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Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer
This study has been completed.
First Received: November 1, 1999   Last Updated: February 6, 2009   History of Changes
Sponsors and Collaborators: Radiation Therapy Oncology Group
National Cancer Institute (NCI)
Eastern Cooperative Oncology Group
Cancer and Leukemia Group B
Southwest Oncology Group
North Central Cancer Treatment Group
Information provided by: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT00003596
  Purpose

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug or combining radiation therapy with chemotherapy may kill more tumor cells. It is not yet known whether fluorouracil and mitomycin plus radiation therapy is more effective than fluorouracil and cisplatin plus radiation therapy for anal cancer.

PURPOSE: This randomized phase III trial is studying fluorouracil and mitomycin plus radiation therapy to see how well it works compared to fluorouracil and cisplatin plus radiation therapy in treating patients with stage II or stage III anal cancer.


Condition Intervention Phase
Anal Cancer
Drug: cisplatin
Drug: fluorouracil
Drug: mitomycin C
Radiation: radiation therapy
Phase III

MedlinePlus related topics: Anal Cancer Cancer Radiation Therapy
Drug Information available for: Mitomycin Fluorouracil Cisplatin Mitomycins
U.S. FDA Resources
Study Type: Interventional
Study Design: Active Control, Randomized, Treatment
Official Title: A Phase III Randomized Study of 5-Fluorouracil, Mitomycin-C, and Radiotherapy Versus 5-Fluorouracil, Cisplatin, and Radiotherapy in Carcinoma of the Anal Canal

Further study details as provided by National Cancer Institute (NCI):

Estimated Enrollment: 650
Study Start Date: October 1998
Primary Completion Date: April 2008 (Final data collection date for primary outcome measure)
Detailed Description:

OBJECTIVES:

  • Compare the initial and total local and distant failure rates in patients with anal canal cancer treated with either fluorouracil (5-FU) plus mitomycin concurrently with radiotherapy or 5-FU plus cisplatin followed by 5-FU plus cisplatin concurrently with radiotherapy.
  • Identify any differences in local control and colostomy rates at 2 years in patients treated with these regimens.
  • Determine any difference in colostomy free, disease free, or overall survival in patients treated with these regimens.
  • Compare the toxic effects of these regimens in these patients.
  • Evaluate the prognostic effects of tumor markers P53 overexpression, human papilloma virus status, and enzyme HAP1 in patients treated with these regimens.

OUTLINE: This is a randomized study. Patients are stratified according to gender, nodal status (positive vs negative), and primary tumor size (greater than 2 cm to 5 cm vs greater than 5 cm). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients receive fluorouracil (5-FU) IV continuously over 96 hours beginning on days 1 and 29 and mitomycin IV on days 1 and 29 with concurrent radiotherapy.
  • Arm II: Patients receive induction chemotherapy comprising 5-FU IV continuously over 96 hours beginning on days 1, 29, 57, and 85 and cisplatin IV over 1 hour on days 1, 29, 57, and 85. Beginning on day 57, patients receive concurrent radiotherapy.

In both arms, radiotherapy is administered daily, 5 days a week, for 5-6.5 weeks. Patients with T3, T4, or N+ lesions or T2 lesions with residual disease receive additional radiotherapy to a reduced field.

Patients are followed every 3 months for 1 year, every 6 months for 1 year, and then annually thereafter.

PROJECTED ACCRUAL: A total of 650 patients will be accrued for this study within 5 years.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Histologically confirmed primary squamous, basaloid, or cloacogenic carcinoma of the anal canal, other than carcinoma in situ

    • T2-4, Any N, M0 (stage II or III)
  • No local or regional recurrence after local excision or abdominal peritoneal resection

PATIENT CHARACTERISTICS:

Age:

  • 18 and over

Performance status:

  • Karnofsky 60-100%

Life expectancy:

  • Not specified

Hematopoietic:

  • WBC at least 4,000/mm^3
  • Absolute neutrophil count at least 1,800/mm^3
  • Platelet count at least 100,000/mm^3
  • Hemoglobin at least 10 g/dL

Hepatic:

  • Bilirubin less than 1.4 mg/dL

Renal:

  • Creatinine no greater than 1.5 mg/dL OR
  • Creatinine clearance at least 80 mL/min

Cardiovascular:

  • No uncompensated heart disease
  • No uncontrolled high blood pressure

Other:

  • No AIDS
  • No active systemic infection
  • No uncontrolled diabetes
  • No other prior malignancy within the past 5 years except nonmelanoma skin cancer
  • No mental condition that would preclude study participation
  • Not pregnant or nursing
  • Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

  • Prior epoetin alfa allowed in lieu of blood transfusions

Chemotherapy:

  • At least 5 years since prior chemotherapy

Endocrine therapy:

  • Not specified

Radiotherapy:

  • At least 5 years since prior radiotherapy

Surgery:

  • No prior surgery of anal canal except for biopsy of study site
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00003596

