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Treponema denticola Search Results

Record: 1 of 1  
MiniMap tRNA-Ala-1 rRNA-16SrRNA_1 IGR0499 IGR0496 IGR0500 IGR0495 IGR0497 IGR0501 IGR0498 IGR0502 TDE0579 gatC, - TDE0577 gatB, - TDE0575 TDE0578 TDE0573 bspA, - TDE0574 TDE0572 xynR, - TDE0571 TDE0579 gatC, - TDE0577 gatB, - TDE0575 TDE0578 TDE0573 bspA, - TDE0574 TDE0572 xynR, - TDE0571 Type: tandem, Name: TDE-TR-26 - 26 Type: tandem, Name: TDE-TR-26 - 26 TDE0579 gatB, - TDE0575 gatA, - TDE0576 gatA, - TDE0576 gatC, - TDE0577 TDE0578 bspA, - TDE0574 TDE0572 xynR, - TDE0571 TDE0573


Gene ID:TDE0575

DNA Molecule Name:
1  

GenBank ID:
42526091

Gene Name:
gatB  

Definition:
glutamyl-tRNA-Gln amidotransferase, subunit B

Cellular Location:
Cytoplasm [Evidence]

Gene Start:
607823

Gene Stop:
606345

Gene Length:
1503

Molecular Weight*:
56475

pI*:


Net Charge*:


EC:
3.5.1.4  6.3.5.-  

Functional Class:
Translation; Amino acyl tRNA synthetases and tRNA modification  

Gene Ontology:

Pathway: pathway table
Alanine and aspartate metabolism
Arginine and proline metabolism
Benzoate degradation via CoA ligation
Cyanoamino acid metabolism
Glutamate metabolism
Phenylalanine metabolism
Styrene degradation
Tryptophan metabolism

Secondary Evidence:
Salazar JC, Zúñiga R, Raczniak G, Becker H, Söll D, Orellana O.
A dual-specific Glu-tRNA(Gln) and Asp-tRNA(Asn) amidotransferase is involved in decoding glutamine and asparagine codons in Acidithiobacillus ferrooxidans.
FEBS Lett. 2001 Jul;500(3):129-31.
PMID: 11445070

Curnow AW, Hong K, Yuan R, Kim S, Martins O, Winkler W, Henkin TM, Söll D.
Glu-tRNAGln amidotransferase: a novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation.
Proc Natl Acad Sci U S A. 1997 Oct;94(22):11819-26.
PMID: 9342321

Nobelmann B, Lengeler JW.
Molecular analysis of the gat genes from Escherichia coli and of their roles in galactitol transport and metabolism.
J Bacteriol. 1996 Dec;178(23):6790-5.
PMID: 8955298

Comment:
Related 'gat' genes are glutamyl-tRNA-Gln amidotransferase subunit A (gatA) TDE0576 and the probable subunit C (gatC) TDE0577.

View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search

TDE0575 has significant similarity to the Treponema pallidum gene TP1021 (1e-170).

TDE0575 has significant similarity to the Borrelia burgdorferi gene 15594686 (1e-135).


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|42526091|ref|NP_971189.1|  aspartyl/glutamyl-tRNA amidotr...   985   0.0  
 gi|15640005|ref|NP_219458.1|  aspartyl/glutamyl-tRNA amidotr...   611   e-173
 gi|15594686|ref|NP_212475.1|  aspartyl/glutamyl-tRNA amidotr...   473   e-131
 gi|111115165|ref|YP_709783.1|  Glu-tRNA(Gln) amidotransferas...   467   e-130
 gi|51598599|ref|YP_072787.1|  aspartyl/glutamyl-tRNA amidotr...   464   e-129
 gi|83590838|ref|YP_430847.1|  glutamyl-tRNA(Gln) amidotransf...   439   e-121
 gi|89210601|ref|ZP_01188989.1|  Glutamyl-tRNA(Gln) amidotran...   434   e-120
 gi|118444129|ref|YP_878901.1|  glutamyl-tRNA(Gln) amidotrans...   434   e-120
 gi|76796056|ref|ZP_00778425.1|  Glutamyl-tRNA(Gln) amidotran...   432   e-119
 gi|78043368|ref|YP_359949.1|  aspartyl/glutamyl-tRNA amidotr...   431   e-119


COGS Summary:  COGS Search
BeTs to clades of COG0064
COG name: Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog)
Functional Class:  J
The phylogenetic pattern of COG0064 is aom--zyqvdrlbc-f---nujxitw
Number of proteins in this genome belonging to this COG is


Blocks Summary:  Blocks Search

Significant hit (1.4e-111) to 9/9 blocks of the IPB001773 family, which is described as "Glutamyl-tRNA(Gln) amidotransferase subunit B". Interpro entry for IPR001773.
    IPB001773A    13-24    1.1e-05
    IPB001773B    39-58    2.2e-08
    IPB001773C    82-100    1.1e-14
    IPB001773D    125-137    1.2e-07
    IPB001773E    151-167    9.8e-11
    IPB001773F    196-209    2.6e-07
    IPB001773G    222-245    5e-12
    IPB001773H    274-294    1e-09
    IPB001773I    441-480    8.3e-24

ProDom Summary:  Protein Domain Search

Residues 24 to 305 match (2e-103) PD:PD002690 which is described as SUBUNIT B PROTEOME COMPLETE AMIDOTRANSFERASE LIGASE GLUTAMYL-TRNAGLN 6.3.5.- BIOSYNTHESIS GLU-ADT

Residues 328 to 492 match (8e-39) PD:PD309942 which is described as SUBUNIT B COMPLETE PROTEOME AMIDOTRANSFERASE LIGASE 6.3.5.- GLUTAMYL-TRNAGLN BIOSYNTHESIS GLU-ADT

Paralogs:  Local Blast Search

TDE0575 has no significant similarity (blastp p-value < 1e-3) to any other gene in this genome.


