Melnick S, Hannan P, Decher L, Rhame FS, Little JW, Balfour HH, Volberding P; International Conference on AIDS.
Int Conf AIDS. 1991 Jun 16-21; 7: 248 (abstract no. M.B.2265).
U of MN, Minneapolis, Minnesota, USA
OBJECTIVE: To assess the relationships among trends in T-lymphocyte counts and development of intraoral lesions (IOL) among patients in the early stages of HIV disease. METHODS: Between January and October, 1989, participants of two placebo-controlled trials of zidovudine (AIDS Clinical Trials Group Protocols 016 and 019) were examined by specialists in oral medicine at approximately 12-week intervals to determine the presence of IOL, specifically candidiasis, (CA); hairy leukoplakia (HL); ulcerations (UL) such as herpes simplex; and gingivitis/periodontitis (G/P). CD4 and CD8 counts, as well as CD4:CD8 ratios, were obtained during the intervals before and after each oral examination. The maximum likelihood estimation technique of BMDP P5V was used to measure the association between trends in T-lymphocyte counts and development of IOL. RESULTS: 106 patients (97 asymptomatic, 9 symptomatic) were examined at baseline; 91 were examined twice; 65 three times; and 25 four times. The mean study duration in weeks for those with IOL was 28, versus 23 for those without IOL (p=.06). Participants were 98% male; 92% white; 94% bi/homosexual; mean age 38 years. 36% of patients had IOL at some point during the study. Specific IOL identified at examinations 1 to 4, respectively, were: CA (5%, 1%, 3%, 0%); HL (9,9,12,16); UL (12,12,0,4); G/P (0,7,2,4). 53% with IOL were current cigarette smokers, versus 44% without IOL (p=.52). No association was found between CD4 or CD4:CD8 at an exam and the presence of IOL (p=.08). Using repeated measures analysis, a minimally significant effect was found between elevated average CD8 before exam and the presence of IOL at the exam (within-person slope=+0.01247; p=.04). DISCUSSION AND CONCLUSIONS: Increases in CD8 counts predicted development of IOL; therefore monitoring trends in CD8 counts may be important for oral management of HIV-infected patients.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Antigens, CD4
- Antigens, CD8
- HIV Infections
- HIV Seropositivity
- Homosexuality
- Humans
- Leukoplakia, Hairy
- Lymphocyte Count
- Male
- Zidovudine
- immunology
Other ID:
UI: 102183186
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