National Institute of Arthritis and Muscloskeletal and Skin Diseases (NIAMS)
New Directions in Biology and Disease of Skeletal Muscle
January 25 – 28, 2004 • San Diego, CA
Agenda
| Sunday, January 25 |
|
| 1:00 p.m. | Welcome Richard W. Lymn, H. Lee Sweeney, Elizabeth McNally, Thomas Rando, Charles A. Thornton |
| Keynote Address | |
| 1:30 p.m. | High-Throughput Genetic Approaches Define
Signaling Pathways Responsible for Muscle Atrophy and Hypertrophy George Yancopoulos, Regeneron |
| Session I: Pathogenetic Mechanisms Chair: Jerry Mendell |
|
| 2:30 p.m. | Overview Jerry Mendell, Ohio State Univ |
| 2:50 p.m. | Muscular dystrophies with abnormal alphadystroglycan
glycosylation Francesco Muntoni, Imperial College London |
| 3:35 p.m. | Sarcoglycan in cardiac and skeletal muscle Elizabeth McNally, Univ. of Chicago |
| 4:05 p.m. | Dystroglycan: Interactions and functions at synapses Sal Carbonetto, McGill University |
| New and Notable | |
| 4:35 p.m. | The role of the nuclear envelope in muscle disease Cecilia Ostlund, Columbia University |
| 4:50 p.m. | Emerin binds the pointed end of actin filaments
and stimulates polymerization: Evidence for an Actin cortical Network at the Nuclear Membrane Jim Holaska, Johns Hopkins Med. School |
| 5:05 p.m. | Localization of the FSHD region to the nuclear peripheral: Is
FSHD a nuclear envelope disease? Sara Winokur, UC Irvine |
| 7:30 p.m. | Poster Session I |
| Pathogenic Mechanisms | |
| Conserved and Muscle Group-Specific Pathogenic Mechanisms in mdx Skeletal Muscles
with Phenotypically Divergent Disease Responses J.D. Porter. Case Western Reserve Univ., Cleveland, OH, USA. |
|
| Role of troponin T isoforms in muscle function and disease. J.-P. Jin. Case Western Reserve Univ., Cleveland, OH, USA. |
|
| Cancer cachexia is regulated by selective targeting of skeletal muscle gene products S. Acharyya, K.J. Ladner, L.L. Nelsen, J. Damrauer, P.J. Reiser, S. Swoap and D.C. Guttridge. The Ohio State Univ., Columbus, Ohio, USA and Williams College, Williamstown, Massachusetts, USA. |
|
| The ferlin proteins in muscle membrane fusion K.R. Doherty, D. Belt Davis and E.M. McNally. Univ. of Chicago. |
|
| Functional nitric oxide synthase mislocalization in sarcoglycan-mediated cardiomyopathy A. Heydemann, J. Huber, R. Kakkar, M. Wheeler and E. McNally. The Univ. of Chicago. |
|
| Structural and functional roles of desmin in mouse skeletal muscle during passive
deformation S.B. Shah, J. Davis, N. Weislede, I. Kostavassili, A.D. McCulloch, E. Ralston, Y. Capetanaki and R.L. Lieber. Univ. of California and VA Med. Centers, San Diego, CA, USA, Baylor College of Med., Houston, TX, USA and National Insts. of Health, Bethesda, MD, USA. |
|
| Loss of the dystrophin glycoprotein complex impairs mechanical signal transduction in
murine skeletal muscle E.R. Barton. Univ. of Pennsylvania Sch. of Dental Med., Philadelphia, PA USA. |
|
| DM1 and DM2 transcriptome profiling reveals global gene expression changes R. Krahe, M. Sirito, S. Colella, K. Virtaneva, T. Ashizawa, G. Bassez, B. Eymard, B. Udd and F.A. Wright. Univ. of Texas M. D. Anderson Cancer Ctr., Houston, Human Bacterial Pathogenesis, NIAID, Hamilton, MN, Univ. of Texas Med. Branch, Galveston, TX, Henri Mondor Univ. Hosp., Criteil, Salpjtrihre Hosp., Paris, France, Vaasa Central Hosp., Finland and Univ. of North Carolina, Chapel Hill, NC. |
