Phair J, Detels R, Jacobson L, Rinaldo C, Saah A, Munoz A; International Conference on AIDS.

Int Conf AIDS. 1991 Jun 16-21; 7: 47 (abstract no. M.C.95).

Multicenter AIDS Cohort Study, Chicago, IL

OBJECTIVE: Describe homosexual men with incident HIV-1 infection who develop AIDS within five years and compare behavioral, clinical and immunologic characteristics of those progressing to AIDS (grp A) with those seroconverters remaining AIDS-free (grp B). METHODS: Between entry into the study (4/84 - 3/85) and 7/89, 349 seronegative men developed HIV-1 antibody; as of 3/90, 32 had developed AIDs with known dates of seroconversion (SC) and AIDS diagnosis. Grp B were matched to individuals in grp A based upon time from entry to SC and AIDS-free time post-SC. Participants were seen semiannually. RESULTS: The Kaplan-Meier estimates of the proportion of men with incident infection remaining AIDS-free were: 6 mo 100%, 12 mo 99%, 24 mo 97%, and 48 mo 86%. The AIDS-defining events included: PCP 50%, other OI 22%, KS 19%, and other 9%. The two groups were demographically similar. Sexually transmitted disease was reported more frequently pre-SC in grp A than grp B (p = 0.05) and grp A engaged in receptive anal intercourse with more partners before (p = 0.003) and after SC (p less than 0.005) than grp B. Grp A reported more symptoms at the visit within 3 mo. of SC than did grp B (42% vs 15%); at 6, 12, and 24 mo, symptoms were equally prevalent in both groups. Significantly greater decreases in number and percent of CD4+ cells at 6 mo (p = 0.023), 12 mo (p = 0.001) and 24 mo (p = 0.0009) post SC were noted in Grp A as compared to grp B. A significant rise in proportion of CD8+ cells post-SC was also noted in grp A; 6 mo (p = 0.048), 12 mo (p = 0.013) and 24 mo (p = 0.006). CONCLUSIONS: These findings suggest that sexually-transmitted co-factors, pre or post-SC, play a role in the progression of HIV-1 infection. Alternatively, greater sexual activity could increase the hazard of exposure to a more virulent HIV-1 strain.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• CD4-Positive T-Lymphocytes
• CD8-Positive T-Lymphocytes
• Case-Control Studies
• Disease Progression
• HIV Antibodies
• HIV Infections
• HIV-1
• Homosexuality
• Humans
• Male
• Sexual Behavior
• Sexually Transmitted Diseases

Other ID:

• 1009591

UI: 102182532

From Meeting Abstracts