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Locations
United States, Alabama
Comprehensive Cancer Center at University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Mobile Infirmary Medical Center
Mobile, Alabama, United States, 36607
United States, Alaska
Alaska Regional Hospital
Anchorage, Alaska, United States, 99508
Providence Alaska Medical Center
Anchorage, Alaska, United States, 99508
United States, Arizona
CCOP - Mayo Clinic Scottsdale Oncology Program
Scottsdale, Arizona, United States, 85259
Foundation for Cancer Research and Education
Phoenix, Arizona, United States, 85013
United States, Arkansas
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
Ft. Smith, Arkansas, United States, 72903
United States, California
Alta Bates Comprehensive Cancer Center
Berkeley, California, United States, 94705
California Cancer Center - Woodward Park Office
Fresno, California, United States, 93720
California Pacific Medical Center - California Campus
San Francisco, California, United States, 94118
CCOP - Bay Area Tumor Institute
Oakland, California, United States, 94609
CCOP - Santa Rosa Memorial Hospital
Sana Rosa, California, United States, 95405
City of Hope Comprehensive Cancer Center
Duarte, California, United States, 91010
Highland General Hospital
Oakland, California, United States, 94602
J.C. Robinson, M.D. Regional Cancer Center
San Pablo, California, United States, 94806
Sutter Health Western Division Cancer Research Group
Greenbrae, California, United States, 94904
Loma Linda University Cancer Institute at Loma Linda University Medical Center
Loma Linda, California, United States, 92354
Marin Cancer Institute at Marin General Hospital
Greenbrae, California, United States, 94904
Memorial Medical Center Cancer Services
Modesto, California, United States, 95355
Mills-Peninsula Health Services
Burlingame, California, United States, 94010
Mount Diablo Regional Cancer Center
Concord, California, United States, 94520
Naval Medical Center - San Diego
San Diego, California, United States, 92134
Palo Alto Medical Foundation
Palo Alto, California, United States, 94301
Pomona Valley Hospital Medical Center
Pomona, California, United States, 91767
Providence Holy Cross Cancer Center
Mission Hills, California, United States, 91346-9600
Providence Saint Joseph Medical Center - Burbank
Burbank, California, United States, 91505
Radiological Associates of Sacramento Medical Group, Inc.
Sacramento, California, United States, 95815
Saint Rose Hospital
Hayward, California, United States, 94545
Summit Medical Center
Oakland, California, United States, 94609
Leavey Cancer Center at Northridge Hospital Medical Center
Northridge, California, United States, 91325
Sutter Solano Medical Center
Vallejo, California, United States, 94589
Torrance Memorial Medical Center
Torrance, California, United States, 90509
University of California Davis Cancer Center
Sacramento, California, United States, 95817
USC/Norris Comprehensive Cancer Center and Hospital
Los Angeles, California, United States, 90033-0804
Valley Memorial Hospital
Livermore, California, United States, 94550
United States, Colorado
Aurora Presbyterian Hospital
Aurora, Colorado, United States, 80012
Boulder Community Hospital
Boulder, Colorado, United States, 80301
CCOP - Colorado Cancer Research Program, Incorporated
Denver, Colorado, United States, 80224-2522
Presbyterian - St. Luke's Medical Center
Denver, Colorado, United States, 80218
Hope Cancer Care Center at Longmont United Hospital
Longmont, Colorado, United States, 80502
Memorial Hospital Cancer Center
Colorado Springs, Colorado, United States, 80909
North Suburban Medical Center
Thorton, Colorado, United States, 80229
Penrose Cancer Center at Penrose Hospital
Colorado Springs, Colorado, United States, 80933
Porter Adventist Hospital
Denver, Colorado, United States, 80210
Front Range Cancer Specialists
Fort Collins, Colorado, United States, 80524
Rose Medical Center
Denver, Colorado, United States, 80220
Sky Ridge Medical Center
Lone Tree, Colorado, United States, 80124
St. Joseph Hospital
Denver, Colorado, United States, 80218
St. Mary-Corwin Regional Medical Center
Pueblo, Colorado, United States, 81004
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
Grand Junction, Colorado, United States, 81502
Swedish Medical Center
Englewood, Colorado, United States, 80110
United States, Connecticut
Middlesex Hospital Cancer Center
Middletown, Connecticut, United States, 06457
United States, Delaware
Beebe Medical Center
Lewes, Delaware, United States, 19958
CCOP - Christiana Care Health Services
Newark, Delaware, United States, 19718
St. Francis Hospital
Wilmington, Delaware, United States, 19805
United States, District of Columbia
Lombardi Cancer Center at Georgetown University Medical Center
Washington, District of Columbia, United States, 20007
United States, Florida
21st Century Oncology - Fort Myers
Fort Myers, Florida, United States, 33901
CCOP - Mount Sinai Medical Center
Miami Beach, Florida, United States, 33140
Baptist-South Miami Regional Cancer Program
Miami, Florida, United States, 33176
Baptist Cancer Institute - Jacksonville
Jacksonville, Florida, United States, 32207
Ella Milbank Foshay Cancer Center at Jupiter Medical Center
Jupiter, Florida, United States, 33458
Gulf Coast Cancer Treatment Center
Panama City, Florida, United States, 32405
H. Lee Moffitt Cancer Center and Research Institute at University of South Florida
Tampa, Florida, United States, 33612
Mayo Clinic - Jacksonville
Jacksonville, Florida, United States, 32224-9980
Tallahassee Memorial Hospital
Tallahassee, Florida, United States, 32308
Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
Fort Lauderdale, Florida, United States, 33308
Memorial Cancer Institute at Memorial Regional Hospital
Hollywood, Florida, United States, 33021
University of Miami Sylvester Comprehensive Cancer Center
Miami, Florida, United States, 33136
United States, Georgia
Emory University Hospital - Atlanta
Altanta, Georgia, United States, 30322
Northeast Georgia Medical Center
Gainesville, Georgia, United States, 30501
Pearlman Comprehensive Cancer Center at South Georgia Medical Center
Valdosta, Georgia, United States, 31603
United States, Idaho
Mountain States Tumor Institute - Boise
Boise, Idaho, United States, 83712
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
Boise, Idaho, United States, 83706
United States, Illinois
BroMenn Regional Medical Center
Normal, Illinois, United States, 61761
Cancer Care Center at Advocate Good Samaritan Hospital
Downers Grove, Illinois, United States, 60515
Cancer Treatment Center at Pekin Hospital
Pekin, Illinois, United States, 61554
Hopedale Medical Complex
Hopedale, Illinois, United States, 61747
CCOP - Carle Cancer Center
Urbana, Illinois, United States, 61801
CCOP - Illinois Oncology Research Association
Peoria, Illinois, United States, 61615
Community Cancer Center
Normal, Illinois, United States, 61761
Community Hospital of Ottawa
Ottawa, Illinois, United States, 61350
Creticos Cancer Center at Advocate Illinois Masonic Medical Center
Chicago, Illinois, United States, 60657
Edward Hospital Cancer Center
Naperville, Illinois, United States, 60566
Eureka Hospital
Eureka, Illinois, United States, 61530
Evanston Northwestern Health Care - Evanston Hospital
Evanston, Illinois, United States, 60201
Galesburg Clinic
Galesburg, Illinois, United States, 61401
Galesburg Cottage Hospital
Galesburg, Illinois, United States, 61401
Good Shepherd Hospital
Barrington, Illinois, United States, 60010
Graham Hospital
Canton, Illinois, United States, 61520
Hinsdale Hematology Oncology Associates
Hinsdale, Illinois, United States, 60521
Carle Cancer Center at Carle Foundation Hospital
Urbana, Illinois, United States, 61801
Illinois Valley Community Hospital
Peru, Illinois, United States, 61354
InterCommunity Cancer Center of Western Illinois
Galesburg, Illinois, United States, 61401
Joliet Oncology Hematology Associates, Limited - West
Joliet, Illinois, United States, 60435
Kewanee Hospital
Kewanee, Illinois, United States, 61443
Lutheran General Cancer Care Center
