELLKSRH-DFDISVAAFPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D+C AGIDV I GI+P+ N QA R + +P + + + DP + + G
Sbjct: 196 DRCVAAGIDVEIVPGILPVSNFKQASRFAGM-NKVKVPGWMQKQFEGLDDDPVTRQLVGA 254
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
+ A+D + L + V H YT+N AE Y H+L
Sbjct: 255 SQAIDMVRVLSREGVKDFHFYTLNRAEMT---YALCHTL 290
>gi|126665867|ref|ZP_01736848.1| 5,10-methylenetetrahydrofolate reductase [Marinobacter sp. ELB17]
gi|126629801|gb|EBA00418.1| 5,10-methylenetetrahydrofolate reductase [Marinobacter sp. ELB17]
Length = 318
Score = 152 bits (384), Expect = 3e-35, Method: Composition-based stats.
Identities = 90/273 (32%), Positives = 141/273 (51%), Gaps = 10/273 (3%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVT---ASNNKYNIKETTVPLADHIQND 84
SFE FPP G K+ D++ P F SVT + + ET L H Q
Sbjct: 40 FSFEFFPPKTEQGKIKLQGVRDELAAVNPDFFSVTFGAGGSTRDRTLETVFSL--HQQ-- 95
Query: 85 LAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEF 144
I T HL + ++ ++++ L A G+NRI+ALRGD+ G+ + RYA +L+ F
Sbjct: 96 -GISTAPHLSCVGGTRAEISELLDTYKANGINRIVALRGDLPSGMGAAGELRYANELVSF 154
Query: 145 IKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQD 203
I+ + + F++ A YPE HP + + D++N +KV+AG +S +TQ FF+ + + F D
Sbjct: 155 IREHSGDYFNLEVAAYPEFHPQARSAEEDLKNFARKVEAGANSAITQYFFNADSYLYFID 214
Query: 204 KCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLA 263
+ +GI +P+ GIMPI+N + +R C +PR R L+ Y D ES+R G
Sbjct: 215 RLEKSGITIPVVPGIMPIVNFSSLVRFSDMC-GAEIPRWIRKQLEAYGDDSESIRQFGEE 273
Query: 264 YAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ G+H YT+N E + I++
Sbjct: 274 VVTRMCEKLLKAGAPGLHFYTLNQVEPSLGIWK 306
>gi|16762329|ref|NP_457946.1| 5,10-methylenetetrahydrofolate reductase [Salmonella enterica
subsp. enterica serovar Typhi str. CT18]
gi|25285412|pir||AB0937 5,10 methylenetetrahydrofolate reductase [imported] - Salmonella
enterica subsp. enterica serovar Typhi (strain CT18)
gi|16504633|emb|CAD09516.1| 5,10 methylenetetrahydrofolate reductase [Salmonella enterica
subsp. enterica serovar Typhi]
Length = 296
Score = 152 bits (384), Expect = 3e-35, Method: Composition-based stats.
Identities = 92/275 (33%), Positives = 145/275 (52%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I+
Sbjct: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE-RDRTHSVIKGIKERTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I +++++ R+ G+ I+ALRGD+ PG K YA DL+ +K
Sbjct: 83 LEAAPHLTCIDATRDELRTIARDYWNNGIRHIVALRGDLPPGSG--KPEMYAADLVGLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E +FDI A YPE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+D+C
Sbjct: 141 -EVVDFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA + N+ +P + + + D E+ + G A+
Sbjct: 200 SAGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPSWMSLMFEGLDDDAETRKLVGANIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 290
>gi|118602824|ref|YP_904039.1| 5,10-methylenetetrahydrofolate reductase [Candidatus Ruthia
magnifica str. Cm (Calyptogena magnifica)]
gi|118567763|gb|ABL02568.1| 5,10-methylenetetrahydrofolate reductase [Candidatus Ruthia
magnifica str. Cm (Calyptogena magnifica)]
Length = 273
Score = 152 bits (384), Expect = 3e-35, Method: Composition-based stats.
Identities = 90/265 (33%), Positives = 133/265 (50%), Gaps = 3/265 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
+SFE FPP EK+ + +P + S T ++ T+ IQ + I
Sbjct: 3 ISFEFFPPRTNQAKEKLNQVRQSLSVVSPEYFSTTFGAGG-TTQDATLGAVLDIQKNDNI 61
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
P HL I K + + L + + +NRI+ALRGDI G+ + DF YA +L+EFI++
Sbjct: 62 PAAPHLSCIGSEKSNIVELLDQYKSTNINRIIALRGDIPLGIGDIGDFHYANELVEFIRS 121
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E F I A YPE HP + N +SD+ + K+ AG + +TQ F++ + ++ F+D
Sbjct: 122 EYNYYFHIEVAAYPEMHPQAKNIVSDLTHFVNKIKAGANGAITQYFYNADAYFRFKDDVQ 181
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G+D+PI GIMPI N Q L C +P+ L YE+D ESL G
Sbjct: 182 KLGVDIPITPGIMPITNYTQLLNFSNMC-GTQIPKWILERLKLYENDLESLGDFGFDVVA 240
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETA 291
+ L +Q V H Y+MN AE +
Sbjct: 241 NLCQTLKSQGVNSFHFYSMNCAEPS 265
>gi|84701754|ref|ZP_01016329.1| 5,10-methylenetetrahydrofolate reductase [Parvularcula bermudensis
HTCC2503]
gi|84691000|gb|EAQ16840.1| 5,10-methylenetetrahydrofolate reductase [Parvularcula bermudensis
HTCC2503]
Length = 290
Score = 152 bits (383), Expect = 4e-35, Method: Composition-based stats.
Identities = 92/279 (32%), Positives = 138/279 (49%), Gaps = 9/279 (3%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + +++ + P F+SVT + +E T + +
Sbjct: 5 NVSFEFFPPKTDAMEQTLWASVEKLAPLDPAFVSVTYGAGG-STRERTHRTVSRLVQETG 63
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGV----EPLKDFRYATDLI 142
+P AHL + S+E + LR A GV I+ALRGD G+ EP D +
Sbjct: 64 LPVAAHLTTVAASREDIDAVLRAYWAAGVRHIVALRGDPPGGLGAAYEPHPDGYANAAAL 123
Query: 143 EFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
+F++ CYPE HP+S N+ +DI LK+KVDAG + +TQ FFDN + +
Sbjct: 124 TEAARRVGDFEVTVGCYPETHPESANREADIDWLKQKVDAGATRAITQFFFDNNVYERYV 183
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D AGID+PI GIMP+ + R+ C +P + + ++DPE+ R A +
Sbjct: 184 DDVRRAGIDIPIVPGIMPVGSYKALSRMAGLC-GATIPPTIKDCFEDLDNDPETRRLAAV 242
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
DQ DLV + V +H YT+N A+ A Y H L
Sbjct: 243 TTVADQCRDLVRRGVEDLHFYTLNRADIA---YAVCHLL 278
>gi|26991654|ref|NP_747079.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas putida
KT2440]
gi|24986750|gb|AAN70543.1|AE016696_8 5,10-methylenetetrahydrofolate reductase [Pseudomonas putida
KT2440]
Length = 295
Score = 152 bits (383), Expect = 4e-35, Method: Composition-based stats.
Identities = 90/277 (32%), Positives = 143/277 (51%), Gaps = 4/277 (1%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADH 80
+ SQ SFE FP G+EK++ + P F S T + ++ T+
Sbjct: 14 LMSQERRYSFEFFPTKTDAGHEKLMGVARQLATYNPDFFSCTYGAGG-STRDRTLNTVLQ 72
Query: 81 IQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK-DFRYAT 139
+++++ IP HL + +K ++ L E A G+ RI+ALRGD+ G+ + RYA+
Sbjct: 73 LESEVKIPAAPHLSCVGDTKAELRALLAEYKAAGIKRIVALRGDLPSGMGMASGELRYAS 132
Query: 140 DLIEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERF 198
DL+EFI+ E A +F + A YPE HP + N +D+ N KV AG S +TQ FF+ + +
Sbjct: 133 DLVEFIREETADHFHLEVAAYPEMHPQARNFEADLANFVHKVKAGADSAITQYFFNADSY 192
Query: 199 YDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLR 258
+ F ++ G+++P+ GIMPI N ++ R C +PR R L+ Y D S++
Sbjct: 193 FYFVERAQKLGVEIPVVPGIMPITNYSKLARFSDAC-GAEIPRWIRKQLEAYADDTASIQ 251
Query: 259 AAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
A G L+ G+H YT+N AE + I+
Sbjct: 252 AFGEEVITRMCEQLLQGGAPGLHFYTLNQAEPSLAIW 288
>gi|123440514|ref|YP_001004508.1| 5,10-methylenetetrahydrofolate reductase [Yersinia enterocolitica
subsp. enterocolitica 8081]
gi|122087475|emb|CAL10256.1| 5,10-methylenetetrahydrofolate reductase [Yersinia enterocolitica
subsp. enterocolitica 8081]
Length = 294
Score = 151 bits (382), Expect = 4e-35, Method: Composition-based stats.
Identities = 90/275 (32%), Positives = 146/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I+
Sbjct: 24 NVSFEFFPPRTSEMEDTLWSSIDRLSTLKPKFVSVTYGANSGE-RDRTHSIIKGIKERTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL + S ++ + + G+ I+ALRGD+ P + K YA+DL+ +K
Sbjct: 83 LEAAPHLTCVDASPTQLREIATDYWNSGIRHIVALRGDLPP--DSGKPEMYASDLVGLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ +FDI A YPE HP++ + +D+ NLK+K+DAG + +TQ FFD E + F+D+C
Sbjct: 141 -DVGDFDISVAAYPEVHPEAKSAQADLINLKRKIDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
GIDV I GI+P+ N Q L+ T N+ +P I + + DPE+ + G + A+
Sbjct: 200 ATGIDVEIVPGILPVSNFKQ-LQRFATMTNVRVPNWMTRIFEGLDDDPETRKMVGASVAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAELS---YAICHTL 290
>gi|121593047|ref|YP_984943.1| 5,10-methylenetetrahydrofolate reductase [Acidovorax sp. JS42]
gi|120605127|gb|ABM40867.1| 5,10-methylenetetrahydrofolate reductase [Acidovorax sp. JS42]
Length = 279
Score = 151 bits (382), Expect = 5e-35, Method: Composition-based stats.
Identities = 95/273 (34%), Positives = 132/273 (48%), Gaps = 4/273 (1%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
S T +SFE FPP G +K+ + P F SVT T + + +
Sbjct: 4 STTFPVSFEFFPPKTPEGADKLRAVRQQLYARRPEFCSVTYGAGGSTQAGTFGTVREILA 63
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLI 142
+ +H I +K+ V L EL A+GV R++ALRGD+ G +F YA+DL+
Sbjct: 64 E--GVSAASHFSCIGATKDGVRAQLAELKAMGVKRLVALRGDLPSGYGIGGEFHYASDLV 121
Query: 143 EFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDF 201
FI+AE +F I A YPE HP + + +D+Q KV AG S +TQ FF+ + + F
Sbjct: 122 AFIRAETGRDFHIEVAAYPEVHPQARSSDADLQAFATKVRAGADSAITQYFFNADAYLRF 181
Query: 202 QDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAG 261
G+DVP+ GIMPI+ +Q LR C +PR R L Y D S+RA G
Sbjct: 182 VQDVRRLGLDVPVVPGIMPIMGASQLLRFSDAC-GAEIPRWIRLRLQGYGDDVASIRAFG 240
Query: 262 LAYAVDQIVDLVTQDVAGVHLYTMNNAETARHI 294
L L + V G+H YTMN + I
Sbjct: 241 LDVVTHLCEQLRREGVPGLHFYTMNQSAATLEI 273
>gi|26250713|ref|NP_756753.1| 5,10-methylenetetrahydrofolate reductase [Escherichia coli CFT073]
gi|75240339|ref|ZP_00724279.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Escherichia coli
F11]
gi|91213488|ref|YP_543474.1| 5,10-methylenetetrahydrofolate reductase [Escherichia coli UTI89]
gi|110644282|ref|YP_672012.1| 5,10-methylenetetrahydrofolate reductase [Escherichia coli 536]
gi|117626211|ref|YP_859534.1| 5,10-methylenetetrahydrofolate reductase [Escherichia coli APEC O1]
gi|26111144|gb|AAN83327.1|AE016770_127 5,10-methylenetetrahydrofolate reductase [Escherichia coli CFT073]
gi|91075062|gb|ABE09943.1| 5,10-methylenetetrahydrofolate reductase [Escherichia coli UTI89]
gi|110345874|gb|ABG72111.1| 5,10-methylenetetrahydrofolate reductase [Escherichia coli 536]
gi|115515335|gb|ABJ03410.1| 5,10-methylenetetrahydrofolate reductase [Escherichia coli APEC O1]
Length = 296
Score = 151 bits (382), Expect = 5e-35, Method: Composition-based stats.
Identities = 92/275 (33%), Positives = 145/275 (52%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I++
Sbjct: 24 NVSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIKGIKDRTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I + ++ R+ G+ I+ALRGD+ PG K YA+DL+ +K
Sbjct: 83 LEAAPHLTCIDATPAELRIIARDYWNNGIRHIVALRGDLPPGSG--KPEMYASDLVTLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E +FDI A YPE HP++ + +D+ NL++KVDAG + +TQ FFD E + F+D+C
Sbjct: 141 -EVADFDISVAAYPEVHPEAKSAQADLLNLRRKVDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA + N+ +P + D + D E+ + G A+
Sbjct: 200 SAGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPAWMAQMFDGLDDDAETRKLVGANIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 290
>gi|56476457|ref|YP_158046.1| 5,10-methylenetetrahydrofolate reductase oxidoreductase [Azoarcus
sp. EbN1]
gi|56312500|emb|CAI07145.1| 5,10-methylenetetrahydrofolate reductase oxidoreductase protein
[Azoarcus sp. EbN1]
Length = 277
Score = 151 bits (382), Expect = 5e-35, Method: Composition-based stats.
Identities = 91/272 (33%), Positives = 132/272 (48%), Gaps = 4/272 (1%)
Query: 26 PSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDL 85
P LS E FPP G EK+ + P F SVT + +E T I D
Sbjct: 4 PELSIEFFPPQTPEGEEKLRATRTALAALKPTFFSVTYGAGG-STRERTFSTVREIAAD- 61
Query: 86 AIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFI 145
HL I ++ + + L + + G+ RI+ALRGD+ GV +FRYA +L+EFI
Sbjct: 62 GFEAAPHLSCIGSTRAGIREILDDYASAGIRRIVALRGDLPSGVGDPGEFRYANELVEFI 121
Query: 146 KAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDK 204
+ E + F I A YPE HP + N D+ ++K +AG S +TQ F++ + + F D+
Sbjct: 122 RTETGDRFRIEVAAYPEWHPQAKNPKDDLTAFRRKAEAGADSAITQYFYNFDAYLHFVDQ 181
Query: 205 CTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAY 264
G+++PI GIMPI + ++ R C LPR R + Y D +S+RA GL
Sbjct: 182 VRAMGVEIPIVPGIMPIASFSKLARFSDAC-GAELPRWMRRKFEGYGDDADSIRAFGLDV 240
Query: 265 AVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ G+H Y+MN A I E
Sbjct: 241 VTSLCERLLAAGAPGLHFYSMNQAGLTTAICE 272
>gi|118069248|ref|ZP_01537495.1| 5,10-methylenetetrahydrofolate reductase [Serratia proteamaculans
568]
gi|118016589|gb|EAV30514.1| 5,10-methylenetetrahydrofolate reductase [Serratia proteamaculans
568]
Length = 297
Score = 151 bits (382), Expect = 5e-35, Method: Composition-based stats.
Identities = 91/275 (33%), Positives = 145/275 (52%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I+
Sbjct: 24 NVSFEFFPPRTSEMEDTLWQSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIKGIKERTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I S ++ + + G+ I+ALRGD+ PG K YATDL+ +K
Sbjct: 83 LEAAPHLTCIDASPAQLREIATDYWNSGIRHIVALRGDLPPGSG--KPDMYATDLVALLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ +FDI A YPE HP++ + +D+ NLK+K+DAG + +TQ FFD E + F+D+C
Sbjct: 141 -DVGDFDISVAAYPEVHPEAKSPQADLINLKRKIDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
GIDV I GI+P+ N Q L+ T N+ +P ++ + + D E+ + G A+
Sbjct: 200 ATGIDVEIVPGILPVSNFKQ-LQRFATMTNVRVPSWMTSMFEGLDDDAETRKMVGANIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 290
>gi|37681190|ref|NP_935799.1| 5,10-methylenetetrahydrofolate reductase [Vibrio vulnificus YJ016]
gi|37199941|dbj|BAC95770.1| 5;10-methylenetetrahydrofolate reductase [Vibrio vulnificus YJ016]
Length = 332
Score = 151 bits (381), Expect = 5e-35, Method: Composition-based stats.
