Frome, E. L. and Beauchamp, J. J. (1968), "Maximum Likeli-
hood Estimation of Survival Curve Parameters," Biometrics, 24,
595-605.
Lushbaugh, C. C., Frome, E. L., Davis, H. T., and Bibler, D.
S. (1969), "Power Spectrum of the Impedance Pneumograph: A Data
Reduction System Producing an Analytical Parameter of Potential
Clinical Usefulness," Aerospace Medicine, 30, 425-429.
Frome, Edward L. (1969),"Measurement and Interpretation of
Subjective Similarity:An Application of Nonmetric Multidimensional
Scaling", Research Rpt 69-10,Marketing Research Dept, Coca-Cola USA
Ricks, R. C., Lushbaugh, C. C., McDow, E., and Frome, E.
(1972), "Pulmonary- Impedance Power Spectral Analysis: A Facile
Means of Detecting Radiation- Induced Gastrointestinal Distress
and Performance Decrement in Man," Proceedings of the National
Symposium on Natural and Man-made Radiation in Space, ed., E. A.
Warman, NASA TM X-2440.
Frome, E. L., Kutner, M. H., and Beauchamp, J. J. (1973),
"Regression Analysis of Poisson-Distributed Data," Journal of The
American Statistical Association, 68, 935-940.
Frome, E. L.(1974), "Algorithm AS 73: Cross-Spectrum
Smoothing Via the Finite Fourier Transform," Applied Statistics,
23, 238-244.
Frome, E. L., and Frederickson, E. L. (1974), "Digital Spec-
trum Analysis of The First and Second Heart Sounds," Computers
and Biomedical Research . 7, 421-432.
Frome, E. L., Frederickson, E. L., and Ricks, R. C. (1973),
"Power Spectrum of the Respiratory System Via the Pulmonary Im-
pedance Pneumograph," In: Proc. Tenth Symposium on Biomathemat-
ics and Computer Science in the Life Sciences, 8-9.
Charnes, A., Frome, E. L. and Yu, P. L. (1976). "The
Equivalence of Generalized Least Squares and Maximum Likelihood
Estimation in the Exponential Family," Journal of The American
Statistical Association, 71: 169-172.
Armstrong, R. D. and Frome, E. L. (1976). "The Calculation
of Least Absolute Value Estimators for Two-Way Tables," In:
Proc. Stat. Comput. Sec., Am. Stat. Assoc., Boston, MA, 101-106.
Frome, E. L., Frederickson, E. L. and Lushbaugh, C. C.
(1976). "Power Spectrum of the Respiratory System," Biometrics,
32: 423-428.
Armstrong, R. D., and Frome, E. L. (1976), "A Branch and
Bound Solution of a Restricted Least Squares Problem," Tech-
nometrics, 18, 447-450.
Armstrong, R. D., and Frome, E. L. (1976), "A Comparison of
Two Algorithms for Absolute Deviation Curve Fitting," Journal of
The American Statistical Association, 71, 328-330.
Armstrong, R. D., and Frome, E. L. (1977), "A Special Pur-
pose Linear Programming Algorithm for Obtaining Least Absolute
Value Estimators in a Linear Model with Dummy Variables," Commun.
Stat., B6(4), 383-398.
Yakatan, G. J., Smith, R. B., Frome, E. L., and Dolluisio,
J. T. (1977), "Pharmacokinetics of Orally Administered Hydro-
flumethiazide in Man," J. Clin. Pharm., 17: 37-47.
Frome, E. L., and Armstrong, R. D. (1977), "A Robust Pro-
cedure for Estimating the Trend-Cycle Component of an Economic
Time Series," Computer Science and Statistics: Tenth Annual Sym-
posium on the Interface, U.S. National Bureau of Standards Spe-
cial Publication 503, 271-375.
Armstrong, R. D., and Frome, E. L. (1978), "A Remark on Al-
gorithm AS 108," Applied Statistics, 27, 378.