Park Ridge, Illinois, United States, 60068
Mason District Hospital
Havana, Illinois, United States, 62644
McDonough District Hospital
Macomb, Illinois, United States, 61455
Memorial Hospital
Carthage, Illinois, United States, 62321
Proctor Hospital
Peoria, Illinois, United States, 61614
Northwest Community Hospital
Arlington Heights, Illinois, United States, 60005
Oncology Hematology Associates of Central Illinois - Ottawa
Ottawa, Illinois, United States, 61350
Oncology/Hematology Associates of Central Illinois, P.C.
Peoria, Illinois, United States, 61615
OSF St. Francis Medical Center
Peoria, Illinois, United States, 61637
Perry Memorial Hospital
Princeton, Illinois, United States, 61356
Methodist Medical Center of Illinois
Peoria, Illinois, United States, 61603
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago, Illinois, United States, 60611
Rush-Copley Cancer Care Center
Aurora, Illinois, United States, 60507
Saint Anthony's Hospital at Saint Anthony's Health Center
Alton, Illinois, United States, 62002
St. Anthony's Memorial Hospital
Effingham, Illinois, United States, 62401
Valley Cancer Center
Spring Valley, Illinois, United States, 61362
St. Margaret's Hospital
Spring Valley, Illinois, United States, 61362
Swedish American Hospital
Rockford, Illinois, United States, 61104
St. Joseph Medical Center
Bloomington, Illinois, United States, 61701
United States, Indiana
Saint Anthony Memorial Health Centers
Michigan City, Indiana, United States, 46360
Cancer Center at Ball Memorial Hospital
Muncie, Indiana, United States, 47303
CCOP - Northern Indiana CR Consortium
South Bend, Indiana, United States, 46601
Center for Cancer Therapy at LaPorte Hospital and Health Services
La Porte, Indiana, United States, 46350
Elkhart General Hospital
Elkhart, Indiana, United States, 46515
Memorial Hospital of South Bend
South Bend, Indiana, United States, 46601
Bloomington Hospital
Bloomington, Indiana, United States, 47403
Saint Joseph Regional Medical Center - Plymouth Campus
Plymouth, Indiana, United States, 46544
St. Francis Hospital and Health Centers
Beech Grove, Indiana, United States, 46107
Union Hospital
Terre Haute, Indiana, United States, 47804
United States, Iowa
Alegent Health Community Memorial Hospital
Missouri Valley, Iowa, United States, 51555
Alegent Health Mercy Hospital
Council Bluffs, Iowa, United States, 51503
Burgess Health Center
Onawa, Iowa, United States, 51040
CCOP - Iowa Oncology Research Association
Des Moines, Iowa, United States, 50309
Cedar Rapids Oncology Associates
Cedar Rapids, Iowa, United States, 52403
Medical Oncology and Hematology Associates at John Stoddard Cancer Center
Des Moines, Iowa, United States, 50309
Genesis Regional Cancer Center at Genesis Medical Center
Davenport, Iowa, United States, 52803
Holden Comprehensive Cancer Center at University of Iowa
Iowa City, Iowa, United States, 52242
John Stoddard Cancer Center at Iowa Lutheran Hospital
Des Moines, Iowa, United States, 50316
John Stoddard Cancer Center at Iowa Methodist Medical Center
Des Moines, Iowa, United States, 50309
McFarland Clinic, P.C.
Ames, Iowa, United States, 50010
Medical Oncology and Hematology Associates - West Des Moines
West Des Moines, Iowa, United States, 50266
Genesis Medical Center - West Campus
Davenport, Iowa, United States, 52804
Medical Oncology and Hematology Associates at Mercy Cancer Center
Des Moines, Iowa, United States, 50314
Mercy Cancer Center at Mercy Medical Center - Des Moines
Des Moines, Iowa, United States, 50314
Mercy Cancer Center at Mercy Medical Center - North Iowa
Mason City, Iowa, United States, 50401
Mercy Cancer Center at Mercy Medical Center
Cedar Rapids, Iowa, United States, 52403
Siouxland Hematology-Oncology Associates
Sioux City, Iowa, United States, 51101
Mercy Medical Center - Sioux City
Sioux City, Iowa, United States, 51104
Saint Anthony Regional Hospital
Carroll, Iowa, United States, 51401
Mercy Capitol Hospital
Des Moines, Iowa, United States, 50307
St. Luke's Hospital
Cedar Rapids, Iowa, United States, 52402
St. Luke's Regional Medical Center
Sioux City, Iowa, United States, 51104
Wendt Regional Cancer Center at Finley Hospital
Dubuque, Iowa, United States, 52001
United States, Kansas
Associates in Womens Health
Wichita, Kansas, United States, 67203
Cancer Center of Kansas - Kingman
Kingman, Kansas, United States, 67068
Cancer Center of Kansas - Dodge City
Dodge City, Kansas, United States, 67801
Cancer Center of Kansas - Chanute
Chanute, Kansas, United States, 66720
Cancer Center of Kansas - Newton
Newton, Kansas, United States, 67114
Cancer Center of Kansas - Ottawa
Ottawa, Kansas, United States, 66067
Cancer Center of Kansas - Salina
Salina, Kansas, United States, 67042
Cancer Center of Kansas - Wellington
Wellington, Kansas, United States, 67152
Cancer Center of Kansas - Winfield
Winfield, Kansas, United States, 67156
Cancer Center of Kansas, P.A. - Wichita
Wichita, Kansas, United States, 67214
Cancer Center of Kansas, P.A. - El Dorado
El Dorado, Kansas, United States, 67042
Cancer Center of Kansas, P.A. - Parsons
Parsons, Kansas, United States, 67357
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita, Kansas, United States, 67214
CCOP - Wichita
Wichita, Kansas, United States, 67214
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Pratt Cancer Center of Kansas
Pratt, Kansas, United States, 67124
South Central Kansas Regional Medical Center
Arkansas City, Kansas, United States, 67005
Southwest Medical Center
Liberal, Kansas, United States, 67901
Cancer Center of Kansas, P.A.
Wichita, Kansas, United States, 67208
Wesley Medical Center
Wichita, Kansas, United States, 67214
United States, Kentucky
Cancer Treatment Center at the Medical Center - Bowling Green
Bowling Green, Kentucky, United States, 42101
Central Baptist Hospital
Lexington, Kentucky, United States, 40503
Markey Cancer Center at University of Kentucky Chandler Medical Center
Lexington, Kentucky, United States, 40536
Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins County
Madisonville, Kentucky, United States, 42431
United States, Louisiana
Feist-Weiller Cancer Center at Louisiana State University Health Sciences
Shreveport, Louisiana, United States, 71130
Louisiana State University Health Sciences Center - Monroe
Monroe, Louisiana, United States, 71210
Tulane Cancer Center
New Orleans, Louisiana, United States, 70112
Veterans Affairs Medical Center - Shreveport
Shreveport, Louisiana, United States, 71101
United States, Maine
CancerCare of Maine at Eastern Maine Medial Center
Bangor, Maine, United States, 04401
Central Maine Medical Center
Lewiston, Maine, United States, 04240
Maine General Medical Center - Waterville
Waterville, Maine, United States, 04901
United States, Maryland
Union Hospital Cancer Center at Union Hospital
Elkton MD, Maryland, United States, 21921
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, United States, 21287-8936
DeCesaris Cancer Institute at Anne Arundel Medical Center
Annapolis, Maryland, United States, 21401
United States, Massachusetts
Bethke Cancer Center at Emerson Hospital
Concord, Massachusetts, United States, 01742
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Cancer Research Center at Boston Medical Center
Boston, Massachusetts, United States, 02118
Cape Cod Hospital
Hyannis, Massachusetts, United States, 02601
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02115
South Suburban Oncology Center
Quincy, Massachusetts, United States, 02169
Massachusetts General Hospital Cancer Center
Boston, Massachusetts, United States, 02114
Newton - Wellesley Hospital
Newton, Massachusetts, United States, 02162
Hudner Oncology Center at Saint Anne's Hospital
Fall River, Massachusetts, United States, 02721
United States, Michigan
Battle Creek Health System
Battle Creek, Michigan, United States, 49017
Borgess Medical Center
Kalamazooaa, Michigan, United States, 49001
Bronson Methodist Hospital
Kalamazoo, Michigan, United States, 49007
CCOP - Grand Rapids
Grand Rapids, Michigan, United States, 49503
CCOP - Michigan Cancer Research Consortium
Ann Arbor, Michigan, United States, 48100
Genesys Hurley Cancer Institute
