Agoramoorthy, G. and M.J. Hsu
(1999). Rehabilitation and release of chimpanzees on a natural island.
Methods hold promise for other primates as well. Journal of
Wildlife Rehabilitation 22(1): 3-7. ISSN: 1071-2232.
NAL Call Number: SF996.45.J69
Descriptors: Pan troglodytes, chimpanzees, release and relocation program, feeding behavior, nest building, aggression, abnormal behavior, stereotypic behavior.
Baker, K. (2002). Rearing
and housing history of rhesus macaques (Macaca mulatta) displaying
self-injurious and noninjurious abnormal behaviors. American
Journal of Primatology 57(Suppl. 1): 82. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 25th Annual Meeting of The American Society of Primatologists, Oklahoma City, Oklahoma, USA; June 1-4, 2002.
Descriptors: rhesus macaque, Macaca mulatta, animal behavior, age when first single housed, noninjurious abnormal behavior, rearing background, self-injurious behavior (SIB), meeting abstract.
Baker, K., M. Bloomsmith, C.
Griffis, and M. Gierhart (2003). Self injurious behavior and response
to human interaction as enrichment in rhesus macaques. American
Journal of Primatology 60 (Suppl. 1): 94-95. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Descriptors: self-injurious behavior (SIB), abnormal behavior, vocalizations, human interaction as environmental enrichment, Macaca mulatta, rhesus macaques, stress.
Bellanca, R.U. and C.M.
Crockett (2002). Factors predicting increased incidence of abnormal
behavior in male pigtailed macaques. American Journal of
Primatology 58(2): 57-69. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Abstract: To identify factors predicting abnormal behavior
in laboratory monkeys, we observed all available singly housed 4- to
11-year-old male pigtailed macaques (Macaca nemestrina), the
species/age/sex group most likely to be refer red to the Washington
National Primate Research Center's Psychological Well-Being Program for
behavioral assessment. Of the 87 subjects, 29 had been referred to the
program whereas 58 had not. Abnormal behavior was unrelated to the
subject's housing locat ion (biocontainment vs. other facility) or
invasiveness of research. Nursery-reared subjects displayed more abnormal
behavior than mother-reared subjects. Across and within rearing
categories, the proportion of the first 48 months of life spent singly hou
sed was positively related to the amount of abnormal behavior at maturity.
This effect was stronger for subjects separated from the mother for
clinical rather than experimental reasons, and least for mother-reared
subjects. Locomotor stereotypy, by far th e most frequent form of abnormal
behavior, was positively related to time in single housing but was
unrelated to rearing. These results reinforce the importance of tactile
social contact during juvenility for the prevention of abnormal behavior
in social
primates. They also suggest that self-directed abnormal behaviors and locomotor stereotypies have different etiologies.
Descriptors: Macaca nemestrina, aging, housing, animal, maternal deprivation, motor activity, risk factors, self-injurious behavior, social behavior, stereotypic behavior.
Bellanca, R.U. and C.M.
Crockett (2001). Male pigtailed macaques neonatally separated from
mothers for clinical reasons show increased abnormal behavior as
adults. American Journal of Primatology 54(Suppl. 1): 52-53.
ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 24th Annual Meeting of the American Society of Primatologists, Savannah, Georgia, USA; August 8-11, 2001.
Descriptors: animal behavior, abnormal behavior as adults,
effects of mother rearing, effects of nursery rearing, social contact,
meeting abstract, Macaca nemestrina, pigtailed
macaques.
Bellanca, R.U., K.S. Heffernan,
J.E. Grabber, and C.M. Crockett (1999). Behavioral profiles of
laboratory monkeys referred to a regional primate research center's
psychological well-being program. American Journal of
Primatology 49(1): 33. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 22nd Annual Meeting of the American Society of Primatologists, New Orleans, Louisiana, USA; August 12-16, 1999.
Descriptors: abnormal behavior of captive animals, behavioral profiles, self-injurious behavior (SIB), psychological well-being program, meeting abstract.
Bloomsmith, M., K. Baker, and M. Novak (2004). Understanding and managing self-injurious behavior in nonhuman primates. American Journal of
Primatology 62(Suppl. 1): 119. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 27th Annual Meeting of The American Society of Primatologists, Madison, Wisconsin, USA, June 8-11, 2004.
Descriptors: roundtable discussion, definition of
self-injurious behavior (SIB), physiological basis, literature review,
treatment options, current research, meeting
abstract.
Bloomsmith, M.L., S. Lambeth,
and T. Stoinski (2001). The behavioral effects of meal predictability
on chimpanzees. American Journal of Primatology 54(Suppl. 1):
96. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 24th Annual Meeting of The American Society of Primatologists, Savannah, Georgia, USA; August 8-11, 2001.
Descriptors: chimps, Pan troglodytes, feeding schedules, animal behavior, abnormal behavior, housing type, self-directed behavior, timing of animal husbandry events, meeting abstract.
Bollen, K.S. and M.a. Novak (2000). A survey of abnormal behavior in captive zoo primates. American Journal of Primatology 51(Suppl. 1):
47. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 23rd Annual Meeting of the American Society of Primatologists, Denver, Colorado, USA; June 21-24, 2000.
Descriptors: nonhuman primate behavior, abnormal behavior, effects of captive environments, zoos, meeting abstract.
Bolton, I. (2004). The management of behavioral issues in captive nonhuman primates. American Journal of Primatology 62(Suppl. 1): 43.
ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 27th Annual Meeting of The American Society of Primatologists, Madison, Wisconsin, USA, June 8-11, 2004.
Descriptors: behavioral needs, introduction to symposium, species appropriate behaviors, behavioral management, enrichment, meeting abstract.
Bourgeois, S. and L. Brent
(2003). The effect of four enrichment conditions on abnormal behavior
in seven singly caged baboons (Papio hamadryas anubis).
American Journal of Primatology 60(Suppl. 1): 80-81. ISSN:
0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 26th Annual Meeting of the American Society of Primatologists, Calgary, Alberta, Canada; July 29-August 2, 2003.
Descriptors: Papio hamadryas anubis, baboons, single
housing, comparison study, effects of environmental enrichment, positive
reinforcement training, food enrichment, non-food enrichment, social
enrichment, self-directed behavior, caging, meeting
abstract.
Bourgeois, S.R. and L. Brent
(2005). Modifying the behaviour of singly caged baboons: Evaluating the
effectiveness of four enrichment techniques. Animal Welfare
14(1): 71-81. ISSN: 0962-7286.
NAL Call Number: HV4701.A557
Descriptors: adolescent male olive hybrid baboons, Papio
hamadryas anubis, abnormal behavior, effectiveness of enrichment
techniques to reduce abnormal behavior, positive reinforcement training,
food enrichment, manipulable toys and objects, social environment,
activity levels, animal welfare implications, social enrichment as a means
of behavior modification for captive baboons.
Brent, L., D.M. Foley, and T.
Koban (2001). Abnormal behavior in baboons (Papio hamadryas anubis
sp.) during the postpartum period. American Journal of
Primatology 54(Suppl. 1): 88-89. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 24th Annual Meeting of the American Society of Primatologists, Savannah, Georgia, USA; August 8-11, 2001.
Descriptors: postpartum period, adult female baboons, social groups, animal models, stereotypic behavior, self directed behavior, meeting abstract.
Brent, L., T. Koban, and S.
Ramirez (2002). Abnormal, abusive, and stress-related behaviors in
baboon mothers. Biological Psychiatry 52(11): 1047-1056. ISSN:
0006-3223.
NAL Call Number: RC321.B55
Abstract: BACKGROUND: Psychiatric disturbances during pregnancy and the postpartum period are especially serious, given the negative effects on the mother as well as the child. Understanding the causes of such disturbances has been difficult
owing to the complexity of psychological, social, experiential,
biological, and genetic factors involved. METHODS: To determine the
potential utility of a nonhuman primate model for the study of postpartum
disorders, the pathologic and stress-related behavior of 62 female baboons
living in social groups was studied during pregnancy and after the birth
of an infant. RESULTS: The prevalence of abnormal behavior and
self-directed scratching (a measure of stress response) was higher after
birth of the infant. Subjects displayed a significantly higher frequency
per hour of these behaviors postpartum, which increased over 8 weeks.