|
| Limb-girdle muscular dystrophy 1F maps to chromosome 7q32.1-32.1 M. Hirano, L. Palenzuela, I.F. Cadenas, M. Vila, J. Gamez and A.L. Andreu. Columbia Univ., New York, NY, USA and Hospital Universitari Vall d'Hebron, Barcelona, Spain. |
|
| Variability of clinical, pathological and molecular findings in Nemaline Myopathy patients
with ACTA1 gene mutations P.B. Agrawal and A.H. Beggs. Children's Hospital Boston and Harvard Med. Sch., Boston, MA USA. |
|
| Inhibition of muscle differentiation by a muscleblind-related protein, CHCR, implicated in
myotonic dystrophy R.M. Squillace, C.J. Sutton and E.H. Wang. Univ. of Washington, Seattle WA, USA. |
|
| A fast and furious singing muscle as a model of nemaline myopathy K. Wang, P. Nahirney and M. Lewis. NIAMS, NIH, Bethesda, MD. |
|
| Does DMPK play a role in the CNS-associated problems of myotonic dystrophy-1? H.F. Epstein, P.E. Schulz and A. Balasubrmanyam. Baylor College of Med., Houston, Texas. |
|
| Heavy-chain antibody fragments for proteomic applications in muscular dystrophies S. van der Maarel1, P. Verheesen2, A. Roussis1, Y. Huang1, S. van Koningsbruggen1, J. den Dunnen1, R. Frants1 H. de Haard3, T. Verrips2 1 Leiden Univ. Medical Center, Leiden, The Netherlands. 2 Univ. of Utrecht, Utrecht, The Netherlands. 3 Ablynx NV, Gent, Belgium. |
|
| Common Mechanisms | |
| Myogenesis in myotonic dystrophy 1: the role of RNA CUG repeats and RNA CUGbinding
proteins R. Patel, P. Iakova, Z-J. Cai, L. Quan, N.A. Timchenko and L. Timchenko. Baylor College of Med., Houston, Texas, USA. |
|
| Biochemical pathways in muscle regeneration in vivo: Tead2/TEF4 directly induces Fgfr4 P. Zhao, G. Caretti, V. Sartorelli and E.P. Hoffman. Children's National Med. Center, Washington DC, USA and NIAMS, National Insts. of Health, Bethesda, MD, USA. |
|
| Dynamics of Z-band based proteins in living skeletal muscle cells J.W. Sanger, J. Wang, N. Shaner, B. Mittal, Q. Zhou, J. Chen and J.M. Sanger. Univ. of Pennsylvania Sch. of Med, Philadelphia, PA and Univ. of California, San Diego, La Jolla, CA. |
|
| Muscle paralysis in patients with Acute Quadriplegic Myopathy (AQM): Underlying
mechanism at the cell, protein and gene levels. Studies in patients and experimental animal models L. Larsson, H. Settle, K. Chitanya, R. Kolluri, L.I. Eriksson, P. Radell, S. Schiaffino and B. Dworkin. Uppsala Univ, Sweden, Karolinska Inst, Sweden, Padova Univ, Italy and Penn State Univ., Hershey, PA, USA. |
|
| Muscle specific and regeneration associated gene expression changes after eccentric
contractions I. Barash, L. Mathew, A. Ryan, J. Chen and R. Lieber. UCSD/VAMC, San Diego, CA. |
|
| Actomyosin structure and dynamics as seen by electron microscopy N. Volkmann, L. Hazelwood, H. Liu, G. Ouyang, S. Lowey, K.M. Trybus and D. Hanein. The Burnham Inst., La Jolla CA, Brandeis Univ., Waltham MA and Univ. of Vermont, Burlington, VT. |
|
| Ectoderm-derived lipid microdomains (Rafts) regulate chicken embryo somite myotome