Flint, Michigan, United States, 48532
Seton Cancer Institute - Saginaw
Saginaw, Michigan, United States, 48601
Hackley Hospital
Muskegon, Michigan, United States, 49443
Hickman Cancer Center at Bixby Medical Center
Adrian, Michigan, United States, 49221
Holland Community Hospital
Holland, Michigan, United States, 49423
Hurley Medical Center
Flint, Michigan, United States, 48502
Josephine Ford Cancer Center at Henry Ford Health System
Detroit, Michigan, United States, 48202
Lacks Cancer Center at Saint Mary's Mercy Medical Center
Grand Rapids, Michigan, United States, 49503
Mecosta County General Hospital
Big Rapids, Michigan, United States, 49307
Mercy Hospital
Port Huron, Michigan, United States, 48060
Metropolitan Hospital
Grand Rapids, Michigan, United States, 49506
Munson Medical Center
Traverse City, Michigan, United States, 49684
Northern Michigan Hospital
Petoskey, Michigan, United States, 49770
Oncology Care Associates, P.L.L.C.
Saint Joseph, Michigan, United States, 49085
Providence Cancer Institute at Providence Hospital - Southfield Campus
Southfield, Michigan, United States, 48075
Great Lakes Cancer Institute at McLaren Regional Medical Center
Flint, Michigan, United States, 48532
Spectrum Health Cancer Care - Butterworth Campus
Grand Rapids, Michigan, United States, 49503
Spectrum Health Hospital - Blodgett Campus
Grand Rapids, Michigan, United States, 49506
St. John Macomb Hospital
Warren, Michigan, United States, 48903
St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital
Ann Arbor, Michigan, United States, 48106-0995
West Michigan Cancer Center
Kalamazoo, Michigan, United States, 49007
Upper Michigan Cancer Center at Marquette General Hospital
Marquette, Michigan, United States, 49855
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan, United States, 48109
United States, Minnesota
Adult and Pediatric Urology, P.L.L.P.
St. Cloud, Minnesota, United States, 56303
Brainerd Medical Center
Brainerd, Minnesota, United States, 56401
Cancer Care Center at Regions Hospital
Saint Paul, Minnesota, United States, 55101
Cancer Care Center at St. Luke's Hospital
Duluth, Minnesota, United States, 55805
CCOP - Duluth
Duluth, Minnesota, United States, 55805
CCOP - Metro-Minnesota
Saint Louis Park, Minnesota, United States, 55416
CentraCare Clinic - River Campus
St. Cloud, Minnesota, United States, 56303
Chippewa County - Montevideo Hospital
Montevideo, Minnesota, United States, 56265
Ridgeview Medical Center
Waconia, Minnesota, United States, 55387
Fairview Southdale Hospital
Edina, Minnesota, United States, 55435
Fairview University Medical Center - University Campus
Minneapolis, Minnesota, United States, 55455
Hennepin County Medical Center - Minneapolis
Minneapolis, Minnesota, United States, 55415
Hubert H. Humphrey Cancer Center at North Memorial Medical Center
Robbinsdale, Minnesota, United States, 55422
Hutchinson Area Health Care
Hutchinson, Minnesota, United States, 55350
Mayo Clinic Cancer Center
Rochester, Minnesota, United States, 55905
Meeker County Memorial Hospital
Litchfield, Minnesota, United States, 55355
Mercy and Unity Cancer Center at Mercy and Unity Hospitals
Fridley, Minnesota, United States, 55432
Mercy Hospital
Coon Rapids, Minnesota, United States, 55433
MeritCare Clinic - Bemidji
Bemidji, Minnesota, United States, 56601
Miller-Dwan Medical Center
Duluth, Minnesota, United States, 55805
Park Nicollet Clinic
St. Louis Park, Minnesota, United States, 55416
Rice Memorial Hospital
Willmar, Minnesota, United States, 56201
Fairview Ridges Hospital
Burnsville, Minnesota, United States, 55337
St. John's Hospital
Maplewood, Minnesota, United States, 55109
St. Joseph's Hospital
St Paul, Minnesota, United States, 55102
St. Mary's - Duluth Clinic Cancer Center
Duluth, Minnesota, United States, 55805
United Hospital
St. Paul, Minnesota, United States, 55102
Virginia Piper Cancer Institute at Abbott-Northwestern Hospital
Minneapolis, Minnesota, United States, 55407
Woodwinds Hospital
Woodbury, Minnesota, United States, 55125
Saint Francis Cancer Center
Shakopee, Minnesota, United States, 55379
United States, Mississippi
Regional Cancer Center at Singing River Hospital
Pascagoula, Mississippi, United States, 39581
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
Veterans Affairs Medical Center - Jackson
Jackson, Mississippi, United States, 39216
United States, Missouri
CCOP - Kansas City
Kansas City, Missouri, United States, 64131
CCOP - St. Louis-Cape Girardeau
St. Louis, Missouri, United States, 63141
Hulston Cancer Center at Cox Medical Center South
Springfield, Missouri, United States, 65807
David C. Pratt Cancer Center at St. John's Mercy
St. Louis, Missouri, United States, 63141
Ellis Fischel Cancer Center at University of Missouri - Columbia
Columbia, Missouri, United States, 65203
Center for Cancer Care and Research
St. Louis, Missouri, United States, 63141
Missouri Baptist Cancer Center
St. Louis, Missouri, United States, 63131
Missouri Cancer Associates
Columbia, Missouri, United States, 65201
Saint Luke's Hospital
Chesterfield, Missouri, United States, 63017
Siteman Cancer Center at Barnes-Jewish Hospital
St Louis, Missouri, United States, 63110
Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
Gape Girardeau, Missouri, United States, 63701
St. Francis Medical Center
Cape Girardeau, Missouri, United States, 63701
St. John's Regional Health Center
Springfield, Missouri, United States, 65804
United States, Montana
CCOP - Montana Cancer Consortium
Billings, Montana, United States, 59101
Great Falls Clinic
Great Falls, Montana, United States, 59405
Sletten Regional Cancer Institute
Great Falls, Montana, United States, 59405
United States, Nebraska
Alegent Health - Immanuel Medical Center
Omaha, Nebraska, United States, 68122
Bergan Mercy Medical Center
Omaha, Nebraska, United States, 68124
Cancer Center at the Good Samaritan Health Systems
Kearney, Nebraska, United States, 68847
Cancer Center at Creighton University Medical Center
Omaha, Nebraska, United States, 68131
Bryan LGH Medical Center West
Lincoln, Nebraska, United States, 68502
Cancer Resource Center - Lincoln
Lincoln, Nebraska, United States, 68510
CCOP - Missouri Valley Cancer Consortium
Omaha, Nebraska, United States, 68106
Fremont Area Medical Center
Fremont, Nebraska, United States, 68025
Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha
Omaha, Nebraska, United States, 68114
Midlands Cancer Center at Midlands Community Hospital
Papillion, Nebraska, United States, 68046
St. Elizabeth Regional Medical Center
Lincoln, Nebraska, United States, 68510
United States, Nevada
CCOP - Southern Nevada Cancer Research Foundation
Las Vegas, Nevada, United States, 89106
Sunrise Hospital and Medical Center
Las Vegas, Nevada, United States, 89109
University Medical Center of Southern Nevada
Las Vegas, Nevada, United States, 89102
Washoe Cancer Services at Washoe Medical Center - Reno
Reno, Nevada, United States, 89502
United States, New Hampshire
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
United States, New Jersey
Atlantic City Medical Center - Mainland Division
Pomona, New Jersey, United States, 08240
Cancer Institute of New Jersey at the Cooper University Hospital
Camden, New Jersey, United States, 08103
Cancer Center at the Mountainside Hospital
Montclair, New Jersey, United States, 07042
Booker Cancer Center at Riverview Medical Center
Red Bank, New Jersey, United States, 07701
Capital Health System Regional Cancer Center
Trenton, New Jersey, United States, 08618
CCOP - Northern New Jersey
Hackensack, New Jersey, United States, 07601
Community Medical Center
Toms River, New Jersey, United States, 08755
Fox Chase Cancer Center at St. Francis Medical Center
Trenton, New Jersey, United States, 08611
South Jersey Healthcare Regional Cancer Center
Millville, New Jersey, United States, 08332
Monmouth Medical Center
Long Branch, New Jersey, United States, 07740
Newark Beth Israel Medical Center
Newark, New Jersey, United States, 07112
Fox Chase Virtua Health Cancer Program - Marlton
Mount Holly, New Jersey, United States, 08060
United States, New Mexico
Hematology-Oncology Associates, PC