Identities = 95/279 (34%), Positives = 146/279 (52%), Gaps = 8/279 (2%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
S ++SFE FPP+ E + ++ +K P F+SVT N ++ T + I+
Sbjct: 55 SDNINVSFEFFPPSTPQMEETLWNSVHRLKTLQPKFVSVTYGANSGE-RDRTHSIIKEIK 113
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLI 142
+ HL I S+E++ + + A G+ I+ALRGDI PG YA+DL+
Sbjct: 114 AQTGLVAAPHLTCIDASREELINIANDYWANGIKNIVALRGDIPPGGGAPD--MYASDLV 171
Query: 143 EFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
+K+ +FDI A +PE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+
Sbjct: 172 TLLKS-LHDFDISVAAFPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 230
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D+C AGIDV I GI+P+ N QA R N+ +P + + DP + + G
Sbjct: 231 DRCVAAGIDVEIVPGILPVSNFKQASRFAAQ-NNVKVPGWMAKQFEGLDDDPVTRQLVGA 289
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
+ A+D + L + V H YT+N AE Y H+L
Sbjct: 290 SQAIDMVRILSREGVKDFHFYTLNRAEMT---YALCHTL 325
>gi|145590179|ref|YP_001156776.1| 5,10-methylenetetrahydrofolate reductase [Polynucleobacter sp.
QLW-P1DMWA-1]
gi|145048585|gb|ABP35212.1| 5,10-methylenetetrahydrofolate reductase [Polynucleobacter sp.
QLW-P1DMWA-1]
Length = 276
Score = 151 bits (381), Expect = 5e-35, Method: Composition-based stats.
Identities = 95/265 (35%), Positives = 137/265 (51%), Gaps = 7/265 (2%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGS-APHFISVTASNNKYNIKETTVPLAD-HIQNDL 85
LS E FPP G K+ L + + P F SVT T ++D H
Sbjct: 3 LSVEFFPPKTPEGESKLHLVRERFSETLKPSFYSVTFGAGGSTQSGTLKVVSDIHAAGAA 62
Query: 86 AIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFI 145
P HL + S+E V + L++ A+GV RI+ALRGD+ G+ +F +A +L+EFI
Sbjct: 63 VAP---HLSCVGSSRESVREMLKQYQALGVKRIVALRGDLPSGMGQYGEFHHANELVEFI 119
Query: 146 KAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDK 204
+AE + F I A YPE HP + + SD+ +K+ AG +S VTQ F++++ ++ F D+
Sbjct: 120 RAETGDWFHIDVAAYPETHPQAKSPASDVDFFVQKIKAGANSAVTQYFYNSDAYFRFVDE 179
Query: 205 CTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAY 264
G+ PI AGIMPI N Q LR TC +PR R L Y D S++A G
Sbjct: 180 AYDLGVTQPIIAGIMPITNCTQLLRFSDTC-GAEIPRWIRLRLQSYGDDIASIKAFGEEV 238
Query: 265 AVDQIVDLVTQDVAGVHLYTMNNAE 289
D L+T G+H Y++N A+
Sbjct: 239 VTDLCDQLLTAGAPGLHFYSLNQAD 263
>gi|134096106|ref|YP_001101181.1| 5,10-methylenetetrahydrofolate reductase. [Herminiimonas
arsenicoxydans]
gi|133740009|emb|CAL63060.1| 5,10-methylenetetrahydrofolate reductase. [Herminiimonas
arsenicoxydans]
Length = 283
Score = 151 bits (381), Expect = 6e-35, Method: Composition-based stats.
Identities = 96/283 (33%), Positives = 144/283 (50%), Gaps = 16/283 (5%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVT---ASNNKYNIKETTVPL 77
MT Q + S E FPP +G EK+ + + P + SVT + ++ +T + +
Sbjct: 1 MTQQ--NFSIEFFPPKTPLGVEKLRVTCAKLAELNPKYFSVTFGAGGSTQHGTLDTVLEI 58
Query: 78 ADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPL----K 133
+ A P HL + S+E + L+E + G+ RI+ALRGD+ G +
Sbjct: 59 RSAGHD--AAP---HLSCLGSSRENLRAILQEYKSHGIKRIVALRGDLPSGYGAMDASSS 113
Query: 134 DFRYATDLIEFIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLF 192
+F YA +L+EFI+AE + F I A YPE HP + + DI + +KV AG S +TQ F
Sbjct: 114 EFHYANELVEFIRAETGDWFHIEVAAYPEMHPQAKSPSDDIASYVRKVKAGADSAITQYF 173
Query: 193 FDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEH 252
++ + ++ F D AG DVP+ AG+MPI N +Q +R C +PR R L Y
Sbjct: 174 YNADAYFRFVDDARKAGADVPVTAGVMPITNYSQLMRFSDMC-GAEIPRWIRLKLASYND 232
Query: 253 DPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
D +S+RA GL D L+ G+H YT+N A I+
Sbjct: 233 DTDSIRAFGLDVVTDLCERLLAGGAPGLHFYTLNQAAATHAIW 275
>gi|156972427|ref|YP_001443334.1| hypothetical protein VIBHAR_00047 [Vibrio harveyi ATCC BAA-1116]
gi|156524021|gb|ABU69107.1| hypothetical protein VIBHAR_00047 [Vibrio harveyi ATCC BAA-1116]
Length = 300
Score = 151 bits (381), Expect = 6e-35, Method: Composition-based stats.
Identities = 95/279 (34%), Positives = 145/279 (51%), Gaps = 8/279 (2%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
S ++SFE FPP+ E + ++ +K P F+SVT N ++ T + I+
Sbjct: 20 SDNINVSFEFFPPSSEKMEETLWNSVHRLKTLQPKFVSVTYGANSGE-RDRTHSIIKEIK 78
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLI 142
+ HL I +++++ D + G+ I+ LRGDI PG YA+DL+
Sbjct: 79 AATGLVAAPHLTCIDATRDELIDIADDYWNNGIKNIVTLRGDIPPGGGAPD--MYASDLV 136
Query: 143 EFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
E +KA +FDI A +PE HP++ + SD+ NLK+KVDAG + +TQ FFD E + F+
Sbjct: 137 ELLKARH-DFDISVAAFPEVHPEAKSAQSDLLNLKRKVDAGANRAITQFFFDVESYLRFR 195
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D+C AGIDV I GI+P+ N QA R N+ +P + + DP + + G
Sbjct: 196 DRCVAAGIDVEIVPGILPVSNFKQASRFAAQ-NNVKVPGWMSKQFEGLDDDPVTRQLVGA 254
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
+ A+D + L + V H YT+N AE Y H+L
Sbjct: 255 SQAIDMVRVLSREGVKDFHFYTLNRAEMT---YALCHTL 290
>gi|90020117|ref|YP_525944.1| 5,10-methylenetetrahydrofolate reductase (FADH) [Saccharophagus
degradans 2-40]
gi|89949717|gb|ABD79732.1| 5,10-methylenetetrahydrofolate reductase [Saccharophagus degradans
2-40]
Length = 297
Score = 150 bits (380), Expect = 7e-35, Method: Composition-based stats.
Identities = 89/267 (33%), Positives = 142/267 (53%), Gaps = 4/267 (1%)
Query: 24 QTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQN 83
Q LSFE FPP VG EK++ ++ P F SVT + ++ T + ++
Sbjct: 5 QEFRLSFEFFPPKTDVGREKLITVRKELNDIHPDFFSVTYGAGG-STRDNTKGIVKKMRE 63
Query: 84 DLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIE 143
+ + HL +++ + L+E +GV+RI+ALRGD+ GV + YA +L+
Sbjct: 64 E-GLNVAPHLSFGGDTEQTILPLLQEYKDMGVDRIVALRGDMPSGVGGAQQLVYANELVA 122
Query: 144 FIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
FI+ + F + A YPE HP++ + + D++ LK K DAG +S +TQ FF+ + ++ F
Sbjct: 123 FIRKHFDDYFHLEVAAYPEIHPEATSYLDDVRYLKGKFDAGANSAITQYFFNPDAYFYFM 182
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D+C GID PIY GIMPILN R +C +PR R ++ + + E+L + G+
Sbjct: 183 DQCQKEGIDQPIYPGIMPILNYRNLARFSDSC-GADIPRWMRKRMESFGDNQEALISFGI 241
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAE 289
+ + L+ G+H YTMN E
Sbjct: 242 DWISELCDTLLDAGAPGLHFYTMNQTE 268
>gi|118731860|ref|ZP_01580375.1| 5,10-methylenetetrahydrofolate reductase [Delftia acidovorans
SPH-1]
gi|118668719|gb|EAV75314.1| 5,10-methylenetetrahydrofolate reductase [Delftia acidovorans
SPH-1]
Length = 275
Score = 150 bits (380), Expect = 7e-35, Method: Composition-based stats.
Identities = 92/262 (35%), Positives = 134/262 (51%), Gaps = 4/262 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
+SFE FP G K + ++ P F SVT + + T + IQ++ +
Sbjct: 5 ISFEFFPTKTPEGAAKHVQVRKNLYARKPQFCSVTYGAGG-STQAGTFNMVRDIQSE-GV 62
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
+H + + +KV L+EL A+GV RI+ALRGD+ G +F+YA+DL+EFI+
Sbjct: 63 SAASHFSCVGATHDKVRAELQELKAMGVRRIVALRGDLPSGYGLGGEFQYASDLVEFIRR 122
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E + F I A YPE HP + + SD++ KV AG S +TQ F++ + + F D
Sbjct: 123 EFGDWFHIEVAAYPEVHPQAKSPHSDLEAFAAKVRAGADSAITQYFYNADAYCRFVDAAR 182
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G+DVP+ GIMPI + Q +R C +PR R L Y D S+RA GL
Sbjct: 183 GMGLDVPVVPGIMPITSSTQLMRFSDAC-GAEIPRWIRLRLQAYGDDTASIRAFGLDVVS 241
Query: 267 DQIVDLVTQDVAGVHLYTMNNA 288
L +Q G+H YTMN +
Sbjct: 242 RLCEQLRSQGAPGLHFYTMNQS 263
>gi|118756992|ref|ZP_01604760.1| 5,10-methylenetetrahydrofolate reductase [Shewanella pealeana ATCC
700345]
gi|118691503|gb|EAV97751.1| 5,10-methylenetetrahydrofolate reductase [Shewanella pealeana ATCC
700345]
Length = 296
Score = 150 bits (380), Expect = 7e-35, Method: Composition-based stats.
Identities = 94/275 (34%), Positives = 145/275 (52%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP+ + + ++ ++ P F+SVT N +++ T + + IQ +
Sbjct: 24 NVSFEFFPPSTPEMEKLLWNSIRRLEPLNPKFVSVTYGANS-GVRDRTHGVIERIQTETD 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL + S E++ + + G+ I+ALRGD+ P P K R+A DL+ ++
Sbjct: 83 LLAAPHLTLVDASDEELKELAKHYWNSGIRDIVALRGDL-PDGSP-KPTRFANDLVRLLR 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ A +FDI A YPE HPD+ N SD+ NLKKK+DAG + +TQ FFD E + F+D+C
Sbjct: 141 SVA-DFDISVAAYPEVHPDASNAQSDLINLKKKIDAGANRAITQFFFDVESYLRFRDRCA 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGID I GI+P+ N NQ R N+ +P + E D + + G A+
Sbjct: 200 AAGIDAEIIPGILPVTNFNQTKR-FAAMTNVSIPSWLHRQFEGLEDDAITRQMVGANVAI 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE Y H+L
Sbjct: 259 DMVKVLSREGVKDFHFYTLNRAELT---YAICHTL 290
>gi|28899537|ref|NP_799142.1| 5,10-methylenetetrahydrofolate reductase [Vibrio parahaemolyticus
RIMD 2210633]
gi|153839013|ref|ZP_01991680.1| 5,10-methylenetetrahydrofolate reductase [Vibrio parahaemolyticus
AQ3810]
gi|28807773|dbj|BAC61026.1| 5,10-methylenetetrahydrofolate reductase [Vibrio parahaemolyticus
RIMD 2210633]
gi|149747520|gb|EDM58460.1| 5,10-methylenetetrahydrofolate reductase [Vibrio parahaemolyticus
AQ3810]
Length = 300
Score = 150 bits (380), Expect = 7e-35, Method: Composition-based stats.
Identities = 94/279 (33%), Positives = 146/279 (52%), Gaps = 8/279 (2%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
S ++SFE FPP+ E + ++ +K P F+SVT N ++ T + I+
Sbjct: 20 SDNINVSFEFFPPSSEKMEETLWNSVHRLKTLKPKFVSVTYGANSGE-RDRTHSIIKEIK 78
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLI 142
+ + HL I ++ ++ + + G+ I+ALRGDI PG YA+DL+
Sbjct: 79 AETGLVAAPHLTCIDATRSELIEIADDYWNNGIENIVALRGDIPPGGGAPD--MYASDLV 136
Query: 143 EFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
E +K+ +FDI A +PE HP++ + SD+ NLK+KVDAG + +TQ FFD E + F+
Sbjct: 137 ELLKSRH-DFDISVAAFPEVHPEAKSAQSDLLNLKRKVDAGANRAITQFFFDVESYLRFR 195
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D+C AGIDV I GI+P+ N QA R N+ +P + + DP + + G
Sbjct: 196 DRCVAAGIDVEIVPGILPVSNFKQASRFAAQ-NNVKVPGWMSKQFEGLDDDPVTRQLVGA 254
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
+ A+D + L + V H YT+N AE Y H+L
Sbjct: 255 SQAIDMVRVLSREGVKDFHFYTLNRAEMT---YALCHTL 290
>gi|146305485|ref|YP_001185950.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas mendocina
ymp]
gi|145573686|gb|ABP83218.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas mendocina
ymp]
Length = 281
Score = 150 bits (380), Expect = 8e-35, Method: Composition-based stats.
Identities = 90/275 (32%), Positives = 139/275 (50%), Gaps = 4/275 (1%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
SQ SFE FP G+EK++ + P F S T + ++ T+ +
Sbjct: 2 SQERRYSFEFFPTKTEAGHEKLMDVARQLATYKPDFFSCTYGAGG-STRDRTLNTVLQLD 60
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK-DFRYATDL 141
++ +PT HL + SK ++ + L G+ RI+ALRGD+ G+ + RYA +L
Sbjct: 61 GEVKVPTAPHLSCVGDSKAELRELLNLYKNAGIKRIVALRGDLPSGMGMASGELRYANEL 120
Query: 142 IEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
+EFI+ E +F I A YPE HP + N SDI N +K AG S +TQ FF+ + ++
Sbjct: 121 VEFIRTETGDHFHIEVAAYPEMHPQARNFESDIANFVRKAKAGADSAITQYFFNADSYFY 180
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
F ++ G+D+P+ GIMPI N ++ R C +PR R L+ Y D +S+RA
Sbjct: 181 FVERVRKLGVDIPVVPGIMPITNYSKLARFSDAC-GAEIPRWVRKQLEAYGDDADSIRAF 239
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
G + L+ G+H Y+MN A + I+
Sbjct: 240 GEQVITEMCERLLQGGAPGLHFYSMNLAGPSLAIW 274
>gi|152972739|ref|YP_001337885.1| 5,10-methylenetetrahydrofolate reductase [Klebsiella pneumoniae
subsp. pneumoniae MGH 78578]
gi|150957588|gb|ABR79618.1| 5,10-methylenetetrahydrofolate reductase [Klebsiella pneumoniae
subsp. pneumoniae MGH 78578]
Length = 295
Score = 150 bits (380), Expect = 8e-35, Method: Composition-based stats.
Identities = 91/275 (33%), Positives = 146/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I+
Sbjct: 24 NVSFEFFPPRTSEMEQTLWKSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIKGIKERTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I S++++ ++ G+ I+ALRGD+ PG K YA DL+ +K
Sbjct: 83 LEAAPHLTCIDASRDELRTIAQDYWNNGIRHIVALRGDLPPGSG--KPDMYAADLVTLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E +FDI A YPE HP++ + +D+ NLK+KV+AG + +TQ FFD E + F+D+C
Sbjct: 141 -EVGDFDISVAAYPEVHPEAKSAQADLLNLKRKVEAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA + N+ +P + + ++D E+ + G A+
Sbjct: 200 SAGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPVWMSKMFEGLDNDAETRQLVGANIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 290
>gi|150378688|ref|ZP_01917885.1| 5,10-methylenetetrahydrofolate reductase [Shewanella sediminis
HAW-EB3]
gi|150255857|gb|EDM93550.1| 5,10-methylenetetrahydrofolate reductase [Shewanella sediminis
HAW-EB3]
Length = 296
Score = 150 bits (380), Expect = 8e-35, Method: Composition-based stats.
Identities = 98/277 (35%), Positives = 150/277 (54%), Gaps = 12/277 (4%)
Query: 27 SLSFEVFPP-NPAVGNEKILL-ALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQND 84
++SFE FPP P + EKIL ++ ++ P F+SVT N +++ T + + IQ +
Sbjct: 24 NVSFEFFPPATPEM--EKILWNSIRRLEPLNPKFVSVTYGANS-GVRDRTHGVIERIQKE 80
Query: 85 LAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEF 144
+ HL + S E++ + + G+ I+ALRGD+ P P K R+A DL+
Sbjct: 81 TDLVAAPHLTLVDASDEELKELAKHYWNSGIRDIVALRGDL-PEGSP-KPTRFANDLVRL 138
Query: 145 IKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDK 204
+++ A +FDI A YPE HPD+ N +D+ NLKKK+DAG + +TQ FFD E + F+D+
Sbjct: 139 LRSVA-DFDISVAAYPEVHPDALNAQADLINLKKKIDAGANRAITQFFFDVESYLRFRDR 197
Query: 205 CTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAY 264
C AGIDV I GI+P+ N Q L+ N+ +P + + DP + + G
Sbjct: 198 CVAAGIDVEIVPGILPVTNFKQ-LKRFAGMTNVSIPGWLHKQFEGLDDDPTTRQMVGANV 256
Query: 265 AVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
A+D + L + V H YT+N AE Y H+L
Sbjct: 257 AIDMVKVLSREGVKDFHFYTLNRAELT---YAICHTL 290
>gi|54307484|ref|YP_128504.1| 5,10-methylenetetrahydrofolate reductase [Photobacterium profundum
SS9]
gi|46911904|emb|CAG18702.1| putative 5,10-methylenetetrahydrofolate reductase [Photobacterium
profundum SS9]
Length = 299
Score = 150 bits (380), Expect = 8e-35, Method: Composition-based stats.