Abusive behaviors toward the infant were common, occurring in 55% of the
subjects. Mothers with low dominance rank, who usually hav e lower levels
of social support, had higher levels of abusive behavior during the
postpartum period. CONCLUSIONS: Baboons show variation in measurable
behaviors related to stress and abnormal functioning during the pre- and
postpartum periods, indicating
that a nonhuman primate model may be useful in the study of factors affecting postpartum psychiatric disorders and infant abuse.
Descriptors: self-directed scratching, female baboons, abnormal behavior, social groups, effect of birth on abnormal behaviors, infant abuse, dominance ranking, possible animal models.
Brune, M., U. Brune Cohrs, and W.C. McGrew (2004). Psychiatric treatment for great apes? Science 306(5704): 2039. ISSN: 1095-9203.
Online: http://www.sciencemag.org/cgi/reprint/306/5704/2039b.pdf | (327 KB)
Descriptors: laboratory animal psychology, abnormal behaviors, therapeutic use of neurotransmitter agents, Pan troglodytes, chimps, animal welfare, animal behavior, letter to the editor.
Chase, W.K., L.M. Marinus, M.J.
Jorgensen, K.L. Rasmussen, S.J. Suomi, and M.A. Novak (1999). Heart
rate patterns in rhesus monkeys with self-injur ious behavior (SIB): Are
these monkeys "high reactors?" American Journal of
Primatology 49(1): 42-43. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 22nd Annual Meeting of the American Society of Primatologists, New Orleans, Louisiana, USA; August 12-16, 1999.
Descriptors: self-biting, heart rate, reactive temperament, self-injurious behavior (SIB), macaques, meeting abstract.
Crockett, C.M. (2004). Abnormal behaviour in laboratory monkeys. Folia Primatologica 75(Suppl. 1): 130-131. ISSN: 0015-5713.
NAL Call Number: QL737.P9F6
Meeting Information: Spring Meeting of the Primate Society of Great Britain, St Andrews, Scotland; April 10-11, 2003.
Descriptors: abnormal behavior, animal welfare, single housing of nonhuman primates, macaques, meeting abstract.
Crockett, C.M. and R.U.
Bellanca. (2001). Using behaviour profiles to identify correlates and
possible prevention of abnormal behaviour in laboratory monkeys. In:
The 18th Congress of the International Primatological Society: Primates
in the New Millenium. Abstracts and Programme, Adelaide, South Australia,
IPS: Adelaide, South Australia, p. 448. [CD-Rom].
Descriptors: self-injurious behavior (SIB), stereotypies,
activity levels, motor activity, self-direct behavior, macaques, baboons,
meeting abstract
Crockett, C.M. and G.M. Gough
(2002). Onset of aggressive toy biting by a laboratory baboon coincides
with cessation of self-injurious behavior. American Journal of
Primatology 57(Suppl. 1): 39. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 25th Annual Meeting of The American Society of Primatologist, Oklahoma City, Oklahoma, USA; June 1-4, 2002.
Descriptors: self-injurious behavior (SIB), Papio cynocephalus anubis, baboons, animals on a bone marrow transplant protocol, biting of toys, re-direction of tension-related aggression, meeting abstract.
Crockett, C.M., G.P. Sackett,
C. Sandman, and a. Chicz Demet (2003). Beta endorphin levels in
longtailed and pigtailed macaques vary by species, sex, and abnormal
behavior rating: A pilot study. American Journal of Primatology
60(Suppl. 1): 109-110. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 26th Annual Meeting of the American Society of Primatologists, Calgary, Alberta, Canada; July 29-August 2, 2003.
Descriptors: Macaca fascicularis, Macaca nemestrina, cynomolgus macaques, pigtailed macaques, rating abnormal behavior, behavioral reinforcement, sex differences, species differences, meeting abstract.
Davenport, M.D., S. Strand, S.
Tiefenbacher, J.S. Meyer, C. Shannon, S.J. Suomi, and M.A. Novak. (2002).
Steroid hormone levels in differentially reared juvenile rhesus monkeys. In: Society for Neuroscience Abstract Viewer and Itinerary Planner: 32nd Annual Meeting of the Society for Neuroscience, Orlando, Florida, USA, Society for
Neuroscience: Washington, DC, p. Abstract No. 207.6.
Online: http://sfn.scholarone.com
Descriptors: comparison study of rearing conditions, cortisol
levels, juvenile rhesus macaques, Macaca mulatta, separation
stress, sex differences, aggression, stereotypical behavior, behavioral
development
Dorey, N., J. Rosales Ruiz, R.
Smith, and B. Lovelace. (2004). A functional analysis of self-injurious
behavior in an olive baboon (Papio hamadryas anubis). In:
Animal Behavior Managment Alliance (ABMA) Conference Proceedings 2004,
Baltimore, Maryland, USA, p. 81. [CD-Rom].
Descriptors: problematic behavior, zoo animal management, reinforcement, self-injurious behavior (SIB), meeting abstract
Eaton, G.G., J.M. Worlein, S.T. Kelley, S. Vijayaraghavan, D.L. Hess, M.K. Axthelm, and C.L. Bethea (1999). Self injurious behavior is decreased by
cyproterone acetate in adult male rhesus (Macaca mulatta). Hormones and Behavior 35(2): 195-203. ISSN: 0018-506X.
NAL Call Number: QP801.H7H64
Abstract: Self-injurious behavior (SIB) presents a serious problem in laboratory macaques that cannot be socially housed for scientific reasons and among institutionalized children and adults where it is often associated with different forms
of brain dysfunction. We have experienced limited success in reducing SIB
in macaques by enhancing their environment with enrichment devices.
Psychotropic drugs also help, but problems are associated with their use.
Because sexual and aggressive behavioral problems in men have been treated
with progestational drugs, we tested the efficacy of cyproterone acetate
(CA, 5-10 mg/kg/week) on reducing SIB in 8 singly housed, adult male
rhesus macaques. The main findings were: (1) SIB and other atypical
behaviors were significantly reduced during CA treatment; (2) serum
testosterone was significantly reduced during CA treatment; (3) cerebral
spinal fluid (CSF) levels of 5HIAA and HVA, metabolites of serotonin and
dopamine, respectively, declined significantly during CA treatment; (4)
the duration of SIB positively correlated with levels of 5HIAA in CSF; but
(5) sperm counts were not reduced during treatment. Thus, CA was a
partially effective treatment (3 months) for adult male macaques whose
behavioral problems
include SIB. In summary, CA reduced SIB, overall aggression, serum testosterone, CSF 5HIAA, and CSF HVA. We hypothesized that the progestin activity of CA represses the hypothalamic gonadal axis and decreases testosterone, which in turn decreases SIB. In
addition, we speculate that the decrease in 5HIAA and HVA in CSF may have
been caused by progestins decreasing the activity of MAO. Therefore, the
reduction of SIB may also be related to an increase in the availability of
active monoamines in the CNS.
Descriptors: self-injurious behavior (SIB), environmental
enrichment, use of psychotropic drugs, progestational drugs, cyproterone
acetate (CA), adult male rhesus macaques, Macaca mulatta,
aggression, central nervous system, drug effects on behavior, social
isolation, yawning, testosterone levels.
Espinosa Aviles, D., G.
Elizondo, M. Morales Martinez, F. Rodriguez Herrejon, and P. Varela
(2004). Treatment of acute self-aggressive behaviour in a captive
gorilla (Gorilla gorilla gorilla). Veterinary Record
154(13): 401-402. ISSN: 0042-4900.
Descriptors: captive gorillas, aggression, mental disorders,
anxiety, self-directed behavior, self-injurious behavior
(SIB).
Honess, P., J. Gimpel, S.
Wolfensohn, and G. Mason (2005). Alopecia scoring: The quantitative
assessment of hair loss in captive macaques. Alternatives to
Laboratory Animals 33(3): 193-206. ISSN: 0261-1929.