Albuquerque, New Mexico, United States, 87106
Lovelace Medical Center at Lovelace Sandia Health System
Albuquerque, New Mexico, United States, 87108
University of New Mexico Cancer Research and Treatment Center
Albuquerque, New Mexico, United States, 87106
United States, New York
Catskill Regional Medical Center
Harris, New York, United States, 12742
Community General Hospital of Greater Syracuse
Syracuse, New York, United States, 13215
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
Syracuse, New York, United States, 13057
CCOP - North Shore University Hospital
Manhasset, New York, United States, 11030
Crouse Hospital
Syracuse, New York, United States, 13210
Finger Lakes Hematology and Oncology
Clifton Springs, New York, United States, 14432
Highland Hospital of Rochester
Rochester, New York, United States, 14620
James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester, New York, United States, 14642
SUNY Downstate Medical Center
Brooklyn, New York, United States, 11203
New York Methodist Hospital
Brooklyn, New York, United States, 11215
New York Weill Cornell Cancer Center at Cornell University
New York, New York, United States, 10021
Louis Busch Hager Cancer Center at Mary Imogene Bassett Hospital
Cooperstown, New York, United States, 13326
Veterans Affairs Medical Center - Syracuse
Syracuse, New York, United States, 13210
United States, North Carolina
Annie Penn Cancer Center
Reidsville, North Carolina, United States, 27320
Blumenthal Cancer Center at Carolinas Medical Center
Charlotte, North Carolina, United States, 28203
Forsyth Regional Cancer Center at Forsyth Medical Center
Winston-Salem, North Carolina, United States, 27103
Moses Cone Regional Cancer Center at Wesley Long Community Hospital
Greensboro, North Carolina, United States, 27401
Lenoir Memorial Cancer Center
Kinston, North Carolina, United States, 28501
John Smith, Jr./Dalton McMichael Cancer Center at Morehead Memorial Hospital
Eden, North Carolina, United States, 27288
Presbyterian Cancer Center at Presbyterian Hospital
Charlotte, North Carolina, United States, 28233
Randolph Hospital
Asheboro, North Carolina, United States, 27203
Wayne Memorial Hospital, Incorporated
Goldsboro, North Carolina, United States, 27534
Wayne Radiation Oncology
Goldsboro, North Carolina, United States, 27534
Wilson Medical Center
Wilson, North Carolina, United States, 27893
Zimmer Cancer Center at New Hanover Regional Medical Center
Wilmington, North Carolina, United States, 28401
United States, North Dakota
Altru Cancer Center at Altru Hospital
Grand Forks, North Dakota, United States, 58201
Trinity Cancer Care Center
Minot, North Dakota, United States, 58701
CCOP - MeritCare Hospital
Fargo, North Dakota, United States, 58122
Medcenter One Health System
Bismarck, North Dakota, United States, 58501
MeritCare Medical Group
Fargo, North Dakota, United States, 58122
Mid Dakota Clinic, P.C.
Bismarck, North Dakota, United States, 58501
St. Alexius Medical Center
Bismarck, North Dakota, United States, 58501
Bismarck Cancer Center
Bismarck, North Dakota, United States, 58501
United States, Ohio
Licking Memorial Cancer Care Program at Licking Memorial Hospital
Newark, Ohio, United States, 43055
Adena Regional Medical Center
Chillicothe, Ohio, United States, 54601
Middletown Regional Hospital
Middletown, Ohio, United States, 45044
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University
Columbus, Ohio, United States, 43210
Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford
Salem, Ohio, United States, 44460
Cancer Treatment Center
Wooster, Ohio, United States, 44691
CCOP - Columbus
Columbus, Ohio, United States, 43215
CCOP - Dayton
Dayton, Ohio, United States, 45429
CCOP - Toledo Community Hospital
Toledo, Ohio, United States, 43623
Charles F. Kettering Memorial Hospital
Kettering, Ohio, United States, 45429
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, United States, 44195
Community Hospital of Springfield and Clark County
Springfield, Ohio, United States, 45505
Doctors Hospital at Ohio Health
Columbus, Ohio, United States, 43228
Euclid Hospital
Cleveland, Ohio, United States, 44119
Fairfield Medical Center
Lancaster, Ohio, United States, 43130
Firelands Regional Medical Center
Sandusky, Ohio, United States, 44870
Genesis - Good Samaritan Hospital
Zanesville, Ohio, United States, 43701
Good Samaritan Hospital
Dayton, Ohio, United States, 45406
Grady Memorial Hospital
Delaware, Ohio, United States, 43015
Grandview Hospital
Dayton, Ohio, United States, 45405
Grant Riverside Cancer Services
Columbus, Ohio, United States, 43215
Hillcrest Cancer Center at Hillcrest Hospital
Mayfield Heights, Ohio, United States, 44124
Huron Hospital Cancer Care Center
Cleveland, Ohio, United States, 44112
Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University
Cleveland, Ohio, United States, 44106
Lima Memorial Hospital
Lima, Ohio, United States, 45804
McDowell Cancer Center at Akron General Medical Center
Akron, Ohio, United States, 44307
Medical College of Ohio Cancer Institute
Toledo, Ohio, United States, 43614
Mercy Hospital of Tiffin
Tiffin, Ohio, United States, 44883
Mercy Medical Center Oncology Unit
Springfield, Ohio, United States, 45504
MetroHealth's Cancer Care Center at MetroHealth Medical Center
Cleveland, Ohio, United States, 44109
Miami Valley Hospital
Dayton, Ohio, United States, 45409
Akron City Hospital at Summa Health System
Akron, Ohio, United States, 44304
Mount Carmel Cancer Services at Mount Carmel St. Ann's Hospital
Westerville, Ohio, United States, 43081
Mount Carmel West Hospital
Columbus, Ohio, United States, 43222
Promedica Cancer Center at Flower Hospital
Sylvania, Ohio, United States, 43560
Riverside Methodist Hospital Cancer Care
Columbus, Ohio, United States, 43214
Ruth G. McMillan Cancer Center at Greene Memorial Hospital
Xenia, Ohio, United States, 45385
Samaritan North Cancer Care Center
Dayton, Ohio, United States, 45415
South Pointe Hospital Cancer Care Center
Warrensville Heights, Ohio, United States, 44122
St. Charles Mercy Hospital
Oregon, Ohio, United States, 43616
UVMC Cancer Care Center at Upper Valley Medical Center
Troy, Ohio, United States, 45373
St. Rita's Medical Center
Lima, Ohio, United States, 45801
St. Vincent Mercy Medical Center
Toledo, Ohio, United States, 43608
Strecker Cancer Center at Marietta Memorial Hospital
Marietta, Ohio, United States, 45750
Toledo Clinic, Incorporated
Toledo, Ohio, United States, 43623
Toledo Hospital
Toledo, Ohio, United States, 43606
University Hospitals Ireland Cancer Center at Mercy Medical Center
Canton, Ohio, United States, 44708
St. Luke's Hospital
Maumee, Ohio, United States, 43537
Veterans Affairs Medical Center - Dayton
Dayton, Ohio, United States, 45428
United States, Oklahoma
LaFortune Cancer Center at St. John Health System
Tulsa, Oklahoma, United States, 74104
Natalie Warren Bryant Cancer Center at St. Francis Hospital
Tulsa, Oklahoma, United States, 74136
United States, Oregon
Cancer Institute at Oregon Health and Science University
Portland, Oregon, United States, 97239
Kaiser Permanente Health Care - Portland
Portland, Oregon, United States, 97232
Comprehensive Cancer Center at Legacy Good Samaritan Hospital & Medical Center
Portland, Oregon, United States, 97210
Institute of Oncology at Vilnius University
Portland, Oregon, United States, 97227
CCOP - Columbia River Oncology Program
Portland, Oregon, United States, 97225
Legacy Meridian Park Hospital
Tualatin, Oregon, United States, 97062
Legacy Mount Hood Medical Center
Glesham, Oregon, United States, 97030
Providence Cancer Center at Providence Portland Medical Center
Portland, Oregon, United States, 97213
Providence Milwaukie Hospital
Milwaukie, Oregon, United States, 97222
Providence St. Vincent Medical Center
Portland, Oregon, United States, 97225
Salem Hospital Regional Cancer Center
Salem, Oregon, United States, 97309
United States, Pennsylvania
Albert Einstein Cancer Center
Philadelphia, Pennsylvania, United States, 19141
Allegheny Cancer Center at Allegheny General Hospital
Pittsburgh, Pennsylvania, United States, 15212
Bryn Mawr Hospital
Bryn Mawr, Pennsylvania, United States, 19010
