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EIMS SUMMARY REPORT
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| Entry ID: 12180 |
Version: 1.0 |
| Title: TOXICOLOGICAL REVIEW OF CADMIUM AND COMPOUNDS (EXTERNAL REVIEW DRAFT) |
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Notice: This document has been replaced with a final document which may be found on the IRIS web site at
www.epa.gov/iris/subst/0141.htm |
Abstract:
The critical effect proposed for both the oral RfD and inhalation RfC is renal dysfunction as judged by minimal proteinuria/enzymuria. This critical effect is evidenced from several cross-sectional population studies and is best supported by the CadmiBel population study of Buchet et al. (Lancet 336, 1990, 699). A toxicokinetic model was used with the data in this study to calculate both a daily oral intake and a continuous air concentration of cadmium that would result in a 10% occurrence of minimal enzymuria (the critical effect) in the population at the age of 70. A representative level of dietary cadmium intake was integrated into the toxicokinetic model. The net oral intake (model - diet) at 0.7 ug/kg-day (7E-4 mg/kg-day) was designated the oral RfD. The modeled concentration of cadmium inhaled concomitant with this same representative dietary intake at 0. 65 ug/m3 (7E-4 mg/m3) was designated the inhalation RfC.
For both the RfD and the RfC, alternate backgrounds (and therefore different RfDs and RfCs ) are described in the Toxicological Review. Cadmium is classified as a probable human carcinogen by inhalation exposure based on limited evidence from human occupational studies and on animal inhalation studies in which lung cancer was observed. Evidence for cadmium carcinogenicity via the oral route is judged inadequate.
(CAS No. 7440-43-9)
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| Citation: TOXICOLOGICAL REVIEW OF CADMIUM AND COMPOUNDS (EXTERNAL REVIEW DRAFT). U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment, Washington Office, Washington, DC, 1999. |
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| DOWNLOADS / URL LINKS |
6 Files found |
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| 1) |
File Name: |
CAD1.PDF |
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File Description: |
Allows one to view on line the entire document. If you wish to download the entire document, we recommend downloading the cadium.zip file. If you do not wish to download the zip file but want to download the entire document, you must download each of the following files: cad1.pdf, cadcncr5.pdf, cadrfd3.pdf, cadrfc4.pdf, and cadappxc.pdf. |
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PDF |
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409 |
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| 2) |
File Name: |
CADCNCR5.PDF |
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File Description: |
Carcinogenicity Assessment for Lifetime Exposure |
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PDF |
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File Size (KB): |
50 |
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File Date: |
04-MAR-99 |
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NONE |
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EIMS Certification: |
Level 1 |
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NOTE: Some browser versions may not interpret the
filename correctly.
You may need to correct the name manually after downloading.
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| 3) |
File Name: |
CADAPPXC.PDF |
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File Description: |
Appendix C, Benchmark Dose Calculations |
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PDF |
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File Size (KB): |
108 |
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File Date: |
04-MAR-99 |
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NONE |
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EIMS Certification: |
Level 1 |
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NOTE: Some browser versions may not interpret the
filename correctly.
You may need to correct the name manually after downloading.
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| 4) |
File Name: |
CADRFD3.PDF |
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File Description: |
Reference Dose for Chronic Oral Exposure (RfD) |
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PDF |
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File Size (KB): |
34 |
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File Date: |
04-MAR-99 |
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Compression Status: |
NONE |
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EIMS Certification: |
Level 1 |
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NOTE: Some browser versions may not interpret the
filename correctly.
You may need to correct the name manually after downloading.
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| 5) |
File Name: |
CADRFC4.PDF |
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File Description: |
Reference Concentration for Chronic Inhalation (RfC) |
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PDF |
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File Size (KB): |
61 |
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File Date: |
04-MAR-99 |
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Compression Status: |
NONE |
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EIMS Certification: |
Level 1 |
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Connection Type: |
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NOTE: Some browser versions may not interpret the
filename correctly.
You may need to correct the name manually after downloading.
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| 6) |
File Name: |
CADMIUM.ZIP |
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File Description: |
Zip file of entire cadmium document. |
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ZIP |
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File Size (KB): |
521 |
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ZIP |
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EIMS Certification: |
Level 1 |
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NOTE: Some browser versions may not interpret the
filename correctly.
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| CONTACTS |
1 Contact found |
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| Name: GARY L. FOUREMAN |
| Role: PRINCIPAL INVESTIGATOR |
| Primary Phone: 9195411183 |
Alternate Phone: |
| Mobile Phone: |
Pager: |
| Fax: 919-541-1818 |
| Primary Email: foureman.gary@epa.gov |
| Alternate Email: foureman.gary@epamail.epa.gov |
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Administrative Details
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| ADMINISTRATIVE DETAILS |
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| Entry ID: 12180 |
Version: 1.0 |
| Title: TOXICOLOGICAL REVIEW OF CADMIUM AND COMPOUNDS (EXTERNAL REVIEW DRAFT) |
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| Information Type: DOCUMENT |
Information Subtype: |
| Entry Date: 09-FEB-00 |
Revision Date: 03-JAN-06 |
| Release Date: 09-FEB-00 |
Review Date: |
| Sunset Date: |
Retire Date: |
| Status: REVIEWED |
| EIMS Partner: NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT (ORD-NCEA) |
| Collections: GENERAL, ARCHIVE, SCIENCE INVENTORY, ORD PUBLICATIONS |
| DEP: MAUREEN JOHNSON |
| Availability: PUBLIC |
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