Yakatan, G. J., Frome, E. L., Leonard, R. G., Shah, A. C.,
and Dolluisio, J. T. (1978), "Bioavailability of Acetazolamide
Tablets," J. Clin. Pharm. Sci., 67, 252-255.
Armstrong, R. D., and Frome, E. L. (1979), "Least Absolute
Value Estimators for One-Way and Two-Way Tables," Nav. Log. Res.
Quart., 26, 79-96.
Armstrong, R. D., Frome, E. L., and Kung, D. S. (1979), "A
Revised Simplex Algorithm for the Absolute Deviation Curve Fit-
ting Problem," Commun. Stat., 8B, 175-190.
DuFrain, R. J., Littlefield, L. G., Joiner, E. E., and
Frome, E. L. (1979), "Human Cytogenetic Dosimetry: A Dose
Response Relationship for Alpha Particle Radiation from
Americium-241," Health Physics, 37, 279-289.
Frome, E. L., and DuFrain, R. D. (1979), "Estimation of the
Amount of Exposure to an Environmental Clastogen Using Human
Cytogenetic Dosimetry," Proceedings of the 1978 DOE Statistical
Symposium, November 1-3, Albuquerque, NM, 169-172.
DuFrain, R. J., Littlefield, L. G., Joiner, E. E., and
Frome, E. L. (1980), "In Vitro Human Cytogenetic Dose Response
Systems," The Medical Basis for Radiation Accident Preparedness,
Proc. Int. Conf. Oak Ridge, TN 1979, eds., K. F. Hubner and S. A.
Fry, 357-374.
Frome, E. L., and Hudson, D. R. (1980), "A Jackknife Pro-
cedure for Estimating Standardized Mortality Ratios," Proceedings
of the American Statistical Association, Computing Section, Au-
gust 13-16, Washington, DC, 323-327.
Frome, E. L., and Khare, M. (1980), "Comments on Brodsky's
Statistical Methods for Evaluating Epidemiological Results
(Letter to the Editor)," Health Phys., 39, 695-697.
Frome, E. L., and Yakatan, G. J. (1980), "Statistical Esti-
mation of the Pharmacokinetic Parameters in the One-Compartment
Open Model," Commun. Stat., B9(3), 201-222.
Polednak, A. P., and Frome. E. L (1980), "Mortality Among
Men Employed (Between 1943 and 1947) at a Uranium-Processing
Plant," Proceedings of the 1979 DOE Statistical Symposium,
Gatlinburg, TN, 116-127.
Armstrong, R. D., Frome, E. L., and Sklar, M. G. (1981),
"Linear Programming in Exploratory Data Analysis," Journal of
Educational Statistics, 5, 293-308.
Frome, E. L. (1981), "Poisson Regression Analysis," The
American Statistician, (35: 262-263).
Frome, E. L. (1981), AS335: A Remark on AS 73: Cross-
Spectrum Smoothing via the Finite Fourier Transform," Applied
Statistics, 30, 354.
Frome, E. L., and Hudson, D. R. (1981), "A General Statisti-
cal Data Structure for Epidemiologic Studies of DOE Workers,"
Proceedings of the 1980 DOE Statistical Symposium, October 29-31,
Oakland/Berkeley, CA, 206-218.
Frome, E., and Hudson, D. (1981), "Interval Estimation for
X-Predictions When the Dependent Variable Follows the Poisson
Distribution," Proc. of the Am. Stat. Assoc., Statistical Comput-
ing Section, August 11-14, Houston, TX, 294-297.
Polednak, A. P., and Frome, E. L. (1981), "Mortality Among
Men Employed Between 1943 and 1947 at a Uranium-Processing
Plant," Journal of Occupational Medicine , 23, 169-178.
DuFrain, R. J., Littlefield, L. G., Wilmer, J. L, and Frome,
E. L. (1982), "Evaluation of Chemically Induced Cytogenetic Le-
sions in Rabbit Oocytes, II, A Comparison of Streptonigrin Ef-
fects on Somatic and Germ Cells," Mutation Research, 94: 103-114.
