Gaitan L, Santos V, Cashat M, Fragoso R, Cuairan V; IAS Conference on HIV Pathogenesis and Treatment (2nd : 2003 : Paris, France).

Antivir Ther. 2003; 8 (Suppl.1): abstract no. 1083.

Lab of Oral Pathology, Dental School, National Autonomous University of Mexico

BACKGROUND: Opportunists oral infections (OOI) related to paediatric HIV infection, have an important diagnostic and prognostic value. Nowadays, anti-HIV therapies, including HIV protease inhibitors, have been associated to decrease in opportunistic infections, however it is not know if HIV+ paediatric patients under antiretroviral therapy (ARVT), including protease inhibitors, shown decrease in OOI. OBJECTIVE: To establish the prevalence of OOI in HIV+ children under different types of ARVT. Material and methods: 57 Mexican HIV/AIDS children (<13 years old); Immunodeficiency Clinic, Child's Hospital of Mexico, Federico Gomez, under ARVT (minimum 12 months); were included. In accordance to their ARVT, the children were grouped as follows: double therapy (didanosine+ stavudine): 15 patients (5 boys; 10 girls); triple therapy (two analogue nucleosides + one protease inhibitor): 20 patients (8 children; 12 girls); quadruple therapy (two analogue nucleosides + one analogue non-nucleoside + one protease inhibitor): 22 children (7 boys and 15 girls). The children were orally examined following the diagnostic criteria for oral lesions related to HIV infection in paediatric patient (EC-Clearinghouse-WHO). The research protocol was approved by the Research and Bioethical Committees of respective participant institutions. RESULTS: IIO-HIV prevalences: 20%; 25%; and 13.6% (P=0.645), for double; triple and quadruple therapy group, respectively. In all the groups the most common oral infection was oral candidiasis. The severe immunodeficiency children under triple or quadruple therapy shows highest IOO-HIV prevalences. CONCLUSIONS: Ours results suggest that HIV/AIDS children under quadruple anti-retroviral therapy shown diminish of IOO-HIV. Supported by PAPIIT 225202, DGAPA-UNAM.

Publication Types:

• Meeting Abstracts

Keywords:

• AIDS Vaccines
• Acquired Immunodeficiency Syndrome
• Antiretroviral Therapy, Highly Active
• Candidiasis, Oral
• Child
• Didanosine
• Female
• HIV Infections
• HIV Protease Inhibitors
• HIV Seropositivity
• Humans
• Male
• Mexico
• Opportunistic Infections
• Prevalence
• Stavudine
• drug therapy
• therapy

Other ID:

• GWAIDS0023737

UI: 102263361

From Meeting Abstracts