Pfam Summary:  Pfam Search

Residues 7 to 252 (E-value = 5.7e-139) place TDE0575 in the GatB_N family which is described as PET112 family, N terminal region (PF02934)

Residues 274 to 342 (E-value = 1.1e-26) place TDE0575 in the GatB family which is described as PET112 family, C terminal region (PF01162)

Residues 344 to 491 (E-value = 9.1e-58) place TDE0575 in the GatB_Yqey family which is described as GatB/Yqey domain (PF02637)


Top PDB Hits:
No PDB hits found using the nr database and 5 rounds of Psi-BLAST (E-value < 0.01)

Gene Protein Sequence:
MLKHGNLEYEIIIGCEIHCQLLTKTKAFCSCENRYGGIPNTRVCPCCLGL
PGALPRVSKEYVEFGIKAGHALGCRINNFSKFDRKHYFYPDLVKGYQITQ
FYTPLCEEGEVEVNLAAQNEEPKFKKIRIERIHLEEDVGKSLHIEGSHSY
IDFNRSGVPLIEIVSKPDMSTPDEAAKYMQTIREILKFIGVTDGNMEEGA
LRCDANVNLKIIDNGVEFRTPISEIKNMNSFKAVKDACTYEVSRQLEEYN
SKDRIAFKTGFKRTMGWDEPSGQTVVQRTKTIAEDYRFMPEPDLRALELS
DKFIKEVSDSVGELPEAKRLRFKKEYHLSEFDVQTLTSERELAEWFEEAA
KKSSSPKKCANWILAEVLAILNETNSSLSDLKFGPEAIAELVNVIEEGKI
TSKQAKDVFAEMIACGKKPSAVIAEKGMEQVSDSSFIEKIVEEVFAENAE
AVQDWKNGKTNVAGWLMGQVMKKSGGKANPKQAADLVNKRLTE

Gene Nucleotide Sequence:  Sequence Viewer
ATGCTTAAACACGGCAATTTAGAATACGAAATAATTATAGGCTGCGAAAT
ACACTGCCAGCTTTTAACAAAGACAAAGGCTTTTTGTTCTTGTGAAAACC
GTTACGGCGGAATTCCAAACACGAGGGTCTGTCCCTGCTGTCTCGGTCTG
CCCGGAGCTCTTCCCAGAGTAAGCAAGGAATATGTAGAATTCGGAATTAA
GGCCGGACACGCCCTCGGCTGCCGGATAAATAATTTTTCCAAATTCGACA
GAAAGCATTATTTTTATCCCGACCTTGTAAAGGGCTATCAGATAACTCAA
TTTTACACACCTCTGTGCGAAGAAGGTGAAGTTGAGGTGAACCTTGCAGC
TCAAAATGAAGAGCCGAAATTCAAAAAGATAAGAATTGAGAGAATCCATT
TGGAAGAAGACGTAGGCAAAAGTCTTCACATAGAAGGCTCGCATAGTTAT
ATTGACTTTAACCGCTCAGGCGTTCCTCTAATCGAAATTGTTTCAAAGCC
CGATATGTCTACCCCCGATGAGGCTGCAAAATATATGCAGACAATCAGAG
AGATTTTAAAATTTATCGGCGTTACCGACGGAAACATGGAAGAAGGAGCC
CTGCGCTGTGATGCAAATGTCAACCTAAAAATCATCGACAACGGCGTAGA
ATTTAGAACTCCTATTTCCGAAATAAAAAATATGAACTCCTTTAAGGCTG
TAAAGGATGCCTGCACCTATGAGGTTTCCCGTCAACTGGAAGAATACAAC
AGCAAGGACCGCATCGCTTTTAAGACGGGCTTTAAACGCACCATGGGCTG
GGACGAACCTTCGGGGCAGACCGTAGTACAGCGTACAAAAACAATAGCGG
AAGATTACCGCTTTATGCCCGAACCGGATTTAAGAGCCTTGGAGCTGAGC
GATAAGTTTATCAAAGAGGTAAGTGATTCGGTCGGAGAATTACCGGAAGC
AAAACGGCTCCGTTTTAAAAAAGAATATCATTTGTCGGAATTCGATGTTC
AAACCCTGACCTCTGAAAGAGAGCTGGCGGAATGGTTTGAAGAGGCGGCT
AAAAAATCTTCTTCTCCCAAAAAATGTGCCAACTGGATATTGGCGGAAGT
TCTGGCTATTTTAAACGAAACAAACTCTTCTCTTTCGGATTTAAAATTCG
GGCCTGAGGCTATAGCCGAGCTTGTAAATGTTATTGAAGAAGGAAAGATA
ACAAGCAAGCAGGCCAAAGATGTTTTTGCCGAGATGATAGCTTGCGGTAA
AAAACCTTCTGCCGTAATAGCCGAAAAAGGCATGGAACAGGTAAGCGATT
CTTCCTTTATCGAAAAAATTGTAGAAGAAGTTTTTGCCGAAAATGCCGAA
GCCGTCCAAGATTGGAAAAACGGAAAAACCAATGTTGCAGGCTGGCTTAT
GGGGCAGGTTATGAAAAAATCAGGCGGCAAGGCCAACCCAAAACAAGCGG
CTGACCTTGTGAATAAAAGACTGACAGAG

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