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OCD and human genetics
Wheaton MG, Timpano KR, LaSalle-Ricci VH, Murphy DL. Characterizing the hoarding phenotype in individuals with OCD: Associations with comorbidity, severity, and gender. J Anx Dis 22:243-252, 2008.
Wendland JR, Moya PR, Kruse MR, Ren-Patterson RF, Jensen CL, Cromer KR, Murphy DL. A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder. Hum Mol Genet. 17:717-23, 2008.
Hasler G, Pinto A, Greenberg BD, Samuels J, Fyer AJ, Pauls D, Knowles JA, McCracken JT, Piacentini J, Riddle MA, Rauch SL, Rasmussen SA, Willour VL, Grados MA, Cullen B, Bienvenu OJ, Shugart YY, Liang KY, Hoehn-Saric R, Wang Y, Ronquillo J, Nestadt G, Murphy DL. Familiality of Factor Analysis-Derived YBOCS Dimensions in OCD-Affected Sibling Pairs from the OCD Collaborative Genetics Study. Biol Psychiatry, 2007 Mar 1; 61( 5): 617-25.
Cromer KR, Schmidt NB, Murphy DL. An investigation of traumatic life events and obsessive-compulsive disorder. Behav Res Ther, 2007 Jul; 45( 7): 1683-91.
Wendland JR, Kruse MR, Murphy DL. Functional SLITRK1 var321, varCDfs and SLC6A4 G56A variants and susceptibility to obsessive-compulsive disorder. Mol Psychiatry,11:802-4, 2006.
Wendland JR, Martin BJ, Kruse MR, Lesch KP, Murphy DL. Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry, 11:224-6, 2006.
Hu X-Z, Lipsky RH, Zhu G, Akhtar LA, Taubman J, Greenberg BD, Xu K, Arnold PD, Richter MA, Kennedy JL, Murphy DL, Goldman D. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Gen 78:815-26, 2006.
Wendland JR, Kruse MR, Murphy DL. Functional SLITRK1 var321, varCDfs and SLC6A4 G56A variants and susceptibility to obsessive-compulsive disorder. Mol Psychiatry 11:802-4, 2006.
Shugart YY, Samuels J, Willour VL, Grados MA, Greenberg BD, Knowles JA, McCracken JT, Rauch SL, Murphy DL, Wang Y, Pinto A, Fyer AJ, Piacentini J, Pauls DL, Cullen B, Page J, Rasmussen SA, Bienvenu OJ, Hoehn-Saric R, Valle D, Liang KY, Riddle MA, Nestadt G. Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q. Mol Psychiatry, 11:763-70, 2006.
LaSalle-Ricci VH, Arnkoff DB, Glass CR, Crawley SA, Ronquillo JG, Murphy DL.The hoarding dimension of OCD: psychological comorbidity and the five-factor personality model. Behav Res Ther, 44:1503-12, 2006.
Hasler G, LaSalle-Ricci VH, Ronquillo JG, Crawley SA, Cochran LW, Kazuba D, Greenberg BD, Murphy DL.Obsessive-compulsive disorder symptom dimensions show specific relationships to psychiatric comorbidity. Psychiatry Res, 135:121-32, 2005.
Murphy DL, Lerner A, Rudnick G, Lesch KP.Serotonin transporter: gene, genetic disorders, and pharmacogenetics. Mol Interv, 4:109-23, 2004.
Lesch K-P, Murphy DL.Molecular genetics of transporters for norepinephrine, dopamine, and serotonin in behavioral traits and complex diseases. In S. Broer and C. A. Wagner (Eds.): Membrane Transport Diseases: Molecular Basis of Inherited Transport Defects, 2004.
LaSalle VH, Cromer KR, Nelson KN, Kazuba D, Justement L, Murphy DL.Diagnostic interview assessed neuropsychiatric disorder comorbidity in 334 individuals with
obsessive-compulsive disorder. Depress Anxiety, 19:163-173, 2004.
Ozaki N, Goldman D, Kaye WH, Plotnicov K, Greenberg BD, Lappalainen J, Rudnick G, Murphy DL.Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Mol Psychiatry, 8:895, 933-936, 2003.