Cancer Center at Paoli Memorial Hospital
Paoli, Pennsylvania, United States, 19301
CCOP - MainLine Health
Wynnewood, Pennsylvania, United States, 19096
Delaware County Regional Cancer Center at Delaware County Memorial Hospital
Drexel Hill, Pennsylvania, United States, 19026
Fox Chase Cancer Center
Philadelphia, Pennsylvania, United States, 19111-2497
Geisinger Medical Center
Danville, Pennsylvania, United States, 17822-2001
Geisinger Medical Group
State College, Pennsylvania, United States, 16801
Lewistown Hospital
Lewistown, Pennsylvania, United States, 17044
Guthrie Medical Center - Sayre
Sayre, Pennsylvania, United States, 18840
Joan Karnell Cancer Center at Pennsylvania Hospital
Philadelphia, Pennsylvania, United States, 19107
John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital
Allentown, Pennsylvania, United States, 18105
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
Philadelphia, Pennsylvania, United States, 19107
Lankenau Cancer Center at Lankenau Hospital
Wynnewood, Pennsylvania, United States, 19096
Geisinger Wyoming Valley Medical Center
Wilkes-Barre, Pennsylvania, United States, 18711
Mercy Hospital Cancer Center - Scranton
Scranton, Pennsylvania, United States, 18501
Mercy Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15219
Mount Nittany Medical Center
State College, Pennsylvania, United States, 16803
Penn State Cancer Institute at Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033-0850
St. Luke's Hospital Cancer Center
Bethlehem, Pennsylvania, United States, 18015
Reading Hospital and Medical Center
West Reading, Pennsylvania, United States, 19612
St. Joseph Medical Center
Reading, Pennsylvania, United States, 19604
Pottstown Memorial Regional Cancer Center
Pottstown, Pennsylvania, United States, 19464
St. Mary Regional Cancer Center
Langhorne, Pennsylvania, United States, 19047
Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
Pittsburgh, Pennsylvania, United States, 15224-1791
United States, South Carolina
Bon Secours St. Francis Health System
Greenville, South Carolina, United States, 29601
CCOP - Greenville
Greenville, South Carolina, United States, 29615
Greenville Hospital System Cancer Center
Greenville, South Carolina, United States, 29605
United States, South Dakota
Avera McKennan Hospital and University Health Center
Sioux Falls, South Dakota, United States, 57105
Medical X-Ray Center
Sioux Falls, South Dakota, United States, 57105
Rapid City Regional Hospital
Rapid City, South Dakota, United States, 57701
Sioux Valley Hospital and University of South Dakota Medical Center
Sioux Falls, South Dakota, United States, 57104
United States, Tennessee
Baptist Centers for Cancer Care
Memphis, Tennessee, United States, 38146
United States, Texas
Brooke Army Medical Center
Fort Sam Houston, Texas, United States, 78234
M.D. Anderson Cancer Center at University of Texas
Houston, Texas, United States, 77030
Harrington Cancer Center
Amarillo, Texas, United States, 79106
Joe Arrington Cancer Research and Treatment Center
Lubbock, Texas, United States, 79410
Cancer Therapy and Research Center
San Antonio, Texas, United States, 78229
St. Joseph Regional Cancer Center
Bryan, Texas, United States, 77802
University Hospital - San Antonio
San Antonio, Texas, United States, 78229
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78284
Veterans Affairs Medical Center - San Antonio (Murphy)
San Antonio, Texas, United States, 78209
Wilford Hall Medical Center
Lackland AFB, Texas, United States, 78236
United States, Utah
Cottonwood Hospital Medical Center
Murray, Utah, United States, 84107
Dixie Regional Medical Center
St. George, Utah, United States, 84770
Huntsman Cancer Institute at University of Utah
Salt Lake City, Utah, United States, 84112
LDS Hospital
Salt Lake City, Utah, United States, 84143
McKay-Dee Hospital Center
Ogden, Utah, United States, 84403
Utah Cancer Specialists at UCS Cancer Center
Salt Lake City, Utah, United States, 84106
Utah Valley Regional Medical Center - Provo
Provo, Utah, United States, 84603
United States, Vermont
Fletcher Allen Health Care - University Health Center Campus
Burlington, Vermont, United States, 05401
Mountainview Medical
Berlin, Vermont, United States, 05602
United States, Virginia
Bon Secours Cancer Care at St. Mary's Hospital
Richmond, Virginia, United States, 23226
Danville Regional Medical Center
Danville, Virginia, United States, 24541
Virginia Oncology Associates - Hampton
Hampton, Virginia, United States, 23666
United States, Washington
Cancer Care Center at Skagit Valley Hospital
Mt. Vernon, Washington, United States, 98273
Cancer Care Northwest - Spokane South
Spokane, Washington, United States, 99202
Central Washington Hospital
Wenatchee, Washington, United States, 98801
CCOP - Virginia Mason Research Center
Seattle, Washington, United States, 98101
Cancer Center at Southwest Washington Medical Center
Vancouver, Washington, United States, 98668
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States, 98104
Group Health Central Hospital
Seattle, Washington, United States, 98104
Harborview Medical Center
Seattle, Washington, United States, 98104
Madigan Army Medical Center
Tacoma, Washington, United States, 98431
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
Seattle, Washington, United States, 98114
Providence Cancer Institute at Providence Everett Medical Center - Pacific Campus
Everett, Washington, United States, 98201
St. Joseph Hospital Community Cancer Center
Bellingham, Washington, United States, 98225
Olympic Hematology and Oncology
Bremerton, Washington, United States, 98310
University Cancer Center at University of Washington Medical Center
Seattle, Washington, United States, 98195
Wenatchee Valley Clinic
Wenatchee, Washington, United States, 98801
United States, West Virginia
Camden-Clark Memorial Hospital
Parkersburg, West Virginia, United States, 26101
Mary Babb Randolph Cancer Center at West Virginia University Hospitals
Morgantown, West Virginia, United States, 26506
United States, Wisconsin
Central Wisconsin Cancer Program at Agnesian Health Care
Fond Du Lac, Wisconsin, United States, 54935
Bay Area Cancer Care Center at Bay Area Medical Center
Marinette, Wisconsin, United States, 54143
All Saints Cancer Center at All Saints Healthcare
Racine, Wisconsin, United States, 53405
Community Memorial Hospital
Menomonee Falls, Wisconsin, United States, 53051
Green Bay Oncology, Limited at St. Mary's Hospital
Green Bay, Wisconsin, United States, 54303
Green Bay Oncology, Limited at St. Vincent Hospital
Green Bay, Wisconsin, United States, 54301-3526
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
La Crosse, Wisconsin, United States, 54601
Midelfort Clinic - Luther
Eau Claire, Wisconsin, United States, 54702
Marshfield Clinic - Marshfield Center
Marshfield, Wisconsin, United States, 54449
Medical College of Wisconsin Cancer Center
Milwaukee, Wisconsin, United States, 53226
Luther Mildelfort Hospital
Eau Claire, Wisconsin, United States, 54702
St. Mary's Hospital Medical Center
Green Bay, Wisconsin, United States, 54303
St. Vincent Hospital
Green Bay, Wisconsin, United States, 54301
University of Wisconsin Comprehensive Cancer Center
Madison, Wisconsin, United States, 53792
Veterans Affairs Medical Center - Milwaukee (Zablocki)
Milwaukee, Wisconsin, United States, 53295
Vince Lombardi Cancer Clinic at St. Luke's Medical Center
Milwaukee, Wisconsin, United States, 53215
West Allis Memorial Hospital
West Allis, Wisconsin, United States, 53227
South Africa
Pretoria Academic Hospital
Pretoria, 0001, South Africa
Sponsors and Collaborators
Radiation Therapy Oncology Group
Eastern Cooperative Oncology Group
Cancer and Leukemia Group B
Southwest Oncology Group
North Central Cancer Treatment Group
Investigators
Study Chair: Jaffer A. Ajani, MD M.D. Anderson Cancer Center
Study Chair: Al B. Benson, MD, FACP Robert H. Lurie Cancer Center
Study Chair: Joel E. Tepper, MD UNC Lineberger Comprehensive Cancer Center
Study Chair: John S. MacDonald, MD St. Vincent's Comprehensive Cancer Center - Manhattan
Study Chair: Michael G. Haddock, MD Mayo Clinic
  More Information

