October 14-24, 1997
Antalya, Turkey
Tekirova Corinthia Hotel & Resort
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Organizing Committee
Sponsorship
Introduction
Objectives
Lecturers
Participants
Program
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Dr. Miral Dizdaroglu, Director of the Advanced Study Institute, Senior Scientist, Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
Dr. Barry Halliwell, Professor of Biochemistry, Department of Pharmacology, University of London, King's College, London SW3 6LX, UK
Dr. Ali E. Karakaya, Professor of Toxicology, Faculty of Pharmacy, Gazi University, 06330 Hipodrom, Ankara, Turkey
Dr. Hans E. Krokan, Professor of Molecular Biology, UNIGEN Center for Molecular Biology, Norwegian University of Science and Technology, N-7005 Trondheim, Norway
Dr. Jacques Laval, Research Director, Institut Gustave Roussy,
94805 Villejuif Cedex, France
This NATO Advanced Study Institute (ASI) is sponsored by the NATO
Scientific and Environmental Affairs Division. Additional support is
provided by the Biotechnology Division, National Institute of
Standards and Technology, USA, the Danish Centre for Molecular
Gerontology, Denmark, and the Turkish Society of Toxicology, Turkey.
An Advanced Study Institute (ASI) is a high-level tutorial course of ten working days duration where a carefully defined subject is treated in depth by lecturers of international standing. ASIs contribute to dissemination of scientific knowledge and the formation of international scientific contacts. Presentations are made by the lecturers to about 60-80 ASI students who are mostly at the post-doctoral level. However, this does not exclude students who are about to obtain their doctoral degrees, and may also include other appropriately qualified senior scientists. Attendance at ASIs is open to all suitably qualified applicants irrespective of nationality. ASI students normally come from NATO countries; those from non-NATO countries may only receive financial support from the NATO grant if they are from NATO Cooperation Partner countries. ASI students are chosen by the organizing committee for their appropriate qualifications following their responses to advertisement of the ASI. Students are required to stay for the entire duration of the ASI to ensure full interaction.
NATO countries: Belgium, Canada, Denmark, France, Germany, Greece, Iceland, Italy, Luxembourg, Netherlands, Norway, Portugal, Spain, Turkey, United Kingdom, Unites States of America.
NATO Cooperation Partner countries: Albania, Armenia,
Azerbaijan, Belarus, Bulgaria, Czech Republic, Estonia, Georgia,
Hungary, Kazakhstan, Kyrgyzstan, Latvia, Lithuania, the former
Republic of Macedonia, Moldova, Poland, Romania, Russia, Slovak
Republic, Slovania, Tajikistan, Turkmenistan, Ukraine, Uzbekistan.
Damage to DNA by both exogenous and endogenous sources is increasingly regarded as highly important in the initiation and progression of cancer and in the occurrence of other pathological events. DNA damage caused by reactive oxygen-derived species, also called oxidative DNA damage, is the most frequent type encountered by aerobic cells. Mechanistic studies of carcinogenesis indicate an important role of this type of damage to DNA. There is also strong evidence to support the role of oxidative DNA damage in the aging process.
DNA damage is opposed in vivo by repair systems. If not repaired, DNA damage may lead to detrimental biological consequences. Therefore, the repair of DNA damage is regarded as one of the essential events in all life forms. In recent years, the field of DNA repair flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. In 1994, DNA repair enzymes have been named Science magazine's Molecule of the Year.
There is an increasing awareness of the relevance of DNA damage and
repair to human health. A detailed knowledge of mechanisms of DNA
damage and repair, and how individual repair enzymes function may lead
to manipulation of DNA repair in cells and ultimately to an increase
of the resistance of human cells to DNA-damaging agents. Our knowledge
in this field has increased vastly in recent years. The time is ripe
to convene a NATO-ASI meeting of scientists of international standing
from the fields of biochemistry, molecular biology, enzymology,
biomedical science and radiation biology to analyze these questions in
detail and to teach the student participants the basics and new
developments of the field of DNA damage and repair. The lecturers
will present and discuss the state-of-the-art knowledge and recent
developments in this research field, and its pertinence to human
health. In this meeting, we expect the interactions between the
lecturers and participants to be synergistic and challenging, and to
contribute greatly to dissemination of scientific knowledge and the
formation of international scientific collaborations.