NAL Call Number: Z7994.L3A5
Abstract: Many captive animals show forms of pelage loss that are absent in wild or free-living conspecifics, which result from grooming or plucking behaviours directed at themselves or at other individuals. For instance, dorsal hair loss in
primates such as rhesus macaques (Macaca mulatta) in research
facilities, results from excessive hair-pulling or over-grooming by
cage-mates. This behaviour appears to be associated with stress, and is
controllable to some extent with environmental enrichment. Quantifying
alopecia in primates (as in many species) is therefore potentially useful
for welfare assessment. A simple system for scoring alopecia was developed
and its reliability was tested. Study 1 showed high interobserver
reliability between two independent scorers in assessing the state of
monkeys coats from photographs. Study 2 showed that there were no
significant differences between the scores derived from photographs and
from direct observations. Thus, where hair loss due to hair pulling exists
in captive primates, this scoring system provides an easy, rapid, and
validated quantitative method, for use in assessing the success of
attempts to reduce it via improved husbandry. In the future, such scoring
systems might also prove useful for quantifying barbering in laboratory
rodents.
Descriptors: rhesus macaques, Macaca mulatta, grooming or plucking behaviors, primates in captive environments, quantifying hair loss (alopecia), welfare assessment using hair loss measurements, development of alopecia scoring system.
Honess, P.E. and C.M. Marin (2006). Enrichment and aggression in primates: Relationship between the brain and aggression. Neuroscience &
Biobehavioral Reviews 30(3): 413-436.
Online: http://www.sciencedirect.com/science/article/B6T0J-4GSBGTS-2/2/a8223b3e4dc4ccec415a2e70d2257335
Descriptors: abnormal behavior, self-injurious behavior
(SIB), psychological well-being, literature review, housing of nonhuman
primates, effects of housing, feeding, and environmental enrichment,
aggression, animal welfare.
Hook, M.A., S.P. Lambeth, J.E.
Perlman, R. Stavisky, M.A. Bloomsmith, and S.J. Schapiro (2002).
Inter-group variation in abnormal behaviour in chimpanzees (Pan
troglodytes) and rhesus macaques (Macaca mulatta).
Applied Animal Behaviour Science 76(2): 165-176. ISSN:
0168-1591.
NAL Call Number: QL750.A6
Descriptors: social transmission of behavior, culture,
categorization of abnormal behaviors, group membership, housing
environment, gender differences, social learning
processes.
Hosey, G. and L. Skyner.
(2004). Self-injurious behaviour in primates: A survey of British and
Irish zoos. In: Proceedings of the Sixth Annual Symposium on Zoo
Research, Edinburgh Zoo, Edinburgh, UK, The Federation of Zoological
Gardens of Great Britain and Ireland: London, UK, p. 85.
Online: http://www.biaza.org.uk/resources/library/images/ARSP6.pdf
Descriptors: self-injurious behavior (SIB),
questionnaire-based survey, low frequency of SIB in zoos, self-biting,
hair pulling, effects of age and sex, meeting
abstract
Hugo, C., J. Seier, C.
Mdhluli, W. Daniels, B.H. Harvey, D. Du Toit, S. Wolfe Coote, D. Nel, and
D.J. Stein (2003). Fluoxetine decreases stereotypic behavior in
primates. Progress in Neuro-Psychopharmacology and Biological
Psychiatry 27(4): 639-643. ISSN: 0278-5846.
Abstract: BACKGROUND: Primates reared in captivity may display stereotypic behaviors. These behaviors are arguably reminiscent of human obsessive-compulsive or posttraumatic symptoms, which respond to selective serotonin reuptake inhibitors
(SSRIs). Captive primates with marked stereotypic behaviors were entered into a randomized controlled study of the SSRI, fluoxetine. METHODS: A sample of 10 vervet monkeys with behaviors such as marked saluting, somersaulting, weaving, or head tossing was
selected. Subjects were randomized to receive fluoxetine 1 mg/kg for 6 weeks (n=5) or no treatment (n=5). A rater blind to the medication status of subjects noted the frequency of the stereotypic behaviors. RESULTS: Repeated-measures analysis of variance
(RM-ANOVA) demonstrated a significant GroupxTime difference with
significantly fewer stereotypic symptoms in the fluoxetine group by
endpoint. At this time, three of the five fluoxetine-treated subjects (but
none of the no-treatment subjects) were responders on the Clinical Global
Impressions (CGI) change item (CGI < or =2). CONCLUSIONS: Stereotypic
behaviors in captive vervets gradually and partially decrease in response
to administration of an SSRI, paralleling research on human anxiety
symptoms. Further research on animal stereotypies may be useful in
providing appropriate veterinary care, and in exploring the underlying
neurobiology of certain psychiatric disorders.
Descriptors: stereotypic behavior, serotonin re-uptake
inhibitors (SSRIs), fluoxetine, African green monkeys, vervets,
Cercopithecus aethiops, treatment of psychiatric
disorders.
Kaufman, B.M., A.L. Pouliot, S.
Tiefenbacher, and M.A. Novak (2002). Effects of cage size on abnormal
behavior in rhesus monkeys. American Journal of Primatology
57(Suppl. 1): 39-40. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 25th Annual Meeting of The American Society of Primatologists, Oklahoma City, Oklahoma, USA; June 1-4, 2002.
Descriptors: abnormal behavior, rhesus macaques, Macaca
mulatta, cage size, baboons, hair pulling, cage shaking, individual
housing, open pens, self-biting, meeting abstract.
Kaufman, B.M., A.L. Pouliot, S.
Tiefenbacher, and M.A. Novak (2004). Short and long-term effects of a
substantial change in cage size on individually housed, adult male rhesus
monkeys (Macaca mulatta). Applied Animal Behaviour
Science 88(3-4): 319-330. ISSN: 0168-1591.
NAL Call Number: QL750.A6
Descriptors: abnormal behavior, effects of cage size,
general activity reduction, rhesus macaques, Macaca mulatta,
tension related behavior, individual housing.
Kessel, A. and L. Brent (2001).
The rehabilitation of captive baboons. Journal of Medical
Primatology 30(2): 71-80. ISSN: 0047-2565.
NAL Call Number: QL737.P9J66
Abstract: Eleven baboons who had been singly housed indoors
for an average of 5 years were moved to outdoor social groups in an
attempt to provide a more species-typical environment and reduce high
levels of abnormal behavior. Nine of the baboons were observed while in
single housing and, over a 6-month period, while housed outdoors socially
to document long-term changes in behavior. Abnormal behavior decreased
significantly from an average of 14% of the observation time in the single
cages
to 3% in the sixth month of social housing. Cage manipulation and
self-directed behaviors also significantly decreased, while social
behavior, enrichment-directed behavior, and locomotion increased in social
housing. Baboons that had been in long-term indoor single housing were
able to reproduce and form stable social groups without injury. This study
provides evidence that even behaviorally disturbed nonhuman primates can
be successfully rehabilitated to live in social groups.
Descriptors: captive baboons, species-typical behaviors,
abnormal behavior, baboons, single housing to outdoor social housing,
animal behavior, cage manipulation, behavioral
rehabilitation.
Lutz, C., L. Marinus, W. Chase,
J. Meyer, and M. Novak (2001). Self-injurious behavior in male rhesus
macaques: Association with aggression and stress. American Journal
of Primatology 54(Suppl. 1): 76-77. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 24th Annual Meeting of the American Society of Primatologists, Savannah, Georgia, USA; August 8-11, 2001.
Descriptors: stress, self-injurious behavior (SIB), abnormal behavior, aggression, male macaques, Macaca mulatta, meeting abstract.
Lutz, C., L. Marinus, W. Chase, J. Meyer, and M. Novak (2003). Self-injurious behavior in male rhesus macaques does not reflect externally directed
aggression. Physiology and Behavior 78(1): 33-39. ISSN: 0031-9384.
NAL Call Number: QP1.P4
Abstract: Self-injurious behaviors (SIB), such as
self-biting and self-wounding, have been observed in a small percentage of
captive nonhuman primates. Because rhesus monkeys that exhibit SIB also
tend to be more aggressive, it was hypothesized that SIB is related to
externally directed aggression and is associated with contexts in which
physical contact between participants is prevented. The purpose of this
study was to test the hypothesized relationship between SIB and outward
aggression.
