From: ncbi-seminar-admin@ncbi.nlm.nih.gov on behalf of Wataru Fujibuchi
[wataru@ncbi.nlm.nih.gov]
Sent: Monday, December 17, 2001 11:28 AM
To: ncbi-seminar@ncbi.nlm.nih.gov
Subject: CBB seminar(Dec 18) announcement

CBB seminar tomorrow(Tue, Dec 18) 11:00am.
Natcher South Conference Room.
 
New Aspects of Gene Regulation on Yeast with Microarray Analysis
Wataru Fujibuchi
 
The advent of microarrays and the availability of completely sequenced
eukaryotic genomes have shown us a new stage of transcriptional regulation
studies. Using microarray analysis, we here focused on two interesting
computational aspects; promoter cis-element searches and chromosomal
localization preferences of expressed genes.
First, we did an evaluation study of how the microarray-based gene clusters
can enhance the identification of true cis-elements, as compared to the
naive traditional pattern searches. We found that although it reduce the
noise level for many elements, we still need to be cautious in handling
cases such as ubiquitous elements, GCN4 or TATA-box.*
We also tested if there are any chromosomal localization preferences of
genes when they are co-expressed. Surprisingly, we found that there is
a high tendency to find co-expressed genes adjacent on the same
chromosome and distant genes on the same chromosome also seem to be
co-expressed. We are currently seeking an interpretation for the
mechanism for this type of gene regulation(?).

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_/  Wataru Fujibuchi, Ph.D.,  Computational Biology Branch    _/
_/      National Center for Biotechnology Information         _/
_/   Bldg 45, Rm 6th Floor, NIH, 45 Center Drive, MSC 6510    _/
_/          Bethesda, MD 20892-6510 USA (301)435-5896         _/
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