Publications

1. Ravni A, Vaudry D, Gerdin MJ, Eiden MV, Falluel-Morel A, Gonzalez B, Vaudry H, Eiden LE.
   A cAMP-dependent, PKA_independent signaling pathway mediating neuritogenesis through Egr1 in PC12 cells.
   Mol Pharmacol. 2008 Mar 24; [Epub ahead of print]
   PMID: 18362103
   
   
2. Ait-Ali D, Turquier V, Tanguy Y, Thouënnon E, Ghzili H, Mounien L, Derambure C, Jégou S, Salier JP, Vaudry H, Eiden LE, Anouar Y.
   TNF-{alpha} persistently activates NF-{kappa}B signaling through the TNF-R2 in chromaffin cells. Implications for long-term regulation of neuropeptide gene expression in inflammation.
   Endocrinology. 2008 Feb 21; [Epub ahead of print]
   PMID: 18292192
   
   
3. Depboylu C, Eiden LE, Weihe E.
   Increased APOBEC3G expression is associated with extensive G-to-A hypermutation in viral DNA in rhesus macaque brain during lentiviral infection.
   J Neuropathol Exp Neurol. 2007 Oct;66(10):901-12. Erratum in: J Neuropathol Exp Neurol. 2007 Dec;66(12):1159.
   PMID: 17917584
   
   
4. Samal B, Gerdin MJ, Huddleston D, Hsu CM, Elkahloun AG, Stroth N, Hamelink C, Eiden LE.
   Meta-analysis of microarray-derived data from PACAP-deficient adrenal gland in vivo and PACAP-treated chromaffin cells identifies distinct classes of PACAP-regulated genes.
   Peptides. 2007 Sep;28(9):1871-82. Epub 2007 Jun 19.
   PMID: 17651866
   
   
5. Gerdin MJ, Eiden LE.
   Regulation of PC12 cell differentiation by cAMP signaling to ERK independent of PKA: do all the connections add up?
   Sci STKE. 2007 Apr 17;2007(382):pe15. Review.
   PMID: 17440132
   
   
6. Mustafa T, Grimaldi M, Eiden LE.
   The hop cassette of the PAC1 receptor confers coupling to Ca2+ elevation required for pituitary adenylate cyclase-activating polypeptide-evoked neurosecretion.
   J Biol Chem. 2007 Mar 16;282(11):8079-91. Epub 2007 Jan 9.
   PMID: 17213203
   
   
7. Depboylu C, Eiden LE, Schafer MK, Reinhart TA, Mitsuya H, Schall TJ, Weihe E
   Fractalkine expression in the rhesus monkey brain during lentivirus infection and its control by 6-chloro-2',3'-dideoxyguanosine.
   J Neuropathol Exp Neurol. 2006 Dec;65(12):1170-80.
   PMID: 17146291
   
   
8. Chen Y, Samal B, Hamelink CR, Xiang CC, Chen Y, Chen M, Vaudry D, Brownstein MJ, Hallenbeck JM, Eiden LE.
   Neuroprotection by endogenous and exogenous PACAP following stroke
   Regul Pept. 2006 Nov 15;137(1-2):4-19.
   PMID: 17027094
   
   
9. Anouar Y, Eiden LE, Vaudry D.
   Foreword to special issue: molecular and cellular mechanisms of VIP, PACAP and secretin signaling applied to systems biology.
   Regul Pept. 2006 Nov 15;137(1-2):1-3 No abstract available.
   PMID: 16930742
   
   
10. Ravni A, Bourgault S, Lebon A, Chan P, Galas L, Fournier A, Vaudry H, Gonzalez B, Eiden LE, Vaudry D.
    The neurotrophic effects of PACAP in PC12 cells: control by multiple transduction pathways.
    J Neurochem. 2006 Jul;98(2):321-9. Review.
    PMID: 16805827
    
    
11. Ravni A, Eiden LE, Vaudry H, Gonzalez BJ, Vaudry D.
    Cycloheximide treatment to identify components of the transitional transcriptome in PACAP-induced PC12 cell differentiation.
    J Neurochem. 2006 Aug;98(4):1229-41.
    PMID: 16787409
    
    
12. Weihe E, Depboylu C, Schutz B, Schafer MK, Eiden LE.
    Three types of tyrosine hydroxylase-positive CNS neurons distinguished by dopa decarboxylase and VMAT2 co-expression.
    Cell Mol Neurobiol. 2006 Jul-Aug;26(4-6):659-78.
    PMID: 16741673
    
    
13. Weihe E, Schutz B, Hartschuh W, Anlauf M, Schafer MK, Eiden LE.
    Coexpression of cholinergic and noradrenergic phenotypes in human and nonhuman autonomic nervous system.
    J Comp Neurol. 2005 Nov 21;492(3):370-9.
    PMID: 16217790
    
    
14. Depboylu C, Schafer MK, Schwaeble WJ, Reinhart TA, Maeda H, Mitsuya H, Damadzic R, Rausch DM, Eiden LE, Weihe E.
    Increase of C1q biosynthesis in brain microglia and macrophages during lentivirus infection in the rhesus macaque is sensitive to antiretroviral treatment with 6-chloro-2',3'-dideoxyguanosine.
    Neurobiol Dis. 2005 Oct;20(1):12-26.
    PMID: 16137563
    
