Squires KE, Stempien MJ, Shadman A, Buhles WC; National Conference on Human Retroviruses and Related Infections.
Program Abstr First Natl Conf Hum Retrovir Relat Infect Natl Conf Hum Retrovir Relat Infect 1st 1993 Wash DC. 1993 Dec 12-16; 154.
The University of Alabama at Birmingham, Birmingham, AL.
216 patients with CMV retinitis judged to be stable after receiving 4 wks to 4 mo. of a standard IVG regimen were randomized to 20 wks of IVG at 5 mg/kgd (n=68), or POG at either 500 mg 6x/d (n=72), or 1000 mg TID (n=76). Serial ophthalmologic evaluations, including 1) visual acuity, 2) assessment of functional vision, 3) dilated fundus examinations, and 4) retinal photographs, were performed. The time from randomization to progression as indicated by indirect ophthalmoscopy was as follows: (table: see text). A blinded analysis of the retinal photographs is ongoing. Earlier preliminary results, based on 152 patients, suggested that time to deterioration of vision, incidence of a new CMV lesion, or incidence of bilateral disease did not differ significantly among treatment groups. The incidence of hematologic and gastrointestinal adverse events was also similar among the 3 treatment groups. Conclusion: Oral ganciclovir is well-tolerated by patients with AIDS. Serial fundoscopy by study ophthalmologists indicates that IV ganciclovir and oral ganciclovir are not equivalent with respect to time to progression of CMV retinitis. Ongoing studies will define the role of oral ganciclovir in the treatment of CMV infection in patients with AIDS.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Biomedical Research
- Cytomegalovirus Retinitis
- Disease Progression
- Evaluation Studies
- Ganciclovir
- Humans
- Incidence
- Ophthalmoscopy
- Visual Acuity
- therapy
Other ID:
UI: 102214505
From Meeting Abstracts