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EIMS SUMMARY REPORT
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| Entry ID: 29528 |
Version: 3.0 |
| Title: IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR BORON AND COMPOUNDS (THIRD EXTERNAL REVIEW DRAFT) |
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| Notice: These draft documents have been or are in the process of being replaced with final documents which may be found on the IRIS home page at www.epa.gov/iris/. |
Abstract:
The U. S. EPA is conducting a peer review of the scientific basis supporting the health hazard and dose response assessment for Boron that will appear on the Agency's online data base, the Integrated Risk Information System (IRIS). Peer Review is meant to ensure that science is used credibly and appropriately in derivation of these dose-response assessments. The primary function of the peer reviewer should be to judge whether the choice, use and interpretation of the data employed in the derivation of the assessment is appropriate and scientifically sound. The IRIS Toxicological Review for Boron and IRIS Summary Sheets have previously gone through an internal and external review. However certain sections of the Toxicological Review have been revised since these peer reviews took place. Revisions to the last external review draft were made based on some external reviewer comments and comments from the public when the external review was posed on the NCEA web. The previous method for using data to derive an uncertainty factor has been revised with this new draft. This method has been through the agency's internal review process and has been submitted for one more formal external peer review. Due to the amount of review that this document has already received we are requesting review comments only on the revised method of using toxicokinetic data to replace uncertainty factors. This review would include an analysis of Section 5.1.3. of the Toxicological Review and the Section 1.A.3. of the RfD Summary Sheet. This review is needed before the Toxicological Review and IRIS Summary sheets for Boron are forwarded to the EPA's Consensus Review Process for final approval and adoption by the EPA. These hazard and dose-response assessments will then appear on IRIS and become available as agency consensus health effect information.
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| Citation: U.S. EPA. IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR BORON AND COMPOUNDS (THIRD EXTERNAL REVIEW DRAFT). 2002. |
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| Additional Information: EPA is hereby providing for public information a draft Toxicological Review, draft IRIS Summary, and charge to external peer reviewers for EPA's health assessment of boron. These documents are provided for public viewing during an external scientific peer review period. While EPA is not soliciting public comments by this action, any scientific views received on the content of the Toxicological Review or IRIS Summary prior to May 30, 2002 will be considered in subsequent drafts. To access or download the external review draft boron document and related IRIS Summary, please refer to the Downloads/URL Links on the left sidebar.
Please direct any correspondence to: Carolyn Smallwood c/o US EPA/NCEA (MS 190) 26 W Martin Luther King Cincinnati, Ohio 45268 or email to smallwood.carolyn@epa.gov. Also, please send a recordkeeping copy to: IRIS Submission Desk, c/o ASRC, 6301 Ivy Lane, Suite 300, Greenbelt, MD 20770 or email to IRIS.desk@epa.gov. |
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| DOWNLOADS / URL LINKS |
3 Files found |
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| 1) |
File Name: |
BORON_IRIS_SUMMARY3.PDF |
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File Description: |
IRIS Summary - Boron (External Review Draft)
This document presents background information and justification for the hazard and dose-response assessment summaries in EPA's Integrated Risk Information System (IRIS). IRIS summaries may include an oral reference dose (RfD), inhalation reference concentration (RfC), and a carcinogenicity assessment. |
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File Type: |
PDF |
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Application Version: |
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File Size (KB): |
312 |
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File Date: |
25-APR-02 |
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Compression Status: |
NONE |
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EIMS Certification: |
Level 1 |
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Connection Type: |
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| 2) |
File Name: |
BORON_CHARGE_TO_REVIEWERS3.PDF |
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File Description: |
Instructions to Peer Reviewers for Reviewing IRIS Summaries and Supporting Documentation for Boron (CAS No. 1330-20-7) |
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File Type: |
PDF |
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Application Version: |
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File Size (KB): |
35 |
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File Date: |
25-APR-02 |
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Compression Status: |
NONE |
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EIMS Certification: |
Level 1 |
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| 3) |
File Name: |
BORON_TOXREVIEW_EXTDRAFT3.PDF |
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File Description: |
Toxicological Review of Boron (External Review Draft) The purpose of this Toxicological Review is to provide scientific support and rationale for the hazard identification and dose-response assessment in IRIS pertaining to chronic exposure to boron. It is not intended to be a comprehensive treatise on the chemical or toxicological nature of boron.
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File Type: |
PDF |
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Application Version: |
3.0 |
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File Size (KB): |
1121 |
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File Date: |
01-APR-02 |
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Compression Status: |
NONE |
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EIMS Certification: |
Level 1 |
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Connection Type: |
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NOTE: Some browser versions may not interpret the
filename correctly.
You may need to correct the name manually after downloading.
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| CONTACTS |
2 Contacts found |
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| Name: U.S. EPA |
| Role: AUTHOR |
| Primary Phone: |
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| Alternate Email: |
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| Name: CAROLYN SMALLWOOD |
| Role: PRINCIPAL INVESTIGATOR |
| Primary Phone: 5135697425 |
Alternate Phone: |
| Mobile Phone: |
Pager: |
| Fax: |
| Primary Email: smallwood.carolyn@epa.gov |
| Alternate Email: smallwood.carolyn@epamail.epa.gov |
| Organization: |
| U.S. Environmental Protection Agency |
| Office of Research and Development |
| National Center for Environmental Protection |
| Cincinnati Office |
| Mailing Address: |
| 26 W. Martin Luther King Drive |
| MS 117 |
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Cincinnati
, OH
45268
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| Organization: |
| US ENVIRONMENTAL PROTECTION AGENCY |
| OFFICE OF RESEARCH AND DEVELOPMENT |
| NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT |
| CINCINNATI OH |
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| RELATED ENTRIES |
1 Related Entry found |
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1)
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Related Entry ID:
20852
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Version: 1.0
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Information Type: DOCUMENT
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Title: TOXICOLOGICAL REVIEW OF BORON AND COMPOUNDS [AND IRIS SUMMARY] (EXTERNAL REVIEW DRAFT)
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Relationship Reason: PREVIOUS VERSION OF EXTERNAL REVIEW DRAFT.
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Administrative Details
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| ADMINISTRATIVE DETAILS |
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| Entry ID: 29528 |
Version: 3.0 |
| Title: IRIS TOXICOLOGICAL REVIEW AND SUMMARY DOCUMENTS FOR BORON AND COMPOUNDS (THIRD EXTERNAL REVIEW DRAFT) |
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| Information Type: DOCUMENT |
Information Subtype: |
| Entry Date: 03-MAY-02 |
Revision Date: 24-JUL-07 |
| Release Date: 03-MAY-02 |
Review Date: 10-DEC-02 |
| Sunset Date: |
Retire Date: |
| Status: REVIEWED |
| EIMS Partner: NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT (ORD-NCEA) |
| Collections: GENERAL, SCIENCE INVENTORY, ORD PUBLICATIONS |
| DEP: MAUREEN JOHNSON |
| Availability: PUBLIC |
Access Procedures:
No access procedures specified. |
Access Restrictions:
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| 1-5) |
IRIS; Integrated Risk Information System; Toxicological Review; Boron and Compounds; Boron |
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| Acronym: |
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| IRIS |
Integrated Risk Information System |
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