Organism

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Organism

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Chemical Name: Benzamide, N-[1-[(2S,4R)-4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]tetrahydro-4-phenyl-2-furanyl]-1,2-dihydro-2-oxo-4-pyrimidinyl]-			Synonyms		AIDS# 415453
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 415453
.BETA.-ISOMER
C28 H35 N3 O4 Si		MW: 505.69			Links to PubMed by CAS#
H-bond donors: 1	H-bond acceptors: 7	PHIA (Flexible Bonds): 7.77	Calc. LogP (MDL QSAR): 7.13
Company:			Calc. LogP (KowWin): 5.63
Lines of Data: 1	Anti-HIV Enzyme data: 0	Lines of Data: 3	TB Min MIC	TB Min IC50	Links to NIST by AIDS#
Number of References: 1	Number of References: 0	Number of References: 1	Lipinski: 2 (Score, out of 4)
Classes: PYRIMIDINE DIDEOXYNUCLEOSIDES; NUCLEOSIDES, APIO

Anti-HIV Cellular Data Summary

*HIV STRAIN TYPE*	*CELL TYPE*	*EC50*	*IC50*	TI	*TARGET*	*MUTATIONS*	REL RESISTANCE FOLD INCREASE	*LIT. REF. #*	ALL IN-VITRO DATA
HIV-1	MT-4	> 100000						15129	View

Chemical Name: Benzamide, N-[1-[(2R,4R)-4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]tetrahydro-4-phenyl-2-furanyl]-1,2-dihydro-2-oxo-4-pyrimidinyl]-			Synonyms		AIDS# 415454
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 415454
.ALPHA.-ISOMER
C28 H35 N3 O4 Si		MW: 505.69			Links to PubMed by CAS#
H-bond donors: 1	H-bond acceptors: 7	PHIA (Flexible Bonds): 7.77	Calc. LogP (MDL QSAR): 7.13
Company:			Calc. LogP (KowWin): 5.63
Lines of Data: 1	Anti-HIV Enzyme data: 0	Lines of Data: 3	TB Min MIC	TB Min IC50	Links to NIST by AIDS#
Number of References: 1	Number of References: 0	Number of References: 1	Lipinski: 2 (Score, out of 4)
Classes: PYRIMIDINE DIDEOXYNUCLEOSIDES; NUCLEOSIDES, APIO

Anti-HIV Cellular Data Summary

*HIV STRAIN TYPE*	*CELL TYPE*	*EC50*	*IC50*	TI	*TARGET*	*MUTATIONS*	REL RESISTANCE FOLD INCREASE	*LIT. REF. #*	ALL IN-VITRO DATA
HIV-1	MT-4	> 100000						15129	View

Chemical Name: 2(1H)-Pyrimidinone, 4-amino-1-[(2S,4R)-4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]tetrahydro-4-phenyl-2-furanyl]-			Synonyms		AIDS# 415455
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 415455

C21 H31 N3 O3 Si		MW: 401.58			Links to PubMed by CAS#
H-bond donors: 1	H-bond acceptors: 6	PHIA (Flexible Bonds): 5.98	Calc. LogP (MDL QSAR): 5.09
Company:			Calc. LogP (KowWin): 3.78
Lines of Data: 1	Anti-HIV Enzyme data: 0	Lines of Data: 3	TB Min MIC	TB Min IC50	Links to NIST by AIDS#
Number of References: 1	Number of References: 0	Number of References: 1	Lipinski: 3 (Score, out of 4)
Classes: PYRIMIDINE DIDEOXYNUCLEOSIDES; NUCLEOSIDES, APIO

Anti-HIV Cellular Data Summary

*HIV STRAIN TYPE*	*CELL TYPE*	*EC50*	*IC50*	TI	*TARGET*	*MUTATIONS*	REL RESISTANCE FOLD INCREASE	*LIT. REF. #*	ALL IN-VITRO DATA
HIV-1	MT-4	> 100000						15129	View

Chemical Name: 2(1H)-Pyrimidinone, 4-amino-1-[(2S,4S)-tetrahydro-4-(hydroxymethyl)-4-phenyl-2-furanyl]-			Synonyms		AIDS# 415456
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 415456

C15 H17 N3 O3		MW: 287.32			Links to PubMed by CAS#
H-bond donors: 2	H-bond acceptors: 6	PHIA (Flexible Bonds): 3.69	Calc. LogP (MDL QSAR): 1.09
Company:			Calc. LogP (KowWin): -0.05
Lines of Data: 1	Anti-HIV Enzyme data: 0	Lines of Data: 3	TB Min MIC	TB Min IC50	Links to NIST by AIDS#
Number of References: 1	Number of References: 0	Number of References: 1	Lipinski: 4 (Score, out of 4)
Classes: PYRIMIDINE DIDEOXYNUCLEOSIDES; NUCLEOSIDES, APIO

Anti-HIV Cellular Data Summary

*HIV STRAIN TYPE*	*CELL TYPE*	*EC50*	*IC50*	TI	*TARGET*	*MUTATIONS*	REL RESISTANCE FOLD INCREASE	*LIT. REF. #*	ALL IN-VITRO DATA
HIV-1	MT-4	> 100000						15129	View