Subjects were first presented with videotapes of conspecifics, scenery and
a blank screen, and their behavior was recorded. Levels of salivary
cortisol, an indicator of stress, were also measured before and after
presentation of the videos. Although aggression increased when subjects
viewed tapes containing conspecifics, neither cortisol levels nor
self-biting behavior varied as a function of tape content. The subjects
were then placed in two additional test situations: an empty room and the
same room containing an unfamiliar conspecific. Aggression was
significantly higher in the stranger condition compared to the empty room
condition. The two situations yielded parallel increases in cortisol,
suggesting that being alone was just as stressful as being paired with an
unfamiliar conspecific. Self-biting rates were also similar in these two
conditions. Thus, contrary to our prediction, increases in aggression did
not correlate with increases in SIB. These results suggest that under
similarly stressful conditions, SIB and externally directed aggression are
unrelated.
Descriptors: captive nonhuman primates, social behavior,
salivary cortisol levels, indicators of stress, videotapes of
conspecifics, relationship between self-injurious behavior (SIB) and
aggression, rhesus macaques.
Lutz, C., S. Tiefenbacher, J.
Meyer, and M. Novak (2004). Extinction deficits in male rhesus macaques
with a history of self-injurious behavior. American Journal of
Primatology 63(2): 41-48. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Abstract: Self-injurious behavior (SIB) occurs in both human
and nonhuman primate populations. Despite the potential for harm, SIB may
persist in part because of an inability to inhibit behavior that results
in wounding. A lever-pressing task was used to test the prediction that
monkeys with SIB would show greater persistence in lever-pressing on
extinction trials than monkeys without the disorder. The subjects were 15
individually-housed adult male rhesus macaques, 10 of which (the SIB
group) had a veterinary record of self-inflicted wounding. All of the
monkeys were trained to lever-press for food rewards to a criterion of 400
total responses. The test procedures consisted of five daily 30-min
sessions divided into six 5-min intervals. On day 1, the subjects received
continuous reinforcement. On days 2-4, testing consisted of alternating
reinforced/unreinforced 5-min intervals, beginning with reinforcement.
Reinforced intervals were cued with a buzzer. On day 5, the subjects
received no reinforcement. The number of lever-presses and behavioral
responses were recorded during each session. Saliva samples were collected
for cortisol measurement before and after test sessions on days 1, 2, and
5. As predicted, monkeys with SIB lever-pressed more than controls during
extinction intervals on days 2-4. There was no difference on day 1 or day
5. The frequency of scratching, yawning, and abnormal behavior increased
when reinforcement was intermittent (days 2-4) or absent (day 5). Cortisol
levels were highest with continuous reinforcement (day 1), and may reflect
differential levels of food intake rather than stress. The presence of
extinction deficits suggests that SIB may persist in some monkeys because
they lack the ability to regulate the intensity of their biting
behavior.
Descriptors: self-injurious behavior (SIB), male macaques,
lever-press task trials, levels of reinforcement, frequency of abnormal
behavior, cortisol, ability to regulate behavior, five day
trial.
Lutz, C., A. Well, and M. Novak
(2003). Stereotypic and self-injurious behavior in rhesus macaques: A
survey and retrospective analysis of environm ent and early
experience. American Journal of Primatology 60(1): 1-15. ISSN:
0275-2565.
NAL Call Number: QL737.P9A5
Abstract: Abnormal behavior in captive rhesus monkeys can
range from active whole-body and self-directed stereotypies to
self-injurious behavior (SIB). Although abnormal behaviors are common in
singly-housed rhesus monkeys, the type and frequency of these behaviors
are highly variable across individual animals, and the factors influencing
them are equally varied. The purpose of this investigation was to survey
abnormal behavior in a large population of rhesus macaques, to
characterize the relationship between stereotypies and self-injury, and to
identify potential risk factors for these aberrant behaviors. Behavioral
assessments of 362 individually housed rhesus monkeys were collected at
the New England Regional Primate Research Center (NERPRC) and combined
with colony records. Of the 362 animals surveyed, 321 exhibited at least
one abnormal behavior (mean: 2.3, range: 1-8). The most common behavior
was pacing. Sex differences were apparent, with males showing more
abnormal behavior than females. SIB was also associated with stereotypies.
Animals with a veterinary record of self-injury exhibited a greater number
of self-directed stereotypies than those that did not self-injure. Housing
and protocol conditions, such as individual housing at an early age,
longer time housed individually, greater number of blood draws, and
nursery rearing, were shown to be risk factors for abnormal behavior.
Thus, many factors may influence the development and maintenance of
abnormal behavior in captive primates. Some of these factors are intrinsic
to the individual (e.g., sex effects), whereas others are related to
colony management practices, rearing conditions, and research
protocols.
Descriptors: abnormal behavior, relationship between stereotypies and self-injury, risk factors, behavioral assessments, captive primates, sex differences, housing conditions, rearing conditions, research protocols, colony management, rhesus
macaques.
Lutz, C.K., W.K. Chase, and M.A. Novak (2000). Abnormal behavior in singly-housed Macaca mulatta: prevalence and potential risk factors.
American Journal of Primatology 51(Suppl. 1): 71. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 23rd Annual Meeting of the American Society of Primatologists, Denver, Colorado, USA; June 21-24, 2000.
Descriptors: abnormal behavior, risk factors, age effects,
gender effects, colony management, rearing condition, housing conditions,
rhesus macaques, Macaca mulatta, meeting
abstract.
Macy, J.D. Jr., T.A. Beattie,
S.E. Morganstern, and A.F.T. Arnsten (2000). Use of guanfacine to
control self-injurious behavior in two rhesus macaques (Macaca
mulatta) and one baboon (Papio anubis). Comparative
Medicine 50(4): 419-425. ISSN: 1532-0820.
NAL Call Number: SF77.C65
Abstract: Background and purpose: Self-injurious behavior
(SIB) affects 0.8 to 10% of individually housed non-human primates, and is
a substantial threat to their health and well being. The potential for SIB
to involve multiple neurotransmitters and the complex variations in
response to external stressors complicate case management. Modulation of
the adrenergic system by use of guanfacine, an alpha2A-adrenergic receptor
agonist, was assessed as a novel therapeutic strategy for SIB. Methods:
The efficacy of guanfacine against SIB was evaluated in 11 self-biting episodes among two rhesus macaques (Macaca mulatta) and one baboon (Papio cynocephalus anubis). Affected animals were given guanfacine IM or PO at 0.5 mg/kg of body weight twice daily
(rhesus) or 0.3 mg/kg (baboon) for 5 to 10 days, followed by gradual
reduction of the dose to 0.25 mg/kg (rhesus) or 0.15 mg/kg (baboon) once
daily over an average of 33 days. Results: The 0.5 mg/kg twice daily
regimen of guanfacine halted all self-biting, whereas reducing the dose to
0.25 mg/kg given twice daily or 0.5 mg/kg given once daily resulted in
reversion to self-biting in four of the 11 episodes. Recurrence was
controlled by returning to twice daily 0.5 mg/kg dosing for one aggressive
episode, and resolved in the three milder episodes without dose or
frequency being increased. Self-biting after discontinuation of therapy
recurred six times over five years in case 1, three times over 1.5 years
in case 2, and three times over one year in case 3. Clinical assessment
suggested that guanfacine therapy decreased agitation without overt side
effects associated with alpha2-agonists, such as profound sedation.
Conclusion: The mechanism for. guanfacine inhibition of self-biting is
unclear, but could result from strengthening of prefrontal cortex
inhibitory functions. Guanfacine therapy provides an effective
psychological stabilizing tool that alleviates self-biting, and provides
time to assess and address external stressors and triggers.
Descriptors: Macaca mulatta, Papio anubis, laboratory animals, abnormal behavior, guanfacine, alpha adrenergic receptor agonists, drug therapy, animal welfare, neuroleptics, case reports.
Mallapur, A. and B.C. Choudhury (2003). Behavioral abnormalities in captive nonhuman primates. Journal of Applied Animal Welfare Science
6(4): 275-284. ISSN: 1088-8705.