Frome, E. L. (1982), "Fisher's Exact Variance Test for the
Poisson Distribution," Applied Statistics, 31: 67-71.
Littlefield, L. G., Colyer, S. P., Joiner, E. E., DuFrain,
R. J., Frome, E. L., and Cohen, M. M. (1982), "Chromosomal Radia-
tion Sensitivity in Ataxia Telangiectasia Long-Term, Lymphoblas-
toid Cell Lines," Cytogenetics and Cell Genetics, 31: 203-213.
Holland, J. M. and Frome, E. L. (1983), "Statistical Evalua-
tions in the Carcinogenesis of Bioassay of Petroleum Hydrocar-
bons," In : Advances in Modern Environmental Toxicology, Applied
Toxicology of Hydrocarbons, MacFarland, H.N. et al, ed., Prince-
ton, New Jersey, Vol. VI, pp. 151-166.
Frome, E. L. (1983), "The Analysis of Rates Using Poisson
Regression Models," Biometrics,39: 665-674.
Lushbaugh, C. C., Fry, S. A., Shy, C. M. and Frome, E. L.
(1983), "DOE Health and Mortality Study at Oak Ridge," In:
Health Physics Society: Epidemiology Applied to Health Physics,
Proceedings of the Sixteenth Midyear Topical Symposium, U.S.
Department of Energy Report, CONF-830101, pp. 105- 114, Albu-
querque, NM 1983.
Frome, E. L. and McLain, R. (1984), "A SAS Macro for Fitting
Nonlinear Models to Poisson Distributed Data," In: Proceedings
of the Ninth Annual SUGI Conference, Hollywood Beach, Florida,
pp. 883-883.
Frome, E. L. (1984), "Response to Nelder's Reaction on Pois-
son Rate Analysis," Biometrics, 40: 1160-1162.
Frome, E. L. and Checkoway, H. (1985), "The Use of Poisson
Regression Models in Estimating Incidence Rates and Ratios,"
American Journal of Epidemiology, 309-323.
Frome, E. L. (1986), "Regression Methods for Binomial and
Poisson Distributed Data," In: Proceedings of American Associa-
tion of Physicists in Medicine First Midyear Topical Symposium on
Multiple Regression Analysis, Applications in the Health Sci-
ences, Herbert, D., and Meyers, R., eds., The American Institute
of Physics, New York, 84-123.
Frome, E. L. and DuFrain, R. J. (1986), "Maximum Likelihood
Estimation for Cytogenetic Dose-Response Curves," Biometrics, 42:
73-84 .
Lindenschmidt, R. C., Tryka, A. F., Godfrey, G. A., Frome,
E. L., and Witschi, H., (1986), "Intratracheal versus Intravenousred
Administration of Bleomycin in Mice: Acute Effects," Toxicol.
Appl. Pharmacol., vol. 85, pp. 69-77.
McLain,R. and Frome,E.L. (1986),"A System for the Analysis
of Cohort Mortality Data",in SAS Users Group International
Proceedings,874-876.
Littlefield, L.G., Joiner, E.E., Colyer, S.P., and Frome,
E.L., (1987), "Effects of Cryopreservation on the Recovery of
Radiation-Induced Chromosome Aberrations in Human Lymphocytes,"
Radiation Protection Dosimetry Journal,18: 25-29.
Witschi, H., Godfrey, G. A., Frome, E. L., and Linden-
schmidt, R. C., (1987), "Pulmonary Toxicity of Cytostatic Drugs:
Cell Kinetics",Fundamental and Applied Toxicology ,8: 253-262.
Carpenter,A.V., Flanders,W.D., Frome,E.L., Crawford-
Brown,D.J., and Fry,S.A. (1987), "Central Nervous System Cancers
and Radiation Exposures: A Case-Control Study Among Workers at
Two Nuclear Facilities," Journal of Occupational Medicine,29:
601-604.