Additional Information:
Publications of Results:
Ajani JA, Winter KA, Gunderson LL, et al.: Intergroup RTOG 98-11: a phase III randomized study of 5-fluorouracil (5-FU), mitomycin, and radiotherapy versus 5-fluorouracil, cisplatin and radiotherapy in carcinoma of the anal canal. [Abstract] J Clin Oncol 24 (Suppl 18): A-4009, 2006.
Gunderson LL, Winter KA, Ajani JA, et al.: Intergroup RTOG 9811 phase III comparison of chemoradiation with 5-FU and mitomycin vs 5-FU and cisplatin for anal canal carcinoma: impact on disease-free, overall and colostomy-free survival. [Abstract] Int J Radiat Oncol Biol Phys 66 (3 Suppl 1): A-43, S24, 2006.
Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett CG. US Intergroup Anal Carcinoma Trial: Tumor Diameter Predicts for Colostomy. J Clin Oncol. 2009 Jan 12; [Epub ahead of print]
Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett C. Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial. JAMA. 2008 Apr 23;299(16):1914-21.

Other Publications:
Study ID Numbers: CDR0000066667, CALGB-89808, ECOG-R9811, GUMC-00125, NCCTG-R9811, RTOG-9811, SWOG-R9811
Study First Received: November 1, 1999
Last Updated: February 6, 2009
ClinicalTrials.gov Identifier: NCT00003596     History of Changes
Health Authority: United States: Federal Government