NAL Call Number: HV4701.J68
Abstract: In this study, we dealt with 11 species of
nonhuman primates across 10 zoos in India. We recorded behavior as
instantaneous scans between 9 a.m. and 5 p.m. In the study, we segregated
behaviors for analyses into abnormal, undesirable, active, and resting.
The 4 types of abnormal behavior exhibited included floating limb,
self-biting, self-clasping, and stereotypic pacing. In the study, we
recorded 2 types of undesirable behavior: autoerotic stimulation and
begging. Langurs and group-housed macaques did not exhibit undesirable
behaviors. A male lion-tailed macaque and a male gibbon exhibited begging
behavior. autoerotic stimulation and self-biting occurred rarely. Males
exhibited higher levels of undesirable behavior than did females. Animals
confiscated from touring zoos, circuses, and animal traders exhibited
higher levels of abnormal behaviors than did animals reared in larger,
recognized zoos. The stump-tailed macaque was the only species to exhibit
floating limb, autoerotic stimulation, self-biting, and self-clasping. Our
results show that rearing experience and group composition influence the
proportions of abnormal behavior exhibited by nonhuman primates in
captivity. The history of early social and environmental deprivation
in these species of captive nonhuman primates probably is critical in the development of behavioral pathologies. Establishing this will require further research.
Descriptors: Semnipithecus entellus,
Trachypithecus pileatus, Trachypithecus geei,
Trachypithecus johnii, Trachypithecus phayrei, Macaca
silenus, Macaca nemestrina, Macaca arctoides, Macaca
assamensis, Macaca radiata, Hylobates hoolook, housing,
primate psychology, self-injurious behavior (SIB), stereotypic movement
disorder, zoo animals, India.
Marinus, L.M., W.K. Chase, K.L.
Rasmussen, M.J. Jorgensen, and M.A. Novak (1999). Reaction of rhesus
monkeys with self-injurious behavior to heart
rate testing: is biting a coping strategy? American Journal of Primatology 49(1): 79. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 22nd Annual Meeting of the American Society of Primatologists, New Orleans, Louisiana, USA; August 12-16, 1999.
Descriptors: self-biting, coping strategy, heart rate,
macaques, locomotor activity, tension reduction, meeting
abstract.
Martin, J. (2002). Early
life experiences: Activity levels and abnormal behaviours in resocialised
chimpanzees. Animal Welfare 11(4): 419-436. ISSN:
0962-7286.
NAL Call Number: HV4701.A557
Descriptors: chimpanzees, Pan troglodytes, rearing
histories, social deprivation, developmental period, activity levels,
abnormal behavior, zoos, enriched social
environment.
Meyer, J.S., S. Tiefenbacher,
C.K. Lutz, and M.A. Novak (2002). Physiological correlates of
self-injurious behavior in socially reared adult male rhesus monkeys.
Neurotoxicology and Teratology 24(3): 420. ISSN: 0892-0362.
Meeting Information: 26th Annual Meeting of the Neurobehavioral Teratology Society in conjunction with the Forty-Second Annual Meeting of the Teratology Society, Scottsdale, Arizona, USA; June 22-27, 2002.
Descriptors: adult male rhesus macaques, Macaca
mulatta, animal behavior, physiology, self-injurious behavior, meeting
abstract.
Nash, L.T., J. Fritz, P.A.
Alford, and L. Brent (1999). Variables influencing the origins of
diverse abnormal behaviors in a large sample of captive chimpanzees
(Pan troglodytes). American Journal of Primatology
48(1): 15-29. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Abstract: The developmental origin of abnormal behaviors is
generally associated with early rearing environments that lack sufficient
physical and sensory stimulation. However, other factors should also be
considered. A large sample of captive chimpanzees (128 males and 140
females) was surveyed for the presence or absence of 18 abnormal
behaviors. Origin variables included the subject's source (zoo, pet,
performer, or laboratory), rearing (mother- or hand-reared), and sex.
Animals were assessed while held at the Primate Foundation of Arizona,
University of Texas M. D. Anderson Cancer Center, or White Sands Research
Center. There was a confound among origin variables; more hand-reared
animals than expected were from laboratories. Logistic regression tested
the relationship of rearing and source, with sex as a secondary predictor
variable, to each of the abnormal behaviors. There was no clear
association between any abnormal behavior and source. However, for
coprophagy, relative to animals from the laboratory, zoo animals tended to
show a higher prevalence, while performers tended to show a lower
prevalence (when rearing and sex were controlled). Rocking and
self-sucking were significantly more likely in hand-reared animals.
Coprophagy and depilation of self were significantly more likely in
mother-reared animals. When rearing and source were statistically
controlled, the only significant sex difference was a higher prevalence of
coprophagy in females and a higher prevalence of rocking in males. In a
second, smaller sample of 25 males and 33 females from Southwest
Foundation for Biomedical Research, no significant sex association was
found for coprophagy, urophagy, rocking, or self-depilation. In this
second sample, coprophagy was also significantly more likely in
mother-reared than hand-reared subjects. The association of some abnormal
behaviors with mother-rearing suggests that some form of social learning
may be involved in the origin of some of these behavior patterns. This
indicates that
some abnormal behaviors may not be always be indicative of reduced psychological well-being in captive chimpanzees.
Descriptors: rearing conditions, abnormal behavior, type of captive setting, coprophagy, rocking, psychological well-being, rearing effects on males and females, chimps, Pan troglodytes.
Novak, M.A. (2001). Primate psychopathology: New insights on etiology and physiology. American Journal of Primatology 54(Suppl. 1): 111.
ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 24th Annual Meeting of the American Society of Primatologists, Savannah, Georgia, USA; August 8-11, 2001.
Descriptors: aggression, behavioral disorder, self-injurious
behavior (SIB), risk factors, analgesia, arousal, coping strategy, heart
rate, meeting abstract.
Novak, M.A. (2003).
Self-injurious behavior in rhesus monkeys: New insights into its
etiology, physiology, and treatment. American Journal of
Primatology 59(1): 3-19. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Abstract: Self-injurious behavior (SIB) is a significant human health problem frequently associated with profound intellectual disabilities, genetic diseases, and psychiatric conditions. However, it also occurs in subclinical populations and
appears to be on the rise in adolescents and young adults. SIB is also
seen in a small percentage of nonhuman primates that injure themselves
through biting. We have begun to characterize SIB in rhesus monkeys to
identify some of the risk factors associated with this disorder, and to
determine the parallels with the human condition. In our study population,
14% of individually housed monkeys (the vast majority of which are males)
have a veterinary record for self-inflicted wounding. Wounding is rare,
but
self-directed biting is common. SIB can be elicited during aggressive
altercations and may be associated with husbandry events. Some monkeys
appear to be more vulnerable to acquiring SIB. This increased
vulnerability is associated with certain social experiences in the first 2
years of life and with exposure to a larger number of moderately stressful
events as compared to controls. Monkeys with SIB also have a dysregulation
of the hypothalamic-pituitary-adrenal (HPA) axis, indicated by a blunted
cortisol
response to mild stressors. Our findings suggest that SIB may be a coping
strategy to reduce arousal. Biting appears to rapidly lower an escalating
heart rate. The potentially reinforcing effects of SIB may account for the
failure of some treatment regimens. These findings are compared to studies
of SIB in humans, and concordances are identified.
Descriptors: self-injurious behavior (SIB), nonhuman
primates, risk factors, aggression, effects of husbandry procedures,
social experiences, coping strategy, lowering heart rate by
biting.
Palit, G., A. Kalsotra, R.
Kumar, C. Nath, and M.P. Dubey (2001). Behavioural and anti-psychotic
effects of Ca2+ channel blockers in rhesus monkey. European Journal
of Pharmacology 412(2): 139-144. ISSN: 0014-2999.
Abstract: The potential utility of Ca2+ channel blockers in
the treatment of various psychiatric disorders has been recently
suggested. In the present study, the behavioural and anti-psychotic
effects of Ca2+ channel blockers were investigated in unrestrained rhesus
monkeys (Macaca mulatta) living together in a colony. The different
behaviours categorised as social, solitary and abnormal were video
recorded and analysed. Graded doses of verapamil (5-20 mg/kg, i.m.) and
nimodipine (7.5-30 mg/kg, p.o.) produced a mild decrease in social and
solitary behaviour without producing any cataleptic posture in the tested
monkeys. In order to determine potential antipsychotic effects, Ca2+
channel blockers were studied in the model of amphetamine-induced
psychosis. Amphetamine, at the dose of 2 mg/kg, i.m., induced suppression
of approach, contact, grooming, and feeding, whilst vigilance (checking),
stereotyped behaviour and oral hyperkinesia were increased in the monkeys.