Identities = 95/275 (34%), Positives = 144/275 (52%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP+ E + ++ +K P F+SVT N ++ T + I++
Sbjct: 24 NVSFEFFPPSSEKMEETLWHSIHRLKTLKPKFVSVTYGANSGE-RDRTHSIIKDIKDQTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I S++++ R+ G+ I+ALRGD+ + K YA DL+E ++
Sbjct: 83 LIAAPHLTCIDASRDELRTIARDYWRNGIRDIVALRGDL--PAQGTKPDMYAADLVELLR 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
EA +FDI A YPE HP++ + +D+ NLK+KVDAG S +TQ FFD E + F+D+C
Sbjct: 141 KEA-DFDISVAAYPEVHPEAKSAQADLINLKRKVDAGASRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA R N+ +P + D S + G + A+
Sbjct: 200 AAGIDVEIVPGILPVSNMTQAKR-FAVANNVKIPGWLEKQYQGLDDDLLSRQMLGASNAI 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE Y H+L
Sbjct: 259 DMVRVLSREGVKDFHFYTLNRAELT---YAICHTL 290
>gi|90413611|ref|ZP_01221601.1| 5,10-methylenetetrahydrofolate reductase [Photobacterium profundum
3TCK]
gi|90325384|gb|EAS41873.1| 5,10-methylenetetrahydrofolate reductase [Photobacterium profundum
3TCK]
Length = 299
Score = 150 bits (379), Expect = 9e-35, Method: Composition-based stats.
Identities = 95/275 (34%), Positives = 144/275 (52%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP+ E + ++ +K P F+SVT N ++ T + I++
Sbjct: 24 NVSFEFFPPSSEKMEETLWHSIHRLKTLKPKFVSVTYGANSGE-RDRTHSIIKDIKDQTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I S++++ R+ G+ I+ALRGD+ + K YA DL+E ++
Sbjct: 83 LIAAPHLTCIDASRDELRTIARDYWRNGIRDIVALRGDL--PAQGTKPDMYAADLVELLR 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
EA +FDI A YPE HP++ + +D+ NLK+KVDAG S +TQ FFD E + F+D+C
Sbjct: 141 KEA-DFDISVAAYPEVHPEAKSAQADLINLKRKVDAGASRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA R N+ +P + D S + G + A+
Sbjct: 200 AAGIDVEIVPGILPVSNMTQAKR-FAAANNVKIPGWLEKQYQGLDDDLLSRQMLGASNAI 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE Y H+L
Sbjct: 259 DMVRVLSREGVKDFHFYTLNRAELT---YAICHTL 290
>gi|120612695|ref|YP_972373.1| 5,10-methylenetetrahydrofolate reductase [Acidovorax avenae subsp.
citrulli AAC00-1]
gi|120591159|gb|ABM34599.1| 5,10-methylenetetrahydrofolate reductase [Acidovorax avenae subsp.
citrulli AAC00-1]
Length = 282
Score = 150 bits (379), Expect = 1e-34, Method: Composition-based stats.
Identities = 92/268 (34%), Positives = 134/268 (50%), Gaps = 4/268 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
+SFE FPP G +K+ + P F SVT + +E T I ++ +
Sbjct: 12 VSFEFFPPKTPEGADKLRTVRQQLYAHRPEFCSVTYGAGG-STQEGTFGTVREILSE-GV 69
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
+H I ++E V L +L A+GV+R++ALRGD+ G +F+YA+DL+ FI+A
Sbjct: 70 QAASHFSCIGATREGVRTQLAQLKAMGVSRLVALRGDLPSGYGAGGEFQYASDLVAFIRA 129
Query: 148 EA-PNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
EA +F I A YPE HP + + +D+Q KV AG S +TQ FF+ + ++ F D
Sbjct: 130 EAGDDFHIEVAAYPEVHPQARSPEADLQAFATKVRAGAHSAITQYFFNPDAYWRFVDDVR 189
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G+DVP+ GIMPI+ Q +R C +PR R L + D S+RA GL
Sbjct: 190 ALGLDVPVIPGIMPIMGSTQLMRFSDAC-GAEIPRWIRLRLLGFGDDSASIRAFGLDVVT 248
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHI 294
L +H YTMN + I
Sbjct: 249 ALCERLRAGGAPSLHFYTMNQSAATLEI 276
>gi|77972987|ref|ZP_00828541.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Yersinia
frederiksenii ATCC 33641]
Length = 294
Score = 150 bits (379), Expect = 1e-34, Method: Composition-based stats.
Identities = 90/275 (32%), Positives = 144/275 (52%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I+
Sbjct: 24 NVSFEFFPPRTSEMEDTLWSSIDRLSTLKPKFVSVTYGANSGE-RDRTHSIIKGIKERTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I S ++ + G+ I+ALRGD+ P K YA+DL+ ++
Sbjct: 83 LEAAPHLTCIDASPTQLRAIATDYWNSGIRHIVALRGDLPPNSG--KPEMYASDLVTLLR 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ +FDI A YPE HP++ + +D+ NLK+K+DAG + +TQ FFD E + F+D+C
Sbjct: 141 -DVGDFDISVAAYPEVHPEAKSAQADLINLKRKIDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
GIDV I GI+P+ N Q L+ T N+ +P I + + DPE+ + G + A+
Sbjct: 200 ATGIDVEIVPGILPVSNFKQ-LQRFATMTNVRVPNWMSTIFEGLDDDPETRKMVGASVAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAELS---YAICHTL 290
>gi|27364761|ref|NP_760289.1| 5,10-methylenetetrahydrofolate reductase [Vibrio vulnificus CMCP6]
gi|27360906|gb|AAO09816.1|AE016801_135 5,10-methylenetetrahydrofolate reductase [Vibrio vulnificus CMCP6]
Length = 297
Score = 150 bits (378), Expect = 1e-34, Method: Composition-based stats.
Identities = 95/279 (34%), Positives = 146/279 (52%), Gaps = 8/279 (2%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
S ++SFE FPP+ E + ++ +K P F+SVT N ++ T + I+
Sbjct: 20 SDNINVSFEFFPPSTPQMEETLWNSVHRLKTLQPKFVSVTYGANSGE-RDRTHSIIKEIK 78
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLI 142
+ HL I S+E++ + + A G+ I+ALRGDI PG YA+DL+
Sbjct: 79 AQTGLVAAPHLTCIDASREELINIANDYWANGIKNIVALRGDIPPGGGAPD--MYASDLV 136
Query: 143 EFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQ 202
+K+ +FDI A +PE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+
Sbjct: 137 TLLKS-LHDFDISVAAFPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFR 195
Query: 203 DKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGL 262
D+C AGIDV I GI+P+ N QA R N+ +P + + DP + + G
Sbjct: 196 DRCVAAGIDVEIVPGILPVSNFKQASRFAAQ-NNVKVPGWMAKQFEGLDDDPVTRQLVGA 254
Query: 263 AYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
+ A+D + L + V H YT+N AE Y H+L
Sbjct: 255 SQAIDMVRILSREGVKDFHFYTLNRAEMT---YALCHTL 290
>gi|87311048|ref|ZP_01093173.1| 5,10-methylenetetrahydrofolate reductase [Blastopirellula marina
DSM 3645]
gi|87286338|gb|EAQ78247.1| 5,10-methylenetetrahydrofolate reductase [Blastopirellula marina
DSM 3645]
Length = 293
Score = 150 bits (378), Expect = 1e-34, Method: Composition-based stats.
Identities = 90/271 (33%), Positives = 136/271 (50%), Gaps = 6/271 (2%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
LSFE+FPP G+ ++L ++ + P +I+ T + + T+ + + ++ +
Sbjct: 14 LSFELFPPKTDKGDASLMLHVEKLVKFKPDYITCTYGAGG-STRGKTLDIVEKVKQVFGV 72
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPL----KDFRYATDLIE 143
P +HL + + + L E + GV+ I+ALRGD G K YA++L+E
Sbjct: 73 PVASHLTLVDSTVGDLRLYLAEAERRGVDYIVALRGDPPQGQTKFRPTAKGLSYASELVE 132
Query: 144 FIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQD 203
IK E F + A YPE H ++ + DI LK KVD G ++TQLF+ N+ FY F++
Sbjct: 133 LIKDEFQEFGVAVAGYPEKHQEAESLDVDIDRLKHKVDCGADIIITQLFYRNQDFYAFRE 192
Query: 204 KCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLA 263
KC AGI VPI GI PI+N Q R+ C PR L K D + G+
Sbjct: 193 KCAAAGITVPIIPGIFPIVNGAQIQRIATMC-GAKFPRALVEALQKKPEDTDYHMQVGVE 251
Query: 264 YAVDQIVDLVTQDVAGVHLYTMNNAETARHI 294
YA QI +L + G+H Y +N +E I
Sbjct: 252 YASKQIEELTEAGIPGLHFYVLNRSEATAAI 282
>gi|83721420|ref|YP_443657.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia
thailandensis E264]
gi|83655245|gb|ABC39308.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia
thailandensis E264]
Length = 276
Score = 150 bits (378), Expect = 1e-34, Method: Composition-based stats.
Identities = 91/271 (33%), Positives = 142/271 (52%), Gaps = 6/271 (2%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDL-A 86
LSFE FPP A G +K+ + P F+SVT + T + D + L A
Sbjct: 6 LSFEFFPPKTAEGVDKLRATRAQLAPLKPKFVSVTFGAGGSTQQGTLDTVLDMQKAGLEA 65
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
P HL I SK+ + L + + G+ I+ALRGD+ G+ + + RYA++L+ FI+
Sbjct: 66 AP---HLSCIGSSKDSLRAILDQYRSHGIRHIVALRGDLPSGMGEVGELRYASELVSFIR 122
Query: 147 AEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKC 205
AE + F I A YPE HP + + +D++N +KV AG ++ +TQ F++ + ++ F D
Sbjct: 123 AEHGDWFRIEVAAYPEYHPQARSPKADLENFARKVKAGANAAITQYFYNADAYFRFVDDA 182
Query: 206 TLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYA 265
G+DVP+ GIMPI N +Q +R + C +PR L+ + D +S+RA G
Sbjct: 183 AKLGVDVPVVPGIMPITNFSQLMRFSEMC-GAEVPRWIARRLESFGDDKDSIRAFGADVV 241
Query: 266 VDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ V G+H YT+N A + + E
Sbjct: 242 TGLCRRLIDAGVPGLHFYTLNGAAATKAVCE 272
>gi|58261226|ref|XP_568023.1| methylenetetrahydrofolate reductase (NADPH) [Cryptococcus
neoformans var. neoformans JEC21]
gi|134091034|ref|ZP_01761968.1| hypothetical protein CNBI2020 [Cryptococcus neoformans var.
neoformans B-3501A]
gi|134115749|ref|XP_773588.1| hypothetical protein CNBI2020 [Cryptococcus neoformans var.
neoformans B-3501A]
gi|50256214|gb|EAL18941.1| hypothetical protein CNBI2020 [Cryptococcus neoformans var.
neoformans B-3501A]
gi|57230105|gb|AAW46506.1| methylenetetrahydrofolate reductase (NADPH), putative [Cryptococcus
neoformans var. neoformans JEC21]
Length = 617
Score = 150 bits (378), Expect = 1e-34, Method: Composition-based stats.
Identities = 98/279 (35%), Positives = 142/279 (50%), Gaps = 14/279 (5%)
Query: 26 PSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDL 85
P SFE FPP A G + + ++ M+ P FI +T N + T L Q +
Sbjct: 16 PFWSFEFFPPRTAQGLQNLYDRIERMRDLGPEFIDITWGAGGKN-ADLTNSLVQVCQATI 74
Query: 86 AIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGV---EPLKD-FRYATDL 141
I T HL + KEKV LRE + G ILALRGD + G EP F A DL
Sbjct: 75 GIETCMHLCCTEMPKEKVEWALREAKSHGCQNILALRGDPVAGTSTWEPTPGGFMNAVDL 134
Query: 142 IEFIKAEAP-NFDIIGACYPEGHPDSPN----QISDIQNLKKKVDAGCSSLVTQLFFDNE 196
+ +I P +F + A +P+GHP++P+ + +++ LK KVDAG + TQ+F+D
Sbjct: 135 VRYIHEHYPGDFCVAVAGFPQGHPETPDTPEGRAQEMEWLKAKVDAGAEFIFTQMFYDTS 194
Query: 197 RFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPES 256
F+D+ + AGI+VPI GIMPI N + + ++ ENI +P F L+ D E
Sbjct: 195 IFFDWVKRVREAGINVPIIPGIMPIQNWEKFEKWVQR-ENIIVPSHFYEALNPVRGDDEK 253
Query: 257 LRAAGLAYAVDQ---IVDLVTQDVAGVHLYTMNNAETAR 292
+R G D I+D + G+H+YT+N + AR
Sbjct: 254 VRQVGTKLVADMCKTILDNKEAGIKGLHIYTLNLEKGAR 292
>gi|92112529|ref|YP_572457.1| 5,10-methylenetetrahydrofolate reductase [Chromohalobacter
salexigens DSM 3043]
gi|91795619|gb|ABE57758.1| 5,10-methylenetetrahydrofolate reductase [Chromohalobacter
salexigens DSM 3043]
Length = 282
Score = 149 bits (377), Expect = 1e-34, Method: Composition-based stats.
Identities = 90/279 (32%), Positives = 136/279 (48%), Gaps = 5/279 (1%)
Query: 20 LMTSQTP-SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLA 78
+ T + P +SFE FPP+ G EK+ D + P F SVT T +
Sbjct: 1 MSTREHPLGVSFEFFPPSTEAGREKLKGVRDTLAERRPRFFSVTYGAGGSTQARTFETVQ 60
Query: 79 DHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYA 138
Q+ I T HL I K ++ + L G++ ++ALRGD+ G+ + + RYA
Sbjct: 61 TVRQS--GIDTAPHLSCIGSDKGELRERLASFREAGIDSLVALRGDLPSGMGGMGELRYA 118
Query: 139 TDLIEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNER 197
+L+EFI+ E +F I A YPE HP +P+ D+QN +K+ AG +TQ FF +
Sbjct: 119 NELVEFIREETGDHFQIAVAAYPEAHPQAPSYEHDLQNFVRKMQAGADLAITQYFFSADA 178
Query: 198 FYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESL 257
++ F ++ G++ PI GIMPI N + R C +PR R L+ Y D ES+
Sbjct: 179 YFHFVERARALGVEAPIVPGIMPITNYTKLARFSDAC-GADIPRWIRKQLEAYGDDSESI 237
Query: 258 RAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
+A G L+ G+H YT+N A A + +
Sbjct: 238 QAFGSEVVTRLCQRLLDGGAPGLHFYTLNQATPALRVLD 276
>gi|53720898|ref|YP_109884.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia pseudomallei
K96243]
gi|53724305|ref|YP_104351.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia mallei ATCC
23344]
gi|67639804|ref|ZP_00438637.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Burkholderia
mallei GB8 horse 4]
gi|76811025|ref|YP_331472.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia pseudomallei
1710b]
gi|82533701|ref|ZP_00892759.1| hypothetical protein Bpse110_02005016 [Burkholderia pseudomallei
1106b]
gi|83617606|ref|ZP_00928101.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Burkholderia
mallei FMH]
gi|83622722|ref|ZP_00933021.1| COG0685: 5,10-methylenetetrahydrofolate reductase [Burkholderia
mallei JHU]
gi|90290277|ref|ZP_01209943.1| hypothetical protein Bpse17_02005019 [Burkholderia pseudomallei
1710a]
gi|99908399|ref|ZP_01316103.1| hypothetical protein Bpse1_03004559 [Burkholderia pseudomallei
1655]
gi|100060221|ref|ZP_01322306.1| hypothetical protein BpseP_03003923 [Burkholderia pseudomallei
Pasteur]
gi|100121443|ref|ZP_01327443.1| hypothetical protein BpseS_03004500 [Burkholderia pseudomallei S13]
gi|100231056|ref|ZP_01332632.1| hypothetical protein Bpse4_03004909 [Burkholderia pseudomallei
406e]
gi|100263999|ref|ZP_01338709.1| hypothetical protein Bmal2_03003521 [Burkholderia mallei
2002721280]
gi|100916506|ref|ZP_01344989.1| hypothetical protein Bmal10_03002335 [Burkholderia mallei 10399]
gi|121600913|ref|YP_994693.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia mallei
SAVP1]
gi|124385348|ref|YP_001027683.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia mallei NCTC
10229]
gi|126438559|ref|YP_001060830.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia pseudomallei
668]
gi|126451436|ref|YP_001082655.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia mallei NCTC
10247]
gi|126454447|ref|YP_001068137.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia pseudomallei
1106a]
gi|52211312|emb|CAH37301.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia pseudomallei
K96243]
gi|52427728|gb|AAU48321.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia mallei ATCC
23344]
gi|76580478|gb|ABA49953.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia pseudomallei
1710b]
gi|121229723|gb|ABM52241.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia mallei
SAVP1]
gi|124293368|gb|ABN02637.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia mallei NCTC
10229]
gi|126218052|gb|ABN81558.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia pseudomallei
668]
gi|126228089|gb|ABN91629.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia pseudomallei
1106a]
gi|126244306|gb|ABO07399.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia mallei NCTC
10247]
gi|147747320|gb|EDK54396.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia mallei FMH]
gi|147752310|gb|EDK59376.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia mallei JHU]
gi|148026273|gb|EDK84358.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia mallei
2002721280]
Length = 276
Score = 149 bits (377), Expect = 1e-34, Method: Composition-based stats.