Dr. Steven A. Akman, Wake Forest Comprehensive Cancer Center, Winston-Salem, North Carolina 27157, USA. "Mapping reactive oxygen-induced DNA damage at nucleotide resolution."
Dr. Okezie I. Aruoma, University of London King's College, London SW3 6LX, UK. "Novel application of oxidative DNA damage to study antioxidant actions of plant extracts."
Dr. Serge Boiteux, UMR217 CNRS/CEA, Dpt. Radiobiologie et Radiopathologie, 92265-Fontenay aux Roses , FRANCE. "Repair of 8-oxoguanine in eukaryotes: the OGG1 enzymes."
Dr. Vilhelm A. Bohr, Chief of the Laboratory of Molecular Genetics, National Institute on Aging, NIH, Baltimore, MD 21224, USA. "Repair and transcription in premature aging syndromes."
Dr. Jean Cadet, CEA/Department de Recherche Fondamentale sur la Matiere Condensee, SCIB/LAN, F-38054 Grenoble Cedex 9, FRANCE "Oxidative base damage to DNA; recent mechanistic aspects."
Dr. Bruce Demple, Professor of Toxicology, Harvard School of Public Health, Boston, MA 02115, USA. "Roles of AP endonucleases in repair and genetic stability."
Dr. Walter A. Deutsch, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA. "Drosophila ribosomal protein S3 contains N-glycosylase, abasic site, and deoxyribophosphodiesterase DNA repair activities."
Dr. Miral Dizdaroglu, Senior Scientist, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA. "Mechanisms of oxidative DNA damage; lesions and their measurement."
Dr. Paul W. Doetsch, Professor of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA. "Bypass of DNA damage by RNA polymerases: implications for DNA repair and transcriptional mutagenesis."
Dr. Errol C. Friedberg, Professor, University of Texas Southwestern Medical Center Dallas, TX 75235, USA. "Nucleotide excision repair in eukaryotes: yeast as a model system."
Dr. Matthew B. Grisham, Professor of Physiology and Biophysics, Louisiana State University School of Medicine, Shreveport, LA 71130. "Modulation of nitrosation and oxidation reactions by superoxide and nitric oxide."
Dr. Arthur P. Grollman, Professor of Pharmacology and Medicine, State University at Stony Brook School of Medicine, Stony Brook, NY 11794, USA. "Oxidative DNA damage; mechanisms of mutagenesis and repair."
Dr. Lawrence Grossman, Professor of Biochemistry, Johns Hopkins University, Baltimore, MD 21205. "DNA repair as a biomarker in aging and for skin and lung cancer epidemiology studies."
Dr. Barry Halliwell, Professor of Biochemistry, University of London King's College, London SW3 6LX, UK. "Oxidative DNA damage and human health."
Dr. Philip C. Hanawalt, Professor of Biology, Stanford University, Stanford, CA 94305, USA. "Role of transcription-coupled DNA repair in human health."
Dr. Ali E. Karakaya, Professor of Toxicology, Faculty of Pharmacy, Gazi University, Ankara, Turkey. "Genotoxicity tests; applications for occupational exposure."
Dr. Kazimierz S. Kasprzak, Research Chemist, National Cancer Institute, NIH, Frederick. MD 21702, USA. "Studies on oxidative genotoxicity of human metal carcinogens: recent developments."
Dr. Hans E. Krokan, Professor of Molecular Biology, Norwegian University of Science and Technology, N-7005 Trondheim, Norway. "Human uracil DNA glycosylase: gene structure, regulation and structural basis for enzyme catalysis."
Dr. Yoke W. Kow, Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA 30335, USA. "Mechanism of action of Escherichia coli formamidopyrimidine N-glycosylase."
Dr. Jacques Laval, Research Director, Institut Gustave Roussy, 94805 Villejuif Cedex, France. "Repair of DNA damaged by free radicals."
