LOCUS P35524 994 aa linear ROD 10-FEB-2009
DEFINITION RecName: Full=Chloride channel protein, skeletal muscle; AltName:
Full=Chloride channel protein 1; Short=ClC-1.
ACCESSION P35524
VERSION P35524.1 GI:544025
DBSOURCE UniProtKB: locus CLCN1_RAT, accession P35524;
class: standard.
created: Jun 1, 1994.
sequence updated: Jun 1, 1994.
annotation updated: Feb 10, 2009.
xrefs: X62894.1, CAA44683.1, S19595, NP_037279.1
xrefs (non-sequence databases): IPI:IPI00199559, UniGene:Rn.10440,
PhosphoSite:P35524, Ensembl:ENSRNOG00000016917, GeneID:25688,
KEGG:rno:25688, RGD:2360, HOVERGEN:P35524, NextBio:607681,
ArrayExpress:P35524, GO:0016021, GO:0031404, GO:0005247,
GO:0006821, InterPro:IPR014743, InterPro:IPR001807,
InterPro:IPR002243, InterPro:IPR000644, Gene3D:G3DSA:1.10.3080.10,
PANTHER:PTHR11689, Pfam:PF00571, Pfam:PF00654, PRINTS:PR00762,
PRINTS:PR01112, PROSITE:PS51371
KEYWORDS CBS domain; Chloride; Chloride channel; Ion transport; Ionic
channel; Membrane; Repeat; Transmembrane; Transport; Voltage-gated
channel.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (residues 1 to 994)
AUTHORS Steinmeyer,K., Ortland,C. and Jentsch,T.J.
TITLE Primary structure and functional expression of a developmentally
regulated skeletal muscle chloride channel
JOURNAL Nature 354 (6351), 301-304 (1991)
PUBMED 1659664
REMARK NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Skeletal muscle
COMMENT On Mar 15, 2005 this sequence version replaced gi:103752.
[FUNCTION] Voltage-gated chloride channel. Chloride channels have
several functions including the regulation of cell volume; membrane
potential stabilization, signal transduction and transepithelial
transport.
[SUBCELLULAR LOCATION] Membrane; Multi-pass membrane protein.
[TISSUE SPECIFICITY] Predominantly expressed in skeletal muscles.
[SIMILARITY] Belongs to the chloride channel (TC 2.A.49) family.
[SIMILARITY] Contains 2 CBS domains.
FEATURES Location/Qualifiers
source 1..994
/organism="Rattus norvegicus"
/db_xref="taxon:10116"
gene 1..994
/gene="Clcn1"
Protein 1..994
/gene="Clcn1"
/product="Chloride channel protein, skeletal muscle"
/note="Chloride channel protein 1; ClC-1"
Region 1..994
/gene="Clcn1"
/region_name="Mature chain"
/experiment="experimental evidence, no additional details
recorded"
/note="Chloride channel protein, skeletal muscle.
/FTId=PRO_0000094431."
Region 1..117
/gene="Clcn1"
/region_name="Topological domain"
/inference="non-experimental evidence, no additional
details recorded"
/note="Cytoplasmic (Potential)."
Region 117..592
/gene="Clcn1"
/region_name="ClC_1_like"
/note="ClC-1-like chloride channel proteins. This CD
includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is
expressed in skeletal muscle and its mutation leads to
both recessively and dominantly-inherited forms of muscle
stiffness or myotonia. ClC-K is...; cd03683"
/db_xref="CDD:79365"
Region 118..137
/gene="Clcn1"
/region_name="Transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="1 (Potential)."
Region 159..182
/gene="Clcn1"
/region_name="Transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="2 (Potential)."
Region 170..571
/gene="Clcn1"
/region_name="Voltage_CLC"
/note="Voltage gated chloride channel; pfam00654"
/db_xref="CDD:109702"
Site order(188..192,230..234,482..486,578)
/gene="Clcn1"
/site_type="other"
/note="putative Cl- selectivity filter"
/db_xref="CDD:79365"
Region 206..227
/gene="Clcn1"
/region_name="Transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="3 (Potential)."
