Fairon Y, Henrivaux P; International Conference on AIDS.
Int Conf AIDS. 1993 Jun 6-11; 9: 484 (abstract no. PO-B26-2092).
ASBL ID, Liege, Belgium.
OBJECTIVE. In our experience, AZT + INF alpha combination has beneficial antiretroviral effects considering the immunological follow-up. The present report aimed to assess the antiviral efficacy of the addition of INF alpha (Intron A, Schering-Plough) to previously longterm AZT. METHODS. HIV infected patients free of any CDC criteria of AIDS or Kaposi sarcoma and continuously on AZT therapy for at least 6 months, were educated to self administration of subcutaneous INF alpha injection. Two protocols are performed: Pr. A (n = 10) with 15 MUI and Pr. B (n = 13) with 9 MUI INF alpha/week. Every two weeks, clinical and biological evolution were evaluated and p24 Ag was retrospectively determined using a quantitative antigen capture enzyme-linked immunosorbent assay after acid dissociation following the method proposed by Kagayema et al. The results are presented after the first 6 weeks of therapy. RESULTS. Detection of p24 Ag was positive in 4/10 patients in Pr. A and in 8/13 patients in Pr. B. All the patients with p24 Ag+ presented a regularly decrease of p24 Ag levels. The period of analysis seems to be to short to reach negativation. T4/T8 ratio or CD4% was improved in 5/6 p24 Ag- and 2/4 p24 Ag+ during Pr. A and in 5/5 p24 Ag- and 5/8 p24 Ag+ during Pr. B. CONCLUSIONS. The regular decrease of p24 Ag after the addition of INF alpha to a previous longterm AZT therapy confirms that INF alpha has antiretroviral effects. Longer periods of treatment are to be evaluated. The observation that INF alpha has beneficial effects in case of p24 Ag- suggests that INF alpha could also act as immunomodulator.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Anti-HIV Agents
- Evaluation Studies
- HIV
- HIV Antibodies
- HIV Antigens
- HIV Infections
- HIV Seropositivity
- Hemagglutination Tests
- Humans
- Immunologic Techniques
- Infarction
- Zidovudine
- immunology
- organization & administration
Other ID:
UI: 102205082
From Meeting Abstracts