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#489Protein and Interface Design: A Real-world Example - Antibody Design, Publication-Quality Graphics
 
Description:
The course will cover:

  • Antibody modeling
    • Biochemistry review
    • Modeling considerations
    • Techniques

  • Advanced Visualization
    • Servers: ConSurf, elNémo, MolMovDB, OPM
    • PyMOL: movies with ProMol and eMovie, alternative representations, advanced lighting, electrostatic potential maps
    • Chimera: viruses and surface slicing and dicing!

This is the eighth lecture in a nine-part series on computational structural biology presented by the NIAID Bioinformatics and Scientific IT Program. Please click on the following links to view and/or register for the other lectures.

Protein Structure Analysis: Introduction and Visualization

Introduction to Homology Modeling: Sequence Alignment and Template Selection

Advanced Homology Modeling: Model Optimization, Alignment Improvement (Threading), Protein Complexes

Loop Modeling and Protein Folding: Rosetta, Secondary Structure Predictions, Structure Validation, Database Mining

Protein-Protein Docking: Complexes Revisited, Constraints, Multi-domain Proteins

in silico Drug Screening: Small Molecule Docking

Molecular Dynamics: Macromolecular Simulations

Structural Biology Laboratory

 
Who should attend:
NIH staff who work with protein modeling and would like to know more about the context.
 
Instructor(s):
Dr. Darrell Hurt, Ph.D., NIAID OCICB Bioinformatics and Computational Biosciences Branch (BCBB)
 
Time Required:
2 hours
 
Sections Available:
-- Concluded -- 489-09F December 3 9:00 - 11:00 Building 12A, Room B51
 
NOTE: Although this course has already taken place, we'll put you on a waiting list for the next available session.

Course Listing

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