|
 |
|
EDRI Federal Project Inventory:
Determination of the Endocrine Disrupters, Bisphenol-A and Nonyl Phenol, Migrating to Foods as the Result of Their Use as Approved Indirect Additive Chemicals in Food Packaging
- Sponsor Organization: DEPARTMENT OF HEALTH AND HUMAN SERVICES, UNITED STATES PUBLIC HEALTH
SERVICE,FOOD AND DRUG ADMINISTRATION
- Project Title: DETERMINATION OF THE ENDOCRINE DISRUPTERS, BISPHENOL-A AND NONYL
PHENOL, MIGRATINGTO FOODS AS THE RESULT OF THEIR USE AS APPROVED
INDIRECT ADDITIVE CHEMICALS IN FOOD PACKAGING.
- Project Focus: EXPOSURE ASSESSMENT
- Description: Bisphenol-A is used to make epoxy based food contact surface coatings
for cans
and metal jar lids. It is also used in the manufacture of
polycarbonate plastic which
then is formed into containers for repeat
use such as water carboys, and baby bottles.
One of the first reports
of the estrogenic activity of migrating BPA from polycarbonate
plastic was reported by Krishnan, et. al.(1). Nonyl phenol, which is
a mixture of isomers
is used to make the antioxidant
trisnonylphenylphosphite (TNPP), a widely used
antioxidant in many
plastic food packages. As an antioxidant, TNPP readily
decomposes
forming NP which has been shown to migrate into food (2). When NP is
polyethoxylated a series of nonionic surfactants are formed which are
also used in the
manufacture of food packaging. Polyethoxylated NP
(NPEO)has been shown to be
quite stable under many conditions. What
is not known is, what are the levels of
residual NP in NPEO that could
migrate into food. Analytical procedures are being
developed utilizing
both capillary gas chromatography with mass selective detection
and
high performance liquid chromatography with fluorescence detection to
measure
NP and BPA residues in food extracts at very low parts per
billion levels.
- References: Krishnan, A.V., Stathis, P., Permouth, S.F., Tokes, L., & Feldman, D.,
1993."Bisphenol-A: Am Estrogenic Substance Is Released from
Polycarbonate Flasks duringAutoclaving", Endocrinology, Vol 132, No.6,
2279-2286. McNeal, T.P., & Hollifield, H.C., 1995, "Determination
of Nonyl Phenol in PlasticFood Packaging by Capillary Gas
Chromatography with Mass Selective Detection",Abstract of Presentation
#464P at the Pittsburgh Conference and Exposition, NewOrleans, LA.
- Category: MEASUREMENTS
- Subcategory: EXPOSURE DETERMINATIONS/FOLLOW UP, DATABASE DEVELOPMENT
- Keywords for Experimental System/Species: FOOD, INFANT FORMULA, BABY FOOD, FOOD PACKAGING.
- Keywords for Experimental Endpoints: ANALYTE DETECTION, QUANTITATION, EXPOSURE MONITORING, RISK ASSESSMENT
- Chemical Agents: Alkylphenols: Bisphenol-A, 4,4'-isopropylidenebisdiphenol CAS# 80-05-
7 Nonylphenol, technical grade CAS# 25154-52-3, technical grade, 85
purity CAS#104-40-5, practical grade, 994aurity CAS# 84852-15-7,
Trisnonylphenylphosphite,TNPP CAS# 26523-78-4, w/.75
triisopropanolamine CAS# 122-20-3, Ethoxylatednonylphenols CAS# 9016-
45-9.
- Performing Institution: Food and Drug Administration, Center for Food Safety and Applied
Nutrition Office of Premarket Approval, Division of Product
Manufacture and Use Chemistry Methods Branch HFS-248, 200 C Street,
South West Washington, DC 20204
- Contact: Gregory W. Diachenko, PhD, Director, Division of Product Manufacture
and UseHFS-245, Food and Drug Administration, 200 C Street, South
West, Washington, DC 20204 Phone (202) 205-5320, FAX: (202) 401-8531
|
|
