Chemical Sampling Information
	Allyl chloride
Quick Links General Description Exposure Limits Health Factors Monitoring Search    [use word(s)/phrase] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: 3-Chloropropene; 1-Chloro-2-propene; 3-Chloropropylene OSHA IMIS Code Number: 0140 Chemical Abstracts Service (CAS) Registry Number: 107-05-1 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: UC7350000 Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1100 131 [27 KB, PDF] NIOSH Pocket Guide to Chemical Hazards, Allyl chloride: chemical description, physical properties, potentially hazardous incompatibilities, and more Exposure Limits OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 1 ppm, 3 mg/m3 TWA OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 1 ppm, 3 mg/m3 TWA OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 1 ppm, 3 mg/m3 TWA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 1 ppm, 3 mg/m3 TWA; 2 ppm, 6 mg/m3 STEL; Appendix A3 - Confirmed Animal Carcinogen with Unknown Relevance to Humans National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 1 ppm, 3 mg/m3 TWA; 2 ppm, 6 mg/m3 STEL Health Factors International Agency for Research on Cancer (IARC) carcinogenic classification: Group 3, not classifiable as to its carcinogenecity to humans. [381 KB, PDF] Environmental Protection Agency (EPA) carcinogenic classification: Group C, possible human carcinogen NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 250 ppm Potential symptoms: Irritation of eyes, skin, nose, mucous membrane; lacrimation, sneezing, cough, sore throat, labored breathing, pulmonary edema (may be delayed); headache, dizziness, weakness; tingling sensation, coldness, numbness in hands and feet; eye redness, pain, blurred vision; in animals: liver, kidney injury; INGES. ACUTE: Burning sensation, abdominal pain, vomiting. Health Effects: : Irritation- Eye, Nose, Throat---Marked (HE14); Polyneuropathy (HE7); Liver damage (HE3); Mutagen (HE2). Affected organs: Eyes, skin, respiratory system, peripheral nervous system, liver, kidneys. Notes: Vapor/air mixtures of Allyl chloride may be explosive. The major urinary metabolite, 3-hydroxypropylmercapturic acid, has been studied as a biomarker for occupational exposure to Allyl chloride, and an 8-hour biological exposure index of 352 µg/gram creatinine has been proposed. However, garlic consumption may interfere with an accurate determination of occupational exposure. This metabolite is not specific for Allyl chloride, as it may also be produced from allyl alcohol, allyl formate (and other allyl esters), allyl nitrate, and acrolein. Mechanistic studies of neurochemical changes in rats gavaged with Allyl chloride in corn oil (200 mg/kg, 3 times/week for 12 weeks) indicated toxic effects in the CNS as well as in the peripheral nervous system. Date Last Revised: 06/26/2007 Literature Basis: NIOSH Pocket Guide to Chemical Hazards: Allyl chloride. International Chemical Safety Cards (WHO/IPCS/ILO): Allyl chloride. EPA Air Toxics Website: Allylchloride. U.S. Environmental Protection Agency Technology Transfer Network. De Rooij, B.M., Boogaard, P.J., Commandeur, J.N., van Sittert, N.J. and Vermeulen, N.P.: Allylmercapturic acid as urinary biomarker of human exposure to Allyl chloride. Occup. Environ. Med. 54(9): 653-661, 1997. He, F.S. and Zhang, S.L.: Effects of Allyl chloride on occupationally exposed subjects. Scand. J. Work Environ. Health 11(Suppl. 4): 43-45, 1985. Kaye, C.M.: Biosynthesis of mercapturic acids from allyl alcohol, allyl esters and acrolein. Biochem. J. 134(4): 1093-1101, 1973. Pohanish, R.P. (editor): Allyl chloride. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 97-100. Wang, Q.-S., Song, F., Zhao, X., Hou, L.-Y. and Xie, K.-Q.: Expression changes of apoptic-related proteins in nerve tissues of rats treated with Allyl chloride. Toxicology 231(1): 58-67, 2007. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh) analytical solvent: Benzene alternate analytical solvent: (99:1) Carbon Disulfide/Dimethylformamide maximum volume: 100 Liters   minimum volume: 16 Liters   maximum flow rate: 1.0 L/min current analytical method: Gas Chromatography; GC/FID method reference: NIOSH Analytical Method (NIOSH 1000) [20 KB, PDF] method classification: Fully Validated All Trademarks are the property of their respective owners. Accessibility Assistance: Contact the OSHA Directorate of Science, Technology and Medicine at 202-693-2300 for assistance accessing PDF materials.