Pre-treatment with verapamil (10 and 20 mg/kg, i.m.) significantly
suppressed amphetamine-induced hypervigilance, stereotypy, oral
hyperkinesia and tachypnoea but was unable to reverse other
amphetamine-induced behavioural effects. Nimodipine showed insignificant
anti-psychotic effects at both 15 and 30 mg/kg doses. These results
suggest that verapamil has a definite antipsychotic effect without any
extrapyramidal side effects and thus may be of clinical significance in
the treatment of psychosis.
Descriptors: anti-psychotic effects of Ca2+ channel
blockers, group housing, rhesus macaques, Macaca mulatta, social
behavior, abnormal behavior, behavior classification, verapamil,
nimodipine.
Raper, J.R., M.A. Bloomsmith,
A. Stone, and L. Mayo (2002). Use of positive reinforcement training to
decrease stereotypic behaviors in a pair of orangutans (Pongo
pygmaeus). American Journal of Primatology 57(Suppl. 1):
70-71. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 25th Annual Meeting of The American Society of Primatologists, Oklahoma City, Oklahoma, USA; June 1-4, 2002.
Descriptors: zoo animal behavior, positive reinforcement
training, well-being, reproductive behavior, social behavior, stereotypic
behavior, primates in zoos, meeting abstract.
Reader, S.M. and K.N. Laland
(2001). Primate innovation: Sex, age and social rank differences.
International Journal of Primatology 22(5): 787-805. ISSN:
0164-0291.
NAL Call Number: QL737.P9I54
Descriptors: sex differences, behavioral variation, social
hierarchy, abnormal behavior, innovative behavior, effects of
age.
Reinhardt, V. (2002).
Artificial weaning of Old World monkeys: Benefits and costs.
Journal of Applied Animal Welfare Science 5(2): 151-156. ISSN:
1088-8705.
NAL Call Number: HV4701.J68
Descriptors: Macaca mulatta, Papio sp.,
primates as laboratory animals, early weaning, abnormal behavior, stress,
reproductive efficiency, animal welfare, literature reviews, animal use
refinement and reduction.
Reinhardt, V. (1999).
Pair-housing overcomes self-biting behavior in macaques.
Laboratory Primate Newsletter 38(1): 4-5. ISSN: 0023-6861.
Online: http://www.brown.edu/Research/Primate/lpn38-1.html
NAL Call Number: SF407.P7 L3
Descriptors: abnormal behavior, self-biting, compatible
social housing, effect of prolonged single-housing, reduction in
self-injurious behavior (SIB), macaques.
Reinhardt, V. and M. Rossell
(2001). Self-biting in caged macaques: Cause, effect, and
treatment. Journal of Applied Animal Welfare Science 4(4):
285-294. ISSN: 1088-8705.
NAL Call Number: HV4701.J68
Descriptors: Macaca mulatta, Macaca fascicularis, primates as laboratory animals, vices, animal housing, group size, animal welfare, literature reviews, pair housing.
Sanchez, M.M., C.O. Ladd, and P.M. Plotsky (2001). Early adverse experience as a developmental risk factor for later psychopathology: Evidence from
rodent and primate models. Development and Psychopathology 13(3): 419-449. ISSN: 0954-5794.
Abstract: Increasing evidence supports the view that the
interaction of perinatal exposure to adversity with individual genetic
liabilities may increase an individual's vulnerability to the expression
of psycho- and physiopathology throughout life. The early environment
appears to program some aspects of neurobiological development and, in
turn, behavioral, emotional, cognitive, and physiological development.
Several rodent and primate models of early adverse experience have been
analyzed in
this review, including those that "model" maternal separation
or loss, abuse or neglect, and social deprivation. Accumulating evidence
shows that these early traumatic experiences are associated with long-term
alterations in coping style, emotional and behavioral regulation.
neuroendocrine responsiveness to stress, social "fitness,' cognitive
function, brain morphology, neurochemistry, and expression levels of
central nervous system genes that have been related to anxiety and mood
disorders. Studies are underway to identify important aspects of adverse
early experience, such as (a) the existence of "sensitive
periods" during development associated with alterations in particular
output systems. (b) the presence of "windows of
opportunity" during which targeted interventions (e.g., nurturant
parenting or supportive-enriching environment) may prevent or reverse
dysfunction, (c) the identity of gene polymorphisms contributing to the
individual's variability in vulnerability, and (d) a means to translate
the timing of these developmental "sensitive periods" across
species.
Descriptors: hypothalamo-hypophyseal system
physiopathology, pituitary-adrenal system, stress psychology, age
factors, anxiety, corticosterone metabolism, Macaca mulatta, mental
disorders, risk factors, rats, animal models.
Skyner, L.J., J.R. Amory, and
G. Hosey (2004). The effect of visitors on the self-injurious behaviour
of a male pileated gibbon (Hylobates pileatus). Zoologische
Garten 74(1): 38-41. ISSN: 0044-5169.
NAL Call Number: 410 Z724
Descriptors: zoo animal behavior, self biting, self-injurious behavior (SIB), zoo visitor impact, chewing behavior, male gibbon, Hylobates pileatus.
Tarou, L., M. Jones, and T. Maple (2001). Seasonal and daily variation in stereotypic behavior in two species of zoo-housed lemur. American
Journal of Primatology 54(Suppl. 1): 94. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 24th Annual Meeting of the American Society of Primatologists, Savannah, Georgia, USA; August 8-11, 2001.
Descriptors: zoo animal behavior, repetitive behavior,
stereotypic behavior, lemurs, meeting abstract.
Tarou, L.R., M.A. Bloomsmith,
and T.L. Maple (2005). Survey of stereotypic behavior in
prosimians. American Journal of Primatology 65(2): 181-196.
ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Abstract: Captive animals have been observed to perform a variety of stereotypic behaviors. However, little is known about stereotypic behavior in prosimians. We sent surveys to 96 AZA-accredited institutions to examine stereotypic behavior
in these primates. Forty-eight surveys were returned, providing
information on 440 individuals of 10 genera. According to the responses,
13.2% of the prosimians surveyed exhibited some form of stereotypic
behavior. Pacing was the most common behavior. A logistic regression was
used to examine intrinsic characteristics that might influence the
performance of stereotypic behavior. The genus of the prosimian was a
significant predictor of stereotypic behavior. Individuals of the genus
Varecia and Microcebus were more likely to engage in
stereotypic behavior than members of the other genera. Rearing history,
age, and sex were not significant predictors of stereotypic behavior. To
examine the influence of extrinsic variables on stereotypic behavior, we
transformed the data into the percentage of individuals within the
enclosure that were reported to exhibit stereotypic behavior, and analyzed
them at the enclosure level using a general linear model (GLM) analysis of
variance (ANOVA). The only environmental variable that significantly
predicted stereotypic behavior was the frequency with which enrichment was
provided. Frequent enrichment was provided to those exhibits with a higher
percentage of prosimians that engaged in stereotypic behavior. The
results of this survey suggest that stereotypic behavior in prosimians may
be associated with intrinsic factors (i.e., individual or genus
differences) in addition to extrinsic factors related to housing. This
knowledge may be helpful in identifying the causes of and effective
treatments for stereotypic behavior in prosimians.
Descriptors: abnormal behavior, pacing, stereotypies, Varecia sp., Microcebus sp., intrinsic factors, zoo animals, genus differences, housing and individual effects on stereotypic behavior, captive prosimians.
Taylor, D.K., T. Bass, G.S.
Flory, and F.C. Hankenson (2005). Use of low-dose chlorpromazine in
conjunction with environmental enrichment to eliminate self-injurious
behavior in a rhesus macaque (Macaca mulatta). Comparative
Medicine 55(3): 282-288. ISSN: 1532-0820.