Wistchi,H.P., Smith,L.H., Frome,E.L., Pequet-Goad, M.E.,
Griest,W.H., Ho,C.H., Guerin,M.R.(1987), "Skin Tumorigenic Poten-
tial of Crude and Refined Coal Liquids and Analogous Petroleum
Products",Fundamental and Applied Toxicology ,9: 297-303.
Carpenter,A.V., Flanders,W.D., Frome,E.L., Cole,P.,and
Fry,S.A. (1987), "Brain Cancer and Non-occupational Risk Factors
: A Case-Control Study Among Workers at Two Nuclear Facilities,"
The American Journal of Public Health,77: 1180-1182.
Littlefield, L.G.,Joiner,E.E ,Colyer,S.P., Sayer,A.M. and
Frome,E.L.(1988), "Modualtion of Radiation-Induced Chrosome Aber-
rations By DMSO- An OH Radical Scavenger," The International
Journal of Radiation Biology ,53: 875-890.
Carpenter,A.V., Flanders,W.D., Frome,E.L., Tankersley,
W.G.,and Fry,S.A. (1988), "Chemical Exposures and Central Nervous
System Cancers: A Case-Control Study Among Workers at Two Nuclear
Facilities," The American Journal of Industrial Medicine,13:351-
362.
Frome, E. L., and Morris, M. D. (1989), "Evaluating Goodness
of Fit of Poisson Regression Models in Cohort Studies",The Ameri-
can Statistician,43:144-147.
Littlefield, L. G., Sayer, A. M.,and Frome, E. L. (1989),
"Comparisons of Dose Response Parameters For Radiation-Induced
Acentric Fragments and Micronuclei Observed in Cytokinesis-
Arrested Lymphocytes", Mutagenesis,4:265-270.
Ostrouchov, G. and Frome, E. (1989), "A Model Search Pro-
cedure for Hierarchical Log-Linear Models",Proceedings Of Sta-
tistical Computing Section of American Statistical Assoc,277-282.
Frome, E.L., Cragle ,D.L., and McLain,R. (1990), "Poisson
Regression Analysis of The Morality Among a Cohort of World War
II Nuclear Industry Workers ", Radiation Research,123:138-152.
Frome, E. L., (1991), "Statistical Analysis of Cytogenetic
Dose-Response Curves," in Statistical Methods in Toxicological
Research, eds. D. Krewski and C. Franklin, Gordon & Breach Sci-
ence Publications, Inc., 281-298.
Wing,S., Shy,C.M., Wood,J., Wolf, S., Cragle, D.,and Frome,
E.(1991), "Mortality Among Workers at Oak Ridge National Labora-
tory: Evidence of Radiation Effects in Follow-up Through 1984"
Journal of The American Medical Association,256:1397-1402.
Oakberg, E.F., Generoso, W.M., Cummings, C.C. and Frome,
E.L.(1991), "DNA Synthesis , Mitotic Activity, and Radiation Sen-
sitivity of Spermatogonial Stem Cells Following Single and Frac-
tionated Exposures to X-rays",Biol. Reprod.,(submitted).
Generoso,W.M., Cain,K.T., Cornett,C.V., and
Frome,E.L.(1991), "Comparison of Two Stocks of Mice in Sperma-
tiogonal response to Different Conditions of Radiation
Exposure",Mutation Research,249,301-310.
Littlefield,L.G., Sayer,A.M., Sallam,F., Frome,E.L., and
Kleinerman,R.A., (1992),"Experience With The Cytochalasin-B
Method for Quantifing Radiation Induced Micronuclei in Human Lym-
phocytes" ,Proc. International Congress of Radiation Research,
Toronto, Canada, pp 183-188.
Ostrouchov, G. and Frome, E. (1993), "A Model Search Pro-
cedure for Hierarchical Models",Computational Statistics and Data
Analysis, 15, 285-296.
Littlefield, L.G.,Joiner,E.E ,Colyer,S.P.,Sallam,F., and
Frome,E.L.(1993), "Concentration Dependent Protection Against X-
ray Induced Chromosome Aberrations in Human Lymphocytes by The
Aminothiol WR-1065" Radiation Research 133, 88-93.