Kilic F, Murphy DL, Rudnick G.A human serotonin transporter mutation causes constitutive activation of transport activity. Mol Pharmacol, 64:440-446, 2003.
Dick DM, Foroud T, Flury L, Bowman ES, Miller MJ, Rau NL, Moe PR, Samavedy N, El-Mallakh R, Manji H, Glitz DA, Meyer ET, Smiley C, Hahn R, Widmark C, McKinney R, Sutton L, Ballas C, Grice D, Berrettini W, Byerley W, Coryell W,
DePaulo R, MacKinnon DF, Gershon ES, Kelsoe JR, McMahon FJ, McInnis M, Murphy DL, Reich T, Scheftner W, Nurnberger JI Jr.Genomewide linkage analyses of bipolar disordr: a new sample
of 250 pedigrees from the National Institute of Mental Health Genetics Initiative. Am J Hum Genet, 73:979, 2003.
Lesch K-P, Greenberg BD, Higley JD, Bennett A, Murphy DL. Serotonin transporter, personality, and behavior: Toward a dissection of gene-gene and gene-environment interaction. In Benjamin J, Ebstein RP and Belmaker RH (Eds.): Molecular Genetics and the Human Personality, Washington, DC, American Psychiatric Publishing, Inc., 109-135, 2002.
Murphy DL, Li Q, Engel S, Wichems C, Andrews A, Lesch K-P, Uhl G. Genetic perspectives on the serotonin transporter. Brain Research Bulletin, 56:487-494, 2001.
Wassermann EM, Greenberg BD, Nguyen MB, Murphy DL. Motor cortex excitability correlates with an anxiety-related personality trait. Biol Psychiat, 50:377-382, 2001.
Enoch M-A, Greenberg BD, Murphy DL, Goldman D. Sexually dimorphic relationship of a 5-HT2A promoter polymorphism with obsessive-compulsive disorder. Biol Psychiat, 49:385-388, 2001.
Greenberg BD, Murphy DL, Rasmussen SA. Neuroanatomically based approaches to obsessive-compulsive disorder. Neurosurgery and transcranial magnetic stimulation. Psychiatr Clin North Am, 23:671-86, 2000.
Sher L, Greenberg BD, Murphy DL, Rosenthal NE, Hamer DH. Pleiotropy of the serotonin transporter gene for seasonality and neuroticism. Psychiatr Genet, 10:125-130, 2000.
Wassermann EM, Greenberg BD, Murphy, DL, et al. A relationship between personality traits and cortical synaptic transmission measured with transcranial magnetic stimulation. Ann Neurol, 48:420-420, 2000.
Greenberg BD, Li Q, Lucas FR, Hu S, Sirota LA, Benjamin J, Lesch K-P, Hamer D, Murphy DL. Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genet, 96:202-216, 2000.
Schmidt, N.B. et al. Evaluating gene x psychological risk factor effects in the pathogenesis of anxiety: A new model approach. J Abnormal Psychol, 109:308-320, 2000.
Greenberg BD, Ziemann U, Cora-Locatelli G, Harmon A, Murphy DL, Keel JC, Wassermann EM. Altered cortical excitability in obsessive-compulsive disorder. Neurology, 54:142-147, 2000.
Bengel D, Greenberg BD, Cora-Locatelli G, Altemus M, Heils A, Li Q, Murphy DL. Association of the serotonin transporter promoter regulatory region and obsessive-compulsive disorder. Mol Psychiatry, 4:463-466, 1999.
Sirota LA, Greenberg BD, Murphy DL, Hamer DH. Non-linear association between the serotonin transporter promoter polymorphism and neuroticism: A caution against using extreme samples to identify quantitative trait loci. Psychiatric Genetics, 9:35-38, 1999.
Greenberg BD, Tolliver TJ, Huang SJ, Li Q, Bengel D, Murphy DL. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet, 88:83-87,1999.
