| US 7,385,086 B2 | ||
| Antimicrobial compounds | ||
| Craig A. Townsend, Baltimore, Md. (US); James D. Dick, Upperco, Md. (US); Gary R. Pasternack, Baltimore, Md. (US); Francis P. Kuhajda, Lutherville, Md. (US); and Nicole M. Parrish, Ellicott City, Md. (US) | ||
| Assigned to The Johns Hopkins University School of Medicine, Baltimore, Md. (US) | ||
| Filed on Jan. 27, 2004, as Appl. No. 10/764,451. | ||
| Application 10/764451 is a division of application No. 09/486550, granted, now 6,713,654, previously published as PCT/US98/17830, filed on Aug. 28, 1998. | ||
| Claims priority of provisional application 60/056272, filed on Aug. 29, 1997. | ||
| Prior Publication US 2004/0186176 A1, Sep. 23, 2004 | ||
| Int. Cl. C07C 317/00 (2006.01); C07C 317/02 (2006.01); C07C 317/04 (2006.01); C07C 317/06 (2006.01); C07C 317/08 (2006.01) | ||
| U.S. Cl. 568—27 [568/28; 568/31; 514/550; 514/618] | 11 Claims |
| 1. A method of inhibiting growth of a mycobacterial cell, comprising administering an effective amount of a compound of formula
I to the cell:
R—SOn-Z-CO—Y I
wherein:
R is selected from the group consisting of any alkyl group having from 6-10 carbon atoms, any unsaturated hydrocarbon having
from 6-10 carbon atoms, or any alkyl group having from 6-10 carbon atoms interrupted by at least one aromatic ring;
Z is —CH2—;
Y is selected from the group consisting of —NH2, and —O—CH3; and
n is 1 or 2;
and wherein, the mycobacterial cell is selected from the group consisting of cells of Mycobacteria tuberculosis, drug resistant M. tuberculosis, M. bovis, M. leprae, and M. paratuberculosis.
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