Ortega-Larrocea MD, Reyes-Teran MD, Tapia Aurora MC; International Conference on AIDS (15th : 2004 : Bangkok, Thailand).

Int Conf AIDS. 2004 Jul 11-16; 15: abstract no. MoPeB3201.

Medica Sur, Mexico, Mexico

Background: patients with cytomegalovirus retinitis (CMVR) who receive antiretroviral therapy may develop immune recovery uveitis and sustained increases in their CD4+T lymphocyte counts may develop a severe chronic eye inflammation called immune recovery uveitis (IRU). This uveitis, sometime bilateral, can be a sight-threatening condition and it is the result of an immune restoration in the eye related to HAART therapy. Clinical observation suggests that patients, who start HAART sometime after CMVR, developed less IRU those patients that received it at the same time. Methods: a retrospective cohort study of 86 patients with CMVR was studied (1996-2003). We included patients that survive at least 12 months after CMVR diagnosis, with increases in their CD4+T lymphocyte count (response to antiretroviral treatment). Patients were divided in group 1 if they received HAART before or at the same time of CMVR diagnosis and group 2 if they received non-potent antiretroviral treatment before or at the time of CMVR diagnosis. Descriptive and non-parametric statistics were applied. Results: 43 patients with treated CMV retinitis were included, 40 men,3 female, age 35 year-old (sd +/-7.2). Initial CD4T+ lymphocytes count was 39 (sd +/-27). The prevalence of IRU was 53.5%, CD4T+ lymphocytes count was 287 (sd +/-522). In the first group: 24 patients received HAART and 17 (39.5%) developed IRU (2 bilateral disease) 10.5 months (sd +/-10.2) after CMVR diagnosis. In the second group 19 patients received non-potent antiretroviral treatment and 6 (14%) patient developed bilateral IRU at month 12 (sd +/-9) after HAART was added. In group 2 all patients started HAART sometime after CMVR diagnosis. The OR = 5.26, CI 95% 1.21-23.96; pMH = 0.01 Conclusion IRU is more frequent in patients with HAART at diagnosis of CMVR than in patients with a delayed in HAART initiation.

Publication Types:

• Meeting Abstracts

Keywords:

• AIDS Vaccines
• Acquired Immunodeficiency Syndrome
• Anti-HIV Agents
• Antiretroviral Therapy, Highly Active
• CD4 Lymphocyte Count
• CD4-Positive T-Lymphocytes
• Cohort Studies
• Cytomegalovirus Retinitis
• Female
• HIV
• HIV Infections
• HIV Protease Inhibitors
• HIV Seropositivity
• Humans
• Male
• Prevalence
• Retrospective Studies
• Uveitis
• diagnosis

Other ID:

• GWAIDS0035289

UI: 102279505

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