Dr. Tomas Lindahl, Deputy Director of Research, Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire, EN6 3LD, UK. "Mechanisms of repair of endogenous DNA damage."
Dr. Stuart Linn, Professor of Biochemistry, University of California, Berkeley, CA 94720. "The chemical bases for hydrogen peroxide toxicity and DNA damage."
Dr. Steffen Loft, Panum Institute, University of Copenhagen, DK-2200 Copenhagen N, DENMARK. "Measurement of oxidative damage to DNA nucleobases in vivo: interpretation of nuclear levels and urinary excretion of repair products."
Dr. Joe Lunec, Centre for Mechanisms of Human Toxicity, University of Leicester, Leicester, LE1 9HN, UK. "Effects of vitamin E supplementation on in vivo oxidative DNA damage in normal individuals."
Dr. Sankar Mitra, The University of Texas Med. Branch at Galveston, Sealy Center for Molecular Science, Galveston, TX 77555-1079, USA. "Regulation of the major human AP-endonuclease, a multi-functional protein by oxidative stress."
Dr. Etsuo Niki, Professor of Chemistry, University of Tokyo, 4-6-1 Komaba, Megura, Tokyo, Japan. "Action of antioxidants against oxidative stress."
Dr. Susumu Nishimura, Senior Executive Director, Banyu Tsukuba Research Institute, Tsukuba, 300-33, Japan. "8-Hydroxyguanine in DNA: its formation by oxygen radicals, repair and implication in mutation/carcinogenesis."
Dr. Hiroshi Ohshima, Chief, Unit of Endogenous Cancer Risk Factors, International Agency for Research on Cancer, 69372 Lyon Cedex 08, France. "DNA damage induced by reactive nitrogen-species."
Dr. Nancy Oleinick, Professor, Case Western Reserve University, Cleveland, OH 44106- 4942, USA. "Modification of radiation-induced DNA damage by chromatin organization."
Dr. Ryszard Olinski, Department of Clinical Biochemistry, University School of Medical Sciences, 85-092 Bydgoszcz, POLAND. "Estimation of free radical-induced DNA base damages in cancerous and HIV-infected patients and in healthy subjects."
Dr. Mehmet Öztürk, Professor of Molecular Biology, Bilkent University, 06533 Bilkent, Ankara, Turkey. "p53 tumor suppressor gene: its role in DNA damage response and cancer."
Dr. Dennis J. Reeder, Leader, DNA Technologies Group, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA. "Free radicals, DNA damage and p53 expression: a review of interrelationships with apoptosis and prospects for diagnosis."
Dr. Joyce T. Reardon, Professor of Biochemistry, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. "Molecular mechanisms of nucletide excision repair in mammalian cells."
Dr. Clemens von Sonntag, Max-Planck-Institut für Strahlenchemie, Stiftstr. 34-36, D-45413 Mülheim a.d. Ruhr, GERMANY. "Mechanistic studies of radiation-induced DNA damage"
Dr. Shinya Toyokuni, Department of Pathology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606, JAPAN. "Detection of 8-hydroxy-2´-deoxyguanosine by a monoclonal antibody N45.1 and its application."
Dr. Susan S. Wallace, Professor of Microbiology, University of Vermont College of Medicine, Burlington, VE 05405, USA. "Processing and consequences of oxidative DNA lesions."
Dr. John F. Ward, Professor of Radiobiology, University of California San Diego, La Jolla, CA 92093, USA. "Ionizing radiation damage to DNA: a challenge to repair systems."