Murphy DL, Andrews AM, Wichems CH, Li Q, Tohda M, Greenberg B. Brain serotonin neurotransmission: an overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs. J Clin Psychiatry. 1998;59 Suppl 15:4-12. Review.
Greenberg, B.D., McMahon F.J., and Murphy, D.L.: Serotonin transporter candidate gene studies in affective disorders and personality: promises and potential pitfalls. Mol Psychiatry, 3:186-189, 1998.
Murphy DL, Sims K, Eisenhofer G, Greenberg B, George T, Butler R, Berlin F, Zametkin A, Ernst M, Breakefield XO. Are MAO-A deficiency states in the general population and in putative high-risk populations highly uncommon? J Neural Transm, 52:35-44, 1997.
Karayiorgou M, Altemus M, Galke BL, Goldman D, Murphy DL, Ott J, Gogos JA. Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. PNAS,. 94:4572-4575, 1997.
Lenders JWM, Eisenhofer G, Abeling NG, Berger W, Murphy DL, Konings CH, Wagemakers LM, Kopin IJ, Karoum F, van Gennip AH, Brunne, HG. Specific genetic deficiencies of the A and B isoenzymes of monoamine oxidase are characterized by distinct neurochemical and clinical phenotypes. J Clin Invest, 97:1010-1019, 1996.
Lesch K-P, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller-Reible CR, Hamer DH, Murphy DL. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274:1527-1531, 1996.
Lesch, K.-P., Gross, J., Franzek, E., Wolozin, B.L., Riederer, P., and Murphy, D.L.: Primary structure of the serotonin transporter in unipolar and bipolar disorder. Biol. Psychiatry 37: 215-223, 1995.
Lesch, K.-P., Gross, J., Wolozin, B.L., Franzek, E., Bengel, D., Riederer, P., and Murphy, D.L.: Direct sequencing of the reserpine-sensitive vesicular monoamine transporter complementary DNA in unipolar depression and manic-depressive illness. Psychiatr. Gen. 4: 153-160, 1994.
Lesch, K.-P., Balling, U., Gross, J., Strauss, K., Wolozin, B.L., Murphy, D.L., and Riederer, P.: Organization of the human serotonin transporter gene. J. Neural Transm. 95: 157-162, 1994.
Lesch, K.-P., Wolozin, B.L., Murphy, D.L., and Riederer, P.: Primary structure of the human platelet serotonin uptake site: Identity with the brain serotonin transporter. J. Neurochem. 60: 2319-2322, 1993.
Collins, F.A., Murphy, D.L., Reiss, A.L., Sims, K.B., Lewis, J.G., Freund, L., Karoum, F., Zhu, D., Maumenee, I.H., and Antonarakis, S.E.: Clinical, biochemical, and neuropsychiatric evaluation of a patient with a contiguous gene syndrome due to a microdeletion Xp11.3 including the Norrie disease locus and monoamine oxidase (MAOA and MAOB) genes. Am. J. Med. Genet. 42: 127-134, 1992.
Murphy, D.L., Sims, K.B., Karoum, F., de la Chapelle, A., Norio, R., Sankila, E.-M., and Breakefield, X.O.: Marked amine and amine metabolite changes in Norrie disease patients with an X-chromosomal deletion affecting monoamine oxidase. J. Neurochem. 54: 242-247, 1990.
Sims, K.B., Ozelius, L., Corey, T., Rinehart, W.B., Liberfarb, R., Haines, J., Chen, W.J., Norio, R., Sankila, E., de la Chapelle, A., Murphy, D.L., Gusella, J., and Breakefield, X.O.: Norrie disease gene is distinct from the monoamine oxidase genes. Am. J. Hum. Genet. 45: 424-434, 1989.
Sims, K.B., de la Chapelle, A., Norio, R., Sankila, E.-M., Hsu, Y.-P.P., Rinehart, W.B., Corey, T.J., Ozelius, L., Powell, J.F., Bruns, G., Gusella, J.F., Murphy, D.L., and Breakefield, X.O.: Monoamine oxidase deficiency in males with an X chromosome deletion. Neuron 2: 1069-1076, 1989.
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