NCBI CDD smart00240

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CDD

Structure

Protein

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smart00240: FHA, with user query added

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Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.

Links

Source:	Smart
Taxonomy:	cellular organisms
PubMed:	3 links
Protein:	Related Protein
	Related Structure
	Architectures
	Representatives
Superfamily:	cl00062

Statistics

PSSM-Id:	90499
View PSSM:	smart00240
Aligned:	56 rows
Created:	12-Dec-2003
Updated:	9-Jan-2008

Structure


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PubMed References

The FHA domain is a modular phosphopeptide recognition motif.Mol. Cell 1999 Sep; 4(3):387-394
Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint.Science 1998 Jul 10; 281(5374):272-274
The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors.Trends Biochem. Sci. 1995 Sep; 20(9):347-349

smart00240 is a member of the superfamily cl00062.

Sequence Alignment?

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1K3Q_A        52 VWTFGRNP.[ 1].CDYHLGNIS.[1].LSNKHFQIL.[2].EDGN     LLLNDIS     TNGTWLNGQKV 103
query         22 VTSLGRAD.[ 1].NDIVLGGDL     VSRRHARLF     VDGD.[1].LRIEDLG.[1].RNGSRINGAPL 72
gi 7661966    53 KNVVGRMP.[ 1].CSVALPFPS     ISKQHAEIE     ILAW.[3].PILRDCG.[1].LNGTQILRPPK 105
gi 27923796   68 EFTAGRGE.[ 1].NDLILTLND.[8].ISKVHFIIK.[3].CELT.[2].VYIQDLS     RNGTFVNNEKI 129
gi 731873     75 EVTIGRNT.[16].IDIDLGPAK.[1].VSRKHAAIR     FNLE.[3].WELQIFG     RNGAKVNFRRI 142
gi 127299     46 LVKVGRND.[ 2].CQLVLTNPS     ISSVHCVFW.[3].FDED.[4].FYVKDCS     LNGTYLNGLLL 102
gi 31791197  448 SNIIGRGQ.[ 1].AQFRLPDTG     VSRRHLEIR     WDGQ.[1].ALLADLN.[1].TNGTTVNNAPV 498
gi 15841211   26 DVVVGRDL.[ 1].ADVRVAHPL     ISRAHLLLR     FDQG.[1].WVAIDNG.[1].LNGLYLNNRRV 76
gi 2131533   101 RLAIGRKK.[ 2].CNIILPCRK.[1].ISRQHAFIS     YAAD.[3].IKLECNG     TNGLSVHLPYS 154
gi 7469259    28 YWTVGRSQ.[ 1].NDLVIRDNC     ISRNHAILQ     ATEE.[2].FLLIDLG.[1].RNGTFVNGRRV 79

Citing CDD

Marchler-Bauer A, Anderson JB, Derbyshire MK, DeWeese-Scott C, Gonzales NR, Gwadz M, Hao L, He S, Hurwitz DI, Jackson JD, Ke Z, Krylov D, Lanczycki CJ, Liebert CA, Liu C, Lu F, Lu S, Marchler GH, Mullokandov M, Song JS, Thanki N, Yamashita RA, Yin JJ, Zhang D, Bryant SH. (2007) CDD: a conserved domain database for interactive domain family analysis. Nucleic Acids Res. 35: D237-40

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