formation B.R. Kuo, S.S. Gottlieb, H-N. Nguyen, J. Samos and W.F. Denetclaw, Jr. San Francisco State Univ., San Francisco, CA. |
UNC-45: A myosin chaperone in skeletal muscle H.F. Epstein, A.H. Hutagalung, M.L. Landsverk and M.G. Price. Baylor College of Med., Houston, TX, USA. |
| Responses of rat soleus muscle fibers to unloading and reloading Y. Ohira, X.D. Wang, F. Kawano, Y.B. Lan, K. Goto, M. Sudoh and A. Ishihara. Sch. Health Sport Sci. and Grad. Sch. Med., Osaka Univ., Toyonaka City, Osaka, Japan, St. Marianna Univ. Sch. Med., Kawasaki City, Japan, Jikei Univ. Sch. Med., Tokyo, Japan and Kyoto Univ., Kyoto City, Kyoto, Japan. |
|
| New insights on Calpain-3 activation and role in muscle cytoskeleton organization M. Taveau, N. Bourg, G. Sillon, C. Roudaut, M. Bartoli and I. Richard. Ginithon, CNRS UMR-, rue de l'Internationale, Evry, France. |
|
| Secondary Processes with Pathogenetic or Therapeutic Implications | |
| Elevated insulin-like growth factor II (IGF-II) expression in DMD patient myotubes A. Yong and H.J. Klamut. Univ. of Toronto and Ontario Cancer Inst., Univ. Health Network, Toronto, Ontario, Canada. |
|
| Regulation of the integrin a7ß1 function by ADP-ribosylation A. Zolkiewska, J. Gruszczynska-Biegala and Z. Zhao. Kansas State Univ., Manhattan, KS. |
|
| Gamma delta T cells expressing Vd1, Vd4 and Vd5 represent a large fraction of the cells
infiltrating mdx mouse muscle E. Montecino Rodriguez, M. Zhou and M.J. Spencer. UCLA Duchenne Muscular Dystrophy Res. Center. |
|
| Treatment with the beta-agonist, fenoterol, improves functional repair of rat skeletal
muscle following injury F. Beitzel, J.G. Ryall, D.R. Plant, N. Stupka, L.J. Harcourt, F. Colarossi, M.N. Sillence, J.D. Schertzer, P. Gregorevic and G.S. Lynch. The Univ. of Melbourne, Victoria, Australia. |
|
| The loss of nNOS from dystrophin-deficient muscle causes defects in positive allosteric
regulation of PFK by nNOS M.L. Oltmann and J.G. Tidball. University of California, Los Angeles, CA, USA. |
|
| Magnetic resonance imaging and 1H-MRS of dystrophic murine muscle G.A. Walter, L. Cordier and H.L. Sweeney. Univ. of Florida, Gainesville, FL and Univ. of Pennsylvania, Philadelphia, PA, USA. |
|
| Compensatory fast muscle fiber hypertrophy after chronic hemiparetic stroke C. Hafer- Macko, E. Palmisano, A. Ryan, F. Ivey and R. Macko. Univ. of Maryland and Baltimore VA, Baltimore, MD USA. |
|
| Therapeutic Modulation of Pathogenesis | |
| Comparative analysis of antisense oligonucleotide analogs for targeted DMD exon
skipping in myotubes A. Aartsma-Rus, W. Kaman, M. Bremmer-Bout, A. Janson, G. Platenburg, J. den Dunnen, G-J. van Ommen and J. van Deutekom. Leiden Univ. Med. Center and ProSensa B.V., Einsteinweg, CC Leiden, The Netherlands. |
|
| Development of an antisense therapy for DMD in normal, mdx, and hDMD transgenic
mice J. van Deutekom, M. Bremmer-Bout, E. de Meijer, A. Aartsma-Rus, W. Kaman, G. Platenburg, J. den Dunnen and G.J. van Ommen. Leiden Univ. Med. Center and ProSensa B.V., Leiden, The Netherlands. |
|
| Abnormal evoked calcium release from isolated mdx skeletal muscle fibers C. Woods, D. Novo, M. DiFranco and J. Vergara. David Geffen Sch. of Med. at UCLA, Los Angeles, CA. |