FROM NATO COUNTRIES
Bertrand de Wergifosse, Cellular Biology Laboratory, Université Catholique de Louvain-UCL, Place Croix du Sud, 4 - Bâtiment Carnoy, B-1348 Louvain-la-Neuve, BELGIUM
Kevin Lenton, Centre de Recherche en Gerontologie et Gereatrie, Universite de Sherbrooke, 1036 Belvedere Sud, Sherbrooke, QC, J1H 4C4, CANADA
M. Vakur Bor, Department of Clinical Biochemistry, Aarhus University Hospital, Norrebrogade 44, DK-8000 Aarhus C, DENMARK
Mette Christiansen, Danish Center for Gerantology, University of Aarhus, Langelandsgade 140, bygn. 510, 8000 Aarhus C, DENMARK
Tanja Thybo Frederiksen, Danish Center for Gerantology, University of Aarhus, C.F. Mollers Alle, Bldg. 130, 8000 Aarhus C, DENMARK
Allan Weiman, Department of Clinical Pharmacology, Q7642, Rigshospitalet, 20, Tagensvej, DK-2200 Copenhagen N, DENMARK
Anja Wellejus, Department of Pharmacology, University of Copenhagen, 18.5 Panum Institute, Blegdamsvej 3, DK-2200 Copenhagen N, DENMARK
Valerie Abalea, Laboratoire de Biologie Cellulaire, INSERM U456, 2, Avenue du Pr. L. Bernard, 35043 Rennes Cedex, FRANCE
Martine Defais, CNRS, Institut de Pharmacologie et Biologie Structurale, 205 route de Narbonne, 31077 Toulouse Cedex, FRANCE
Christa Baumstark-Khan, DLR, Institute of Aerospace Medicine, Radiobiolgy Unit, Linder Hoehe, D-51147 Köln, GERMANY
Nair Sreejayan, University of Munich, Klinikum Grosshadern, Department of Medicine D-81377 München, GERMANY
Alexander Georgakilas, Laboratory for Rad. Mol. Genetics, National Centre for Scientific Res., "Demokritos" Aghia Paraskevi, 153 10 Athens, GREECE
Kostas Haveles, Laboratory for Rad. Mol. Genetics, National Centre for Scientific Res."Demokritos" Aghia Paraskevi, 153 10 Athens, GREECE
Lampros Papandreou, University of Ionnina, Medical School , Department of Obstetrics and Gynaecology, 2nd Obstetrics Clinic, GR-451 10 Ionnina, GREECE
Chryssostomos Chatgilialoglu, Consiglio Nazionale Delle Richerche, Via P. Gobetti, 101, 40129 Bologna, ITALY
Antonia M. Pedrini, Instituto di genetica Biochimica, ed Evoluzionistica del CNR, Via Abbiategrasso, 207, 27100 Pavia, ITALY
Niels Aarsaether, Department of Molecular Biology, HIB-University of Bergen, 5020 Bergen, NORWAY
Sangeeta Bharati, UNIGEN Center for Molecular Biology, Norwegian University for Science and Technology, N-7005 Trondheim, Norway
Svein Bjelland, Stavanger College, School of Science and Technology, Ullandhaug, PO Box 2557, N-4004 Stavangar, NORWAY
Hilde Nilsen, UNIGEN Center for Molecular Biology, Norwegian University for Science and Technology, N-7005 Trondheim, NORWAY
Kristin Solum, UNIGEN Center for Molecular Biology, Norwegian University for Science and Technology, N-7005 Trondheim, NORWAY
Teresa Roldan-Arjona, Faculdad de Ciencias, Departamento de Genetica, Universidad de Cordoba, 14071-Cordoba, SPAIN
Rafael Rodriguez, Faculdad de Ciencias, Departamento de Genetica, Universidad de Cordoba, 14071-Cordoba, SPAIN
Bulbin Akbasak, Department of Biology and Genetics, Faculty of Medicine, Inonu University, Malatya, TURKEY
Nursen Basaran, Department of Toxicology, Faculty of Pharmacy, Hacettepe University Ankara, TURKEY
Mustafa Birincioglu, Department of Pharmacology, Faculty of Medicine, Inonu University, Malatya, Turkey
Sema Burgaz, Department of Toxicology, Faculty of Pharmacy, Gazi University, Ankara, TURKEY
Belma Giray, Department of Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, TURKEY