Identities = 91/271 (33%), Positives = 142/271 (52%), Gaps = 6/271 (2%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDL-A 86
LSFE FPP A G +K+ + P F+SVT + T + D + L A
Sbjct: 6 LSFEFFPPKTAEGVDKLRATRAQLAPLKPKFVSVTFGAGGSTQQGTLDTVLDMQKAGLEA 65
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
P HL I SK+ + L + + G+ I+ALRGD+ G+ + + RYA++L+ FI+
Sbjct: 66 AP---HLSCIGSSKDSLRAILDQYRSHGIRHIVALRGDLPSGMGEVGELRYASELVSFIR 122
Query: 147 AEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKC 205
AE + F I A YPE HP + + +D++N +KV AG ++ +TQ F++ + ++ F D
Sbjct: 123 AEHGDWFRIEVAAYPEYHPQARSPKADLENFARKVKAGANAAITQYFYNADAYFRFVDDA 182
Query: 206 TLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYA 265
G+DVP+ GIMPI N +Q +R + C +PR L+ + D +S+RA G
Sbjct: 183 AKLGVDVPVVPGIMPITNFSQLMRFSEMC-GAEVPRWVARRLESFGDDKDSIRAFGADVV 241
Query: 266 VDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ V G+H YT+N A + + E
Sbjct: 242 TGLCRRLIDAGVPGLHFYTLNGAAATKTVCE 272
>gi|119776301|ref|YP_929041.1| 5,10-methylenetetrahydrofolate reductase [Shewanella amazonensis
SB2B]
gi|119768801|gb|ABM01372.1| 5,10-methylenetetrahydrofolate reductase [Shewanella amazonensis
SB2B]
Length = 296
Score = 149 bits (377), Expect = 2e-34, Method: Composition-based stats.
Identities = 97/277 (35%), Positives = 151/277 (54%), Gaps = 12/277 (4%)
Query: 27 SLSFEVFPPN-PAVGNEKILL-ALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQND 84
++SFE FPP+ P + EKIL ++ ++ P F+SVT N +++ T + + IQ +
Sbjct: 23 NVSFEFFPPSTPEM--EKILWNSIRRLEPLNPKFVSVTYGANS-GVRDRTHGVIERIQQE 79
Query: 85 LAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEF 144
+ HL + S E++ + G+ I+ALRGD+ P P K R+A DL+
Sbjct: 80 TQLVAAPHLTLVDASDEELLALAKNYWHQGIRNIVALRGDL-PAGSP-KPTRFAADLVRL 137
Query: 145 IKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDK 204
+K+ A +FDI A YPE HP++ N +D+ NLK+K+DAG + +TQ FFD E + F+D+
Sbjct: 138 LKSVA-DFDISVAAYPEVHPEAANAQADLVNLKRKIDAGANRAITQFFFDVESYLRFRDR 196
Query: 205 CTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAY 264
C AGIDV I GI+P+ N Q L+ N+ +P + E+D + + G
Sbjct: 197 CVAAGIDVEIVPGILPVTNFTQ-LKRFAAMTNVSIPGWLHRQFEGLENDAATRQLVGANV 255
Query: 265 AVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
A+D + L + V H YT+N AE + Y H+L
Sbjct: 256 AIDMVKVLAREGVKDFHFYTLNRAELS---YAICHTL 289
>gi|146313665|ref|YP_001178739.1| 5,10-methylenetetrahydrofolate reductase [Enterobacter sp. 638]
gi|145320541|gb|ABP62688.1| 5,10-methylenetetrahydrofolate reductase [Enterobacter sp. 638]
Length = 296
Score = 149 bits (377), Expect = 2e-34, Method: Composition-based stats.
Identities = 89/275 (32%), Positives = 148/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I++
Sbjct: 24 NVSFEFFPPRTSEMEQTLWSSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIKGIKDRTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL + +++++ ++ G+ I+ALRGD+ PG K YATDL+ +K
Sbjct: 83 LEAAPHLTCVDATRDELRAIAQDYWNNGIRHIVALRGDLPPGSG--KPEMYATDLVTLLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ +FDI A YPE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+D+C
Sbjct: 141 -DVGDFDISVAAYPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGID+ I GI+P+ N QA + N+ +P + + + + D E+ + G A+
Sbjct: 200 NAGIDLEIIPGILPVSNFKQAKKFADM-TNVRIPLWMQKMYEGLDDDAETRKLVGANIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 290
>gi|118053934|ref|ZP_01522476.1| 5,10-methylenetetrahydrofolate reductase [Comamonas testosteroni
KF-1]
gi|117998728|gb|EAV12890.1| 5,10-methylenetetrahydrofolate reductase [Comamonas testosteroni
KF-1]
Length = 275
Score = 149 bits (377), Expect = 2e-34, Method: Composition-based stats.
Identities = 92/262 (35%), Positives = 131/262 (50%), Gaps = 4/262 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
+SFE FP G K + + P F SVT + + T + IQN+ +
Sbjct: 5 VSFEFFPTKTPEGAAKHVGVRQALYARKPEFCSVTYGAGG-STQAGTFTMVRDIQNE-GV 62
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
+H I + EKV L EL A+GV RI+ALRGD+ G +F+YA+DL+ F++
Sbjct: 63 GAASHFSCIGATHEKVRAELNELKAMGVKRIVALRGDLPSGYGLGGEFQYASDLVAFVRQ 122
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E + F I A YPE HP + + SD+ KV AG S +TQ F++ + + F D+
Sbjct: 123 EFGDWFHIEVAAYPETHPQAKSPRSDLDAFVAKVRAGADSAITQYFYNADAYMRFVDEVR 182
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G+DVP+ GIMPI + Q +R C +PR R L + D S+RA GL
Sbjct: 183 ALGLDVPVVPGIMPITSSTQLMRFSDAC-GAEIPRWIRLRLQTFGDDTASIRAFGLDVVT 241
Query: 267 DQIVDLVTQDVAGVHLYTMNNA 288
L +Q G+H YTMN +
Sbjct: 242 HLCEQLRSQGAPGLHFYTMNQS 263
>gi|118071193|ref|ZP_01539389.1| 5,10-methylenetetrahydrofolate reductase [Shewanella woodyi ATCC
51908]
gi|118024255|gb|EAV38063.1| 5,10-methylenetetrahydrofolate reductase [Shewanella woodyi ATCC
51908]
Length = 296
Score = 149 bits (377), Expect = 2e-34, Method: Composition-based stats.
Identities = 93/275 (33%), Positives = 146/275 (53%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + ++ ++ P F+SVT N +++ T + + IQ +
Sbjct: 24 NVSFEFFPPASPEMEQLLWNSIRRLEPLNPKFVSVTYGANS-GVRDRTHGVIERIQKETD 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL + S E++ + + G+ I+ALRGD+ P P K R+A DL+ ++
Sbjct: 83 LVAAPHLTLVDASDEELKELAKHYWNSGIKDIVALRGDL-PEGSP-KPTRFANDLVGLLR 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ A +FDI A YPE HPD+ N +D+ NLKKK+DAG + +TQ FFD E + F+D+C
Sbjct: 141 SVA-DFDISVAAYPEVHPDARNAQADLINLKKKIDAGANRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N Q L+ N+ +P + + DP + + G A+
Sbjct: 200 TAGIDVEIVPGILPVTNFKQ-LKRFAGMTNVGIPGWLHKQFEGLDDDPVTRQMVGANVAI 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE Y H+L
Sbjct: 259 DMVKVLSREGVKDFHFYTLNRAELT---YAICHTL 290
>gi|134281583|ref|ZP_01768291.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia pseudomallei
305]
gi|134247250|gb|EBA47336.1| 5,10-methylenetetrahydrofolate reductase [Burkholderia pseudomallei
305]
Length = 276
Score = 149 bits (377), Expect = 2e-34, Method: Composition-based stats.
Identities = 91/271 (33%), Positives = 142/271 (52%), Gaps = 6/271 (2%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDL-A 86
LSFE FPP A G +K+ + P F+SVT + T + D + L A
Sbjct: 6 LSFEFFPPKTAEGVDKLRATRAQLAPLKPKFVSVTFGAGGSTQQGTLDTVLDMQKAGLEA 65
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
P HL I SK+ + L + + G+ I+ALRGD+ G+ + + RYA++L+ FI+
Sbjct: 66 AP---HLSCIGSSKDSLRAILDQYRSHGIRHIVALRGDLPSGMGEVGELRYASELVSFIR 122
Query: 147 AEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKC 205
AE + F I A YPE HP + + +D++N +KV AG ++ +TQ F++ + ++ F D
Sbjct: 123 AEHGDWFRIEVAAYPEYHPQARSPKADLENFARKVKAGANAAITQYFYNADAYFRFVDDA 182
Query: 206 TLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYA 265
G+DVP+ GIMPI N +Q +R + C +PR L+ + D +S+RA G
Sbjct: 183 AKLGVDVPVVPGIMPITNFSQLMRFSEMC-GAEVPRWVARRLESFGDDKDSIRAFGADVV 241
Query: 266 VDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ V G+H YT+N A + + E
Sbjct: 242 TGLCRRLIDAGVPGLHFYTLNGAAATKTVCE 272
>gi|85060140|ref|YP_455842.1| 5,10-methylenetetrahydrofolate reductase [Sodalis glossinidius str.
'morsitans']
gi|84780660|dbj|BAE75437.1| 5,10-methylenetetrahydrofolate reductase [Sodalis glossinidius str.
'morsitans']
Length = 307
Score = 149 bits (377), Expect = 2e-34, Method: Composition-based stats.
Identities = 91/275 (33%), Positives = 141/275 (51%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + F+SVT N +E T + I+
Sbjct: 24 NVSFEFFPPRTSEMEQTLWQSIDRLSELKQTFVSVTYGANSGE-RERTHSIIKDIKERTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I + ++ ++ G+ I+ALRGD+ PG + Y DL+ +K
Sbjct: 83 LDAAPHLTCIDATPHELQAIAQDYWHSGIRHIVALRGDLPPGSG--RPAMYGADLVALLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ +FDI A YPE HP++ + SD+ NLK+KVDAG S +TQ FFD E + F+D+C
Sbjct: 141 -KVGDFDISVAAYPEVHPEAKSAQSDLINLKRKVDAGASRAITQFFFDVESYLRFRDRCV 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGID I GI+P+ N Q L+ N+ +P + D +HD E+ + G + A+
Sbjct: 200 AAGIDTEIVPGILPVSNFRQ-LQRFAAVTNVKVPNWMTTMFDGLDHDQETRKMVGASIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAELT---YAICHTL 290
>gi|67154852|ref|ZP_00416597.1| 5,10-methylenetetrahydrofolate reductase [Azotobacter vinelandii
AvOP]
gi|67088985|gb|EAM08451.1| 5,10-methylenetetrahydrofolate reductase [Azotobacter vinelandii
AvOP]
Length = 281
Score = 149 bits (376), Expect = 2e-34, Method: Composition-based stats.
Identities = 90/275 (32%), Positives = 138/275 (50%), Gaps = 4/275 (1%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
SQ SFE FP G+EK++ + G P F S T + ++ T+ +
Sbjct: 2 SQERRYSFEFFPTKTEAGHEKLMNVARRLAGCDPDFFSCTYGAGG-STRDRTLNTVLQLD 60
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK-DFRYATDL 141
++ +PT HL + S+ ++ L G+ RI+ALRGD+ G+ + R+A+DL
Sbjct: 61 GEVKVPTAPHLSCVGDSRAELRSLLNTYKDAGIRRIVALRGDLPSGMGLANGELRHASDL 120
Query: 142 IEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
+EFI+AE +F I A YPE HP + N D+ K+ AG S +TQ FF+ + ++
Sbjct: 121 VEFIRAETGGHFHIEVAAYPEMHPQARNLEDDLARFAAKMKAGADSAITQYFFNADSYFH 180
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
F ++ G++ PI GIMPI N ++ R C LPR R L+ Y D ES++A
Sbjct: 181 FVERVRKLGVEQPIVPGIMPITNYSKLARFSDAC-GAELPRWVRKQLEAYGDDLESIQAF 239
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
G L+ G+H YT+N AE + I+
Sbjct: 240 GEQVVTAMCEKLLEGGAPGLHFYTLNQAEPSLAIW 274
>gi|149928231|ref|ZP_01916475.1| 5,10-Methylenetetrahydrofolate reductase [Limnobacter sp. MED105]
gi|149823037|gb|EDM82278.1| 5,10-Methylenetetrahydrofolate reductase [Limnobacter sp. MED105]
Length = 286
Score = 149 bits (375), Expect = 3e-34, Method: Composition-based stats.
Identities = 96/266 (36%), Positives = 139/266 (52%), Gaps = 9/266 (3%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVT--ASNNKYNIKETTVPLADHIQND 84
++SFE FP G EK+ + + P F SVT A + +TV L +
Sbjct: 16 NISFEFFPAKTDEGAEKLRATREKLSERKPEFFSVTFGAGGTTQDGTLSTV-LEIKAAGE 74
Query: 85 LAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEF 144
A P HL + SKEKVA L++ G+ RI+ALRGD+ G+ FRYA++L+EF
Sbjct: 75 EAAP---HLSCVGSSKEKVAALLKQYKEHGIKRIVALRGDLPSGMLETGSFRYASELVEF 131
Query: 145 IKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQD 203
I+ E +F I A YPE HP + + +D+ KV+ G +S +TQ FF+ + F F+D
Sbjct: 132 IRRETGDHFFIEVAAYPETHPQAKSPAADVDAFVHKVNCGANSAITQYFFNLDAFLYFRD 191
Query: 204 KCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLA 263
+ I +P+ GIMP+ N +Q R C +PR R L + D ES+RA GL
Sbjct: 192 QVQ-HRISIPLIPGIMPVTNFSQLARFSDAC-GAEIPRWMRNRLQHFGDDRESIRAFGLE 249
Query: 264 YAVDQIVDLVTQDVAGVHLYTMNNAE 289
+ L+ + G+H YTMNNA+
Sbjct: 250 VVSNLCEQLIREGAPGLHFYTMNNAQ 275
>gi|71734161|ref|YP_272753.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas syringae pv.
phaseolicola 1448A]
gi|71554714|gb|AAZ33925.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas syringae pv.
phaseolicola 1448A]
Length = 291
Score = 149 bits (375), Expect = 3e-34, Method: Composition-based stats.
Identities = 86/275 (31%), Positives = 141/275 (51%), Gaps = 4/275 (1%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
SQ SFE FP G+EK+L + P F S T + ++ T+ ++
Sbjct: 12 SQERRFSFEFFPTKTDAGHEKLLTVARQLATYNPDFFSCTYGAGG-STRDRTLNTVLQLE 70
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK-DFRYATDL 141
N++ +P HL + SK+ + + L + G+ RI+ALRGD+ G+ + R+A DL
Sbjct: 71 NEIKVPAAPHLSCVGDSKDDLRNLLAQYKDAGIKRIVALRGDLPSGMGMASGELRHANDL 130
Query: 142 IEFIKAEA-PNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
+ FI+ E+ +F I A YPE HP + N D+++ K +AG S +TQ FF+ + +++
Sbjct: 131 VSFIRQESGSHFHIEVAAYPEMHPQARNFEDDLKHFVNKANAGADSAITQYFFNADSYFN 190
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
F ++ G+ +PI GIMPI N ++ R C +PR R L+ Y D +S++A
Sbjct: 191 FVERVEKMGVSIPIVPGIMPITNYSKLARFSDAC-GAEIPRWIRKQLEAYGDDVQSIQAF 249
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
G L+ G+H YT+N AE + ++
Sbjct: 250 GEEVITQMCERLLQGGTPGLHFYTLNQAEPSLAVW 284
>gi|58583433|ref|YP_202449.1| 5,10-methylenetetrahydrofolate reductase [Xanthomonas oryzae pv.
oryzae KACC10331]
gi|84625248|ref|YP_452620.1| 5,10-methylenetetrahydrofolate reductase [Xanthomonas oryzae pv.
oryzae MAFF 311018]
gi|58428027|gb|AAW77064.1| 5,10-methylenetetrahydrofolate reductase [Xanthomonas oryzae pv.
oryzae KACC10331]
gi|84369188|dbj|BAE70346.1| 5,10-methylenetetrahydrofolate reductase [Xanthomonas oryzae pv.
oryzae MAFF 311018]
Length = 275
Score = 149 bits (375), Expect = 3e-34, Method: Composition-based stats.