Wing,S., Shy,C.M., Wood,J., Wolf, S., Cragle, D.,and Frome,
E. (1993), "Job Factors, Radiation and Cancer Mortality at Oak
Ridge National Laboratory: Follow-up Through 1984",American Jour-
nal of Industrial Medicine 23, 265-279.
Watkins, J. ,Regan,J.,Cragle,D., Frome,E. et al (1993) "Data
Collection, Validation, and Description For The Oak Ridge Nuclear
Facilities Mortality Study",Technical Report ORISE 93/J-42
Mitchell,T.J., Ostrouchov,G., Frome, E. and Kerr, G.
(1993),"A Method For Estimating Occupational Dose To Individuals,
Using Weekly Dosimetry Data", ORNL 6778 , pp 1-41.
Frome,E.L., Smith,M.,Littlefield,G.,Neubert,R. and Colyer,S.
(1994) , "Statistical Methods For The Analysis of a Screening
Test For Chronic Beryllium Disease", ORNL-6818 ), pp 1-61.
Littlefield, L.G.,Joiner,E.E ,Colyer,S.P., and
Frome,E.L.(1994), "Radioprotective Chemicals as Tools for Study-
ing Mechanisms of Radiation-Induced Chromosome Damage in Human
Lymphocytes" in Chromosomal Alterations, eds. G. Obe and A. T.
Natarajan,Springer-Verlag,New York, pp 132-139.
Fry SA, Cragle DL, Crawford-Brown DJ, Dupree EA, Frome EL,
Gilbert ES, Petersen GR, Shy CM, Tankersley WG, Voelz GL, Wallace
PW, Watkins JP, Watson Jr. JE, and Wiggs LD (1995), "Health and
Mortality Among Contractor Employees at US Department of Energy
Facilities", in Radiation and Public Perception Benefits and
Risks, Advances in Chemistry Series, eds.Young JP and Yalow RS,
American Chemical Society, Washington, DC, 239-258.
Frome,E.L., Smith,M.,Littlefield,G.,Neubert,R. and Colyer,S.
(1996) , "Statistical Methods for the Blood Beryllium Lymphocyte
Proliferation Test ", Environmental Health Perspectives, Vol 105,
Supplement 5,957-968 .
Frome, E.L., Cragle, D.L., Watkins, J., Wing, S., Shy, S.,
Tankersley, W., and West, C. (1997), "A Mortality Study of Em-
ployees of the Nuclear Industry in Oak Ridge, Tennessee", ORNL-
6785, pp 1-67.(See http://www.epm.ornl.gov/~frome/ORMS/)
Watkins,J.P., Reagan, J.L., Cragle, D.L.,Frome, E.L., West,
C.M., Crawford-Brown,D. , and Tankersley, W.G. (1997), "Collec-
tion, Validation, and Treatment of Data for a Mortality Study of
Nuclear Industry Workers ", Applied Occupational and Environmen-
tal Hygiene ,12(3), 195-205.
Frome,E.L., L.S. Newman, and M. M. Mroz (1997) ," Results of the
Analysis of The Blood Lymphocyte Proliferation Test Data From The
National Jewish Center", ORNL/TM-13338, pp 1-36
Frome, E.L., Cragle, D.L., Watkins, J., Wing, S., Shy, S.,
Tankersley, W., and West, C. (1997), "A Mortality Study of
Employees of the Nuclear Industry in Oak Ridge, Tennessee",
Radiation Research,148,64-80.
Mitchell,T.J., Ostrouchov,G., Frome, E. and Kerr, G.
(1997),"A Method For Estimating Occupational Dose To Individuals,
Using Weekly Dosimetry Data", Radiation Research,147:195-207.
Frome, E.L., Watkins, J.P. (1998)"Statistical Issues in Radiation
Dose-Response Analysis of Employees of the Nuclear Industry in Oak Oak
Ridge, Tennessee", Proceedings of the American Statistical
Association, Statistic In Epidemiology Section, 58-63.
