Rose DN, Estok L, Collins M, Kleban R; International Conference on AIDS.

Int Conf AIDS. 1996 Jul 7-12; 11: 301 (abstract no. Th.B.4292).

Mount Sinai Medical Center, New York, NY, USA. Fax: (212) 831-1127. E-mail: drose@smtplink.mssm.edu.

Purpose: To conduct a literature review of complications of surgery in HIV-infected patients and to determine if the postoperative complication rate is higher in HIV-infected than -uninfected patients or in HIV-infected patients with advanced disease stage. Methods: We searched MEDLINE, AIDSLINE, conference proceedings, and literature citations. We included all studies of 5 or more HIV-infected patients and noted events within 1 month of surgery. Results: Seventy-six published reports describe the postoperative courses of 2,680 HIV-infected patients who had 4,624 procedures: 70 descriptive case series, 5 cohort studies, and 1 clinical trial of a dental procedure. Ten reports describe events following splenectomy in 166 patients: 58 complications (median rate, range of rates: 33%, 0%-100%) and 2 deaths occurred. Twenty reports describe 490 other major abdominal operations: 199 complications (33%, 0%-160%) and 86 deaths occurred (14%, 0%-60%). Ten reports describe 500 anorectal operations: 98 wound infections (8%, 0%-77%) and 15 deaths occurred (0%, 0%-18%). Thirty-seven reports describe 3,468 other operations: 265 complications and 10 deaths occurred. Thirteen reports documented postoperative complications in HIV-infected and -uninfected patients: 10 reports showed insubstantial differences in the rates between groups; 3 reports showed higher complication rates in HIV-infected patients. Fourteen reports documented postoperative complications in HIV-infected patients at various disease stages: 7 reports showed insubstantial differences in the rates between early stage and advanced HIV disease; 7 reports showed higher complication rates in patients with advanced HIV disease stages. Conclusions: Most reports of complications of surgery in HIV-infected patients are descriptive and therefore conclusions about rates must be interpreted cautiously. Complication rates vary widely for most procedures. Most reports of HIV-infected and -uninfected patients found insubstantial differences in rates between groups. Half the reports documenting complications in various HIV disease stages found the rates to be higher in more advanced stages; half did not.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Case-Control Studies
• Cohort Studies
• Disease Progression
• HIV Infections
• HIV Seropositivity
• Humans
• Obstetric Surgical Procedures
• surgery

Other ID:

• 96924681

UI: 102220580

From Meeting Abstracts