Klemetti R, Sevon T, Hemminki E, Gissler M, Ritvanen A; Health Technology Assessment International. Meeting (1st : 2004 : Krakow, Poland).
Proc One HTA Health Technol Assess Int Meet 1st 2004 Krakow Pol. 2004; 1: 83.
STAKES, Helsinki, Finland.
OBJECTIVE: The purpose was to study the risk of major malformations among children born after IVF (in vitro fertilizations, microinjections and frozen embryo transfers). METHODS: IVF children (N = 4559) were identified from the reimbursement records of the Social Insurance Institution and the Medical Birth Register (MBR). The control group, consisting naturally conceived children born during the same time period (N = 27 078), was selected randomly from the MBR. Data from malformations were obtained from the Malformation Register (MR). Major malformations were defined as routinely classified in the MR, which follows the International Classification of Diseases, Ninth Revision (ICD-9), using the European Surveillance of Congenital Anomalies (EUROCAT) exclusion list. The IVF and control populations were compared and the risk of major malformations was studied, both overall and by plurality, while controlling for confounding factors using logistic regression. RESULTS: A total 4.3% of IVF and 2.9% of control children had at least one major malformation. The adjusted risk of major malformations among IVF children is presented in the Table 1. Further information on malformations by diagnoses will be presented at the conference. Table 1. The odds ratio of major malformations among IVF children 1) (See author) CONCLUSIONS: The present study suggests that IVF is associated with an increased risk for developing a major malformation among boys.
Publication Types:
Keywords:
- Child
- Embryo Transfer
- Fertilization
- Fertilization in Vitro
- Humans
- In Vitro
- Logistic Models
- Male
- Microinjections
- Odds Ratio
- abnormalities
- hsrmtgs
UI: 103140714
From Meeting Abstracts