[Go]
PubMed | Entrez | Structure | PubChem | Help
PubChem  » Substance Summary
 


Nicardipine - Substance Summary (SID 9473)

A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.


Drug and Chemical Information: (Total:1)         

Medication Information

Cardene (nicardipine HCl) is a calcium ion influx inhibitor (slow channel blocker or calcium channel blocker). Cardene I.V. for intravenous administration contains 2.5 mg/mL of nicardipine hydrochloride. Nicardipine hydrochloride is a
DescriptionClinical PharmacologyContraindications
WarningsPrecautionsOverdosage
Dosage & AdministrationHow Supplied






Pharmacological Action

Antihypertensive Agents - Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive ...

Calcium Channel Blockers - A class of drugs that act by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in ...

Vasodilator Agents - Drugs used to cause dilation of the blood vessels.


  Pharmacological Classification
Chemical Actions and Uses
      Pharmacologic Actions
            Molecular Mechanisms of Pharmacological Action
                  Membrane Transport Modulators
                        Calcium Channel Blockers
            Therapeutic Uses
                  Cardiovascular Agents
                        Antihypertensive Agents
                        Calcium Channel Blockers
                        Vasodilator Agents


  Chemical Classification
Heterocyclic Compounds
      Heterocyclic Compounds, 1-Ring
            Pyridines
                  Dihydropyridines
                        Nicardipine


Safety and Toxicology

CCRIS - Carcinogenicity, tumor promotion, tumor inhibition, and mutagenicity tests

EINECS - European Inventory of Existing Commercial Chemical Substances

EINECS - European Inventory of Existing Commercial Chemical Substances

TOXLINE - Citations to the toxicological literature

TOXLINE - Citations to the toxicological literature

LactMed - Information on chemicals that breastfeeding mothers may be exposed

ClinicalTrials.gov - Registry of federal and private clinical trials

ClinicalTrials.gov - Registry of federal and private clinical trials


Literature Choose by Subheadings:

Literature Keyword Mining Tool



Data Source:   
Depositor: KEGG
External ID: C07264

Depositor-Supplied Synonyms: (Total: 3)
Sort:
nicardipine
C07264
55985-32-5


Properties Computed from Structure:
Molecular Weight479.52496 [g/mol]
Molecular FormulaC26H29N3O6
XLogP33.8
H-Bond Donor1
H-Bond Acceptor8
Rotatable Bond Count10
Tautomer Count3
Exact Mass479.205636
MonoIsotopic Mass479.205636
Topological Polar Surface Area111
Heavy Atom Count35
Formal Charge0
Complexity856
Isotope Atom Count0
Defined Atom StereoCenter Count0
Undefined Atom StereoCenter Count1
Defined Bond StereoCenter Count0
Undefined Bond StereoCenter Count0
Covalently-Bonded Unit Count1


Descriptors Computed from Structure:
IUPAC Name: 5-O-methyl 3-O-[2-[methyl(phenylmethyl)amino]ethyl]
2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Canonical SMILES: CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=
O)OC
InChI: InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)
23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,
13-14,16H2,1-4H3
InChIKey: ZBBHBTPTTSWHBA-UHFFFAOYSA-N


Substance Information:
SID 9473   
Deposit Date: 2005-06-24
Modify Date: 2008-09-10

CID 4474   
Create Date: 2005-03-25

Related Substances:
Same: 62 Links
Same, Connectivity: 73 Links
Same, Stereochemistry: 65 Links
Same, Isotopes: 70 Links

Similar Substances: 1624 Links


Depositor-Supplied Comments:
CAS: 55985-32-5
     
Compound Displayed

2D

3D
Compound ID4474
Molecular Weight479.52496 [g/mol]
Molecular FormulaC26H29N3O6
XLogP33.8
H-Bond Donor1
H-Bond Acceptor8


 Write to Helpdesk | Disclaimer | Privacy statement | Accessibility