Identities = 85/270 (31%), Positives = 137/270 (50%), Gaps = 3/270 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
LSFE +PP ++ +KG AP ++S T + T+ H++
Sbjct: 4 LSFEFYPPKTDDQRAQLDRTAARLKGYAPEYVSCTFGAGGSTLSYTS-ETVRHLKQKHGF 62
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
HL + S++++ + L+ A+G RI+ALRGD+ G+ D RYA+DLI FI+A
Sbjct: 63 EAAPHLSCVGGSRQEIRELLKLYRAIGCTRIVALRGDLPSGMGHPGDLRYASDLIAFIRA 122
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E + F I YPE HP + + +SD++ K KVDAG + +TQ F++ + ++ F+D
Sbjct: 123 EHGDAFRIEVGAYPETHPQATDALSDLRYFKAKVDAGADAAITQYFYNADAYFHFRDAVQ 182
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G++VPI GIMPI N +Q R + C +PR + Y D +++RA G
Sbjct: 183 RMGVEVPIIPGIMPISNFSQLRRFSEQC-GAEIPRWIGKKMQSYADDADAVRAFGADVVA 241
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ +H YT+N A+ + +
Sbjct: 242 ALCERLIAGGAPALHFYTLNLAKPTTQVLQ 271
>gi|66043726|ref|YP_233567.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas syringae pv.
syringae B728a]
gi|63254433|gb|AAY35529.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas syringae pv.
syringae B728a]
Length = 281
Score = 148 bits (374), Expect = 3e-34, Method: Composition-based stats.
Identities = 86/275 (31%), Positives = 141/275 (51%), Gaps = 4/275 (1%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
SQ SFE FP G+EK+L + P F S T + ++ T+ ++
Sbjct: 2 SQERRFSFEFFPTKTDAGHEKLLTVARQLATYNPDFFSCTYGAGG-STRDRTLNTVLQLE 60
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK-DFRYATDL 141
N++ +P HL + SK+ + + L + G+ RI+ALRGD+ G+ + R+A DL
Sbjct: 61 NEIKVPAAPHLSCVGDSKDDLRNLLAQYKDAGIKRIVALRGDLPSGMGMASGELRHANDL 120
Query: 142 IEFIKAEA-PNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
+ FI+ E+ +F I A YPE HP + N D+++ K +AG S +TQ FF+ + +++
Sbjct: 121 VSFIRQESGSHFHIEVAAYPEMHPQARNFEDDLKHFVNKANAGADSAITQYFFNADSYFN 180
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
F ++ G+ +PI GIMPI N ++ R C +PR R L+ Y D +S++A
Sbjct: 181 FVERVEKMGVSIPIVPGIMPITNYSKLARFSDAC-GAEIPRWIRKQLEAYGDDVQSIQAF 239
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
G L+ G+H YT+N AE + ++
Sbjct: 240 GEEVITQMCERLLQGGAPGLHFYTLNQAEPSLAVW 274
>gi|91789969|ref|YP_550921.1| 5,10-methylenetetrahydrofolate reductase [Polaromonas sp. JS666]
gi|91699194|gb|ABE46023.1| 5,10-methylenetetrahydrofolate reductase [Polaromonas sp. JS666]
Length = 277
Score = 148 bits (374), Expect = 4e-34, Method: Composition-based stats.
Identities = 92/268 (34%), Positives = 132/268 (49%), Gaps = 4/268 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
+SFE FPP G +K+ + + P F SVT + +E T I ++ I
Sbjct: 5 ISFEFFPPKTPEGADKLRVTRQALYAHKPEFCSVTFGAGG-STQEGTFGTVKEILDEGVI 63
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
H I +K V L L A+GV ++ALRGD+ G +F YA+DL+ FI+
Sbjct: 64 AA-CHFSCIGATKITVRQQLATLQAMGVKYLVALRGDLPSGYGIGGEFHYASDLVAFIRE 122
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E + F I A YPE HP + + +D+Q KV AG +S +TQ FF+ + ++ F D
Sbjct: 123 ETGDAFHIEVAAYPEVHPQAKSADADLQAFATKVRAGANSSITQYFFNADAYFRFVDDVR 182
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G+DVP+ GIMPI + Q +R C +PR R L + D S+++ GL
Sbjct: 183 KLGLDVPVVPGIMPITSSTQLMRFSDAC-GAEIPRWIRLRLQGFGDDTASIKSFGLDVVT 241
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHI 294
+ L T V G+H YTMN A I
Sbjct: 242 ELCDQLCTAGVPGIHFYTMNQAAATTEI 269
>gi|89899465|ref|YP_521936.1| 5,10-methylenetetrahydrofolate reductase [Rhodoferax ferrireducens
T118]
gi|89344202|gb|ABD68405.1| 5,10-methylenetetrahydrofolate reductase [Rhodoferax ferrireducens
DSM 15236]
Length = 283
Score = 148 bits (373), Expect = 5e-34, Method: Composition-based stats.
Identities = 92/268 (34%), Positives = 135/268 (50%), Gaps = 5/268 (1%)
Query: 22 TSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHI 81
T Q P LSFE FPP G EK+ L + P F SVT + T + D +
Sbjct: 4 TPQIP-LSFEFFPPKTPEGVEKLRLVRQQLYALKPEFCSVTFGAGGSTQEGTFSTVRDIL 62
Query: 82 QNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDL 141
I +H+ I + KV + L L A+GV R++ALRGD+ G +F YA+DL
Sbjct: 63 TE--GIGAASHISCIGATHAKVREQLAILKAMGVKRLVALRGDLPSGFGVGGEFHYASDL 120
Query: 142 IEFIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
+ F++AE + F I A YPE HP + + +D+Q KV AG +S +TQ F++ + ++
Sbjct: 121 VAFVRAETGDYFHIEVAAYPEVHPQARSPEADLQAFATKVKAGANSAITQYFYNADAYFR 180
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
F ++ G+ +PI GIMPI + Q +R C +PR R L + D S++A
Sbjct: 181 FVEEADALGLSLPIVPGIMPIASSTQLMRFSDAC-GAEIPRWIRLRLQGFGDDAVSIKAF 239
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNA 288
GL D L G+H Y+MN +
Sbjct: 240 GLDVVTDLCEQLRAGGAPGLHFYSMNQS 267
>gi|114331866|ref|YP_748088.1| 5,10-methylenetetrahydrofolate reductase [Nitrosomonas eutropha
C91]
gi|114308880|gb|ABI60123.1| 5,10-methylenetetrahydrofolate reductase [Nitrosomonas eutropha
C91]
Length = 284
Score = 148 bits (373), Expect = 5e-34, Method: Composition-based stats.
Identities = 92/280 (32%), Positives = 139/280 (49%), Gaps = 7/280 (2%)
Query: 21 MTSQ---TPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPL 77
M SQ TP+ SFE FPP G EK+ + P F SVT + +E T+
Sbjct: 1 MLSQKNFTPTFSFEFFPPQTPEGMEKLRATRIQLARFNPKFFSVTFGAGG-STRERTLET 59
Query: 78 ADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRY 137
IQ + P HL I +++ + L + + + I+ALRGD+ G+ +FRY
Sbjct: 60 VLEIQAE-GSPVAPHLSCIGSTRDNIRSILEKYHSHNIRHIIALRGDLPSGMAQAGEFRY 118
Query: 138 ATDLIEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNE 196
A +L+ FI+ E F I A YPE HP + + + D N ++KV+AG ++ +TQ F++ +
Sbjct: 119 ANELVAFIRKEFGDTFWIEVAAYPEYHPQARSALEDFTNFRRKVEAGANAAITQFFYNVD 178
Query: 197 RFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPES 256
+ F + C A I VPI GIMPI +Q R C +PR R L+ + D S
Sbjct: 179 AYLHFVEMCEAANISVPIVPGIMPISKFSQLARFSDGC-GAEIPRWIRKKLESFGDDIPS 237
Query: 257 LRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
++A GL L+ G+H YT+N+A I++
Sbjct: 238 IQAFGLDVVTALCARLLEAGAPGLHFYTLNSAVLPTKIWQ 277
>gi|50085383|ref|YP_046893.1| 5,10-methylenetetrahydrofolate reductase [Acinetobacter sp. ADP1]
gi|49531359|emb|CAG69071.1| 5,10-methylenetetrahydrofolate reductase [Acinetobacter sp. ADP1]
Length = 278
Score = 148 bits (373), Expect = 5e-34, Method: Composition-based stats.
Identities = 90/275 (32%), Positives = 139/275 (50%), Gaps = 5/275 (1%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADH 80
M+ +TP +SFE FPP G EK+ +++ P F S+T + T + D
Sbjct: 1 MSKRTP-ISFEFFPPKTDAGAEKLRTVHQELQRLNPEFFSITYGAGGSTRERTLAAINDF 59
Query: 81 IQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATD 140
N P HL I SK ++A+ L G++RI+ALRGD+ G L + YA D
Sbjct: 60 --NGQGTPVAPHLSCIGDSKLRIAELLDLYKRQGIDRIVALRGDLPSGQVGLGELPYAQD 117
Query: 141 LIEFIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFY 199
L+ FI+ + + F I A YPE HP + N +DI+ +KV+AG ++ +TQ FF+ + ++
Sbjct: 118 LVRFIREHSGDHFQIEVAAYPEMHPQAENFDADIKRFIEKVNAGANAAITQFFFNPDSYF 177
Query: 200 DFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRA 259
F ++ GI +P+ GIMPI N + +R +PR R L Y D +S++A
Sbjct: 178 YFVERIQKEGIHIPVAPGIMPITNASNLIRFADG-TGAEIPRWIRKQLQAYGDDTQSIKA 236
Query: 260 AGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHI 294
G + L+ +H Y+MNN E R +
Sbjct: 237 FGHEVILKLCERLIDGGAPSLHFYSMNNTEPTRQL 271
>gi|88798492|ref|ZP_01114076.1| 5,10-methylenetetrahydrofolate reductase [Reinekea sp. MED297]
gi|88778592|gb|EAR09783.1| 5,10-methylenetetrahydrofolate reductase [Reinekea sp. MED297]
Length = 277
Score = 148 bits (373), Expect = 5e-34, Method: Composition-based stats.
Identities = 93/270 (34%), Positives = 134/270 (49%), Gaps = 6/270 (2%)
Query: 21 MTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADH 80
M + P +SFE FPP G + +L A D++K + P F SVT + +E T+
Sbjct: 1 MNTPVP-VSFEFFPPKTDAGYDNLLKAHDELKTTNPEFFSVTYGAGG-STQERTINTVIE 58
Query: 81 IQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPG-VEPLKDFRYAT 139
+ N +P HL I + + D L A G+NRI+ALRGD+ G V DF YA+
Sbjct: 59 L-NKRGVPAAPHLSCIGSKADTIKDLLTTYKAEGINRIVALRGDLPSGMVGTGGDFNYAS 117
Query: 140 DLIEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERF 198
DL+ F+K E F I A YPE HP + N +DI N +K G S +TQ F++ +
Sbjct: 118 DLVTFVKQEFGDTFHIEVAAYPEMHPQAANLDADIDNFVRKAKCGADSAITQYFYNANAY 177
Query: 199 YDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLR 258
F D+ D+ I GIMPI N + +R C +PR R L+ D + ++
Sbjct: 178 KHFVDEVRKRDCDIDIVPGIMPITNYSNLVRFSDAC-GADIPRWMRKALETCSDDVQRIQ 236
Query: 259 AAGLAYAVDQIVDLVTQDVAGVHLYTMNNA 288
GL + VD DL+ +H Y+MN +
Sbjct: 237 RIGLNFVVDLCQDLIQAGAPKLHFYSMNRS 266
>gi|28872182|ref|NP_794801.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas syringae pv.
tomato str. DC3000]
gi|28855436|gb|AAO58496.1| 5,10-methylenetetrahydrofolate reductase [Pseudomonas syringae pv.
tomato str. DC3000]
Length = 281
Score = 147 bits (372), Expect = 6e-34, Method: Composition-based stats.
Identities = 87/275 (31%), Positives = 139/275 (50%), Gaps = 4/275 (1%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
SQ SFE FP G+EK+L + P F S T + ++ T+ ++
Sbjct: 2 SQERRFSFEFFPTKTDAGHEKLLTVARQLATYNPDFFSCTYGAGG-STRDRTLNTVLQLE 60
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK-DFRYATDL 141
N++ +P HL + SKE + L + G+ RI+ALRGD+ G+ + R+A DL
Sbjct: 61 NEVKVPAAPHLSCVGDSKEDLRSLLAQYKDAGIRRIVALRGDLPSGMGMASGELRHANDL 120
Query: 142 IEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYD 200
+ FI+ E +F I A YPE HP + N D+++ K +AG S +TQ FF+ + +++
Sbjct: 121 VAFIREETGSHFHIEVAAYPEMHPQARNFEDDLKHFVTKANAGADSAITQYFFNADSYFN 180
Query: 201 FQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAA 260
F ++ G+ +PI GIMPI N ++ R C +PR R L+ Y D +S++A
Sbjct: 181 FVERVEKMGVSIPIVPGIMPITNYSKLARFSDAC-GAEIPRWIRKQLEAYGDDVQSIQAF 239
Query: 261 GLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
G L+ G+H YT+N AE + ++
Sbjct: 240 GEDVITQMCERLLEGGAPGLHFYTLNQAEPSLAVW 274
>gi|109900254|ref|YP_663509.1| 5,10-methylenetetrahydrofolate reductase [Pseudoalteromonas
atlantica T6c]
gi|109702535|gb|ABG42455.1| 5,10-methylenetetrahydrofolate reductase [Pseudoalteromonas
atlantica T6c]
Length = 294
Score = 147 bits (372), Expect = 6e-34, Method: Composition-based stats.
Identities = 84/269 (31%), Positives = 144/269 (53%), Gaps = 6/269 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + +++ + P ++SVT N ++ T + IQ++
Sbjct: 22 NVSFEFFPPKTETMEKTLWKSVERLAPLKPKYMSVTYGANSGE-RDRTHEIVKRIQSETG 80
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
I HL + S++++ ++ A G+ +I+ALRGD+ G + YA+DL+ ++
Sbjct: 81 IAAAPHLTCVDASRDELKQIAKDYWASGIRKIVALRGDLPEGYT--EHVSYASDLVALLR 138
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ +FDI A YPE HP++PN D+ NLK+K DAG + ++Q FFD E F F+D+
Sbjct: 139 -DVADFDIAVAAYPEKHPEAPNSQFDLLNLKRKADAGANQAISQFFFDAEVFLRFRDRAA 197
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLR-AAGLAYA 265
AGI++ I GI+P+ N Q L+ N+H+P + D + D ++ R G + A
Sbjct: 198 AAGIEMDIVPGILPVTNY-QTLQRFAGFTNVHVPNWLHKMYDGLDKDDQTTRNLMGASIA 256
Query: 266 VDQIVDLVTQDVAGVHLYTMNNAETARHI 294
+D + L + + H YT+N E + I
Sbjct: 257 MDMVKVLAKEGIRDFHFYTLNRCELSYAI 285
>gi|15232215|ref|NP_191556.1| MTHFR1 (METHYLENETETRAHYDROFOLATE REDUCTASE 1);
methylenetetrahydrofolate reductase (NADPH) [Arabidopsis
thaliana]
gi|75313342|sp|Q9SE60|MTHR1_ARATH Methylenetetrahydrofolate reductase 1 (AtMTHFR1)
gi|5911425|gb|AAD55787.1|AF181966_1 methylenetetrahydrofolate reductase MTHFR1 [Arabidopsis thaliana]
gi|7019691|emb|CAB75816.1| methylenetetrahydrofolate reductase MTHFR1 [Arabidopsis thaliana]
gi|17979047|gb|AAL49791.1| putative methylenetetrahydrofolate reductase MTHFR1 [Arabidopsis
thaliana]
gi|21689667|gb|AAM67455.1| putative methylenetetrahydrofolate reductase MTHFR1 [Arabidopsis
thaliana]
Length = 592
Score = 147 bits (372), Expect = 7e-34, Method: Composition-based stats.
Identities = 95/290 (32%), Positives = 149/290 (51%), Gaps = 17/290 (5%)
Query: 17 KVKLMTSQ-TPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTV 75
K+K +T Q + SFE FPP G E + +D + P F +T + + T+
Sbjct: 6 KIKSVTEQGQTAFSFEFFPPKTEDGVENLFERMDRLVSYGPTFCDITWGAGG-STADLTL 64
Query: 76 PLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPG----VEP 131
+A +QN + + T+ HL + EK+ L + + G+ +LALRGD G V+
Sbjct: 65 EIASRMQNVICVETMMHLTCTNMPIEKIDHALETIRSNGIQNVLALRGDPPHGQDKFVQV 124
Query: 132 LKDFRYATDLIEFIKAEAPN-FDIIGACYPEGHPD--------SPNQI-SDIQNLKKKVD 181
F A DL+ I+++ + F I A YPE HPD +P SD+ LKKKVD
Sbjct: 125 EGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEADGLATPESYQSDLAYLKKKVD 184
Query: 182 AGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPR 241
AG +VTQLF+D + F F + C GI+ PI GIMPI N LR+ C+ +P
Sbjct: 185 AGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKT-KIPA 243
Query: 242 KFRAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETA 291
+ A L+ + + E+++A G+ +A + ++ + +HLYT+N ++A
Sbjct: 244 ELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDKSA 293
>gi|114321413|ref|YP_743096.1| 5,10-methylenetetrahydrofolate reductase [Alkalilimnicola ehrlichei
MLHE-1]
gi|114227807|gb|ABI57606.1| 5,10-methylenetetrahydrofolate reductase [Alkalilimnicola ehrlichei
MLHE-1]
Length = 289
Score = 147 bits (372), Expect = 7e-34, Method: Composition-based stats.