Chemical Name: 9H-Purine, 6-chloro-9-[(2S,4R)-4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]tetrahydro-4-phenyl-2-furanyl]-			Synonyms		AIDS# 415457
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 415457
.BETA.-ISOMER
C22 H29 Cl N4 O2 Si		MW: 445.04			Links to PubMed by CAS#
H-bond donors: 0	H-bond acceptors: 6	PHIA (Flexible Bonds): 5.82	Calc. LogP (MDL QSAR): 5.17
Company:			Calc. LogP (KowWin): 5.41
Lines of Data: 1	Anti-HIV Enzyme data: 0	Lines of Data: 3	TB Min MIC	TB Min IC50	Links to NIST by AIDS#
Number of References: 1	Number of References: 0	Number of References: 1	Lipinski: 3 (Score, out of 4)
Classes: PURINE DIDEOXYNUCLEOSIDES; NUCLEOSIDES, APIO

Anti-HIV Cellular Data Summary

*HIV STRAIN TYPE*	*CELL TYPE*	*EC50*	*IC50*	TI	*TARGET*	*MUTATIONS*	REL RESISTANCE FOLD INCREASE	*LIT. REF. #*	ALL IN-VITRO DATA
HIV-1	MT-4	> 100000						15129	View

Chemical Name: 9H-Purine, 6-chloro-9-[(2R,4R)-4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]tetrahydro-4-phenyl-2-furanyl]-			Synonyms		AIDS# 415458
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 415458
.ALPHA.-ISOMER
C22 H29 Cl N4 O2 Si		MW: 445.04			Links to PubMed by CAS#
H-bond donors: 0	H-bond acceptors: 6	PHIA (Flexible Bonds): 5.82	Calc. LogP (MDL QSAR): 5.17
Company:			Calc. LogP (KowWin): 5.41
Lines of Data: 1	Anti-HIV Enzyme data: 0	Lines of Data: 3	TB Min MIC	TB Min IC50	Links to NIST by AIDS#
Number of References: 1	Number of References: 0	Number of References: 1	Lipinski: 3 (Score, out of 4)
Classes: PURINE DIDEOXYNUCLEOSIDES; NUCLEOSIDES, APIO

Anti-HIV Cellular Data Summary

*HIV STRAIN TYPE*	*CELL TYPE*	*EC50*	*IC50*	TI	*TARGET*	*MUTATIONS*	REL RESISTANCE FOLD INCREASE	*LIT. REF. #*	ALL IN-VITRO DATA
HIV-1	MT-4	> 100000						15129	View

Chemical Name: 9H-Purine, 6-amino-9-[(2S,4R)-4-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]tetrahydro-4-phenyl-2-furanyl]-			Synonyms		AIDS# 415459
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 415459

C22 H31 N5 O2 Si		MW: 425.61			Links to PubMed by CAS#
H-bond donors: 1	H-bond acceptors: 6	PHIA (Flexible Bonds): 5.6	Calc. LogP (MDL QSAR): 4.67
Company:			Calc. LogP (KowWin): 4.86
Lines of Data: 1	Anti-HIV Enzyme data: 0	Lines of Data: 3	TB Min MIC	TB Min IC50	Links to NIST by AIDS#
Number of References: 1	Number of References: 0	Number of References: 1	Lipinski: 4 (Score, out of 4)
Classes: PURINE DIDEOXYNUCLEOSIDES; NUCLEOSIDES, APIO

Anti-HIV Cellular Data Summary

*HIV STRAIN TYPE*	*CELL TYPE*	*EC50*	*IC50*	TI	*TARGET*	*MUTATIONS*	REL RESISTANCE FOLD INCREASE	*LIT. REF. #*	ALL IN-VITRO DATA
HIV-1	MT-4	> 100000						15129	View

Chemical Name: 3-Furanmethanol, 5-(6-amino-9H-purin-9-yl)tetrahydro-3-phenyl-, (3S,5S)-			Synonyms		AIDS# 415460
					Links to ChemID Plus by CAS#
					Links to PubChem by AIDS# 415460

C16 H17 N5 O2		MW: 311.34			Links to PubMed by CAS#
H-bond donors: 2	H-bond acceptors: 6	PHIA (Flexible Bonds): 3.42	Calc. LogP (MDL QSAR): 0.82
Company:			Calc. LogP (KowWin): 1.02
Lines of Data: 1	Anti-HIV Enzyme data: 0	Lines of Data: 3	TB Min MIC	TB Min IC50	Links to NIST by AIDS#
Number of References: 1	Number of References: 0	Number of References: 1	Lipinski: 4 (Score, out of 4)
Classes: PURINE DIDEOXYNUCLEOSIDES; NUCLEOSIDES, APIO

Anti-HIV Cellular Data Summary

*HIV STRAIN TYPE*	*CELL TYPE*	*EC50*	*IC50*	TI	*TARGET*	*MUTATIONS*	REL RESISTANCE FOLD INCREASE	*LIT. REF. #*	ALL IN-VITRO DATA
HIV-1	MT-4	> 100000						15129	View

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