Wallace MR, Olson PE, Rossetti RJ, Hill HE; International Conference on AIDS.
Int Conf AIDS. 1992 Jul 19-24; 8: B132 (abstract no. PoB 3275).
Infectious Disease Division, Naval Hospital, San Diego, California.
OBJECTIVES: To establish the incidence of toxoplasmosis (toxo) infection in a North American adult HIV population, and determine whether cat ownership increases the risk of toxo seroconversion. METHODS: We studied 723 HIV seropositive US Navy and Marine Corps personnel. Patients had a toxo IgG antibody determined on their initial evaluation and annually thereafter. Record review and telephone contacts ascertained whether documented seroconverters had a history of cat ownership in the period of observation. A survey of toxo nonconverters was also conducted to permit calculation of estimated relative risk associated with cat ownership. RESULTS: Serial toxo antibody results were available on 723 patients. Seventy (9.7%) were seropositive for toxo on their initial evaluation. Only 13 (2.0%) seronegative patients seroconverted to toxo during a 5 year follow-up period. Of the 13 toxo seroconverters a pet history was available for 12; only 1 of 12 had owned or lived in a household with a cat during the period of toxo seroconversion (8.3%). Nearly half (48.6%) of a random sample of 80 HIV-infected patients report cat ownership or close contact in the 5 year period. Evaluation of the calculated odds ratio (0.096) and attributable risk (-6.3 per 100 persons annually) strongly suggest that cat ownership does not predispose to seroconversion in this population. CONCLUSION: Toxoplasmosis antibody seroconversion in an adult U.S. HIV infected population is unusual; annual toxo antibody determinations yield little clinically useful data. Toxo seroconversion appears unrelated to cat ownership and advising toxo negative HIV-infected patients not to own cats is not supported by our data.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Adult
- Animals
- Animals, Domestic
- Cats
- Evaluation Studies
- Felidae
- Felis
- HIV
- HIV Antibodies
- HIV Infections
- HIV Seropositivity
- Humans
- Incidence
- Ownership
- Toxoplasmosis
- United States
Other ID:
UI: 102198719
From Meeting Abstracts