National Toxicology Program

CASRN: 33857-26-0

Formula: C12 H6 CL2 O2

Synonyms/Common Names:

• DCDD
• 2,7-DICHLORO-DIBENZO(B,E)(1,4)DIOXIN (9CI)

Known Uses:

BY-PRODUCT IN MANUFACTURE OF A GERMICIDE AND HERBICIDE

Short-Term Toxicity

• 2-WEEK (Dosed-Feed)  (C03667B) Completed 
  • NTIS No. PB290570  (Peer Review 01/00/1977)
    Citation: Bioassay of 2,7-Dichlorodibenzo-p-dioxin (DCDD) for Possible Carcinogenicity (CAS No. 33857-26-0)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-WEEK (Dosed-Feed)  (C03667B) Completed 
  • NTIS No. PB290570  (Peer Review 01/00/1977)
    Citation: Bioassay of 2,7-Dichlorodibenzo-p-dioxin (DCDD) for Possible Carcinogenicity (CAS No. 33857-26-0)
  • Rats: Osborne Mendel; Mice: B6C3F1

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C03667B) Report Complete 
  • TR-123 (NTIS No. PB290570)  (Peer Review 01/00/1977)
    Bioassay of 2,7-Dichlorodibenzo-p-dioxin (DCDD) for Possible Carcinogenicity (CAS No. 33857-26-0)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Equivocal 
  • Female Mice Negative 
  • Dose: 0,5000,10000 PPM/35R - 50M PER GROUP

Genetic Toxicology

• Salmonella  (061158) Completed 
  • Citation: Mortelmans, K., Haworth, S., Speck, W., and Zeiger, E. Mutagenicity testing of Agent Orange components and related chemicals Toxicology and Applied Pharmacology Vol. 75 (1984) 137-146
  •  Negative