Rey D, Vidinic-Moularde J, Schmitt C, Fritsch S, Lang JM, Stoll-Keller F; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1998 Sep 24-27; 38: 327 (abstract no. H-41a).

CISIH, Clinical Medicine A, Center Hospital, Strasbourg, France.

Background: GB virus C/hepatitis G virus (HGV) is a recently discovered infectious agent, transmitted parenterally and sexually, and from an HGV-infected mother to her child. GBV- C/HGV genome is detected by PCR, and antibodies occur after the loss of RNA in the serum. Numerous reports have documented a high prevalence of GBV-C/HGV in different population groups, but few of them in immunocompromised patients. Methods: we detected IgG antibodies to the E2 protein of GBV-C/HGV by the enzyme immunoassay microPlate Anti-HGenv (Boehringer Mannheim, Germany), in GBV-C/HGV RNA negative HIV-infected patients from an outpatient clinic. Results: the overall anti-E2 positivity was 16/89 (18%) patients, higher in males: 14/68 (20.6%), compared to females: 2/21 (9.5%). According to the HIV risk group, the prevalences were: 7/35 (20%) in homobisexual males, 5/28 (19%) in heterosexual individuals, 1/15 (6.6%) in ivdu, /8 in patients with unknown risk, and 2/3 hemophiliacs + transfusion recipients. GBV-C/HGV antibodies frequency increased with age: 3/23 (13%) for patients 20-29 years-old, 4/35 (11.4%) between 30-39 years, 8/27 (29.6%) between 40-49 years, and 1/3 over 50 years-old (0/1 under 20 years). The prevalence was not different with the immune status: 2/13 (15.4%) for patients with CD4 cell count below -00/mm3, 9/46 (19.5%) between 200 and 499 CD4/mm3, and 5/30 (16.7%) over 500 CD4/mm3. Conclusion: we found a high prevalence (18%) of GBV-C/HGV Anti-E2 antibodies in HIV-infected patients, increasing with the age, and non influenced by the immune status.

Publication Types:

• Meeting Abstracts

Keywords:

• AIDS Vaccines
• Acquired Immunodeficiency Syndrome
• Antibodies
• Child
• Female
• GB virus C
• Germany
• HIV
• HIV Infections
• HIV Seropositivity
• Hemophilia A
• Humans
• Male
• Polymerase Chain Reaction
• Prevalence

Other ID:

• 20710786

UI: 102188092

From Meeting Abstracts