|
| Adult bone marrow-derived side population cells are insufficient to regenerate dystrophic
skeletal and cardiac muscle in sarcoglycan mutant mice K. Lapidos, A. Heydemann, J. Earley, E. Chen, A. Ma and E. McNally. University of Chicago, Chicago, Illinois. |
|
| Specific and potent RNA interference in terminally differentiated myotubes C.E. Yi, J.M. Bekker, G. Miller, K.L. Hill and R.H. Crosbie. UCLA, Los Angeles, CA, USA. |
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| Monday, January 26 |
|
| 8:30 a.m. | Pathogenetic Mechanisms II Chair: Stephen Tapscott |
| 8:30 a.m. | Overview Stephen Tapscott, Fred Hutchinson Cancer Research Center |
| 8:50 a.m. | Nemaline myopathy - unraveling the thin filament Kathryn North, Univ. of Sydney |
| 9:20 a.m. | Molecular pathogenesis of oculopharyngeal muscular
dystrophy Guy Rouleau, McGill University |
| 9:50 a.m. | Generation of an animal model for FSHD Rossella Tupler, Univ. of Massachusetts |
| 10:35 a.m. | RNA gain-of-function and involvement of
muscleblind proteins in myotonic dystrophy Charles Thornton, Univ. of Rochester |
| New and Notable | |
| 11:05 a.m. | Mouse Muscleblind Knockout Model for Myotonic
Dystrophy Maurice Swanson, Univ. of Florida |
| 11:25 a.m. | Mechanisms of Disrupted splicing regulation in
myotonic dystrophy Tom Cooper, Baylor College of Medicine |
| 11:40 a.m. | A Drosophila model for the study of human
oculopharyngeal muscular dystrophy Aymeric Chartier, IGH-CNRS |
| Therapeutic modulation of pathogenesis Chair: Louis Kunkel |
|
| 2:00 p.m. | Overview Louis Kunkel, Children's Hospital, Boston |
| 2:20 p.m. | Gene expression studies in human derived
muscle SP and MP cells Emanuela Gussoni, Children's Hospital, Boston |
| 2:50 p.m. | Functional improvement of mdx muscles following
viral-vector mediated delivery of dystrophin Jeff Chamberlain, Univ. of Washington |
| 3:20 p.m. | Non-viral gene therapy for muscular dystrophies Thomas Rando, Stanford University |
| 4:05 p.m. | Novel method for vector delivery to muscle Hansell Stedman, Univ. of Pennsylvania |
| New and Notable | |
| 4:35 p.m. | Identification of a putative pathway for the
muscle homing of stem cells in a muscular dystrophy model Yvan Torrente, Policlinico Hospital of Milan |
| 4:50 p.m. | ADAM12 alleviates the skeletal muscle pathology in
mdx dystrophic mice Ulla Wewer, University of Copenhagen |
| 5:05 p.m. | Antisense skipping can produce significant amounts
of dystrophin protein in vivo from mutant dystrophin genes Terry Partridge, Hammersmith Hospital |
| 7:30 p.m. | Poster Session II |
| Pathogenic Mechanisms | |
| Integrin is a compensatory transmembrane linker to sarcoglycan in muscle M. Allikian, A.A. Hack, S. Mewborn, U. Meyer and E.M. McNally. Univ. of Chicago, IL USA and Wellcome Trust Centre for Cell-Matrix Research, Manchester UK. |
|
| Nesprin-1a crosslinks emerin and lamin A/C at the inner nuclear membrane M. Puckelwartz, J. Mislow, J. Holaska, M. Seguar-Totten, K. Wilson and E. McNally. The Univ. of Chicago and Johns Hopkins School of Medicine. |
|
