Cancer Therapy Evaluation Program (CTEP)Last Updated: 07/31/08
PARTNERSHIPS AND COLLABORATIONS
Industry Collaborations
CTEP is in a unique position to facilitate nonclinical and clinical studies involving combinations of investigational anticancer treatments, especially when the agents are developed by more than one pharmaceutical company. At present, CTEP has more than 100 active INDs, and almost half of these are being co-developed with members of industry.
CTEP Collaborators and Agents
| COLLABORATORS | AGENT NAMES |
|---|---|
| As of November 2007 | |
| Abbott Laboratories | ABT-888 (NSC 737664) |
| Ascenta Therapeutics | (R)-(-)-Gossypol acetic acid (AT-101) (NSC 726456) |
| AstraZeneca International | AZD0530 (NSC 735464) AZD2171 (cediranib) (NSC 732208) AZD6244 (NSC 741078) ZD1839 (gefitinib) (NSC 715055) |
| Bayer Group | BAY 43-9006 tosylate (BAY 54-9085; sorafenib tosylate) (NSC 724772) |
| Berlex Laboratories | Alemtuzumab (NSC 715969) GM-CSF (sargramostim) (NSC 613795) |
| Biogen Idec | In2B8/Y2B8 Radiolabeling Kit (ibritumomab tiuxetan) (NSC 710085) Rituximab (MoAb C2B8 anti CD20, chimeric) (NSC 687451) |
| Bristol-Myers Squibb | BMS-247550 (ixabepilone) (NSC 710428) BMS-214662 (farnesyl transferase inhibitor) (NSC 710086) BMS-354825 (dasatinib) (NSC 732517) |
| Celgene Corporation | CC-5013 (lenalidomide) (NSC 703813) Thalidomide (NSC 66847) |
| Cephalon, Inc. | Arsenic trioxide (As203) (NSC 706363) |
| CuraGen Corporation, TopoTarget | Belinostat (PXD101) (NSC 726630) |
| Cytokinetics, Inc. | SB-715992 (ispinesib) (NSC 727990) |
| Eisai, Inc. | E7389 (halichondrin B analog) (NSC 707389) |
| Gemin X Pharmaceuticals | Obatoclax mesylate (GX15-070MS) (NSC 729280) |
| Genentech, Inc. | Bevacizumab (rhuMAb VEGF) (NSC 704865) Pertuzumab (NSC 740102) Trastuzumab (NSC 688097) |
| Genta Inc. | G3139 (oblimersen) (NSC 683428) |
| GlaxoSmithKline | 506U78 (nelarabine) (NSC 686673) GW572016 (lapatinib) (NSC 727989) GW786034 (pazopanib) (NSC 737754) |
| Gloucester Pharmaceuticals | Romidepsin (depsipeptide; FK228) (NSC 630176) |
| Helsinn Group | XL119 (becatecarin, rebeccamycin analog) (NSC 655649) |
| ImClone Systems | IMC-A12 (NSC 742460) Cetuximab (C225) (NSC 714692) |
| Ipsen | SJG-136 (NSC 694501) |
| Johnson & Johnson | R115777 (tipifarnib) (NSC 702818) |
| Keryx Biopharmaceuticals | O(6)-Benzylguanine (NSC 637037) Perifosine (NSC 639966) UCN-01 (7-hydroxystaurosporine) (NSC 638850) |
| Lorus Therapeutics, Inc. | GTI-2040 (NSC 722929) |
| Medarex, Inc. | MDX-010 (MDX-CTLA4; ipilimumab) (NSC 720801) |
| MedImmune, Inc. | MEDI-522 (monoclonal antibody anti-alpha V beta 3 integrin) (NSC 719850) |
| Merck and Company, Inc. | Suberoylanilide hydroxamic acid (SAHA; vorinostat) (NSC 701852) |
| Merck KgaA | EMD 121974 (cilengitide) (NSC 707544) |
| MGI Pharma, Inc. | Decitabine (5-aza-2'-deoxycytidine) (NSC 127716) Irofulven (MGI-114) (NSC 683863) |
| Millennium Pharmaceuticals | MLN-518 (tandutinib) (NSC 726292) PS-341 (bortezomib) (NSC 681239) |
| Mitos Pharmaceuticals | Tempol (NSC 142784) |
| NewLink Genetics | 1-Methyl-[D]-tryptophan (NSC 721782) |
| Novartis Pharmaceuticals | STI-571 (imatinib) (NSC 716051) |
| Oncolytics Biotech, Inc. | Oncolytic Reovirus (Dearing Type 3) (NSC 729968) |
| OSI Pharmaceuticals | OSI-774 (erlotinib) (NSC 718781) |
| Pfizer, Inc. | Sunitinib malate (SU011248 L-malate) (NSC 736511) |
| Pharmacyclics, Inc. | Motexafin gadolinium (NSC 695238) |
| Pharmion Corporation | Azacitidine (NSC 102816) |
| Reata Pharmaceuticals | CDDO (NSC 711193) |
| Sanofi-aventis | Flavopiridol (alvocidib) (NSC 649890) Oxaliplatin (NSC 266046) Docetaxel (NSC 628563) Tirapazamine (NSC 130181) VEGF Trap (aflibercept) (NSC 724770) |
| Syndax Pharmaceuticals | MS-275 (NSC 706995) |
| Seattle Genetics, Inc. | SGN-30 (NSC 731636) |
| Tigris Pharmaceuticals, Inc. | AFP464 (aminoflavone prodrug) (NSC 710464) |
| The Vaccine Company | Proteinase 3 PR1 peptide (NSC 698102) |
| Vion Pharmaceuticals | Triapine (NSC 663249) |
| Wellstat Biologics Corporation | PV701 (NSC 700553) |
| Wyeth Pharmaceuticals | CCI-779 (temsirolimus) (NSC 683864) |
| Total: 46 | Total: 67 |