    
15. Anlauf M, Schafer MK, Schwark T, von Wurmb-Schwark N, Brand V, Sipos B, Horny HP, Parwaresch R, Hartschuh W, Eiden LE, Kloppel G, Weihe E.
    Vesicular Monoamine Transporter 2 (VMAT2) Expression in Hematopoietic Cells and in Patients with Systemic Mastocytosis.
    J Histochem Cytochem. 2005 Aug 22; Epub ahead of print]
    PMID: 16116033
    
16. Vaudry D, Hamelink C, Damadzic R, Eskay RL, Gonzalez B, Eiden LE.
    Endogenous PACAP acts as a stress response peptide to protect cerebellar neurons from ethanol or oxidative insult.
    Peptides. 2005 Jul 8; Epub ahead of print]
    PMID: 16009465
    
    
17. Hand D, Eiden LE.
    Human sorbin is generated via splicing of an alternative transcript from the ArgBP2 gene locus.
    Peptides. 2005 Jul;26(7):1278-82.
    PMID: 15949647
    
    
18. Hamelink C, Hampson A, Wink DA, Eiden LE, Eskay RL.
    Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity.
    J Pharmacol Exp Ther. 2005 Aug;314(2):780-8. Epub 2005 May 5.
    PMID: 15878999
    
    
19. Eiden LE.
    Fusion polypeptides that inhibit exocytosis: fusing aptamer and cell-penetrating peptide technologies and pharmacologies.
    Mol Pharmacol. 2005 Apr;67(4):980-2. Epub 2005 Jan 26.
    PMID: 15673600
    
    
20. Eiden LE.
    A two-way bioinformatic street.
    Science. 2004 Nov 26;306(5701):1437. No abstract available.
    PMID: 15567816
    
    
21. Depboylu C, Reinhart TA, Takikawa O, Imai Y, Maeda H, Mitsuya H, Rausch D, Eiden LE, Weihe E.
    Brain virus burden and indoleamine-2,3-dioxygenase expression during lentiviral infection of rhesus monkey are concomitantly lowered by 6-chloro-2',3'-dideoxyguanosine.
    Eur J Neurosci. 2004 Jun;19(11):2997-3005.
    PMID: 15182307
    
    
22. Anlauf M, Schafer MK, Depboylu C, Hartschuh W, Eiden LE, Kloppel G, Weihe E.
    The vesicular monoamine transporter 2 (VMAT2) is expressed by normal and tumor cutaneous mast cells and Langerhans cells of the skin but is absent from Langerhans cell histiocytosis.
    J Histochem Cytochem. 2004 Jun;52(6):779-88.
    PMID: 15150286
    
    
23. Ait-Ali D, Turquier V, Grumolato L, Yon L, Jourdain M, Alexandre D, Eiden LE, Vaudry H, Anouar Y.
    The proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1 stimulate neuropeptide gene transcription and secretion in adrenochromaffin cells via activation of extracellularly regulated kinase 1/2 and p38 protein kinases, and activator protein-1 transcription factors
    Mol Endocrinol. 2004 Jul;18(7):1721-39. Epub 2004 Apr 15.
    PMID: 15087472
    
    
24. Hamelink C, Hahm SH, Huang H, Eiden LE.
    A restrictive element 1 (RE-1) in the VIP gene modulates transcription in neuronal and non-neuronal cells in collaboration with an upstream tissue specifier element.
    J Neurochem. 2004 Mar;88(5):1091-101.
    PMID: 15009665
    
    
25. Hahm SH, Chen Y, Vinson C, Eiden LE.
    A calcium-initiated signaling pathway propagated through calcineurin and cAMP response element-binding protein activates proenkephalin gene transcription after depolarization.
    Mol Pharmacol. 2003 Dec;64(6):1503-11.
    PMID: 14645681
    
    
26. Schutz B, Damadzic R, Weihe E, Eiden LE.
    Identification of a region from the human cholinergic gene locus that targets expression of the vesicular acetylcholine transporter to a subset of neurons in the medial habenular nucleus in transgenic mice.
    J Neurochem. 2003 Dec;87(5):1174-83.
    PMID: 14622097
    
    
27. Anlauf M, Eissele R, Schafer MK, Eiden LE, Arnold R, Pauser U, Kloppel G, Weihe E.
    Expression of the two isoforms of the vesicular monoamine transporter (VMAT1 and VMAT2) in the endocrine pancreas and pancreatic endocrine tumors.
    J Histochem Cytochem. 2003 Aug;51(8):1027-40.
    PMID: 12871984
    
    
28. Eiden LE, Schafer MK, Weihe E, Schutz B.
    The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine.
    Pflugers Arch. 2004 Feb;447(5):636-40. Epub 2003 Jun 24. Review.
    PMID: 12827358
    
    
29. Feldman SA, Eiden LE.
    The chromogranins: their roles in secretion from neuroendocrine cells and as markers for neuroendocrine neoplasia.
    Endocr Pathol. 2003 Spring;14(1):3-23. Review. No pdf available
    PMID: 12746559
    
