Tsertsvadze T, Gochitashvili NT, Sukhiashvili R; International Conference on AIDS.

Int Conf AIDS. 1998; 12: 561 (abstract no. 32201).

Georgian AIDS & Clin. Immunology Center, Tbilisi.

OBJECTIVES: The relationship between the CNS manifestations of HIV infection and the levels of HIV-1 RNA in CSF and plasma were assessed in 23 untreated HIV patients. DESIGN: Retrospective case-control study. METHODS: 14 adult HIV patients with CNS manifestations (study group) and 9 adult HIV patients with AIDS defining events, but without neurologic manifestations (control group) were studied. Among the study group 6 patients had AIDS dementia complex (ADC), 3 patients--CNS Toxoplasmosis, 2 patients--Progressive Multifocal Leucoencephalopthy (PML), 2 patient--CMV encephalitis and 1 patient--TB meningitis. Measurement of viral load in CSF and plasma was performed by RT PCR method. Diagnosis of ADC was made by characteristic neurologic symptoms and signs that were supported by neurophysiologic assessment and neuroimaging. Diagnosis of CNS opportunistic infections was made by clinical symptoms, neuroimaging and laboratory investigations (viral and bacterial cultures, PCR). RESULTS: HIV RNA in CSF were as follows: in control group--average 574 copies/ml (range undectectable-834), in ADC patients--average 37,000 copies/ml (range 540-143,700), in TB meningitis-83,000 copies/ml, in CNS Toxoplasmosis--average 108,000 copies/ml (range 87,000 7ndash; 139,000), in PML--average 159,000 copies/ml (range 147,000-171,000), in CMV encephalitis--average 163,000 copies/ml (range 152,000-174,000). Viral load in plasma usually was higher than in CSF. No significant differences in plasma viral load between the two groups were found. CONCLUSIONS: There is a significant relationship between increased viral load in CSF and presence of CNS disease. High CSF viral load and CNS involvement was almost always accompanied by elevated concentrations of plasma HIV RNA (except of ADC that may be occured at any level of plasma viral load). And high plasma viral load not always was accompanied by high levels of HIV RNA in CSF.

Publication Types:

• Meeting Abstracts

Keywords:

• AIDS Dementia Complex
• Acquired Immunodeficiency Syndrome
• Adult
• CD4 Lymphocyte Count
• Case-Control Studies
• Central Nervous System
• Central Nervous System Diseases
• Central Nervous System Neoplasms
• HIV Infections
• HIV Seropositivity
• Humans
• Laboratory Techniques and Procedures
• Plasma
• Toxoplasmosis, Cerebral
• Viral Load
• cerebrospinal fluid
• organization & administration

Other ID:

• 98396173

UI: 102229716

From Meeting Abstracts