Perez-Molina JA, Arribas JR, Iribarren JA, Knobel H, Ribera E, Rubio R, Viciana P; International Conference on AIDS (15th : 2004 : Bangkok, Thailand).
Int Conf AIDS. 2004 Jul 11-16; 15: abstract no. WePeB5780.
H La Paz, Madrid, Spain
Background: Adherence is essential for successful AT but its complex treatment schedule is a barrier to adherence and hence to AT efficacy. QD-AT offers potential advantages as a consequence of lower dosing frequency and pill burden. This study began when experience with QD AT was still limited Methods: Non-interventional, multicenter, longitudinal study. Initial (I), simplification (S) and rescue (R) therapies were included. Visits were at baseline, 3 and 6 months. To assess adherence a structured validated questionnaire was used and to assess satisfaction a visual analogical scale was performed by independent consultants who interviewed patients (Pts) Results: From May to Dec/2002, 978 Pts were recruited. Average pill number was 5 in QD and 6.1 in BID [table: see text] Non-detectable VL was achieved at 6 months in 83.7% (I), 87.5% (S) and 57.4% (R), with no significant differences between QD/BID. Adherence and satisfaction with AT were both significantly better in QD vs BID (50.2% vs 43.5%) (64.8% vs 50.8%) respectively. Multivariate models disclosed as explanatory variables for AT adherence (OR): treatment satisfaction (1.6), family support (1.27), sexual transmission (1.22) and CDC stage C (0.84). AT satisfaction (OR): AT adherence (1.53), S-AT (1.42), QD (1.36), I-AT (0.85), CDC stage C (0.83) and R-AT (0.82); Non-detectable viral load (OR): I-AT (2.80), adherence (1.38), Age (1.02), R-AT (0.64) and S-AT (0.56) Conclusion QD schedules appear as effective as BID antiretroviral therapy, improving adherence and treatment satisfaction. This could positively affect treatment efficacy in the long term
Publication Types:
Keywords:
- Antiretroviral Therapy, Highly Active
- Drug Therapy, Combination
- Humans
- Longitudinal Studies
- Prospective Studies
- Viral Load
- drug therapy
- epidemiology
- therapy
Other ID:
UI: 102283707
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