KELLNER JD, SEMENIUK H, ELSAYED S, CHURCH D; Interscience Conference on Antimicrobial Agents and Chemotherapy (42nd : 2002 : San Diego, Calif.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2002 Sep 27-30; 42: abstract no. G-845.

Alberta Children's Hosp., Calgary, AB, Canada.

BACKGROUND: We wished to determine trends in ISP infections before introduction of conjugate pneumococcal vaccine in Canada. METHODS: Population-based surveillance of ISP infections (cultured from sterile sites) at all ages in Calgary (pop. ~900,000) from 1998 onwards. Cases identified by lab surveillance. One SP isolate/case saved for testing. Antibiotic susceptibilities with E-Test and microbroth dilution using NCCLS guidelines. Serotyping with Quellung method. Molecular typing with pulsed-field gel electrophoresis (PFGE) will be performed. RESULTS: From 1/1/1998 to 12/31/2001 there were 498 invasive cases (90% blood, 5% CSF, 5% other sterile sites, 109 from children <5 yrs). From 1998 to 2000, the average annual incidence of invasive disease (cases/100,000/year) was 69, 11, 4, 8, 45 and 66 for <2 yr, 2 - <5 yr, 5 - <16 yr, 16 - <65 yr, 65 - <85 yr and >/= 85 yr, respectively. In 2001, the incidence of ISP increased to 110 and 61 cases/100,000/yr for <2 yr and 2 - <5 yr, respectively but remained stable at 4, 8, 45 and 71 for 5 - <16 yr, 16 - <65 yr, 65 - <85 yr and Publication Types:

• Meeting Abstracts

Keywords:

• Antigens, Bacterial
• Bacteremia
• Canada
• Child
• Epidemiologic Studies
• Humans
• Incidence
• Infection
• Penicillins
• Pneumococcal Vaccines
• Pneumonia
• Pneumonia, Pneumococcal
• Polysaccharides, Bacterial
• Population Surveillance
• Serotyping
• Sjogren's Syndrome
• Streptococcus pneumoniae
• Vaccines, Conjugate
• immunology
• methods

Other ID:

• GWAIDS0028484

UI: 102268108

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