Identities = 89/284 (31%), Positives = 140/284 (49%), Gaps = 7/284 (2%)
Query: 16 KKVKLMTSQT---PSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKE 72
++ + M SQ P S E FPP G EK+ + + P + SVT + ++
Sbjct: 2 EQSQTMESQKQHPPVYSCEFFPPRTEQGVEKLRTTRERLARLNPAYFSVTFGAGG-STRD 60
Query: 73 TTVPLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPL 132
T IQ + H+ I ++E + + L G+ RI+ALRGD+ G +
Sbjct: 61 RTYETVTEIQRS-GLEAAPHISCIGSTRESIRELLHGYREQGIRRIVALRGDMPSGTRDV 119
Query: 133 KDFRYATDLIEFIKAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQL 191
+FRYA +L+ FI+AE +F I ACYPE HP + + +D+ N +KV+AG + +TQ
Sbjct: 120 GEFRYANELVAFIRAETGDHFHIEVACYPEFHPQARDAEADMDNFARKVEAGADAAITQY 179
Query: 192 FFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYE 251
FF+ + ++ F + G+ +PI GIMPI+N Q R C +PR R L+ Y
Sbjct: 180 FFNADAYFHFVGQAEKRGVTLPIVPGIMPIINFTQLARFSDAC-GAEIPRWLRKRLEAYG 238
Query: 252 HDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
D +++A G D L+ G+H Y+MN A ++
Sbjct: 239 DDKAAIQALGHEVVRDLCQRLLDGGAPGLHFYSMNQARPVERLW 282
>gi|30695094|ref|NP_850723.1| MTHFR1 (METHYLENETETRAHYDROFOLATE REDUCTASE 1);
methylenetetrahydrofolate reductase (NADPH) [Arabidopsis
thaliana]
Length = 421
Score = 147 bits (370), Expect = 1e-33, Method: Composition-based stats.
Identities = 95/290 (32%), Positives = 149/290 (51%), Gaps = 17/290 (5%)
Query: 17 KVKLMTSQ-TPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTV 75
K+K +T Q + SFE FPP G E + +D + P F +T + + T+
Sbjct: 6 KIKSVTEQGQTAFSFEFFPPKTEDGVENLFERMDRLVSYGPTFCDITWGAGG-STADLTL 64
Query: 76 PLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPG----VEP 131
+A +QN + + T+ HL + EK+ L + + G+ +LALRGD G V+
Sbjct: 65 EIASRMQNVICVETMMHLTCTNMPIEKIDHALETIRSNGIQNVLALRGDPPHGQDKFVQV 124
Query: 132 LKDFRYATDLIEFIKAEAPN-FDIIGACYPEGHPD--------SPNQI-SDIQNLKKKVD 181
F A DL+ I+++ + F I A YPE HPD +P SD+ LKKKVD
Sbjct: 125 EGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEADGLATPESYQSDLAYLKKKVD 184
Query: 182 AGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPR 241
AG +VTQLF+D + F F + C GI+ PI GIMPI N LR+ C+ +P
Sbjct: 185 AGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKT-KIPA 243
Query: 242 KFRAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETA 291
+ A L+ + + E+++A G+ +A + ++ + +HLYT+N ++A
Sbjct: 244 ELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDKSA 293
>gi|15642680|ref|NP_232313.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae O1 biovar
eltor str. N16961]
gi|121591778|ref|ZP_01678979.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae 2740-80]
gi|147673318|ref|YP_001218174.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae O395]
gi|153212564|ref|ZP_01948311.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae 1587]
gi|153221005|ref|ZP_01952060.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae MAK 757]
gi|153803421|ref|ZP_01958007.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae MZO-3]
gi|153825117|ref|ZP_01977784.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae MZO-2]
gi|153829466|ref|ZP_01982133.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae 623-39]
gi|9657280|gb|AAF95826.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae O1 biovar
eltor str. N16961]
gi|121546360|gb|EAX56622.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae 2740-80]
gi|124116435|gb|EAY35255.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae 1587]
gi|124119916|gb|EAY38659.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae MAK 757]
gi|124121054|gb|EAY39797.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae MZO-3]
gi|125619217|gb|EAZ47747.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae MO10]
gi|125622048|gb|EAZ50371.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae V51]
gi|146315201|gb|ABQ19740.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae O395]
gi|148875049|gb|EDL73184.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae 623-39]
gi|149741263|gb|EDM55305.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae MZO-2]
gi|150421221|gb|EDN13504.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae RC385]
gi|150424058|gb|EDN15997.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae AM-19226]
Length = 304
Score = 146 bits (369), Expect = 1e-33, Method: Composition-based stats.
Identities = 92/275 (33%), Positives = 144/275 (52%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP+ E + ++ +K P F+SVT N ++ T + I++
Sbjct: 32 NVSFEFFPPSSPQMEETLWGSVHRLKTLQPKFVSVTYGANSGE-RDRTHSIIKAIKDQTG 90
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I +++++ + G+ I+ALRGDI G K YA+DL+ +K
Sbjct: 91 LIAAPHLTCIDATRDELIQIADDYWHNGIQNIVALRGDIPAGGG--KPEMYASDLVTLLK 148
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ +FDI A +PE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+D+C
Sbjct: 149 SRH-DFDISVAAFPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 207
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA R N+ +P + E DP + + G + A+
Sbjct: 208 AAGIDVEIVPGILPVSNFKQASRFAAQ-NNVKVPNWMVKQFEGLEDDPVTRQLVGASQAI 266
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE Y H+L
Sbjct: 267 DMVRVLCREGVKDFHFYTLNRAEMT---YALCHTL 298
>gi|30695097|ref|NP_850724.1| MTHFR1 (METHYLENETETRAHYDROFOLATE REDUCTASE 1);
methylenetetrahydrofolate reductase (NADPH) [Arabidopsis
thaliana]
Length = 407
Score = 146 bits (369), Expect = 1e-33, Method: Composition-based stats.
Identities = 95/290 (32%), Positives = 149/290 (51%), Gaps = 17/290 (5%)
Query: 17 KVKLMTSQ-TPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTV 75
K+K +T Q + SFE FPP G E + +D + P F +T + + T+
Sbjct: 6 KIKSVTEQGQTAFSFEFFPPKTEDGVENLFERMDRLVSYGPTFCDITWGAGG-STADLTL 64
Query: 76 PLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPG----VEP 131
+A +QN + + T+ HL + EK+ L + + G+ +LALRGD G V+
Sbjct: 65 EIASRMQNVICVETMMHLTCTNMPIEKIDHALETIRSNGIQNVLALRGDPPHGQDKFVQV 124
Query: 132 LKDFRYATDLIEFIKAEAPN-FDIIGACYPEGHPD--------SPNQI-SDIQNLKKKVD 181
F A DL+ I+++ + F I A YPE HPD +P SD+ LKKKVD
Sbjct: 125 EGGFACALDLVNHIRSKYGDYFGITVAGYPEAHPDVIEADGLATPESYQSDLAYLKKKVD 184
Query: 182 AGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPR 241
AG +VTQLF+D + F F + C GI+ PI GIMPI N LR+ C+ +P
Sbjct: 185 AGADLIVTQLFYDTDIFLKFVNDCRQIGINCPIVPGIMPISNYKGFLRMAGFCKT-KIPA 243
Query: 242 KFRAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETA 291
+ A L+ + + E+++A G+ +A + ++ + +HLYT+N ++A
Sbjct: 244 ELTAALEPIKDNDEAVKAYGIHFATEMCKKILAHGITSLHLYTLNVDKSA 293
>gi|116190674|ref|ZP_01480411.1| hypothetical protein VchoM_02000436 [Vibrio cholerae MO10]
gi|116214724|ref|ZP_01480953.1| hypothetical protein VchoR_02003196 [Vibrio cholerae RC385]
gi|116221046|ref|ZP_01486462.1| hypothetical protein VchoV5_02000925 [Vibrio cholerae V51]
Length = 295
Score = 146 bits (369), Expect = 2e-33, Method: Composition-based stats.
Identities = 92/275 (33%), Positives = 144/275 (52%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP+ E + ++ +K P F+SVT N ++ T + I++
Sbjct: 23 NVSFEFFPPSSPQMEETLWGSVHRLKTLQPKFVSVTYGANSGE-RDRTHSIIKAIKDQTG 81
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I +++++ + G+ I+ALRGDI G K YA+DL+ +K
Sbjct: 82 LIAAPHLTCIDATRDELIQIADDYWHNGIQNIVALRGDIPAGGG--KPEMYASDLVTLLK 139
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ +FDI A +PE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+D+C
Sbjct: 140 SRH-DFDISVAAFPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 198
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA R N+ +P + E DP + + G + A+
Sbjct: 199 AAGIDVEIVPGILPVSNFKQASRFAAQ-NNVKVPNWMVKQFEGLEDDPVTRQLVGASQAI 257
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE Y H+L
Sbjct: 258 DMVRVLCREGVKDFHFYTLNRAEMT---YALCHTL 289
>gi|62290343|ref|YP_222136.1| MetF, 5,10-methylenetetrahydrofolate reductase [Brucella abortus
biovar 1 str. 9-941]
gi|82700266|ref|YP_414840.1| Methylenetetrahydrofolate reductase:5,10-methylenetetrahydrofolate
reductase [Brucella melitensis biovar Abortus 2308]
gi|148559043|ref|YP_001259341.1| 5,10-methylenetetrahydrofolate reductase [Brucella ovis ATCC 25840]
gi|62196475|gb|AAX74775.1| MetF, 5,10-methylenetetrahydrofolate reductase [Brucella abortus
biovar 1 str. 9-941]
gi|82616367|emb|CAJ11424.1| Methylenetetrahydrofolate reductase:5,10-methylenetetrahydrofolate
reductase [Brucella melitensis biovar Abortus 2308]
gi|148370300|gb|ABQ60279.1| 5,10-methylenetetrahydrofolate reductase [Brucella ovis ATCC 25840]
Length = 303
Score = 146 bits (369), Expect = 2e-33, Method: Composition-based stats.
Identities = 89/271 (32%), Positives = 141/271 (52%), Gaps = 8/271 (2%)
Query: 24 QTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQN 83
QT +SFE FPP +++ + + P F+SVT + +E TV I
Sbjct: 14 QTTRVSFEFFPPKTEEMEQRLWETVTRLAPLQPDFVSVTYGAGG-STRERTVRTVARILK 72
Query: 84 DLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPG-----VEPLKDFRYA 138
+ I AHL + ++E V RE A+GVNR +ALRGD G V ++
Sbjct: 73 ETDIKPAAHLTCVDATREDVDRVAREFAALGVNRFVALRGDPANGIGEKYVPTPGGYQNG 132
Query: 139 TDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERF 198
+L+ ++ A +FDI + YPE HP+SP+ +DI LK+KVD G + +TQ FF+N+ +
Sbjct: 133 AELVGGLRNIA-DFDISVSAYPEKHPESPDFATDIDMLKRKVDNGATRAITQFFFENDLY 191
Query: 199 YDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLR 258
+ ++ AGI +PI G++P+ N Q +R H+P D ++DP++ +
Sbjct: 192 ERYVERVRRAGIYIPIVPGVLPVHNFKQ-VRNFCARSATHIPAWLAERFDGLDNDPQTHQ 250
Query: 259 AAGLAYAVDQIVDLVTQDVAGVHLYTMNNAE 289
A A +Q++DL+ + V H YTMN A+
Sbjct: 251 LVAAAIAAEQVMDLIERGVQDFHFYTMNRAD 281
>gi|156935926|ref|YP_001439842.1| hypothetical protein ESA_03820 [Enterobacter sakazakii ATCC
BAA-894]
gi|156534180|gb|ABU79006.1| hypothetical protein ESA_03820 [Enterobacter sakazakii ATCC
BAA-894]
Length = 301
Score = 146 bits (368), Expect = 2e-33, Method: Composition-based stats.
Identities = 88/275 (32%), Positives = 143/275 (52%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + + ++D + P F+SVT N ++ T + I++
Sbjct: 24 NVSFEFFPPRTSEMEQTLWSSIDRLSSLKPKFVSVTYGANSGE-RDRTHSIIKGIKDRTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I + +++ R+ G+ I+ALRGD+ G K YA+DL+ +K
Sbjct: 83 LEAAPHLTCIDATPDELRSIARDYWNNGIRHIVALRGDLPAGSG--KPEMYASDLVALLK 140
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E +FDI A YPE HP++ + +D+ NL++K+DAG + +TQ FFD E + F+D+C
Sbjct: 141 -EVADFDISVAAYPEVHPEAKSAQADLLNLRRKIDAGANRAITQFFFDVESYLRFRDRCA 199
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
GIDV I GI+P+ N QA + N+ +P + + D E+ + G A+
Sbjct: 200 ATGIDVEIIPGILPVSNFKQAKKFADM-TNVRIPSWMSQMFAGLDDDAETRKLVGANIAM 258
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE + Y H+L
Sbjct: 259 DMVKILSREGVKDFHFYTLNRAEMS---YAICHTL 290
>gi|90418221|ref|ZP_01226133.1| metF, 5,10-methylenetetrahydrofolate reductase [Aurantimonas sp.
SI85-9A1]
gi|90337893|gb|EAS51544.1| metF, 5,10-methylenetetrahydrofolate reductase [Aurantimonas sp.
SI85-9A1]
Length = 303
Score = 146 bits (368), Expect = 2e-33, Method: Composition-based stats.
Identities = 97/291 (33%), Positives = 147/291 (50%), Gaps = 18/291 (6%)
Query: 23 SQTPSL-------SFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTV 75
SQTP L SFE FPP E + +++ + P F+SVT + +E T
Sbjct: 2 SQTPPLAGSGLRVSFEFFPPKTEKMEENLWRSIERLAPLGPSFVSVTYGAGG-STRERTH 60
Query: 76 PLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVE----P 131
+ I + + AHL + S+E+V + +R+ GV +ALRGD GV P
Sbjct: 61 QTIERILKETTLTPAAHLTCVDASREEVDEVVRQYWETGVRHFVALRGDGQNGVGGKYVP 120
Query: 132 LKD-FRYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQ 190
+D +R A +L+ +KA A +F+I A YPE HP+SP+ +DI LK+KVD G + +TQ
Sbjct: 121 REDGYRNAVELVAGLKAFA-DFEISVAAYPEKHPESPDFATDIDLLKRKVDNGATRAITQ 179
Query: 191 LFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKY 250
FFDN+ F + ++ AGI +PI GI+PI + + R +P D
Sbjct: 180 FFFDNDVFERYVERVRRAGIYIPIVPGIVPIHDFVKVAR-FSNATGAKIPSWLAERFDGL 238
Query: 251 EHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
E DP++ A +Q++DL + ++ H YTMN A+ +Y H L
Sbjct: 239 EEDPQTRSHVAAAVCAEQVLDLQKRGLSDFHFYTMNRADL---VYSICHIL 286
>gi|150008401|ref|YP_001303144.1| 5,10-methylenetetrahydrofolate reductase [Parabacteroides
distasonis ATCC 8503]
gi|149936825|gb|ABR43522.1| 5,10-methylenetetrahydrofolate reductase [Parabacteroides
distasonis ATCC 8503]
Length = 317
Score = 146 bits (368), Expect = 2e-33, Method: Composition-based stats.
Identities = 103/314 (32%), Positives = 157/314 (50%), Gaps = 41/314 (13%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTA-------------SNN 66
+ S++ + SFE+ PP +K+ +D +K P +I++T+ S
Sbjct: 7 IRNSKSTAFSFEILPPLKGNSIQKVYNVIDKLKEFDPKYINITSHHSEFVYKTLPDGSFQ 66
Query: 67 KYNIKET--TVPLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGD 124
K NI++ +V +A IQN IP + H+ +K++ L +L+ +GVN +L LRGD
Sbjct: 67 KVNIRKRPGSVAIASAIQNKYGIPAVPHIICKGFTKDETEYALIDLNFLGVNNLLILRGD 126
Query: 125 I----IPGVEPLKDFRYATDLIEFIK---------------AEAPNFDIIGACYPEGHPD 165
I +P +ATDL + + E P F ACYPE H +
Sbjct: 127 IKTLEASQQKPELYHDHATDLQQQVNHFNEGIALDGSKIDGIETP-FSYGMACYPEKHEE 185
Query: 166 SPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRN 225
+PN SDI LK+KV G LVTQ+FFDN+++Y F D+C GI VPI GI PI+ +N
Sbjct: 186 APNMESDIYYLKEKVKNGAEYLVTQMFFDNDKYYAFVDRCRAEGITVPIIPGIKPIVFKN 245
Query: 226 QALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTM 285
Q L +L +P F L K + D E+ + G+ + + Q DL+ V +H YTM
Sbjct: 246 Q-LTVLPKIFRADIPEPFATELRKCKDDAEA-KEVGVEWCIQQCKDLIAHGVPSLHFYTM 303
Query: 286 NNAET----ARHIY 295
+++ A+ IY
Sbjct: 304 MASDSVYKIAKEIY 317
>gi|21230213|ref|NP_636130.1| 5,10-methylenetetrahydrofolate reductase [Xanthomonas campestris
pv. campestris str. ATCC 33913]
gi|66769797|ref|YP_244559.1| 5,10-methylenetetrahydrofolate reductase [Xanthomonas campestris
pv. campestris str. 8004]
gi|21111753|gb|AAM40054.1| 5,10-methylenetetrahydrofolate reductase [Xanthomonas campestris
pv. campestris str. ATCC 33913]
gi|66575129|gb|AAY50539.1| 5,10-methylenetetrahydrofolate reductase [Xanthomonas campestris
pv. campestris str. 8004]
Length = 275
Score = 146 bits (368), Expect = 2e-33, Method: Composition-based stats.
