DAVID Bioinformatics
The Database for Annotation, Visualization and Integrated Discovery
DAVID Bioinformatics Resources 2008
National Institute of Allergy and Infectious Diseases (NIAID), NIH
DAVID Gene Report
Gene Report

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5059 acyl-coa synthetase long-chain family member 1 Related Genes Mus musculus
SP_COMMENT catalytic activity:ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA., cofactor:Magnesium., function:Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses oleate, arachidonate, eicosapentaenoate and docosahexaenoate as substrates., similarity:Belongs to the ATP-dependent AMP-binding enzyme family., subcellular location:Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity). Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type III membrane protein.,
REFSEQ_PROTEIN NP_032007,
REFSEQ_MRNA NM_007981,
GENPEPT_ACCESSION AAA52193, AAH06692, AAH56644, BAB23652, BAE26736, BAE28854, BAE31484, BAE31678, BAE36230, BAE40051, EDL35573, EDL35574, mRNA,
GENE_SYMBOL Acsl1,
GENE_NAME 0 day neonate head cDNA, RIKEN full-length enriched library, clone:4832421C24 product:acyl-CoA synthetase long-chain family member 1, full insert sequence, 13 days pregnant adult female placenta cDNA, RIKEN full-length enriched library, clone:I530012L06 product:acyl-CoA synthetase long-chain family member 1, full insert sequence, Acsl1 protein, Acyl-CoA synthetase long-chain family member 1, Adult male liver tumor cDNA, RIKEN full-length enriched library, clone:C730006H14 product:acyl-CoA synthetase long-chain family member 1, full insert sequence, Bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830084N06 product:acyl-CoA synthetase long-chain family member 1, full insert sequence, Bone marrow macrophage cDNA, RIKEN full-length enriched library, clone:I830120B01 product:acyl-CoA synthetase long-chain family member 1, full insert sequence, LACS 1, Long-chain acyl-CoA synthetase 1, Long-chain-fatty-acid--CoA ligase 1, Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 1) (LACS 1), TIB-55 BB88 cDNA, RIKEN full-length enriched library, clone:I730056H02 product:acyl-CoA synthetase long-chain family member 1, full insert sequence,
GENERIF_SUMMARY Normoleptinemic control ACS-transgenic mice developed severe dilated cardiomyopathy with thickened left ventricular walls and profound impairment of systolic function on echocardiogram, Together, our findings suggest that a constitutive interaction between FATP1 and ACSL1 contributes to the efficient cellular uptake of LCFAs in adipocytes through vectorial acylation.,
CHROMOSOME 8,
ENTREZ_GENE_ID 14081,
PIR_SUMMARY Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses oleate, arachidonate, eicosapentaenoate and docosahexaenoate as substrates (By similarity).,
EC_NUMBER 6.2.1.3,
UNIGENE Mm.210323,
PIR_NREF_ID NF00511882, NF00529986, NF00530874,
UNIREF100_ID UniRef100_P41216,
UNIPROT_ID ACSL1_MOUSE, Q6GTG6_MOUSE, Q922Y9_MOUSE,
CYTOBAND 8 B2,


 Please cite Nature Protocols 2009; 4(1):44 & Genome Biology 2003; 4(5):P3 within any publication that makes use of any methods inspired by DAVID.
                          

        

                 
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