| Lamin A/C mutations in familial cardiomyopathy M. Culley, H. MacLeod, J. Huber, A. Carmel and E. McNally. University of Chicago, Chicago, IL, USA. |
|
| Structure bound calpain activity is increased in maturing dystrophic muscle K.E. Draper and R.W. Grange. Virginia Tech, Blacksburg, VA. |
|
| Myogenesis in facioscapulohumeral dystrophy (FSHD) and control myoblasts D.A. Figlewicz, I. Coltas and Y. Hong. Univ. of Michigan, Ann Arbor, MI, USA. |
|
| Development of a stable muscle cellular model of oculopharyngeal muscular dystrophy S. Routledge and M. Antoniou. GKT Sch. of Med., King's College London, Guy's Campus, London, UK. |
|
| Expression profiling in facioscapulohumeral muscular dystrophy (FSHD): Possible insights
into pathogenesis S.L. Venance, D. Henderson, J. Sowden, S. Welle, C.A. Thornton and R. Tawil. University of Rochester Sch. of Med. and Dentistry, Rochester, NY. |
|
| Testing the role of calpain 3 in mdm mouse muscular dystrophy K.A. Huebsch, M.J. Spencer and G.A. Cox. Bar Harbor, ME and Univ. of California, Los Angeles, CA. |
|
| A Drosophila myosin alternative domain modulates weak-binding states of the ATPase
cycle B.M. Miller, M. Nyitrai, D.M. Swank, K.P. Littlefield, M.A. Geeves and S.I. Bernstein. San Diego State Univ., San Diego, CA, USA and Univ. of Kent, Canterbury, UK. |
|
| Expression profiling in muscle from untreated children with juvenile dermatomyositis
(JDM) with pathological calcifications Y-W. Chen and L.M. Pachman. Childrens National Med. Center, Washington, DC, The Childrens Mem. Inst. for Education and Research, Northwestern University, Chicago, IL. |
|
| CASK and Dlg in skeletal muscle of normal and transgenic mice J.L. Sanford, T.A. Mays, K.L. Gardner and J.A. Rafael-Fortney. The Ohio State Univ., Columbus, OH, USA. |
|
| The effects of ?PDZ-Dlg on mdx and utrophin/dystrophin-deficient skeletal muscle J.A. Kearney, T.A. Mays and J.A. Rafael-Fortney. The Ohio State Univ. College of Med., Columbus, OH. |
|
| Perturbation of subcellular organization in muscle fibers from Desmin null mice J.P.K. Hyatt, Z. Lu, Y. Capetanaki and E. Ralston. NINDS and NIAMS, NIH, Bethesda, MD and Baylor College of Medicine, Houston, TX. |
|
| Common Mechanisms | |
| Clonal analysis of satellite cells identifies separate myogenic and adipogenic progenitors G. Shefer, M. Wleklinski and Z. Yablonka-Reuveni. University of Washington, Seattle, WA, USA. |
|
| Myogenic differentiation of multipotent adult progenitor cells derived from bone marrow
and muscle tissue M. Reyes, S. Li, E. Kimura, L. Meuse and J. Chamberlain. Univ. of Washington School of Medicine, Seattle, WA, USA. |
|
| Characterization and functional analysis of the Drosophila unc-45 (dunc-45) gene Q. Yu, L.C. Hipolito, W.A. Kronert, H. Liu, M.G. Price, H.F. Epstein and S.I. Bernstein. San Diego State Univ., San Diego, CA and Baylor College of Med., Houston, TX. |
|
| Clinical spectrum of autosomal forms of Emery-Dreifuss muscular dystrophy Z. Nanjiani. Children's National Medical Center, Washington, DC. |
|
| Cytoplasmic γ-actin is upregulated in dystrophin-deficient muscle L.M. Hanft, I.N. Rybakova, J.R. Patel, J.S. Chamberlain, J.A. Rafael and J.M. Ervasti. University of Wisconsin, Madison, WI, University of Washington, Seattle, WA and The Ohio State University, Columbus, OH. |