Bensu Karahalil, Department of Toxicology, Faculty of Pharmacy, Gazi University, Ankara, TURKEY
Asuman Karakaya, Department of Toxicology, Faculty of Pharmacy, University of Ankara, Ankara, TURKEY
Okyay Kilinc, Department of Molecular Biology and Genetics, Bogazici University, Istanbul, TURKEY
Hilal Ozdag, Department of Molecular Biology and Genetics, Bilkent University, Ankara, TURKEY
Ibrahim Pirim, Department of Genetics, Faculty of Medicine, Ataturk University, Erzurum, TURKEY
Semra Sardas, Department of Toxicology, Faculty of Pharmacy, Gazi University, Ankara, TURKEY
Sema Senturker, Biochemistry Department, Faculty of Medicine, Osman Gazi University Eskisehir, TURKEY
Sinan Suzen, Gulhane Military Health Academy, Ankara, TURKEY
Aysen Tezcaner, Department of Biological Sciences, Middle East Technical University, Ankara, TURKEY
Berrin Tunca, Department of Molecular Biology, Faculty of Medicine, Uludag University, Bursa, TURKEY
Kezban Unsal, Department of Molecular Biology and Genetics, Bilkent University, Ankara, TURKEY
Ismet Yilmaz, Department of Biochemistry, Faculty of Medicine, Inonu University, Malatya, TURKEY
Suzanne Cholerton, Department of Pharmacological Sciences, University of Newcastle Upon Tyne, Newcastle NE2 4HH, UK
Andrew Jenner, Pharmacology Department, King's College London University, London, SW3 6LX, UK
Tracy Melvin, MRC Radiation and Genomic Stability Unit, Chilton, Oxon, OX11 ORD, UK
Elizabeth Bailey, Laboratory of Toxicology, Harvard School of Public Health, Boston, MA 02115, USA
George J. Broder, Fox Cancer Center, Radiology 1553 Cherry Lane Rydal, PA 19046, USARichard M. Burger, Laboratory of Chromosome Biology, The Public Health Research Institute, New York, NY 10016, USA
Jonathan A. Eisen, Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020, USA
Kevin Geiss, Department of Zoology, Miami University, Oxford, OH 45056, USA
Sandra Gunselman, Colorado State University, Department of Environmental Health Fort Collins, CO 80523, USA
Leonora Lipinski, Laboratory of Molecular Genetics, National Institute on Aging, NIH Baltimore, MD 21224, USA
Monica McTigue, Health Sciences Center, Department of Pharmacology, University of New York at Stony Brook, Stony Brook, NY 11794-8651, USA
Henry Rodriguez, Department of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
Ivan Roussyn, Curriculum in Toxicology, University of North Carolina at Chapel Hill Chapel Hill, NC 27599-7400, USA
David M. Sonntag, University of Cincinnati, Department of Environmental Health, Cincinnati, OH 45220, USA
Robertus Stierum, Laboratory of Molecular Genetics, National Institute on Aging, NIH Baltimore, MD 21224, USA
Steve Waters, Department of Cancer Biology, Wake Forest Comprehensive Cancer Center, Winston-Salem, NC 27157, USA
Dmitry Zharkov, Department of Pharmacology, State University of New York at Stony Brook, Stony Brook, NY 11794-8651, USA
FROM NON-NATO COUNTRIES
Armen K. Nersesyan, Cancer Research Centre, Yerevan State University, Yerevan, ARMENIA
Anton Tontchev, Laboratory of Electron Microscopy, Department of Anatomy and Histology, Medical University of Varna, BG-9002 VARNA, BULGARIA
Maarit Lankinen, Department of Clinical Biochemistry Laboratory of Molecular Hematology, Tempere University Hospital PO Box 200 33521 Tempere, FINNLAND
Vitalija Simkeviciene, Institute of Biochemistry, Department of Bioorganic Compounds Technology, Mokslininku 12, 2600 Vilnius, LITHUANIA