Keywords provided by National Cancer Institute (NCI):
basaloid carcinoma of the anus
cloacogenic carcinoma of the anus
squamous cell carcinoma of the anus
stage II anal cancer
stage III anal cancer

Study placed in the following topic categories:
Antimetabolites
Gastrointestinal Diseases
Rectal Neoplasms
Squamous Cell Carcinoma
Anal Cancer
Rectal Diseases
Mitomycins
Anti-Bacterial Agents
Cisplatin
Mitomycin
Alkylating Agents
Digestive System Neoplasms
Rectal Neoplasm
Intestinal Diseases
Immunosuppressive Agents
Intestinal Neoplasms
Carcinoma
Digestive System Diseases
Rectal Cancer
Radiation-Sensitizing Agents
Fluorouracil
Epidermoid Carcinoma
Gastrointestinal Neoplasms
Carcinoma, Squamous Cell
Anus Neoplasms
Colorectal Neoplasms

Additional relevant MeSH terms:
Antimetabolites
Antimetabolites, Antineoplastic
Immunologic Factors
Molecular Mechanisms of Pharmacological Action
Gastrointestinal Diseases
Rectal Neoplasms
Antineoplastic Agents
Physiological Effects of Drugs
Antibiotics, Antineoplastic
Rectal Diseases
Mitomycins
Neoplasms by Site
Cisplatin
Therapeutic Uses
Mitomycin
Alkylating Agents
Nucleic Acid Synthesis Inhibitors
Digestive System Neoplasms
Enzyme Inhibitors
Intestinal Diseases
Immunosuppressive Agents
Intestinal Neoplasms
Pharmacologic Actions
Neoplasms
Digestive System Diseases
Radiation-Sensitizing Agents
Fluorouracil
Gastrointestinal Neoplasms
Anus Diseases
Anus Neoplasms

ClinicalTrials.gov processed this record on March 16, 2009