|
| Identification of the spectrin-like repeats required for high affinity utrophin/actin interaction I.N. Rybakova and J.M. Ervasti. University of Wisconsin, Madison. |
|
| Mechanical stretch induces tyrosine phosphorylation of Crk-associated substrate (CAS) in
canine skeletal muscle D.D. Tang and P. Tao. Indiana University School of Medicine Indianapolis, IN, USA. |
|
| Activation of muscular regenerative system following heat stresses in rats K. Goto, T. Kobayashi, A. Kojima, T. Akema, T. Sugiura, S. Yamada, Y. Ohira and T. Yoshioka. St. Marianna University Sch. Med., Kawasaki, Japan, Yamaguchi Univ., Yamaguchi, Japan, Univ. Tokyo, Tokyo, Japan, Osaka Univ., Osaka, Japan, Aomori Univ. Health Welfare, Aomori, Japan. |
|
| Secondary Processes with Pathogenetic or Therapeutic Implications | |
| Two cases of Becker Muscular Dystrophy arising from premature stop codon mutations in
exon 31 which result in altered splicing and exclusion of the affected exon M.T. Howard, T.M.F. Tuohy, C.B. Anderson and K.M. Flanigan. University of Utah, Salt Lake City, UT, USA. |
|
| Functional improvement of mdx mouse muscle following treatment with protease
inhibitors C.A. Morris, L.D. Morris, A.R. Kennedy and H.L. Sweeney. University of Pennsylvania School of Medicine, Philadelphia PA. |
|
| Gene expression in skeletal muscle undergoing adaptation to limb lengthening N.A. Elmonoufy, E.J. Smith, M.R. Makarov, D.E. Muirhead, J.G. Birch and M.L. Samchukov. Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas, Texas. |
|
| Targeted disruption of the NF-κB1 and Bcl-3 genes attenuate skeletal muscle atrophy in
mice R.B. Hunter and S.C. Kandarian. Boston University, Boston, MA. |
|
| Macrophage-derived nitric oxide lyses muscle cells in vitro, and increases membrane
permeability in dystrophin-deficient muscle in vivo H.X. Nguyen and J.G. Tidball. UCLA, Los Angeles CA, USA. |
|
| Noninvasive monitoring of muscle damage T.N. Frimel, J.D. Gibbs, G. Gaidosh, G.A. Walter and K. Vandenborne. University of Florida, Gainesville FL and University of Pennsylvania, Philadelphia PA. |
|
| Molecular analysis of muscular dystrophies K.J.A. McCullagh, A. Weir, B. Edwards, A. Potter, S. Squire, D. Powell, Q. Bai and K.E. Davies. University of Oxford-MRC Functional Genetics Unit, Oxford, U.K. |
|
| Therapeutic Modulation of Pathogenesis | |
| A novel MiniDys-eGFP fusion gene for developing cell-based therapies of Duchenne
muscular dystrophy S. Li, E. Kimura, L. Meuse, X. Ye, B. Fall, S.D. Hauschka, J. Faulkner and J.S. Chamberlain. Univ. of Washington Sch. of Med., Seattle, WA, USA, Univ. of Michigan, Ann Arbor, MI, USA. |
|
| Restoration of dystrophin expression in muscle cells of mdx5cv mice by oligonucleotidemediated
gene correction in vitro and in vivo C. Bertoni and T.A. Rando. Stanford Univ., Stanford, CA. |
|
| Pilot trial of albuterol in Duchenne and Becker muscular dystrophy E.G. Fowler, M.C. Graves, G.T. Wetzel and M.J. Spencer. UCLA, Los Angeles, CA. |
|
| Prednisone reduces inflammation and down-regulates cell adhesion molecules in
dystrophin-deficient muscle M. Wehling-Henricks and J.G. Tidball. UCLA, Los Angeles, CA USA. |