Saule Uleckiene, Laboratory of Environmental Carcinogens, Lithuanian Oncology Center, Polocko 4, 2007 Vilnius, LITHUANIA
Jan Barciszewski, Institute of Biorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, POLAND
Pawel Jaruga, Department of Clinical Biochemistry, Medical Academy, 85-094, Bydgoszcz, POLAND
Bogdan Constantinescu, Institute of Atomic Physics, PO BOX MG-6, Bucharest, ROMANIA
Rita Balamirzoeva, Department of Ethnic Populations Genetics, Institute of History, Arch. and Ethnogr., Daghestanian Center of Russian Academy of Sciences, 367030, Makhachkala, Daghestan, RUSSIA
Machbuba Pulatova, Institute of Chemical Physics Russian Academy of Sciences Kosigyns Street, 4 Moscow, 117977, Russia
Alla A. Oudalova, Russian Institute of Agricultural Radiology & Agroecology, 249020 Obninsk, Kaluga Region, RUSSIA
Olga M. Rozanova, Laboratory of Cytogenetics, Institute of Theor. and Exper. Biophysics Pushchino, Moscow Region, 142292, RUSSIA
Vladimir Sharygin, Institute of Chemical Physics Russian Academy of Sciences Kosigyns Street, 4 Moscow, 117977, Russia
Elizabeth Bilsland, Gothenburg University, Lundsbergs Laboratory Department of Molecular Biology Medicinaregatan 9C S-413 90 Gothenburg, Sweden
Cyril Privezentzev, National Academy of Science of Ukraine, The A.O. Kovalevsky Institute of Biology of the Southern Sea, Nakhimova Ave. 2, 335011 Sevastopol, UKRAINE
| 9.00-9.30 | Welcome and introductory remarks (committee members) Chairperson: Nancy L. Oleinick |
|
| 9.30-10.30 | Barry Halliwell, "Oxidative DNA damage and human health." | |
| 10.30-11.00 | Coffee Break | |
| 11.00-12.00 | Philip C. Hanawalt, "Role of transcription-coupled DNA repair in human health." | |
| Afternoon | Chairperson: Barry Halliwell | |
| 15.30-16.30 | Miral Dizdaroglu, "Mechanisms of oxidative DNA damage; lesions and their measurement." | |
| 16.30-17.30 | Jean Cadet, "Oxidative base damage to DNA: recent mechanistic aspects." | |
| 17.30-18.00 | Coffee Break | |
| 18.00-19.00 | Jacques Laval, "Repair of DNA damaged by free radicals." | |
| Evening | ||
| 20.00-22.00 | Welcoming Cocktail |
| Morning | Chairperson: Jacques Laval | |
| 9.00-10.00 | Susumu Nishimura, "8-Hydroxyguanine in DNA: its formation by oxygen radicals, repair and implication in mutagenesis/carcinogenesis." | |
| 10.00-11.00 | Serge Boiteux, "Repair of 8-oxoguanine in eukaryotes: the OGG1 enzymes." | |
| 11.00-11.30 | Coffee Break | |
| 11.30-12.30 | Stuart Linn, "Sequence preferences for cleavage of duplex DNA by Fe+2 and hydrogen peroxide." | |
| Afternoon | Chairperson: Philip C. Hanawalt | |
| 16.00-17.00 | Steven A. Akman, "Mapping reactive oxygen-induced DNA damage at nucleotide resolution." | |
| 17.00-17.30 | Coffee Break | |
| 17.30-18.30 | Joyce Reardon, "Molecular mechanisms of nucleotide excision repair in mammalian cells." |
| Morning | Chairperson: Steve A. Akman | ||
| 9.00-10.00 | Tomas Lindahl, "Mechanisms of repair of endogenous DNA damage." | ||
| 10.00-11.00 | Arthur P. Grollman, "Oxidative DNA damage; mechanisms of mutagenesis and repair." | ||
| 11.00-11.30 | Coffee Break | ||
| 11.30-12.30 | Hans E. Krokan, "Human uracil DNA glycosylase: gene structure, regulation and structural basis for enzyme catalysis." | ||
| Afternoon | |||
| 16.00-18.00 | Poster session |
| Morning | Chairperson: Errol C. Friedberg | |