Site 232
/gene="Clcn1"
/site_type="other"
/note="putative pore gating glutamate residue"
/db_xref="CDD:79365"
Region 235..254
/gene="Clcn1"
/region_name="Transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="4 (Potential)."
Region 266..290
/gene="Clcn1"
/region_name="Transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="5 (Potential)."
Region 305..323
/gene="Clcn1"
/region_name="Transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="6 (Potential)."
Region 348..368
/gene="Clcn1"
/region_name="Transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="7 (Potential)."
Region 391..414
/gene="Clcn1"
/region_name="Transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="8 (Potential)."
Region 456..475
/gene="Clcn1"
/region_name="Transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="9 (Potential)."
Region 478..496
/gene="Clcn1"
/region_name="Transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="10 (Potential)."
Region 524..545
/gene="Clcn1"
/region_name="Transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="11 (Potential)."
Region 553..572
/gene="Clcn1"
/region_name="Transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="12 (Potential)."
Region 573..844
/gene="Clcn1"
/region_name="Topological domain"
/inference="non-experimental evidence, no additional
details recorded"
/note="Cytoplasmic (Potential)."
Region 609..668
/gene="Clcn1"
/region_name="Domain"
/experiment="experimental evidence, no additional details
recorded"
/note="CBS 1."
Region 827..882
/gene="Clcn1"
/region_name="Domain"
/experiment="experimental evidence, no additional details
recorded"
/note="CBS 2."
Region <827..875
/gene="Clcn1"
/region_name="CBS_pair_EriC_assoc_euk_bac"
/note="This cd contains two tandem repeats of the
cystathionine beta-synthase (CBS pair) domains in the EriC
CIC-type chloride channels in eukaryotes and bacteria.
These ion channels are proteins with a seemingly simple
task of allowing the passive flow of...; cd04591"
/db_xref="CDD:73091"
Region 845..863
/gene="Clcn1"
/region_name="Transmembrane region"
/inference="non-experimental evidence, no additional
details recorded"
/note="13 (Potential)."
Region 864..994
/gene="Clcn1"
/region_name="Topological domain"
/inference="non-experimental evidence, no additional
details recorded"
/note="Extracellular (Potential)."
ORIGIN
1 mersqsqqhg geqswwgtap qyqympfehc tsyglpseng glqhrprkdl gprhnahptq
61 iyghhkeqys yqaqdrgipk ktdssstvds ldedhyskcq dcvhrlgrvl rrklgedwif
121 lvllgllmal vswcmdyvsa kslqaykwty aqmqpslplq ylawvtfpli lilfsalfcq
181 lispqavgsg ipemktilrg vvlkeyltlk afvakvvalt aglgsgipvg kegpfvhias
241 icaavlskfm smfsgvyeqp yyytdiltvg cavgvgccfg tplggvlfsi evtstyfavr
301 nywrgffaat fsafvfrvla vwnkdavtit alfrtnfrmd fpfdlkelpa favigiccgf
361 lgavfvylhr qvmlgvrkhk alsqflakhr llypgivtfv iasltfppgm gqfmagelmp
421 reaistlfdn ntwvkhigdp kslgqsavwi hpqvnvviii llffvmkfwm sivattmpip
481 cggfmpvfvl gaafgrlvge imamlfpegi lfddiiykil pggyavigaa altgavshtv
541 stavicfelt gqiahilpmm vavilanmva qslqpslyds iiqvkklpyl pdlgwnqlsk
601 ftifvedimv rdvkfvsasc tygelrnllq tttvktlplv dskdsmillg sverselqsl
661 lqrhlcaerr lkaaqdmark lselpyngqa qlagewhpgg rpesfafvde dededvsrkt
721 elpqtptppp ppppplppqf piapsypeep ngplpshkqp peasdsadqr ssifqrllhc
781 llgkahstkk kitqdstdlv dnmspeeiea wereqlsqpv cfdfccidqs pfqlveqttl
841 hkthtlfsll glhlayvtsm gklrgvlale elqkaikght ksgvqlrppl asfrnttsir
901 ktpggppppa eswnvpeged gaperevmvp tmpetpvppp spevpsclap arvegeleel
961 emvgnlgpee dladilhgps lrstdeeded elil
//