|
| Configuration of recombinant adeno-associated viral vectors for systemic transduction of
the myocardium and skeletal muscles P. Gregorevic, M.J. Blankinship, J.M. Allen, R.W. Crawford, L. Meuse, S. Oakley and J.S. Chamberlain. University of Washington School of Medicine, Seattle, WA, USA. |
|
| Amelioration of Lama2-null pathology by altering Bcl-2 or Bax expression J.B. Miller, J.A. Dominov, C.A. Kostek, M. Ardelt and M. Girgenrath. Boston Biomedical Research Institute, Watertown, MA, USA. |
|
| Tuesday, January 27 | |
| Common pathogenetic mechanisms Chair: Kenneth Fischbeck |
|
| 8:30 a.m. | Overview Kenneth Fischbeck, NIH |
| 8:50 a.m. | Costameric actin defects in muscular
dystrophy James Ervasti, Univ. of Wisconsin-Madison |
| 9:20 a.m. | Analysis of the physiological role of calpain 3 and its interaction
with titin Melissa Spencer, UCLA |
| 10:05 a.m. | New pathways from post-genomics: Analyses
from a 140 biopsy human genome-wide profiling dataset, and a 27 time point regeneration dataset Eric Hoffman, Children's National Medical Center |
| New and Notable | |
| 10:35 a.m. | Identification of Molecular Mediators of Skeletal Muscle Hypertrophy and
Atrophy David Glass |
| 10:50 a.m. | A Hereditary inclusion body myositis with a specific IIA MYHC mutation:
Effects on myosin expression, structure and function Lars Larsson |
| 11:05 a.m. | Epigenetic causes of fascioscapulohumeral muscular dystrophy Silvere Van der Maarel |
| Secondary processes with pathogenetic or therapeutic implications Chair: Kathryn Wagner |
|
| 2:00 p.m. | Overview Kathryn Wagner, Johns Hopkins Univ. |
| 2:20 p.m. | UCLA Immune cell function in dystrophinopathy James Tidball |
| 2:50 p.m. | Blockade of myostatin as a pharmacological
strategy for muscular dystrophy Tejvir Khurana, Univ. of Pennsylvania |
| 3:35 p.m. | Possible therapy for a subset of DMD patients
using suppression of premature stop codons H. Lee Sweeney, Univ. of Pennsylvania |
| New and Notable | |
| 4:05 p.m. | Loss of calcineurin expression impairs
mechanical overload and IGF-1/GH- mediated hypertrophy Stephanie Parsons, Cincinnati Children’s Hospital |
| 4:20 p.m. | a7 ß1 integrin promotes muscle integrity, regeneration
and hypertrophy in dystrophic muscle Stephen Kaufman, Univ. of Illinois |
| 4:35 p.m. | Scar Tissue Formation in Injured Skeletal Muscle Yong Li, Univ. of Pittsburgh |
| 7:30 p.m. | Closing keynote address Kevin Campbell, Univ. of Iowa. MUSCLE, Repair Yourself |
Participants
| Pankaj Agrawal Children's Hospital Boston 300 Longwood Ave Enders 5 Boston, MA 02115 Phone: 617-355-8043 Michael Allikian UCLA 10824 Lindbrook Dr Los Angeles, CA 90024 Phone: 310-475-6130 Ilona A. Barash UCSD, Vet Affairs Medical Center 3350 La Jolla Village Dr, Rm 6009 San Diego, CA 92161 Phone: 858-552-8585 x7026 Fax: 858-552-4381 Rita Barresi University of Iowa 400 EMRB Iowa City, IA 52242 Phone: 319-335-7710 Elisabeth R. Barton University of Pennsylvania School of Dental Medicine 240 S 40th St Philadelphia, PA 19104 Phone: 215-573-0887 Fax: 215-573-2324 Aaron Beedle Children's Hospital Boston 300 Longwood Ave Boston, MA 02115 Phone: 617-355-7574 