| 9.00-10.00 | Susan S. Wallace, "Processing and consequences of oxidative DNA base lesions." | |
| 10.00-11.00 | Bruce Demple,"Roles of AP endonucleases in repair and genetic stability." | |
| 11.00-11.30 | Coffee Break | |
| 11.30-12.30 | Walter A. Deutsch, "Drosophila ribosomal protein S3 contains N- glycosylase, abasic site, and deoxyribophosphodiesterase DNA repair activities." | |
| Afternoon | Chairperson: John F. Ward | |
| 16.00-17.00 | Clemens von Sonntag, "Mechanistic studies of radiation-induced DNA damage" | |
| 17.00-17.30 | Coffee Break | |
| 17.30-18.30 | Shinya Toyokuni, "Detection of 8-hydroxy-2´-deoxyguanosine by a monoclonal antibody N45.1 and its application." |
| Morning | Chairperson: Clemens von Sonntag | |
| 9.00-10.00 | John F. Ward, "Ionizing radiation damage to DNA: a challenge to repair systems." | |
| 10.00-11.00 | Nancy Oleinick, "Modification of radiation-induced DNA damage by chromatin organization." | |
| 11.00-11.30 | Coffee Break | |
| 11.30-12.30 | Sankar Mitra, "Regulation of the major human AP-endonuclease, a multi-functional protein by oxidative stress." | |
| Afternoon | Chairperson: Wilhelm Bohr | |
| 16.00-17.00 | Mehmet Öztürk "p53 tumor suppressor gene: its role in DNA damage response and cancer." | |
| 17.00-17.30 | Coffee Break | |
| 17.30-18.30 | Steffen Loft, "Measurement of oxidative damage to DNA nucleobases in vivo: interpretation of nuclear levels and urinary excretion of repair products." | |
| Evening | ||
| 20.00 | Gala Dinner |
| Break |
| Morning | Chairperson: Stuart M. Linn | |
| 9.00-10.00 | Vilhelm A. Bohr, "DNA repair and transcription deficiencies in premature aging syndromes." | |
| 10.00-11.00 | Paul W. Doetsch, "Bypass of DNA damage by RNA polymerases: implications for DNA repair and transcriptional mutagenesis." | |
| 11.00-11.30 | Coffee Break | |
| 11.30-12.30 | Joe Lunec, "Effects of vitamin E supplementation on in vivo oxidative DNA damage in normal individuals." | |
| Afternoon | Chairperson: Susumu Nishimura | |
| 16.00-17.00 | Dennis J. Reeder, "Free radicals, DNA damage and p53 expression: a review of interrelationships with apoptosis and prospects for diagnostics." | |
| 17.00-17.30 | Coffee Break | |
| 17.30-18.30 | Lawrence Grossman, "DNA repair as a casual factor in chronic diseases in the population." | |
| Evening | Chairperson: Hans Krokan | |
| 20.00-22.00 | Oral poster presentations |
| Henry Rodriguez, USA, | "Genomic Gene Enrichment for LMPCR Analysis." | |
| Teresa Roldán-Arjona, Spain, | "Substrate Specificity of Eukaryotic Nth Homologues." | |
| Andrew Jenner, UK,, | "Hypochlorous Acid-Induced Base Damage in Isolated Calf Thymus DNA." | |
| Leonora Lipinski, USA, | "Processing of Oxidative DNA Damage in Familial Alzheimer Disease." | |
| Tanja Thybo Frederiksen, Denmark, | "Gene Specific Formation and Repair of 8-Hydroxyguanine in Mammalian Cells in vivo." | |
| Maarit Lankinen, Finnland, | "Radiation-Induced DNA Strand Breaks in Human Hematopoietic Cells Measured Using the Comet Assay." | |
| Chryssostomos Chatgilialoglu, Italy, | "Free Radical Chemistry Associated with C-1 Position of Nucleosides." | |
| Mustafa Birincioglu, Turkey, | "Is Free Radical Scavenging Action of Ace Inhibitors Related to Their Protective Effect on Reperfusion Arrhythmias in Rats?" | |
| Ibrahim Pirim, Turkey, | "The Optimization of the PCR-Restriction Isotyping for APO-E Genotype." | |