Identities = 85/270 (31%), Positives = 136/270 (50%), Gaps = 3/270 (1%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
LSFE +PP ++ +K AP ++S T + T+ H++
Sbjct: 4 LSFEFYPPKTDDQRAQLDRTAAKLKAYAPEYVSCTFGAGGSTLSYTS-ETVRHLKQKHGF 62
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIKA 147
HL + S++++ + L+ A+G RI+ALRGD+ G+ D RYA+DLI FI+A
Sbjct: 63 EAAPHLSCVGGSRQEIRELLKLYRAIGCTRIVALRGDLPSGMGHPGDLRYASDLIAFIRA 122
Query: 148 EAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
E + F I YPE HP + + SD++ K KVDAG + +TQ F++ + ++ F+D
Sbjct: 123 EHGDAFRIEVGAYPETHPQAIDADSDLKYFKAKVDAGADAAITQYFYNADAYFHFRDAAQ 182
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
G++VPI GIMPI N +Q R + C +PR + Y D +++RA G
Sbjct: 183 RLGVEVPIIPGIMPISNFSQLRRFSEQC-GAEIPRWIGKKMQSYGDDADAVRAFGAEVVA 241
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
L+ V +H YT+N A+ + +
Sbjct: 242 GLCERLIAGGVPALHFYTLNLAKPTTQVLQ 271
>gi|50545621|ref|XP_500349.1| hypothetical protein [Yarrowia lipolytica]
gi|49646215|emb|CAG82563.1| unnamed protein product [Yarrowia lipolytica CLIB122]
Length = 583
Score = 146 bits (368), Expect = 2e-33, Method: Composition-based stats.
Identities = 98/272 (36%), Positives = 139/272 (51%), Gaps = 16/272 (5%)
Query: 25 TPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVT--ASNNKYNIKETTVPLADHIQ 82
TP+ SFE F P + G + +D M P FI +T A N+ V A Q
Sbjct: 16 TPTFSFEFFVPKTSQGVNNLYDRMDRMYQLGPQFIDITWNAGGRLSNLTNEMVATA---Q 72
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK------DFR 136
+ L + T HL + K+ V + L+ G ILALRGD P VE K FR
Sbjct: 73 SALGLETCMHLTCTGMPKQLVENALQSAFDGGCQNILALRGD--PPVESEKWEAVDGGFR 130
Query: 137 YATDLIEFIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDN 195
YA DL+++IK++ + FDI A YPEG P+ P+ I +LK+KVDAG + +VTQ+F+D
Sbjct: 131 YAKDLVKYIKSKYGDYFDIGVAAYPEGTPEEPDVDILIDHLKEKVDAGGTFIVTQMFYDT 190
Query: 196 ERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPE 255
+ F + DKC GI+VPI GIMPI +R C+ I +P+ F L+ + D
Sbjct: 191 DNFLKWVDKCRAKGINVPIIPGIMPISTYASFMRRANWCQ-IQIPQDFLDQLEPVKDDDM 249
Query: 256 SLRAAGLAYAVDQIVDLV-TQDVAGVHLYTMN 286
+R G D ++ + + +H YTMN
Sbjct: 250 RVRELGTQLVADMCQKMLDSGKIKHLHFYTMN 281
>gi|119896875|ref|YP_932088.1| 5,10-methylenetetrahydrofolate reductase (FADH2 [Azoarcus sp. BH72]
gi|119669288|emb|CAL93201.1| 5,10-methylenetetrahydrofolate reductase (FADH2 [Azoarcus sp. BH72]
Length = 277
Score = 145 bits (367), Expect = 2e-33, Method: Composition-based stats.
Identities = 94/270 (34%), Positives = 131/270 (48%), Gaps = 8/270 (2%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHI--QNDL 85
LS E FPP A G EK+ + P F SVT + +E T I
Sbjct: 6 LSIEFFPPQTAEGAEKLRAVQARLAELKPTFFSVTYGAGG-STRERTFATVKEIAASGSE 64
Query: 86 AIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFI 145
A P HL I +++ + L E GV RI+ALRGD+ GV +FRYA +L+EFI
Sbjct: 65 AAP---HLSCIGSTRDSIRAILAEYADAGVKRIVALRGDLPSGVVDPGEFRYANELVEFI 121
Query: 146 KAE-APNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDK 204
+AE F I A YPE HP + D+ K+K+DAG S +TQ F++ + + F D
Sbjct: 122 RAETGSRFRIEVAAYPEWHPQAKTPADDLAAFKRKMDAGADSAITQYFYNLDAYLHFVDA 181
Query: 205 CTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAY 264
GID P+ GIMPI + ++ R C +PR R + Y D +++RA GL
Sbjct: 182 VRKLGIDKPVVPGIMPIGSFSKLARFSDAC-GAEIPRWMRRKFESYGDDADAIRAFGLDV 240
Query: 265 AVDQIVDLVTQDVAGVHLYTMNNAETARHI 294
+ L+ V G+H Y+MN + I
Sbjct: 241 VTELCEKLLAAGVPGLHFYSMNQSALTTEI 270
>gi|121729836|ref|ZP_01682268.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae V52]
gi|121628415|gb|EAX60910.1| 5,10-methylenetetrahydrofolate reductase [Vibrio cholerae V52]
Length = 304
Score = 145 bits (367), Expect = 3e-33, Method: Composition-based stats.
Identities = 91/275 (33%), Positives = 144/275 (52%), Gaps = 8/275 (2%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP+ E + ++ +K P F+SVT N ++ T + +++
Sbjct: 32 NVSFEFFPPSSPQMEETLWGSVHRLKTLQPKFVSVTYGANSGE-RDRTHSIIKALKDQTG 90
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
+ HL I +++++ + G+ I+ALRGDI G K YA+DL+ +K
Sbjct: 91 LIAAPHLTCIDATRDELIQIADDYWHNGIQNIVALRGDIPAGGG--KPEMYASDLVTLLK 148
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ +FDI A +PE HP++ + +D+ NLK+KVDAG + +TQ FFD E + F+D+C
Sbjct: 149 SRH-DFDISVAAFPEVHPEAKSAQADLLNLKRKVDAGANRAITQFFFDVESYLRFRDRCV 207
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
AGIDV I GI+P+ N QA R N+ +P + E DP + + G + A+
Sbjct: 208 AAGIDVEIVPGILPVSNFKQASRFAAQ-NNVKVPNWMVKQFEGLEDDPVTRQLVGASQAI 266
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETARHIYEATHSL 301
D + L + V H YT+N AE Y H+L
Sbjct: 267 DMVRVLCREGVKDFHFYTLNRAEMT---YALCHTL 298
>gi|115456165|ref|NP_001051683.1| Os03g0815200 [Oryza sativa (japonica cultivar-group)]
gi|75294984|sp|Q75HE6|MTHR_ORYSJ Probable methylenetetrahydrofolate reductase
gi|40786561|gb|AAR89836.1| putative methylenetetrahydrofolate reductase [Oryza sativa
(japonica cultivar-group)]
gi|108711742|gb|ABF99537.1| Methylenetetrahydrofolate reductase, putative, expressed [Oryza
sativa (japonica cultivar-group)]
gi|113550154|dbj|BAF13597.1| Os03g0815200 [Oryza sativa (japonica cultivar-group)]
gi|125546191|gb|EAY92330.1| hypothetical protein OsI_013563 [Oryza sativa (indica
cultivar-group)]
gi|125588378|gb|EAZ29042.1| hypothetical protein OsJ_012525 [Oryza sativa (japonica
cultivar-group)]
Length = 594
Score = 145 bits (366), Expect = 3e-33, Method: Composition-based stats.
Identities = 90/278 (32%), Positives = 143/278 (51%), Gaps = 16/278 (5%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
SFE FPP G + + +D M P+F +T + + T+ +A+ +QN + +
Sbjct: 18 FSFEYFPPKTEEGLDNLFERMDRMVAHGPNFCDITWGAGG-STADLTLEIANRMQNMVCV 76
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPG----VEPLKDFRYATDLIE 143
T+ HL + EK+ D L + + G+ +LALRGD G V+ F A DL++
Sbjct: 77 ETMMHLTCTNMPVEKIDDALTTIKSNGIQNVLALRGDPPHGQDKFVQVAGGFACALDLVQ 136
Query: 144 FIKAEAPN-FDIIGACYPEGHPD--------SPNQIS-DIQNLKKKVDAGCSSLVTQLFF 193
I+A+ + F I A YPE HPD +P S D+ LK+KVDAG ++TQLF+
Sbjct: 137 HIRAKYGDYFGITVAGYPEAHPDAIQSTEGATPEAYSNDLAYLKQKVDAGADLIITQLFY 196
Query: 194 DNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHD 253
D + F F + C GI PI GIMPI N LR+ C+ +P + A L+ + +
Sbjct: 197 DTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCKT-KIPAEITAALEPIKDN 255
Query: 254 PESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETA 291
E+++A G+ + ++ + +HLYT+N ++A
Sbjct: 256 EEAVKAYGIHLGTEMCKKILATGIKTLHLYTLNMEKSA 293
>gi|108711743|gb|ABF99538.1| Methylenetetrahydrofolate reductase, putative, expressed [Oryza
sativa (japonica cultivar-group)]
Length = 573
Score = 145 bits (366), Expect = 3e-33, Method: Composition-based stats.
Identities = 90/278 (32%), Positives = 143/278 (51%), Gaps = 16/278 (5%)
Query: 28 LSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLAI 87
SFE FPP G + + +D M P+F +T + + T+ +A+ +QN + +
Sbjct: 18 FSFEYFPPKTEEGLDNLFERMDRMVAHGPNFCDITWGAGG-STADLTLEIANRMQNMVCV 76
Query: 88 PTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPG----VEPLKDFRYATDLIE 143
T+ HL + EK+ D L + + G+ +LALRGD G V+ F A DL++
Sbjct: 77 ETMMHLTCTNMPVEKIDDALTTIKSNGIQNVLALRGDPPHGQDKFVQVAGGFACALDLVQ 136
Query: 144 FIKAEAPN-FDIIGACYPEGHPD--------SPNQIS-DIQNLKKKVDAGCSSLVTQLFF 193
I+A+ + F I A YPE HPD +P S D+ LK+KVDAG ++TQLF+
Sbjct: 137 HIRAKYGDYFGITVAGYPEAHPDAIQSTEGATPEAYSNDLAYLKQKVDAGADLIITQLFY 196
Query: 194 DNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHD 253
D + F F + C GI PI GIMPI N LR+ C+ +P + A L+ + +
Sbjct: 197 DTDIFLKFVNDCRQIGITCPIVPGIMPINNYKGFLRMTGFCKT-KIPAEITAALEPIKDN 255
Query: 254 PESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETA 291
E+++A G+ + ++ + +HLYT+N ++A
Sbjct: 256 EEAVKAYGIHLGTEMCKKILATGIKTLHLYTLNMEKSA 293
>gi|94676929|ref|YP_588624.1| 5,10-methylenetetrahydrofolate reductase [Baumannia cicadellinicola
str. Hc (Homalodisca coagulata)]
gi|94220079|gb|ABF14238.1| 5,10-methylenetetrahydrofolate reductase [Baumannia cicadellinicola
str. Hc (Homalodisca coagulata)]
Length = 302
Score = 145 bits (366), Expect = 3e-33, Method: Composition-based stats.
Identities = 89/264 (33%), Positives = 136/264 (51%), Gaps = 4/264 (1%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPP + + ++ + P FISVT N + T L I
Sbjct: 24 TVSFEFFPPRSSDMEQMFWQSIQRLSQLKPSFISVTYGANSGE-HQNTYSLIKEINKRTG 82
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFR-YATDLIEFI 145
+ + HL I S ++ + ++E G+ I+ALRGD+ P ++ Y DL+ +
Sbjct: 83 LVAVPHLTCINTSPWELHEIIQEYWHNGIRHIVALRGDLPPDNSSRQNITMYGLDLVVLL 142
Query: 146 KAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKC 205
K + +F+I A YPE HP++ + SD+ NLKKKVDAG + +TQ FFD E + F+D+C
Sbjct: 143 K-KIGDFEISVAAYPEVHPEALSAQSDLINLKKKVDAGANRAITQFFFDVESYLRFRDRC 201
Query: 206 TLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYA 265
GID+ I GIMP+ N Q L+ T N+ +P + D + D ES + G + A
Sbjct: 202 LTVGIDIEIVPGIMPVFNFRQ-LQRFATMTNVKIPLWMNTMFDGLDLDIESSKLVGASIA 260
Query: 266 VDQIVDLVTQDVAGVHLYTMNNAE 289
++ I L + V H YT+N E
Sbjct: 261 IEMIKILSREGVKHFHFYTLNRDE 284
>gi|152979823|ref|YP_001354884.1| 5,10-methylenetetrahydrofolate reductase (FADH2) [Janthinobacterium
sp. Marseille]
gi|151279900|gb|ABR88310.1| 5,10-methylenetetrahydrofolate reductase (FADH2) [Janthinobacterium
sp. Marseille]
Length = 283
Score = 145 bits (366), Expect = 3e-33, Method: Composition-based stats.
Identities = 92/277 (33%), Positives = 138/277 (49%), Gaps = 14/277 (5%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVT---ASNNKYNIKETTVPLADHIQN 83
+ S E FPP G EK+ + + P + SVT + + ET + + Q+
Sbjct: 5 NFSIEFFPPKTPAGVEKLRVTCAKLAELNPKYFSVTFGAGGSTQQGTLETVLEIRGAGQD 64
Query: 84 DLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPL----KDFRYAT 139
A P HL + S++ + L E + G+ RI+ALRGD+ G + +F +A
Sbjct: 65 --AAP---HLSCLGSSRDSLRAILAEYKSHGIKRIVALRGDLPSGYGAMDMSSSEFHHAN 119
Query: 140 DLIEFIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERF 198
+L+EFI+AE + F I A YPE HP + + DI + +K AG S +TQ F++ + +
Sbjct: 120 ELVEFIRAETGDWFHIEVAAYPEMHPQAKSPQDDIASFVRKAKAGADSAITQYFYNADAY 179
Query: 199 YDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLR 258
+ F D AG D+P+ AGIMPI N +Q +R C +PR R L + D ES+R
Sbjct: 180 FRFVDDARKAGTDIPVTAGIMPITNYSQLMRFSDMC-GAEIPRWIRLKLASFGDDSESIR 238
Query: 259 AAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIY 295
A GL D L+ G+H YT+N A I+
Sbjct: 239 AFGLDVVTDLCERLLAGGAPGLHFYTLNQAVATHTIW 275
>gi|154294630|ref|XP_001547755.1| hypothetical protein BC1G_13785 [Botryotinia fuckeliana B05.10]
gi|150844664|gb|EDN19857.1| hypothetical protein BC1G_13785 [Botryotinia fuckeliana B05.10]
Length = 390
Score = 145 bits (365), Expect = 4e-33, Method: Composition-based stats.
Identities = 98/283 (34%), Positives = 143/283 (50%), Gaps = 15/283 (5%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
S PS SFE FPP A G + + +D M G P FI +T + + T + Q
Sbjct: 13 SGNPSFSFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGG-RLAQLTCEMVGVAQ 71
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK------DFR 136
+ + T HL + KEKV + LR G ILALRGD P E K F+
Sbjct: 72 SQYGLETCMHLTCTDMGKEKVDEALRNAYKAGCTNILALRGD--PPREKEKWEATEGGFQ 129
Query: 137 YATDLIEFIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDN 195
YA DL+ I+ N FDI A YPEG D ++ + +LK+KVDAG + +VTQ+F+D
Sbjct: 130 YAKDLVHHIRQTYGNHFDIGVAGYPEGCDDQDDEDLLLDHLKEKVDAGATFIVTQMFYDV 189
Query: 196 ERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENI--HLPRKFRAILDKYEHD 253
+ F D+ K G++VP+ GIMPI N L+ C ++ +P K+ A L++ ++D
Sbjct: 190 DNFIDWLGKVKARGVNVPVIPGIMPI---NTYASFLRRCNHMGCKIPPKWSAALEEVKND 246
Query: 254 PESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
++R G + ++ V +H YTMN A+ R + E
Sbjct: 247 DAAVRNIGKDLVAEMCRRIIEAGVHHLHFYTMNLAQATRMVLE 289
>gi|119877074|ref|ZP_01644098.1| 5,10-methylenetetrahydrofolate reductase [Stenotrophomonas
maltophilia R551-3]
gi|119820391|gb|EAX23003.1| 5,10-methylenetetrahydrofolate reductase [Stenotrophomonas
maltophilia R551-3]
Length = 275
Score = 145 bits (365), Expect = 4e-33, Method: Composition-based stats.