Weresczczak,A., M. Ferber, T. Kirkland, A. Barnes,E. Frome
(1999)"Asymmetric Tensile and Compressive Creep Deformation of
Hot-isostatically-pressed Y2O3-Doped-Si3N4", Journal European Ceramic
Society,19:227-237.
Frome, E. L. Strader, C. H. Dupree, E.A. Stockwell,H. G.(2000),
"Relative Risk Estimation for Occupational Groups in Epidemiologic
Surveillance", Proceedings of the American Statistical Association,
Statistic In Epidemiology Section.
Ostrouchov,G., Frome, E. and Kerr, G.(2000),"Dose Estimation from
Daily and Weekly Dosimetry Data", ORNL/TM-1999/282, pp 1-30.
Farris,G.M. Newman,L.S., Frome, et al (2000), "Detection of
Beryllium Sensitivity Using a Flow Cytometric Lymphocyte Proliferation
Test: the IMMUNO-BE-LPT", Toxicology,143:125-140.
Frome, E.L., D. L. Cragle, L. G Littlefield, and S. P. Colyer,(2001)
"Results of the Analysis of The Blood Beryllium Lymphocyte Proliferation
Test Data From The Oak Ridge Y-12 Study", ORNL/TM-2001/79, pp 1-27.
Frome, E.L., D. L. Cragle, S. P. Colyer, and P. F. Wambach, (2002)
"Development and Evaluation of a Screening Test for Beryllium Sensitization",
Proceedings of the American Statistical Association, Statistic In
Epidemiology Section.
Frome,E.L. Newman, L.S., Cragle, D.L, Colyer, S.P. and P.F. Wambach
(2003)",Identification of an Abnormal Beryllium Lymphocyte Proliferation Test",
Toxicology,183:39-56.(http://www.csm.ornl.gov/~frome/toxsbp/)
Watkins, J. P., G. D. Kerr, E. L. Frome, W. G. Tankersley, and
C. M. West, (2004), Historical Evaluation of the Film Badge Dosimetry
Program at the Y-12 Facility in Oak Ridge, Tennessee, ORAU Technical
Report # 2004-0888. (http://www.orau.gov/cer/reports.htm)
Frome, E. L., and P. G. Groer, (2004), Individual Dose Adjustment
Procedure for Y-12 Dose Reconstruction, ORAUT-TIB-0013, Revision
No. 00-A, Oak Ridge Associate Universities, Oak Ridge, Tennessee
Frome, E. L. and J. Watkins, (2004), Statistical Analysis of Data with
Non-detectable Values,ORNL/TM-2004/146. (http://www.csm.ornl.gov/~frome/sand/)
Kerr, G.D., J.P.Watkins, E.L. Frome, and W. G. Tankersley,
"Historical Evaluation of the Film Badge Dosimetry Program at the Y-12
Facility in Oak Ridge, Tennessee: Part 1 - Gamma Radiation"
ORAUT-OTIB-0044 ( 2005 Under review by NIOSH)
Kerr, G.D. , E.L. Frome, W. G. Tankersley, and J. P. Watkins,
"Historical Evaluation of the Film Badge Dosimetry Program at the Y-12
Facility in Oak Ridge, Tennessee: Part 2 Neutron Radiation",
ORAUT-OTIB-0045 ( 2005 Under review by NIOSH)
E. L. Frome and P. F. Wambach,(June,2005),"Statistical Methods and
Software for the Analysis of Occupational Exposure Data With
Non-Detectable Values" ORNL/TM-2005/52 (http://www.csm.ornl.gov/esh/aoed/)
E. L. Frome and D. P. Frome,(May,2007), R package SAND "Statistical Analysis
Non-Detects" available at (http://www.csm.ornl.gov/esh/statoed/)
Last Modified a May 2007 FromeEL@ORNL.gov
(touches: 10515 )