NAL Call Number: SF77.C65
Abstract: A 7-year-old, captive-bred, female rhesus macaque
was placed in a quarantine facility upon arrival at our institution. At
release from quarantine, she was observed pawing at and chewing on her
left cheek. Physical examination revealed ulcerative lesions on the buccal
surface of the left cheek. Initial differential diagnoses included
Cercopithecine herpesvirus 1 (B virus)-induced lesions and bacterial
infection. Dental abnormalities and cheek pouch foreign body were ruled
out during
the physical exam. Treatment with 30 mg/kg cefazolin intramuscularly
every 12 h was initiated. Twelve days later, the animal presented with a 2
x 2-cm, full-thickness erosion involving the opposite (right) cheek.
Treatment with buprenorphine (0.1 mg/kg intramuscularly every 24 h) was
initiated. Cultures for B virus were negative, and only nonpathogenic
bacteria were isolated from swabs of the lesions. Hematology and serum
chemistry profiles were normal. A wedge biopsy of the lesion revealed no
definitive
etiology. Further observation revealed that the lesions likely resulted from self-injurious behavior (SIB). Treatment with low-dose chlorpromazine (1 mg/kg intramuscularly once daily for 25 days, and then 0.5 mg/kg intramuscularly once daily for 25 days)
was initiated. Bodyweight and condition were maintained during therapy,
and serial hematology and serum chemistry profiles were normal. The animal
was moved into a different room, and a toy "necklace" was
created. The SIB was eliminated, and lesions healed within 35 days.
Presently, 20 months after presentation, this animal remains in good
health.
Descriptors: self-injurious behavior (SIB), abnormal
behavior treatment, primates as laboratory animals, environmental
enrichment, chlorpromazine, location change, adult female rhesus macaque,
Macaca mulatta, pawing and chewing at cheek, behavioral treatment
program, toy necklace, case study.
Tiefenbacher, S., M.D.
Davenport, M.A. Novak, A.L. Pouliot, and J.S. Meyer (2003).
Fenfluramine challenge, self-injurious behavior, and aggression
in rhesus monkeys. Physiology and Behavior 80(2-3): 327-331. ISSN: 0031-9384.
NAL Call Number: QP1.P4
Abstract: Self-injurious behavior (SIB) and aggression have been linked to reduced serotonergic (5-HT) functioning in both humans and nonhuman primates. The present study examined serum prolactin and cortisol responses to the 5-HT releasing
agent D,L-fenfluramine (FEN) in 24 individually housed rhesus monkeys (Macaca mulatta), 15 of which carried a veterinary record of self-wounding (SW). Subjects received two doses of FEN, 4 and 2 mg/kg, separated by an interval of at least 2 months.
For control purposes, monkeys were given an intramuscular saline injection 1 week prior to each FEN challenge. The relationship between the hormonal responses to FEN, wounding history, the rates of self-directed biting and aggression were determined for
each animal based on 100 five-minute observations conducted over a period
of 12 months surrounding the challenge procedures. Prolactin and cortisol
responses to FEN were unrelated either to wounding history or to rates of
self-directed biting. However, there were significant inverse correlations
between levels of aggression and the prolactin response to both doses of
FEN. The present findings provide no evidence for reduced 5-HT system
function in rhesus monkeys with SIB under the present challenge
conditions. However, the results are consistent with a previously reported
inverse relationship between serotonergic activity and aggression.
Moreover, a dose-dependent response to FEN was observed only for
prolactin, suggesting that this variable is more appropriate than cortisol
as an endpoint for FEN challenge in monkeys.
Descriptors: self-injurious behavior (SIB), aggression,
serotonergic functioning, cortisol and prolactin responses,
D,L-fenfluramine (FEN), wounding in rhesus monkeys, single
housing.
Tiefenbacher, S., M.D.
Davenport, M.A. Novak, A.L. Pouliot, and J.S. Meyer (2002). Prolactin
and cortisol response to fenfluramine challenge in socially reared captive
rhesus monkeys (Macaca mulatta) with self-injurious behavior.
American Journal of Primatology 57(Suppl. 1): 63-64. ISSN:
0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 25th Annual Meeting of The American Society of Primatologists, Oklahoma City, Oklahoma, USA; June 1-4, 2002.
Descriptors: self-injurious behavior (SIB), rhesus monkeys,
Macaca mulatta, wounding, aggression, hormonal responses, meeting
abstract.
Tiefenbacher, S., K.E. Gabry,
M.A. Novak, A.L. Pouliot, P.W. Gold, and J.S. Meyer. (2002). Central
levels of CRF and NPY in male rhesus monkeys with self-injurious
behavior. In: Society for Neuroscience Abstract Viewer and
Itinerary Planner: 32nd Annual Meeting of the Society for Neuroscience,
Orlando, Florida, USA, Society for Neuroscience: Washington, DC, p.
Abstract No. 398.3.
Online: http://sfn.scholarone.com
Descriptors: anxiety, self-injurious behavior (SIB), rearing conditions, self-directed biting, age at social separation, corticotropin releasing factor, anxiety-related neuropeptides, male rhesus macaques, meeting abstract
Tiefenbacher, S., M.J. Jorgensen, M.A. Novak, and J.S. Meyer (1999). Hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal activity in
rhesus monkeys with self-injurious behavior. American Journal of Primatology 49(1): 108-109. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 22nd Annual Meeting of the American Society of Primatologists, New Orleans, Louisiana, USA; August 12-16, 1999.
Descriptors: hypothalamic-pituitary-adrenal activity, hypothalamic-pituitary-gonadal activity, self-injurious behavior, rhesus macaques, meeting abstract.
Tiefenbacher, S., L.M. Marinus, M.D. Davenport, A.L. Pouliot, B.M. Kaufman, M.A. Fahey, M.A. Novak, and J.S. Meyer (2003). Evidence for endogenous
opioid involvement in the expression of self-injurious behavior in rhesus monkeys. American Journal of Primatology 60(Suppl. 1): 103. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 26th Annual Meeting of the American Society of Primatologists, Calgary, Alberta, Canada; July 29-August 2, 2003.
Descriptors: acupressure, behavioral expression, central
opioid activity, self-injurious behavior (SIB), rhesus macaques,
stereotypic behavior, self biting, meeting abstract.
Tiefenbacher, S., L.M. Marinus,
M.A. Novak, and J.S. Meyer. (2003). Endogenous opioid activity in a
nonhuman primate model of self - injurious behavior. In: Society
for Neuroscience Abstract Viewer and Itinerary Planner: 33rd Annual
Meeting of the Society of Neuroscience, New Orleans, Louisiana, USA,
Society for Neuroscience: Washington, DC, p. Abstract No. 960.14.
Online: http://sfn.scholarone.com
Descriptors: self-injurious behavior (SIB), self-directed biting,
levels of plasma beta-endorphin-like immunoreactivity (IR), rhesus
macaques, stereotypic behavior, wounding history, plasma opioid activity,
SIB effect on endogenous opioid peptide release
Tiefenbacher, S., M. Novak, L.
Marinus, A. Pouliot, M. Fahey, and J. Meyer (2001). Cortisol response
to ACTH challenge in rhesus monkeys with self-
injurious behavior. American Journal of Primatology 54(Suppl. 1): 61-62. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 24th Annual Meeting of the American Society of Primatologists, Savannah, Georgia, USA; August 8-11, 2001.
Descriptors: captive animal behavior, rhesus monkeys,
self-injurious behavior (SIB), biting frequency, stress,
adrenocorticotropic hormone (ACTH), meeting
abstract.
Tiefenbacher, S., M.A. Novak,
M.J. Jorgensen, and J.S. Meyer (2000). Physiological correlates of
self-injurious behavior in captive, socially-reared rhesus monkeys.
Psychoneuroendocrinology 25(8): 799-817. ISSN: 0306-4530.
Descriptors: self-injurious behavior (SIB), rhesus macaques,
monoamine metabolites, cerebrospinal fluid (CSF), cortisol, testosterone,
adrenocorticotropic hormone (ACTH), individual housing, self-directed
biting, stress.