Identities = 82/264 (31%), Positives = 135/264 (51%), Gaps = 3/264 (1%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE +PP ++ A +K P ++S T + T+ H+
Sbjct: 3 AISFEFYPPKTDEQRSQLDRAAAKLKDYGPEYVSCTFGAGGSTLSYTS-ETVRHLNQHHG 61
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
HL + +++++ + L+ A+G R++ALRGD+ G+ D RYA +LI+FI+
Sbjct: 62 FDAAPHLSCVGGTRQEIRELLKLYRAIGCRRLVALRGDLPSGMGFPGDMRYAAELIDFIR 121
Query: 147 AEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKC 205
AE + F I YPE HP + + ++D+++ K K+DAG + +TQ FF+ + ++ F D+
Sbjct: 122 AEHGDAFHIEVGAYPETHPQASDALADLKHFKAKIDAGADAAITQYFFNPDAYFHFVDEV 181
Query: 206 TLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYA 265
G+ VPI GIMPI N +Q R + C +PR + Y D ES+RA G
Sbjct: 182 RRLGVQVPITPGIMPIANFSQLRRFSEQC-GAEIPRWISRKMQAYGDDAESVRAFGTEVV 240
Query: 266 VDQIVDLVTQDVAGVHLYTMNNAE 289
L+ G+H YT+N A+
Sbjct: 241 ARLCQRLIEDGAPGLHFYTLNLAK 264
>gi|153009053|ref|YP_001370268.1| 5,10-methylenetetrahydrofolate reductase [Ochrobactrum anthropi
ATCC 49188]
gi|151560941|gb|ABS14439.1| 5,10-methylenetetrahydrofolate reductase [Ochrobactrum anthropi
ATCC 49188]
Length = 303
Score = 145 bits (365), Expect = 4e-33, Method: Composition-based stats.
Identities = 85/271 (31%), Positives = 140/271 (51%), Gaps = 8/271 (2%)
Query: 24 QTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQN 83
QT +SFE FPP +++ + + P F+SVT + +E T I
Sbjct: 14 QTTRVSFEFFPPKSEEMEQRLWDTVTRLAPLQPEFVSVTYGAGG-STRERTARTVARILK 72
Query: 84 DLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPG-----VEPLKDFRYA 138
+ + AHL + ++E+V +RE A+GVNR +ALRGD G V ++
Sbjct: 73 ETDVKPAAHLTCVDATREEVDRVVREFAALGVNRFVALRGDPAAGIGEKYVPTPGGYQNG 132
Query: 139 TDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERF 198
+L+ ++ A +FDI + YPE HP+SP+ +DI LK+KVD G + +TQ FF+N+ +
Sbjct: 133 AELVSGLRNIA-DFDISVSAYPEKHPESPDFATDIDMLKRKVDNGATRAITQFFFENDLY 191
Query: 199 YDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLR 258
+ ++ AGI +PI G++P+ N Q H+P + ++DP++ +
Sbjct: 192 ERYVERVRRAGIYIPIVPGVLPVHNFKQVKNFCARSAT-HIPSWLAERFEGLDNDPQTHQ 250
Query: 259 AAGLAYAVDQIVDLVTQDVAGVHLYTMNNAE 289
A A +Q++DL+ + V H YTMN A+
Sbjct: 251 LVAAAIAAEQVMDLIERGVQDFHFYTMNRAD 281
>gi|27904555|ref|NP_777681.1| 5,10-methylenetetrahydrofolate reductase [Buchnera aphidicola str.
Bp (Baizongia pistaciae)]
gi|38258065|sp|Q89B13|METF_BUCBP 5,10-methylenetetrahydrofolate reductase
gi|27903952|gb|AAO26786.1| 5,10-methylenetetrahydrofolate reductase [Buchnera aphidicola str.
Bp (Baizongia pistaciae)]
Length = 295
Score = 145 bits (365), Expect = 5e-33, Method: Composition-based stats.
Identities = 89/265 (33%), Positives = 137/265 (51%), Gaps = 4/265 (1%)
Query: 27 SLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDLA 86
++SFE FPPN + + + +D +K P F SVT N T + I+
Sbjct: 24 NISFEFFPPNNILSEKNLWQVIDKLKLLTPKFFSVTHGTNSKIRATCTSNIVKKIKKYTG 83
Query: 87 IPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKDFRYATDLIEFIK 146
I T+ HL I ++E++ + G+ ILALRGDI K YA DLI+ +K
Sbjct: 84 IETVPHLTCINSTEEELKVIAKTYWDSGIRHILALRGDIFN--TNCKPKIYAVDLIKLLK 141
Query: 147 AEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCT 206
+ A NF+I A YPE HP++ N DI NLK+KV+AG + +TQ FF+ + F F+D C
Sbjct: 142 SIA-NFEISVAAYPEVHPEAVNAKYDIINLKRKVEAGATRAITQFFFNIDCFLRFRDLCV 200
Query: 207 LAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAGLAYAV 266
I + I GI PI N Q L+ + N+ +P+ + ++D + R G + A+
Sbjct: 201 KNNITIDIVPGIFPISNFKQLLK-FSSVSNVSIPKWLCCMFHGLDNDLNTSRIIGSSIAI 259
Query: 267 DQIVDLVTQDVAGVHLYTMNNAETA 291
D + L ++ + H YT+N +E +
Sbjct: 260 DMVKVLYSEGIRSFHFYTLNKSEIS 284
>gi|60687510|ref|NP_001011685.1| 5,10-methylenetetrahydrofolate reductase (NADPH) [Bos taurus]
gi|75061139|sp|Q5I598|MTHR_BOVIN Methylenetetrahydrofolate reductase
gi|57222551|gb|AAW39033.1| methylenetetrahydrofolate reductase [Bos taurus]
Length = 655
Score = 144 bits (364), Expect = 5e-33, Method: Composition-based stats.
Identities = 89/283 (31%), Positives = 150/283 (53%), Gaps = 8/283 (2%)
Query: 11 QKSKTKKVKLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVT---ASNNK 67
++ + K + M S S E FPP A G ++ D M P F+ VT A +
Sbjct: 42 ERLREKMKRKMDSGDKWFSLEFFPPRTAQGAVNLISRFDRMGAGGPLFVDVTWHPAGDPG 101
Query: 68 YNIKETTVPLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIP 127
+ + +++ +A N + TI H+ + S+E++ L + +G+ ILALRGD I
Sbjct: 102 SDKETSSMVIASTAVNYCGLETILHMTCCHQSREEITGHLNKAKQLGLKNILALRGDPIG 161
Query: 128 GV--EPLKDFRYATDLIEFIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGC 184
E F YATDL++ I+ E + FD+ A YP+GHP+ + +D+++LK+KV AG
Sbjct: 162 DQWEEEEGGFNYATDLVKHIRNEFGDYFDVCVAGYPKGHPEGESFEADLKHLKEKVAAGA 221
Query: 185 SSLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFR 244
++TQLFF+ E F+ F C+ GI P+ GI PI + +LR L + +P++ +
Sbjct: 222 DFIITQLFFEAETFFRFVKACSEIGITCPVLPGIFPIQGYH-SLRQLVKLSKLEVPQQIK 280
Query: 245 AILDKYEHDPESLRAAGLAYAVDQIVDLVTQD-VAGVHLYTMN 286
+++ + + ++R G+ AV +L+ V G+H YT+N
Sbjct: 281 DVIEPIKDNDAAIRNYGIEQAVSLCQELLASGLVPGLHFYTLN 323
>gi|156045151|ref|XP_001589131.1| hypothetical protein SS1G_09764 [Sclerotinia sclerotiorum 1980]
gi|154694159|gb|EDN93897.1| hypothetical protein SS1G_09764 [Sclerotinia sclerotiorum 1980]
Length = 590
Score = 144 bits (364), Expect = 5e-33, Method: Composition-based stats.
Identities = 97/283 (34%), Positives = 142/283 (50%), Gaps = 15/283 (5%)
Query: 23 SQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQ 82
S PS SFE FPP A G + + +D M G P FI +T + + T + Q
Sbjct: 13 SGNPSFSFEFFPPKTAQGVQNLYDRMDRMHGLGPSFIDITWGAGG-RLAQLTCEMVGVAQ 71
Query: 83 NDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK------DFR 136
+ + T HL + KEKV + LR G ILALRGD P E K F+
Sbjct: 72 SQYGLETCMHLTCTDMGKEKVDEALRNAYKAGCTNILALRGD--PPREKEKWEATEGGFQ 129
Query: 137 YATDLIEFIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDN 195
YA DL+ +I+ N FDI A YPEG D ++ + +LK+KVDAG + +VTQ+F+D
Sbjct: 130 YAKDLVHYIRQTYGNHFDIGVAGYPEGCDDQDDEDLLLDHLKEKVDAGATFIVTQMFYDV 189
Query: 196 ERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENI--HLPRKFRAILDKYEHD 253
+ F D+ K G+ +P+ GIMPI N L+ C ++ +P K+ A L+ ++D
Sbjct: 190 DNFIDWLGKVKARGVTIPVIPGIMPI---NTYASFLRRCNHMGCKIPPKWSASLEAVKND 246
Query: 254 PESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
++R G + ++ V +H YTMN A+ R + E
Sbjct: 247 DSAVRNIGKDLVAEMCRRIIQAGVHHLHFYTMNLAQATRMVLE 289
>gi|23502319|ref|NP_698446.1| 5,10-methylenetetrahydrofolate reductase [Brucella suis 1330]
gi|23348297|gb|AAN30361.1| 5,10-methylenetetrahydrofolate reductase [Brucella suis 1330]
Length = 303
Score = 144 bits (364), Expect = 6e-33, Method: Composition-based stats.
Identities = 89/271 (32%), Positives = 140/271 (51%), Gaps = 8/271 (2%)
Query: 24 QTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQN 83
QT +SFE FPP +++ + + P F+SVT + +E TV I
Sbjct: 14 QTTRVSFEFFPPKTEEMEQRLWETVTRLAPLQPDFVSVTYGAGG-STRERTVRTVARILK 72
Query: 84 DLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPG-----VEPLKDFRYA 138
+ I AHL + + E V RE A+GVNR +ALRGD G V ++
Sbjct: 73 ETDIKPAAHLTCVDATCEDVDRVAREFAALGVNRFVALRGDPANGIGEKYVPTPGGYQNG 132
Query: 139 TDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERF 198
+L+ ++ A +FDI + YPE HP+SP+ +DI LK+KVD G + +TQ FF+N+ +
Sbjct: 133 AELVGGLRNIA-DFDISVSAYPEKHPESPDFATDIDMLKRKVDNGATRAITQFFFENDLY 191
Query: 199 YDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLR 258
+ ++ AGI +PI G++P+ N Q +R H+P D ++DP++ +
Sbjct: 192 ERYVERVRRAGIYIPIVPGVLPVHNFKQ-VRNFCARSATHIPAWLAERFDGLDNDPQTHQ 250
Query: 259 AAGLAYAVDQIVDLVTQDVAGVHLYTMNNAE 289
A A +Q++DL+ + V H YTMN A+
Sbjct: 251 LVAAAIAAEQVMDLIERGVQDFHFYTMNRAD 281
>gi|118579522|ref|YP_900772.1| 5,10-methylenetetrahydrofolate reductase [Pelobacter propionicus
DSM 2379]
gi|118502232|gb|ABK98714.1| 5,10-methylenetetrahydrofolate reductase [Pelobacter propionicus
DSM 2379]
Length = 290
Score = 144 bits (364), Expect = 6e-33, Method: Composition-based stats.
Identities = 87/282 (30%), Positives = 149/282 (52%), Gaps = 20/282 (7%)
Query: 20 LMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLAD 79
L+ +++P +S E FPP A++ + P F+SVT + + T+ +
Sbjct: 6 LIATRSPFVSLEFFPPKERSEWPAFFQAVEQLAQVDPLFVSVTYGAGG-STQSDTLEIVS 64
Query: 80 HIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLKD----- 134
+ +L + +AHL + + E + + L +L A GV +LALRGD P KD
Sbjct: 65 RLTRNLGLEAMAHLTCVGATPEAILEFLNQLSAAGVRNVLALRGD------PPKDAPDNF 118
Query: 135 -----FRYATDLIEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVT 189
+YA+DL+ +I++ P + A YPE HP + + SD+ L+ K+D G ++T
Sbjct: 119 LSCHSLQYASDLVAYIRSVHPELGLGVAGYPETHPQAKSPQSDLDFLRLKLDNGGDFVIT 178
Query: 190 QLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDK 249
QLFFDN ++DF + GI+ PI GI+P+++ R++ C +P +F A L++
Sbjct: 179 QLFFDNTSYFDFVRRARDQGIEKPIIPGIIPVVSLKVIQRIVSLC-GATIPARFLAELEQ 237
Query: 250 YEHD--PESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAE 289
+ D ++R AG+A+A Q +L+ G+H+YT+N A+
Sbjct: 238 ADRDGGAAAVREAGVAHARRQAEELLAGGAPGIHIYTLNRAD 279
>gi|114326870|ref|YP_744027.1| methylenetetrahydrofolate reductase [Granulibacter bethesdensis
CGDNIH1]
gi|114315044|gb|ABI61104.1| methylenetetrahydrofolate reductase [Granulibacter bethesdensis
CGDNIH1]
Length = 340
Score = 144 bits (364), Expect = 6e-33, Method: Composition-based stats.
Identities = 90/268 (33%), Positives = 135/268 (50%), Gaps = 8/268 (2%)
Query: 26 PSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASNNKYNIKETTVPLADHIQNDL 85
P LSFE FPP ++ + ++ P F+SVT T +A I +
Sbjct: 58 PLLSFEFFPPKTEALERQLWACIRRLEPLGPRFVSVTYGAGGSTQARTHETVA-RIVRET 116
Query: 86 AIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDIIPGVEPLK----DFRYATDL 141
++ AHL + ++++V + R GV I+ALRGD+ PG P + + YA+DL
Sbjct: 117 SLTPAAHLTCVGATRDEVDEVARHYWEAGVRHIVALRGDM-PGGAPYQPHPGGYAYASDL 175
Query: 142 IEFIKAEAPNFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDF 201
+ +K +F+I A YPE HP +P+ D+ NLK+K+DAG + +TQ FFD + F F
Sbjct: 176 VAGLK-RIGDFEISVAAYPETHPAAPDAGFDLDNLKRKLDAGATRAITQYFFDTDTFLRF 234
Query: 202 QDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIHLPRKFRAILDKYEHDPESLRAAG 261
D+C +AGI PI GIMP+ N QA+R T +P + D E D E+ R
Sbjct: 235 LDRCLVAGITAPIVPGIMPVSNYAQAVR-FSTAIGTSVPDWLGRLFDGLEDDVETRRMVA 293
Query: 262 LAYAVDQIVDLVTQDVAGVHLYTMNNAE 289
A +Q+ L + H YT+N +
Sbjct: 294 AVVAAEQVRLLQANGIDEFHFYTLNRPD 321
>gi|111058868|gb|EAT79988.1| hypothetical protein SNOG_12690 [Phaeosphaeria nodorum SN15]
Length = 657
Score = 144 bits (364), Expect = 6e-33, Method: Composition-based stats.
Identities = 100/298 (33%), Positives = 145/298 (48%), Gaps = 16/298 (5%)
Query: 6 MLLSQQKSKTKKVKLMTSQTPSLSFEVFPPNPAVGNEKILLALDDMKGSAPHFISVTASN 65
M +SQ+ ++ K P+ SFE FPP A G + + +D M G P FI +T
Sbjct: 1 MHISQKLAQAK-----AEGKPTFSFEFFPPKTAQGVQNLYDRMDRMHGFGPQFIDLTWGA 55
Query: 66 NKYNIKETTVPLADHIQNDLAIPTIAHLPAIYLSKEKVADTLRELDAVGVNRILALRGDI 125
+ K T + Q + T HL + K K+ + LR+ G ILALRGD
Sbjct: 56 GGRHSK-LTCEMVKVAQTVYGLETCMHLTCTDMEKTKLDEALRDAYQSGCTNILALRGD- 113
Query: 126 IPGVEPLK------DFRYATDLIEFIKAEAPN-FDIIGACYPEGHPDSPNQISDIQNLKK 178
P E K FRYA DL+++IK + N FDI A Y EG D+ N I +LK+
Sbjct: 114 -PPREREKWEATAGGFRYAKDLVKYIKEKYGNHFDIGVAGYSEGSDDNDNVDELIDHLKE 172
Query: 179 KVDAGCSSLVTQLFFDNERFYDFQDKCTLAGIDVPIYAGIMPILNRNQALRLLKTCENIH 238
KVDAG + +VTQ+F+D + F D+ +K G+D I GIMPI LR + +
Sbjct: 173 KVDAGATFIVTQMFYDTDIFIDWVNKVRAKGVDAVIIPGIMPIHTHASFLRRAQWTR-CN 231
Query: 239 LPRKFRAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNAETARHIYE 296
+P+ + L+ ++D +R G D L+ + +H YTMN A+ R + E
Sbjct: 232 IPQHWTDALEPIKNDDVEVREVGKGLVADMCRRLIEAGITHLHFYTMNLAQATRMVLE 289
Database: nr
Posted date: Sep 17, 2007 11:41 AM
Number of letters in database: 999,999,834
Number of sequences in database: 2,976,859
Database: /nucleus1/users/jsaw/ncbi/db/nr.01
Posted date: Sep 17, 2007 11:48 AM
Number of letters in database: 894,087,890
Number of sequences in database: 2,493,262
Lambda K H
0.319 0.136 0.392
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,128,640,433
Number of Sequences: 5470121
Number of extensions: 47649626
Number of successful extensions: 110264
Number of sequences better than 1.0e-05: 500
Number of HSP's better than 0.0 without gapping: 486
Number of HSP's successfully gapped in prelim test: 92
Number of HSP's that attempted gapping in prelim test: 108081
Number of HSP's gapped (non-prelim): 592
length of query: 311
length of database: 1,894,087,724
effective HSP length: 132
effective length of query: 179
effective length of database: 1,172,031,752
effective search space: 209793683608
effective search space used: 209793683608
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 129 (54.3 bits)