| Uleckiene Saule, Lithuania, | "Studies on Genotoxicity of Occupational Exposures." | |
| K. S. Haveles, Greece, | "Effects of Tris and Phenol in ?-Irradiated DNA Samples." |
| Morning | Chairperson: Arthur P. Grollman | |
| 9.00-10.00 | Errol C. Friedberg, "Nucleotide excision repair in the yeast Saccharomyces cerevisiae." | |
| 10.00-11.00 | Lawrence Grossman, "Studies on the role of RNA polymerase in DNA repair." | |
| 11.00-11.30 | Coffee Break | |
| 11.30-12.30 | Hiroshi Ohshima, "DNA damage induced by reactive nitrogen-species." | |
| Afternoon | ||
| 16.00-18.00 | Poster session |
| Morning | Chairperson: Dennis J. Reeder | |
| 9.00-10.00 | Kazimierz S. Kasprzak, "Studies on oxidative genotoxicity of human metal carcinogens: recent developments." | |
| 10.00-11.00 | Yoke W. Kow, "Mechanism of action of Escherichia coli formamidopyrimidine N-glycosylase." | |
| 11.00-11.30 | Coffee Break | |
| 11.30-12.30 | Matthew B. Grisham, "Interactions between superoxide and nitric oxide: implications in DNA damage and repair." | |
| Afternoon | Chairperson: Matthew B. Grisham | |
| 15.30-16.30 | Okezie I. Aruoma, "Novel application of oxidative DNA damage to study antioxidant actions of plant extracts." | |
| 16.30-17.00 | Coffee Break | |
| 17.00-18.00 | Ali E. Karakaya, "Genotoxicity tests; applications for occupational exposure." | |
| Evening | Chairperson: Joe Lunec | |
| 20.00-22.00 | Oral poster presentations |
| Graciela Spivak, USA, | "Repair of Oxidative Damage in Transcribed and Non-Transcribed DNA Strands in Human Cells ." | |
| M. K. Pulatova, Russia, | "Drugs and DNA Synthesis System: The Biochemical Mechanisms of DNA Damage, Repair and Protection." | |
| Dmitry O. Zharkov, USA, | "Cloning and Characterization of Mouse 8- Oxoguanine DNA Glycosylase/AP Lyase (MOGG1)." | |
| Nair Sreejayan, Germany, | "Effect of Bile Acids on Lipid Peroxidation: The Role of Iron." | |
| Martine Defais, France, | "Role of the Hamster RAD51 Protein in DNA Damage Response and Homologous Recombination." | |
| J. Barciszewski, Poland, | "Mechanism of Kinetin Formation IN DNA." | |
| Sandra J. Gunselman, USA, | "Use of Infrared Spectral Models in Cancer Research and Their Potential Clinical Applications." | |
| Svein Bjelland, Norway, | "5-Formyldeoxyuridine-Induced Mutagenesis in Bacteria and Mammalian Cells." | |
| Kevin J. Lenton. Canada, | "DNA Base Damage in Human Lymphocytes." | |
| Stephen B. Waters, USA, | "Factors Affecting 5-Methylcytosine to Thymine Transitions in the P53 Gene of Colorectal Cancers." | |
| Hilde Nilsen, Norway, | "Gene and Promoter Structure of the Murine Uracil-DNA Glycosylase." | |
| Hilal Özdag, Turkey, | "Germline Mutation Analysis of DNA Repair Related BRCA1 and BRCA2 Tumor Supressor Genes." | |
| Semra Sardas, Turkey, | "Evaluation of DNA Damage in Lymphocytes of Cancer Patients Under Gamma-Radiation Therapy by Single Gel Electrophoresis" |
| Morning | Chairperson: Paul W. Doetsch | |
| 9.00-10.00 | Ryszard Olinski, "Estimation of free radical-induced DNA base damages in cancerous and HIV-infected patients and in healthy subjects." | |
| 10.00-10.30 | Coffee break | |
| 10.30-11.30 | Etsuo Niki, "Action of antioxidants against oxidative stress." | |
| Afternoon | ||
| 16.00-18.00 | Poster session | |
| Evening | ||
| 20.00-22.00 | Closing cocktail |
| Departure |