Fax: 617-730-0253 Ulla Bengtsson San Diego State University Life Sciences 371 San Diego, CA 92182-4614 Phone: 619-594-5629 Fax: 619-594-5676 Carmen Bertoni Douglas Biggar Michael J. Blankinship Sue Bodine Kevin P. Campbell Salvatore Carbonetto Pierre G. Carlier Jeff S. Chamberlain Aymeric Chartier Daofen Chen Yi-Wen Chen Martin K. Childers Chow Ida Niaz Cohen Tom A. Cooper Gregory A. Cox Rachelle H. Crosbie Cristina Csimma Univ of Chicago 5841 S Maryland Ave MC6088 Chicago, IL 60637 Phone: 773-702-2684 Fax: 773-702-2681 Diem Dao Wilfred F. Denetclaw Bo Deng Katherine R. Doherty Kati E. Draper Delaina D. Eash Nora Elmonoufy Eva Engvall James M. Ervasti Denise A. Figlewicz Kenneth Fischbeck Robin Fitzsimons Kevin M. Flanigan William H. Foster Eileen Fowler Leslie A. Frieden Tiffany N. Frimel Davide Gabellini Katherine L. Gardner Aggarwall Gaurav Mahaswete Girgenrath David J. Glass Joseph C. Glorioso Ksenija Gorni Katsumasa Goto Robert W. Grange Paul Gregorevic Severine Groh Ling T. Guo Emanuela Gussoni Denis C. Guttridge Charlene Hafer-Macko Susan L. Hamilton Ho Han Renzhi Han Dorit Hanein Laurin M. Hanft Sharon E. Hesterlee Ahlke Heydemann Karen A. Higgs Michio Hirano Eric P. Hoffman James M. Holaska Michael Howard Johnny Huard Kimberly A. Huebsch Bridge Hunter JP K. Hyatt Catherine M. Jankowski J.-P. Jin Motoi Kanagawa Stephen J. Kaufman Jessica A. Kearney Tejvir S. Khurana Yvonne Kobayashi Ralf Krahe Irina Kramerova Elena Y. Kudryashova Louis Kunkel Bryan R. Kuo Karen A. Lapidos Lare Larsson Niall J. Lennon Rebecca Li Sheng Li Zhi Fang Li Richard L. Lieber Qi Long-Lu Sylvia A. Lopez Richard M. Lovering Richard W. Lymn Gordon S. Lynch Fady Malik Paul Martin Karl McCullagh Elizabeth McNally Swapan M. Mehta Jerry R. Mendell Dan Michele Becky M. Miller Gaynor Miller University of Rochester 601 Elmwood Ave Rochester, NY 14642 Phone: 585-275-1200 Fax: 585-756-5189 Behzad Moghadaszadeh Carl A. Morris Richard Moxley III Francesco Muntoni Hal X. Nguyen Kathryn North Jeeyoung Oh Yoshi Ohira Carol S. Okamura Meredith L. Oltmann Cecilia Ostlund Lauren Pachman Stephanie A. Parsons Terence Partridge Grace Pavlath Bradley T. Pawlikowski Masny S. Peter John D. Porter Jill A. Rafael-Fortney Thomas Rando Morayma Reyes Heather I. Rieff Guy Rouleau Samantha J. Routledge Megan J. Roy-Puckelwartz Inna N. Rybakova Jamie L. Sanford Jean M. Sanger Joseph W. Sanger David S. Saperstein James J. Sciote Sameer B. Shah Gloria D. Shelton Kevin J. Sonnemann Espen E. Spangenburg Melissa J. Spencer Hansell H. Stedman Maurice Swanson H. Lee Sweeney Dale D. Tang Stephen J. Tapscott Rabi Tawil Charles A. Thornton James G. Tidball Lubov Timchenko Kinga Tomczak Yuan Torrente Brian S. Tseng Rossella Tupler Silvere M. van der Maarel Judith C. van Deutekom Shannon Venance Peter Verheesen Kathryn Wagner Gregory Q. Wallace Glenn Walter Edith H. Wang Fei Wang Kuan Wang Yaming Wang Michelle Wehling-Henricks Ulla M. Wewer Thurman Wheeler Lisa-Anne Whittemore Sara T. Winokur Christopher Woods Ian Wyglendowski Zipora Yablonka-Reuveni James Yochman Adriane E. Yong Qin Yu Po Zhao Lan Zhou Xiaolan Zhou Anna Zolkiewska |
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