Tiefenbacher, S., M.A. Novak,
C.K. Lutz, and J.S. Meyer (2005). The physiology and neurochemistry of
self-injurious behavior: A nonhuman primate model. Frontiers in
Bioscience: A Journal and Virtual Library 10(1): 1-11. ISSN:
1093-4715.
Online: http://www.bioscience.org/
Abstract: Self-injurious behavior (SIB) is a serious
behavioral condition that afflicts millions of individuals in the United
States alone. The underlying factors contributing to the development of
self-injury in people are poorly understood, and existing treatment
strategies for this condition are limited. A low but persistent percentage
of socially reared individually housed rhesus monkeys also spontaneously
develop SIB. Data obtained from colony records suggest that the risk of
developing
SIB in socially reared rhesus monkeys is heightened by adverse early
experience and subsequent stress exposure. The present review summarizes
the physiological and neurochemical findings obtained in this nonhuman
primate model of SIB, focusing on monoamine neurotransmitters,
neuropeptides, and neuroendocrine systems. The results indicate that
monkeys with SIB exhibit long-lasting disturbances in central and
peripheral opioid and stress response systems, which lead to increased
levels of anxiety. Based on
these findings, we propose an integrated developmental-neurochemical
hypothesis in which SIB arises from adverse life events in a subset of
vulnerable monkeys, is maintained by a persisting dysregulation of several
neurochemical and physiological systems, and functions to periodically
reduce anxiety when the levels of anxiety become excessive. Implications
of this hypothesis for understanding self-injury in patients with
borderline personality disorder and members of the general population are
discussed.
Descriptors: self-injurious behavior (SIB), treatment strategies, rhesus macaques, early experience, stress exposure, literature review, anxiety, implications for human patients, animal models.
Tiefenbacher, S., M.A. Novak, L.M. Marinus, W.K. Chase, J.A. Miller, and J.S. Meyer (2004). Altered hypothalamic-pituitary-adrenocortical function
in rhesus monkeys (Macaca mulatta) with self-injurious behavior. Psychoneuroendocrinology 29(4): 501-515. ISSN: 0306-4530.
Abstract: Individually housed rhesus monkeys sometimes
spontaneously develop self-injurious behavior (SIB) in the form of
self-directed biting that, on occasion, results in severe tissue damage
and mutilation. We previously demonstrated lower levels of plasma cortisol
in rhesus monkeys with a history of self-wounding (SW) when compared to
non-wounders (NW). Furthermore, cortisol levels were negatively correlated
with rates of self-directed biting. The present study was designed to
further characterize the relationships between
hypothalamic-pituitary-adrenocortical (HPA) activity, self-wounding, and
self-directed biting. Basal 24-h urinary free cortisol excretion, the
urinary free cortisol response to a low dose of dexamethasone, and the
plasma cortisol response to ACTH were examined in 24 individually housed
rhesus monkeys, based on wounding history, i.e. the presence/absence of a
veterinary record of self-wounding, and current rates of self-directed
biting, i.e. the median split of self-directed biting frequency
(independent of wounding status). There were no reliable group differences
on any of the physiological measures when analyzed by wounding history.
However, the plasma cortisol response 30 min post-ACTH stimulation was
significantly
correlated with wounding recency, such that lower responsivity was
associated with more recent wounding episodes. When the results were
analyzed on the basis of biting frequency, high frequency biters (HFB)
compared to low frequency biters (LFB) showed decreased HPA negative
feedback sensitivity to dexamethasone and a trend towards an attenuated
plasma cortisol response to ACTH stimulation. These findings suggest that
SIB in socially reared monkeys is associated with complex changes in HPA
axis function that are related to the expression of the pathology, i.e.
self-directed biting, and to the recency of a wounding episode. It remains
to be determined whether humans who exhibit SIB show similar alterations
in HPA function.
Descriptors: self-directed biting, cortisol levels,
self-injurious behavior (SIB), hypothalamic-pituitary-adrenocortical axis
function, biting frequency, socially reared animals, rhesus monkeys,
single housing.
Waitt, C. and H.M.
Buchanan-Smith (2002). What time is feeding? How delays and
anticipation of feeding schedules affect stump-tailed macaque
behavior. Applied Animal Behaviour Science 75(1): 75-85. ISSN:
0168-1591.
NAL Call Number: QL750.A6
Descriptors: husbandry routine, psychological well-being, Macaca arctoides, stump-tailed macaques, timing of food delivery, captive animal behavior, self-directed behavior, predictability of feeding.
Weed, J.L., R. Byrum, S. Parrish, M. Knezevich, D.A. Powell, and P.L.O.N. Wagner (2002 ). Vasectomies as part of an environmental enrichment plan
for primates. American Journal of Primatology 57(Suppl. 1): 41. ISSN: 0275-2565.
NAL Call Number: QL737.P9A5
Meeting Information: 25th Annual Meeting of The American Society of Primatologists, Oklahoma City, Oklahoma, USA; June 1-4, 2002.
Descriptors: social enrichment, clinical management tool,
pair or group housing, self-injurious behavior, behavioral intervention,
male nonhuman primates, vasectomy, meeting abstract.
Weed, J.L., P.O. Wagner, R.
Byrum, S. Parrish, M. Knezevich, and D.A. Powell (2003). Treatment of
persistent self-injurious behavior in rhesus monkeys through
socialization: A preliminary report. Contemporary Topics in
Laboratory Animal Science 42(5): 21-23. ISSN: 1060-0558.
NAL Call Number: SF405.5.A23
Abstract: This paper is a retrospective report describing outcomes for six male rhesus monkeys, each with a history of persistent self-injurious behavior (SIB), after their social introduction to female rhesus monkeys. Pairing procedures for
five of the six male primates were implemented after surgical vasectomy.
One male had previous pairing experience with a female prior to vasectomy
resulting in an unplanned pregnancy. This male was re-socialized with his
former female partner after surgery. The SIB-related medical histories of
the males before and after the pairings are presented. One goal for
promoting pair-housing of chronic SIB male monkeys with female monkeys was
to determine whether this intervention would function to reduce or
eliminate the expression of SIB and thus provide enhanced socialization
opportunities for previously singly housed animals.
Descriptors: Macaca mulatta, male rhesus macaques,
self-injurious behavior, socialization with females, vasectomy, pair
housing conditions, retrospective studies.
Wells, D.L. and E.C. Blaney.
(2003). Camouflaging gorillas: A method of reducing the 'visitor
effect'. In: Proceedings of the Fifth Annual Symposium on Zoo
Research, Marwell Zoological Park, Federation of Zoological Gardens of
Great Britain and Ireland: London, UK, p. 332-333.
Descriptors: gorillas, Gorilla gorilla, zoo housing
and exhibiting techniques, aggressive behavior, abnormal behavior,
stereotypic behavior, camouflage net barrier, visitor effects on
behavior
Yokoyama, C., H. Onoe, K. Onoe,
H. Tsukada, Y. Watanabe, and K. Fukui (2003). [Non-human primate
behaviors as models for development of higher cognitive functions].
Nihon Shinkei Seishin Yakurigaku Zasshi 23(1): 1-9. ISSN:
1340-2544.
Abstract: Non-human primate behaviors have a special value
for the neurobiological study of the development of higher cognitive
functions of humans, because of the near evolutional relation between two
species. We surveyed results and futures of neurobiological studies of a
retrieval task, a learning-set and a self-injurious behavior expressed by
non-human primates. On the retrieval task that is related to the
development of inhibitory control, it was revealed a hierarchical ordering
of inhibitory control processes in which the distinct neuronal circuits
were involved. On the learning-set that is related to the development of
abstract thinking, neural circuits for the individual learning
dramatically changed from an automatic process to a cognitive process
depending on the learning-set formation. The self-injurious behavior is
expressed during early normal development in humans, and no other animals
but non-human primates express it without administration of drugs. For
that behavior, probable change in interactions of multiple monoaminergic
systems was suggested as its underlying causes. Further studies on
development of higher cognitive functions using non-human primates could
be required for understanding the nature of human cognition.
Descriptors: neurobiological studies, retrieval task, learning set, self-injurious behavior, nonhuman primates, monoaminergic system, cognition.
Note: Language of text: Japanese.