    
30. Grumolato L, Elkahloun AG, Ghzili H, Alexandre D, Coulouarn C, Yon L, Salier JP, Eiden LE, Fournier A, Vaudry H, Anouar Y.
    Microarray and suppression subtractive hybridization analyses of gene expression in pheochromocytoma cells reveal pleiotropic effects of pituitary adenylate cyclase-activating polypeptide on cell proliferation, survival, and adhesion.
    Endocrinology. 2003 Jun;144(6):2368-79.
    PMID: 12746297
    
    
31. Anlauf M, Schafer MK, Eiden L, Weihe E.
    Chemical coding of the human gastrointestinal nervous system: cholinergic, VIPergic, and catecholaminergic phenotypes.
    J Comp Neurol. 2003 Apr 21;459(1):90-111.
    PMID: 12629668
    
    
32. Kim T, Tao-Cheng JH, Eiden LE, Peng Loh Y.
    The role of chromogranin A and the control of secretory granule genesis and maturation.
    Trends Endocrinol Metab. 2003 Mar;14(2):56-7. No abstract available.
    PMID: 12591171
    
    
33. Vaudry D, Chen Y, Ravni A, Hamelink C, Elkahloun AG, Eiden LE.
    Analysis of the PC12 cell transcriptome after differentiation with pituitary adenylate cyclase-activating polypeptide (PACAP).
    J Neurochem. 2002 Dec;83(6):1272-84.
    PMID: 12472882
    
    
34. Eiden LE, Hirsch MD.
    Computing the chromaffin cell: a research-community curator/user approach to biocomputation for chromaffin cell biology.
    Ann N Y Acad Sci. 2002 Oct;971:576-83.
    PMID: 12438186
    
    
35. Vaudry D, Chen Y, Hsu CM, Eiden LE.
    PC12 cells as a model to study the neurotrophic activities of PACAP.
    Ann N Y Acad Sci. 2002 Oct;971:491-6. Review. No abstract available.
    PMID: 12438169
    
    
36. Hamelink C, Lee HW, Hsu CM, Eiden LE.
    Role of protein kinases in neuropeptide gene regulation by PACAP in chromaffin cells: a pharmacological and bioinformatic analysis.
    Ann N Y Acad Sci. 2002 Oct;971:474-90.
    PMID: 12438168
    
    
37. Kim T, Tao-Cheng JH, Eiden LE, Loh YP.
    Large dense-core secretory granule biogenesis is under the control of chromogranin A in neuroendocrine cells.
    Ann N Y Acad Sci. 2002 Oct;971:323-31.
    PMID: 12438143
    
    
38. Turquier V, Vaudry H, Yon L, Hsu CM, Ait-Ali D, Grumolato L, Eiden LE, Anouar Y.
    Proinflammatory cytokines TNF-alpha and IL-1alpha stimulate neuropeptide gene expression in adrenochromaffin cells.
    Ann N Y Acad Sci. 2002 Oct;971:45-8. No abstract available.
    PMID: 12438087
    
    
39. Hamelink C, Lee HW, Chen Y, Grimaldi M, Eiden LE.
    Coincident elevation of cAMP and calcium influx by PACAP-27 synergistically regulates vasoactive intestinal polypeptide gene transcription through a novel PKA-independent signaling pathway.
    J Neurosci. 2002 Jul 1;22(13):5310-20.
    PMID: 12097482
    
    
40. Vaudry D, Stork PJ, Lazarovici P, Eiden LE.
    Signaling pathways for PC12 cell differentiation: making the right connections.
    Science. 2002 May 31;296(5573):1648-9. Review.
    PMID: 12040181
    
    
41. Hamelink C, Tjurmina O, Damadzic R, Young WS, Weihe E, Lee HW, Eiden LE.
    Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis.
    Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):461-6. Epub 2001 Dec 26.
    PMID: 11756684
    
    
42. Kim T, Tao-Cheng JH, Eiden LE, Loh YP.
    Chromogranin A, an "on/off" switch controlling dense-core secretory granule biogenesis.
    Cell. 2001 Aug 24;106(4):499-509.
    PMID: 11525735
    
    
43. Schutz B, Weihe E, Eiden LE.
    Independent patterns of transcription for the products of the rat cholinergic gene locus.
    Neuroscience. 2001;104(3):633-42.
    PMID: 11440797
    
    
44. Weihe E, Eiden LE.
    Chemical neuroanatomy of the vesicular amine transporters.
    FASEB J. 2000 Dec;14(15):2435-49. Review.
    PMID: 11099461
    
    
45. Eiden LE.
    The vesicular neurotransmitter transporters: current perspectives and future prospects.
    FASEB J. 2000 Dec;14(15):2396-400. Review. No abstract available.
    PMID: 11099457
    
    
46. Schutz B, Chen L, Schafer MK, Weihe E, Eiden LE.
    Somatomotor neuron-specific expression of the human cholinergic gene locus in transgenic mice.
    Neuroscience. 2000;96(4):707-22.
    PMID: 10727789