Groen H, Pelinck MJ, Hoek A, TenVergert EM; Health Technology Assessment International. Meeting (2nd : 2005 : Rome, Italy).
Ital J Public Health. 2005; 2: 181.
Office for Medical Technology Assessment, University Medical Center Groningen, P.O. Box 30001, Groningen, 9700 RB The Netherlands Tel: +31 503612152, Fax: +31 503611738, E-mail: h.groen@mta.umcg.nl
Introduction: In vitro fertilisation (IVF) is an effective technique for assisted reproduction. A major complication of IVF lies in the large number of multiple pregnancies (25-30%) which is associated with considerable costs. Alternatively, IVF can also be performed in the manipulated natural cycle (MNC-IVF), where one oocyte is harvested per cycle using minimal hormonal manipulation. The aim of this study was to compare the effects and costs of conventional IVF to MNC-IVF. Methods: In a multi-centre study funded by the Dutch ZonMw Health Care Efficiency Research Programme 330 patients less than 37 years of age with ovulatory menstrual cycles were included. All patients underwent up to three cycles of MNC-IVF. Costs per individual treatment cycle of MNC-IVF were assessed on the basis of Dutch tariffs. Costs of conventional IVF were derived from the literature. Medication costs were calculated on the basis of actually prescribed medication in our clinic. Results: Full treatment costs of MNC-IVF, including costs of pregnancy and delivery, ranged from 1,329 to 1,465 Euro per cycle, depending on the treatment phases completed and the number of pregnancies achieved. Medication costs ranged between 265 and 275 Euro per cycle versus 885 Euro for conventional IVF. The costs per live birth after three cycles of MNC-IVF was 17,197 Euro, which is comparable to the costs per live birth after a single cycle of conventional IVF. Conclusion: Three cycles of MNC-IVF achieve similar pregnancy rates as conventional IVF but with much lower twin pregnancy rates. Therefore, MNC-IVF may be a cost-effective alternative for conventional IVF.
Publication Types:
Keywords:
- Cost-Benefit Analysis
- Costs and Cost Analysis
- Female
- Fertilization in Vitro
- Health Care Costs
- Humans
- In Vitro
- Live Birth
- Pregnancy
- Pregnancy Complications
- Pregnancy Outcome
- Pregnancy Rate
- Pregnancy, Multiple
- Twins
- economics
- hsrmtgs
UI: 103141164
From Meeting Abstracts