ROMERO-SANCHEZ A, CASTRO-CASTANEDA B, ABAD-GASTELUM MA, FIGUEROA-ORTIZ JA, AMADOR-LARA F, ANDRADE-VILLANUEVA J; Interscience Conference on Antimicrobial Agents and Chemotherapy (41st : 2001 : Chicago, Ill.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2001 Dec 16-19; 41: abstract no. L-894.

Hospital General de Occidente, SSA, Zapopan, Mexico

BACKGROUND: Multiple treatments for genital warts (GW) have been used, but none have achieved complete remission. Relapses have been found in 20-30% or more. The aim of this study was to compare the efficacy and side effects of 5% Imiquimod (IMQ) cream a new immunomodulator, vs 1% 5-fluorouracil (5-FU) cream for the treatment of GW. METHODS: A prospective, randomized, double-blind study was conducted with the use of 5% IMQ cream vs 1% 5-FU. The cream was applied 3 times weekly in both groups for 16 weeks or less if the GW disappeared. Patients were followed-up for 12 weeks after treatment to evaluate relapses. RESULTS: Fifty five patients were included in each group. Fifty patients (90.9%) of IMQ group and 49 (89%) of 5-FU group completed treatment. Thirty two patients (58.1%) of IMQ group and 20 from the 5-FU group (36-6%) had complete remission of GW (p=NS). Partial response was found in 20 patients (36.3%) of the IMQ and in 26 (47.2%) of the 5-FU group (p=NS). Failure of treatment was found in 3 patients (5.4%) of the IMQ group and in 8 (14.5%) of the 5-FU group (p=NS). The time to achieve remission was shorter in patients treated with IMQ than those with 5-FU (11.7 vs 13.3 weeks respectively, p<.01). Side effects occurred in 24 patients (43.6%) treated with IMQ and in 28 (50.9%) with 5-FU (p=NS). There was no significant difference in the interruption of therapy due to side effects between IMQ group and 5-FU group (1.8% vs 5.4% respectively). One patient from IMQ group relapsed during the 12-week follow-up. CONCLUSIONS: The 5% IMQ cream is as effective as 1% 5-FU cream in the eradication of GC in male patients with less time for achieving cure, similar side effects and lower percentage of relapse.

Publication Types:

• Meeting Abstracts

Keywords:

• Aminoquinolines
• Condylomata Acuminata
• Double-Blind Method
• Genital Diseases, Male
• Humans
• Longitudinal Studies
• Male
• Placebos
• Recurrence
• Remission Induction
• imiquimod
• therapy

Other ID:

• GWAIDS0030870

UI: 102270507

From Meeting Abstracts